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| 1 | Breast cancer development and progression:Risk factors,cancer stem cells,signaling pathways,genomics,and molecular pathogenesis显示文摘As the most commonly occurring cancer in women worldwide,breast cancer poses a formidable public health challenge on a global scale.Breast cancer consists of a group of biologically and molecularly heterogeneous diseases originated from the breast.While the risk factors associated with this cancer varies with respect to other cancers,genetic predisposition,most notably mutations in BRCA1 or BRCA2 gene,is an important causative factor for this malignancy.Breast cancers can begin in different areas of the breast,such as the ducts,the lobules,or the tissue in between.Within the large group of diverse breast carcinomas,there are various denoted types of breast cancer based on their invasiveness relative to the primary tumor sites.It is important to distinguish between the various subtypes because they have different prognoses and treatment implications.As there are remarkable parallels between normal development and breast cancer progression at the molecular level,it has been postulated that breast cancer may be derived from mammary cancer stem cells.Normal breast development and mammary stem cells are regulated by several signaling pathways,such as estrogen receptors(ERs),HER2,and Wnt/b-catenin signaling pathways,which control stem cell proliferation,cell death,cell differentiation,and cell motility.Furthermore,emerging evidence indicates that epigenetic regulations and noncoding RNAs may play important roles in breast cancer development and may contribute to the heterogeneity and metastatic aspects of breast cancer,especially for triple-negative breast cancer.This review provides a comprehensive survey of the molecular,cellular and genetic aspects of breast cancer. | Yixiao Feng Mia Spezia Shifeng Huang Chengfu Yuan Zongyue Zeng Linghuan Zhang Xiaojuan Ji Wei Liu Bo Huang Wenping Luo Bo Liu Yan Lei Scott Du Akhila Vuppalapati Hue H.Luu Rex C.Haydon Tong-Chuan He Guosheng Ren | 2018 | Genes & Diseases2018，5，2： | 24 |
| 2 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 3 | Process optimization of neodymium chloride solutions precipitated by magnesium bicarbonate显示文摘Rare earths(REs) are of vital importance for the development of new materials and green energy.Magnesium bicarbonate is one of the most recyclable and environmental-friendly precipitant for REs recovery from leaching solutions. Nd_2(CO_3)_3 has difficulties in industrial production. So in this study,the precipitation of neodymium from chloride solution by magnesium bicarbonate are investigated. The effects of feeding method, [HCO_3^-]/[Nd^(3+)] mole ratio, feeding speed and reaction temperature on yield and impurity(magnesia) content are systematically studied. Results show that the impurity(magnesia)content decreases to 0.010 wt% with a yield approaching to 100% obtained under the conditions of[HCO_3^-]/[Nd^(3+)] = 3.00 by parallel flow addition at 50 ℃. The major impurity(magnesia) in rare earth carbonates mainly presents in the form of physical absorption, which can be easily removed by scrubbing. Therefore, it offers a promising green process that uses magnesium bicarbonate to produce neodymium carbonate due to its cycling of carbon dioxide, magnesium salt and waste water. | Yannan Yan Yang Xu Xiaowei Huang Zongyu Feng Yongke Hou Kai Li Liangshi Wang Yihanna Hu | 2019 | Journal of Rare Earths2019，37，4： | 10 |
| 4 | Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleiotropic effects on stem cell differentiation,angiogenesis,tumor growth and metabolism显示文摘Bone morphogenetic protein 9(BMP9)(or GDF2)was originally identified from fetal mouse liver cDNA libraries.Emerging evidence indicates BMP9 exerts diverse and pleiotropic functions during postnatal development and in maintaining tissue homeostasis.However,the expression landscape of BMP9 signaling during development and/or in adult tissues remains to be analyzed.Here,we conducted a comprehensive analysis of the expression landscape of BMP9 and its signaling mediators in postnatal mice.By analyzing mouse ENCODE transcriptome datasets we found Bmp9 was highly expressed in the liver and detectable in embryonic brain,adult lungs and adult placenta.We next conducted a comprehensive qPCR analysis of RNAs isolated from major mouse tissues/organs at various ages.We found that Bmp9 was highly expressed in the liver and lung tissues of young adult mice,but decreased in older mice.Interestingly,Bmp9 was only expressed at low to modest levels in developing bones.BMP9-associated TGFβ/BMPR type I receptor Alk1 was highly expressed in the adult lungs.Furthermore,the feedback inhibitor Smads Smad6 and Smad7 were widely expressed in mouse postnatal tissues.However,the BMP signaling antagonist noggin was highly expressed in fat and heart in the older age groups,as well as in kidney,liver and lungs in a biphasic fashion.Thus,our findings indicate that the circulating BMP9 produced in liver and lungs may account for its pleiotropic effects on postnatal tissues/organs although possible roles of BMP9 signaling in liver and lungs remain to be fully understood. | Wei Liu Zhongliang Deng Zongyue Zeng Jiaming Fan Yixiao Feng Xi Wang Daigui Cao Bo Zhang Lijuan Yang Bin Liu Mikhail Pakvasa William Wagstaff Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Huiming Ding Yongtao Zhang Changchun Niu Rex C.Haydon Hue H.Luu Jennifer Moriatis Wolf Michael J.Lee Wei Huang Tong-Chuan He Yulong Zou | 2020 | Genes & Diseases2020，7，2： | 9 |
| 5 | Establishment and functional characterization of the reversibly immortalized mouse glomerular podocytes(imPODs)显示文摘Glomerular podocytes are highly specialized epithelial cells and play an essential role in establishing the selective permeability of the glomerular filtration barrier of kidney.Maintaining the viability and structural integrity of podocytes is critical to the clinical management of glomerular diseases,which requires a thorough understanding of podocyte cell biology.As mature podocytes lose proliferative capacity,a conditionally SV40 mutant tsA58-immortalized mouse podocyte line(designated as tsPC)was established from the Immortomouse over 20 years ago.However,the utility of the tsPC cells is hampered by the practical inconvenience of culturing these cells.In this study,we establish a user-friendly and reversibly-immortalized mouse podocyte line(designated as imPOD),on the basis of the tsPC cells by stably expressing the wildtype SV40 T-antigen,which is flanked with FRT sites.We show the imPOD cells exhibit long-term high proliferative activity,which can be effectively reversed by FLP recombinase.The imPOD cells express most podocyte-related markers,including WT-1,Nephrin,Tubulin and Vinculin,but not differentiation marker Synaptopodin.The imPOD cells do not form tumor-like masses in vivo.We further demonstrate that TGFb1 induces a podocyte injury-like response in the FLP-reverted imPOD cells by suppressing the expression of slit diaphragm-associated proteins P-Cadherin and ZO-1 and upregulating the expression of mesenchymal markers,a-SMA,Vimentin and Nestin,as well as fibrogenic factors CTGF and Col1a1.Collectively,our results strongly demonstrate that the newly engineered im-POD cells should be a valuable tool to study podocyte biology both under normal and under pathological conditions. | Xinyi Yu Liqun Chen Ke Wu Shujuan Yan Ruyi Zhang Chen Zhao Zongyue Zeng Yi Shu Shifeng Huang Jiayan Lei Xiaojuan Ji Chengfu Yuan Linghuan Zhang Yixiao Feng Wei Liu Bo Huang Bo Zhang Wenping Luo Xi Wang Bo Liu Rex C.Haydon Hue H.Luu Tong-Chuan He Hua Gan | 2018 | Genes & Diseases2018，5，2： | 5 |
| 6 | Extraction kinetics of neodymium from chloride medium using HEH/EHP saponified with magnesium bicarbonate solution显示文摘Magnesium bicarbonate solution is considered as an environmentally friendly extractant saponification agent for the solvent extraction of rare earth elements due to its advantage of minimum water pollution.In order to reveal the extraction regularity, optimize production-process and guide the use of this new extraction system, the extraction of Nd(Ⅲ) in chloride medium with HEH/EHP saponified by magnesium bicarbonate solution was investigated with the self-designed constant interfacial area cell. Besides, the effects of stirring rate, temperature, specific interfacial area and concentration of Mg-HEH/EHP on the extraction rate of Nd(Ⅲ) were systematically investigated. Results show that, the rate of extraction is governed by both diffusion and chemical reaction, and the extraction reaction takes place at the interface. The apparent activation energy of the extraction reaction is 16.88 kJ/mol. The corresponding rate equation is deduced. The mechanisms and rate-determining step are speculated based on interfacial reaction models, which is consistent with the experimental results. | Hao Lv Xiaowei Huang Zongyu Feng Meng Wang Xu Sun Xinlin Peng Dali Cui Yihanna Hu | 2019 | Journal of Rare Earths2019，37，3： | 4 |
| 7 | Grain boundary segregation and its influences on ionic conduction properties of scandia doped zirconia electrolytes显示文摘Solid oxide fuel cell is a promising energy conversion system which converts chemical energy into electrical energy directly. Electrolyte is the key component and determines the working temperature. In this paper,ceria and scandia co-doped zirconia electrolytes sintered from 1300 to 1550 ℃ were chosen as research objects. Scanning electron microscopy, X-ray diffraction and transmission electron microscopy were performed to characterize the ceramic samples. The effects of grain size and grain boundary element segregation on the electrical conductivity were focused. Electrochemical impedance spectroscopy was used to calculate the bulk, grain boundary and specific grain boundary conductivity. Results show that the bulk and grain boundary ionic conductivity increases with the increasing grain size.However, the specific grain boundary conductivity decreases with the increasing grain size. This is explained by the fact that Sc^(3+) is segregated at the grain boundary, which leads to higher oxygen vacancy concentration when sintered at lower temperature. | Qiannan Xue Xiaowei Huang Jianxing Zhang He Zhang Zongyu Feng | 2019 | Journal of Rare Earths2019，37，6： | 4 |
| 8 | Recovery of rare earths and aluminum from FCC waste slag by acid leaching and selective precipitation显示文摘This paper investigated the recovery of rare earth elements(REEs) and aluminum(AI) from the waste slag discharged by FCC catalyst factory(FCC waste slag) via acid leaching and selective precipitation.Analysis methods such as ICP-AES, XRF and XRD were applied to obtain experiment data. The maximum leaching efficiency of REEs and Al was achieved at pH value of 1 and with liquid to solid ratio of 4:1,Under such conditions, 91.01%, 92.24% and 94.77% of La, Ce and Al were extracted at 20 ℃ for 2 h from the FCC waste slag, respectively. The SiO_2 content in the leaching residue was 88.3%, which can be used as an available silicon resource. The REEs can be precipitated in the form of REEs and sodium double sulfate(NaRE(SO_4)_2·xH_2 O) by adding Na_2 SO_4 to the leaching solution, while Al remained in the solution. Afterwards, the pH value of the filtrate was adjusted to 4.5, and Al was precipitated as AI(OH)_3. Finally,NaRE(SO_4)_2·xH_2 O and Al(OH)_3 were converted into RECl_3 and Al_2(SO4)_3 solution,respectively, which were recycled to manufacture zeolite. This process recovered REEs and Al from the FCC waste slag and reduced the emissions of waste slag simultaneously, which has an important economic and environment significance. | Jinyu wang Xiaowei Huang Dali Cui Liangshi Wang Zongyu Feng Bin Hu Zhiqi Long Na Zhao | 2017 | Journal of Rare Earths2017，35，11： | 4 |
| 9 | Synthesis of lanthanum oxide nanosheets by a green carbonation process显示文摘Two-dimensional metal oxide nanostructures,such as nanoplates,nanowalls,and nanosheets,have received further attentions in recent years,due to their outstanding properties resulted from the small thickness and quantum size effects.In this work,lanthanum oxide nanosheets with the thickness of 56 nm had been successfully prepared by an originally simple method of carbon dioxide carbonation;the preparation process was green without using surfactants and detergent.The X-ray diffraction,transmission electron microscopy,and scanning electron microscopy were used to characterize the products.Thermogravimetric-differential thermal analysis and FT-IR were introduced to prove that the lanthanum oxide precursor with lamellar morphology was La2(CO3)3 3H2O.The carbon dioxide carbonation method would provide significant benefits containing mild reaction conditions,high efficiency,low cost,and easy to realize large-scale production. | Yanfei Xiao Zongyu Feng Xiaowei Huang Li Huang Zhiqi Long Qiang Wang Yongke Hou | 2014 | Chinese Science Bulletin2014，59，16： | 4 |
| 10 | The development of a sensitive fluorescent protein-based transcript reporter for high throughput screening of negative modulators of lncRNAs显示文摘While the human genome is pervasively transcribed,<2%of the human genome is transcribed into protein-coding mRNAs,leaving most of the transcripts as noncoding RNAs,such as microRNAs and long-noncoding RNAs(lncRNAs),which are critical components of epigenetic regulation.lncRNAs are emerging as critical regulators of gene expression and genomic stability.However,it remains largely unknown about how lncRNAs are regulated.Here,we develop a highly sensitive and dynamic reporter that allows us to identify and/or monitor negative modulators of lncRNA transcript levels in a high throughput fashion.Specifically,we engineer a fluorescent fusion protein by fusing three copies of the PEST destruction domain of mouse ornithine decarboxylase(MODC)to the C-terminal end of the codon-optimized bilirubin-inducible fluorescent protein,designated as dBiFP,and show that the dBiFP protein is highly destabilized,compared with the commonly-used eGFP protein.We further demonstrate that the dBiFP signal is effectively down-regulated when the dBiFP and mouse lncRNA H19 chimeric transcript is silenced by mouse H19-specific siRNAs.Therefore,our results strongly suggest that the dBiFP fusion protein may serve as a sensitive and dynamic transcript reporter to monitor the inhibition of lncRNAs by microRNAs,synthetic regulatory RNA molecules,RNA binding proteins,and/or small molecule inhibitors so that novel and efficacious inhibitors targeting the epigenetic circuit can be discovered to treat human diseases such as cancer and other chronic disorders. | Zongyue Zeng Bo Huang Shifeng Huang Ruyi Zhang Shujuan Yan Xinyi Yu Yi Shu Chen Zhao Jiayan Lei Wenwen Zhang Chao Yang Ke Wu Ying Wu Liping An Xiaojuan Ji Cheng Gong Chengfu Yuan Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Rex C.Haydon Hue H.Luu Lan Zhou Russell R.Reid Tong-Chuan He Xingye Wu | 2018 | Genes & Diseases2018，5，1： | 4 |
| 11 | Extraction mechanism and separation behaviors of low-concentration Nd^(3+) and Al^(3+) in P507-H_(2)SO_(4) system显示文摘In order to clarify the solvent extraction and separation behaviors of rare earths and impurity of Al during the extraction and enrichment of low-concentration leach solution of ion-adsorption rare earth ore,the extraction mechanism and separation behaviors of Nd^(3+)and Al^(3+)in the Nd_(2)(SO_(4))_(3)-AI_(2)(SO_(4))_(3) mixed solution using P507 were studied in this work.The extraction of Nd^(3+)and Al^(3+)follows the cation exchange mechanism.With the increase of the equilibrium pH,β_(Nd/Al) in the extraction of the Nd_(2)(SO_(4))_(3)-Al_(2)(SO_(4))_(3) mixed solution using P507 is always higher than that in the extraction of single Nd_(2)(SO_(4))_(3) and Al_(2)(SO_(4))_(3) solutions.It can be attributed to the fact that the extraction of Nd^(3+)using P507 is much faster than that of Al^(3+),and Al^(3+)is more prone to be hydrolyzed at lower pH.β_(Nd/Al) in the extraction of the Nd_(2)(SO_(4))_(3)-Al_(2)(SO_(4))_(3) mixed solution decreases gradually with the increase of mixing time within the equilibrium pH range of 1.5-1.9.The extraction of Nd^(3+)using P507 is much faster than that of Al^(3+),but the stability of Al^(3+)-Ioaded organic phase is better than that of Nd^(3+)-loaded organic phase,thus Nd^(3+)in the Nd^(3+)-loaded organic phase is gradually replaced by Al^(3+)in the aqueous phase with the increase of mixing time. | Hongyuan Zhang Longsheng Zhao Xudong Zheng Depeng Liu Zongyu Feng Yongqi Zhang Xiaowei Huang | 2022 | Journal of Rare Earths2022，40，6： | 3 |
| 12 | Behavior of phase transformation of Baotou mixed rare earth concentrate during oxidation roasting显示文摘Based on the new process named 'Combination Method' for metallurgy and separation of Baotou mixed rare earth concentrate(BMREC),the aim of this paper is to clearly elucidate the phase change behavior of BMREC without additives during oxidative roasting at 450-800℃.The results indicate that the bastnaesite in BMREC is decomposed at 450-550℃,the weight loss is about 10.3 wt%,and the activation energy(E) is 144 kJ/mol.The bastnaesite in BMREC is decomposed into rare earth fluoride,rare earth oxides(La_(2)O_(3),Ce_(7)O_(12),Pr_(6)O_(11) and Nd_(2)O_(3)),and CO_(2),particularly,with the increase of roasting temperature,bastnaesite in BMREC is more completely decomposed into LaF_(3),which causes a decrease in leaching rate of La during the HCI leaching process.Additionally,the maximum cerium oxidation efficiency reaches about 60 wt% when the roasting temperature is equal to or above 500℃,and the oxidation reaction rate of cerium increases with the increasing roasting temperature. | Deliang Meng Meng Wang Zongyu Feng Chao Xia Yanyan Zhao Xiaowei Huang | 2022 | Journal of Rare Earths2022，40，6： | 3 |
| 13 | Behavior of sulfate in preparation of single light rare earth carbonate by Mg(HCO_(3))_(2) precipitation method显示文摘The precipitation of the water-leaching solution of Baotou mixed rare earth(RE) concentrate roasted with sulfuric acid using ammonium bicarbonate for producing RE carbonate produces a mass of ammonia-nitrogen wastewater because of the relatively low solubility of rare earth sulfate.To solve the serious problem of ammonia-nitrogen pollution,new precipitators need to be developed urgently so as to meet the requirements of environmental protection and impurities content of the product(SO_(4)^(2-)<1.8 wt% in RE carbonates products).In this paper,we studied the effects of feeding modes on the behavior of SO_(4)^(2-) during the preparation of light RE carbonate(RE=La,Ce,Pr,Nd) from their sulfate solutions using Mg(HCO_(3))_(2) as a precipitant.The results indicate that the contents of SO_(4)^(2-) in the La and Ce precipitates using positive feeding mode exceed 16 wt% because of the formation of La_(2)(CO_(3))2.15(-SO_(4))0.85·4 H_(2)O and Ce_(2)(CO_(3))_(2).15(SO_(4))0.85·3H_(2)O,while those of the Pr and Nd precipitates are 4 wt%-5 wt% since they exist in the form of n-carbonate.The precipitates prepared using synchronous feeding mode are all RE carbonate with only 4 wt%-5 wt% of SO_(4)^(2-) enclosed in the precipitation.The content of SO_(4)^(2-) in the RE carbonate obtained using reverse feeding mode is the lowest.Among them,the content of SO_(4)^(2-) in La precipitate is only 1.40 wt%.Both synchronous and reverse feeding modes can effectively reduce the content of SO_(4)^(2-)in RE carbonate,which provides theoretical guidance for the preparation of qualified light RE carbonate products by Mg(HCO3)2 precipitation method. | Meng Wang Xiaowei Huang Zongyu Feng Chao Xia Deliang Meng Zonghe Yu | 2021 | Journal of Rare Earths2021，39，7： | 3 |
| 14 | Simultaneous recovery of rare earth elements and phosphorus from phosphate rock by phosphoric acid leaching and selective precipitation:Towards green process显示文摘Phosphate rock has been considered as one of the potential promising resources for rare earth elements(REEs). But the cost issues and the technical challenges caused by the low content of REEs in ores did hinder the further development of REEs recovery technologies. In order to explore a green process for the recovery of REEs from phosphate rock, this study investigates the effects of phosphoric acid concentration, liquid-to-solid ratio(L/S ratio), leaching time and temperature on the leaching efficiencies of the major components from phosphate rock. A REEs recovery of 94.3% and a phosphorus recovery of 95.3%are achieved under the optimal conditions of attacking phosphate rock using 30%P_2 O_5 acid with an L/S ratio of 10:1 and a stirring speed of 250 r/min at 25 ℃ for 4 h. Then,the selective precipitation of REEs with 81.3% REEs recovery is realized by heating up the leaching solution from 25 to 90 ℃ and keeping for4 h. Thereafter, more than 95% phosphoric acid is recovered by H_2 SO_4 and high purity gypsum, more than95% CaSO_4(tested by XRF), is also produced at the same time. Ultimately, a green process that leaches phosphate rock with H_3 PO_4, selectively precipitates REEs from leaching solution by heating up, recovers H_3 PO_4 with H2 SO4 is proposed. Compared with REE recovery in traditional processes, this process owns the merits of simple operation, energy saving and minimum wastes. | Shengxi Wu Longsheng Zhao Liangshi Wang Xiaowei Huang Yunhan Zhang Zongyu Feng Dali Cui | 2019 | Journal of Rare Earths2019，37，6： | 2 |
| 15 | SO_(4)^(2-)-modified La,Y-doped ceria-zirconia with high oxygen storage capacity and its application in Pd-only three-way catalysts显示文摘As the oxygen redox ability shows great effects on the catalytic performances of ceria-zirconia based materials,many strategies have been utilized to improve the oxygen storage capacity.Here in this study,we report a simple and facile approach to prepare a SO_(4)^(2-)-modified La,Y-doped ceria-zirconia material(SO/CZLY-f)with high oxygen storage capacity.Due to the additional redox process between SO_(4)^(2-)and S^(2-),oxygen storage capacity of SO/CZLY-f(745.3μmol O_(2)/g)is about 1.6 times higher than that of La,Ydoped ceria-zirconia material without SO_(4)^(2-)modification.Moreover,the catalytic activities and stability of the corresponding Pd-only three-way catalyst were measured.Compared to that of Pd@CZLY-f,the operation window of CO,full conversion temperature of HC and NO over Pd@SO/CZLY-f are obviously widened and lowered,respectively.After aging treatment at 1100℃for 4 h,the superiority of aged Pdloading composite is still maintained. | Hao Wang Yongke Hou Yongqi Zhang Meisheng Cui Fang Chen Xiaowei Huang Juanyu Yang Zongyu Feng | 2022 | Journal of Rare Earths2022，40，5： | 2 |
| 16 | Gaussian process based modeling and experimental design for sensor calibration in drifting environments显示文摘 | GENG Zongyu YANG Feng CHEN Xi | 2015 | Sensors and Actuators B2015，216，： | 1 |
| 17 | Effects ofiron and temperature on solubility of light rare earth sulfates in multicomponent system of Fe2(SO4)3-H3PO4-H2SO4 synthetic solution显示文摘Numerous light rare earth elements(LREE)minerals containing Fe and P were processed by sulfuric acid roasting method,and the leaching solution mainly comprises LREE sulfate,Fe2(SO4)3,H3PO4,and H2SO4,however,the solubility data of LREE sulfates in this system is few.This work studies the solubility of LREE sulfates in independent LREE sulfate system RE2(SO4)3-Fe2(SO4)3-H3 PO4-H2SO4(RE=La,Ce,Pr or Nd)and mixed LREE sulfates system(La,Ce,Pr,Nd)2(SO4)3-Fe2(SO4)3-H3 PO4-H2SO4 at different temperature(25-65℃)and concentrations of Fe2(SO4)3(Fe2 O3,0-50.13 g/L),H2SO4(0.5 mol/L),and H3 PO4(P2 O5,20.34 g/L)based on the industrial operating condition at low liquid and solid ratio 2:1.The solubility of each LREE sulfate in the independent system(La2 O3,12.25-20.88 g/L;CeO2,41.93-62.35 g/L;Pr6 O11,37.34-56.69 g/L;Nd2 O3,26.60-37.63 g/L)is much higher than that of the mixed system(La2 O3,6.95-11.03 g/L;CeO2,10.63-21.51 g/L;Pr6 O11,11.56-20.36 g/L;Nd2 O3,12.36-19.79 g/L)under the same other conditions.The results also indicate that,in the two systems,both Fe and the temperature have negative effects on the solubility of LREE sulfates.That may occur due to the complication reactions between the complexes of RESO4+and Fe(SO4)2-.However,the influence degree of temperature and iron concentration on the LREE sulfates solubility varies in the two systems and among different LREE species.This research is of theoretical significance for optimizing the conditions of the sulfuric acid process for recovering the LREE from the mixed LREE bearing minerals as well as the single LREE containing secondary rare earth scraps. | Shiliang Chen Longsheng Zhao Meng Wang Zongyu Feng Chao Xia Yang Xu Xiaowei Huang | 2020 | Journal of Rare Earths2020，38，11： | 1 |
| 18 | Assessment of Geological Security and Integrated Assessment Geo-environmental Suitability in Worst-hit Areas in Wenchuan Quake显示文摘在 2008 的 Wenchuan 地震和地震触发的 geo 危险为象建设,交通和电一样的基础结构引起了大损害和死亡以及破坏损坏。为与高大小地震在高多山的区域构造的镇区和城市选择相对安全的区域是迫切的。这篇论文与高大小地震在高山和沟壑为重建论述基本想法,评估索引和地质的安全评估,水和陆地资源安全示范和对 geo 环境的适用性的综合评价的评估方法,它在最糟点击的区域(12 个县) 被使用。综合评价显示出那:(1 ) 在 Longmenshan 差错地区定位了,评估区域具有差的地区性的外壳稳定性,在哪个不稳定并且第二个不稳定的区域说明 79% 总数;(2 )geo 危险危险性在评估区域高。地震触发的 geo 危险的点主要在中等、高的山区与更高的分发沿着活跃差错地区被散布,在哪个为 40.1% 总数的高、中等的危险性 zoning 报道的区域;(3 ) 地质的安全在评估区域是差的,在哪个区域不合适,建设分别地为 8.3% 评估区域, 9.3% 和 9.3% 在合适的构造区域,地质的安全的区域,第二安全和紧张 zoning 报道占据 73.1% ;(4 )geo 环境的适用性在评估区域,适用性的区域和基本适用性 zoning 在说明 3.5% 整个评估区域和 7.3% 是差的。 | LI Wenpeng WEN Dongguang ZHOU Aiguo SUN Xiaoming MENG Hui SHI Jusong CHEN Zongyu ZHANG Liqin FENG Xiaoming LIU Changli ZHOU Jianwei | 2009 | Acta Geologica Sinica(English Edition)2009，83，4： | 1 |
| 19 | Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis显示文摘As the most commonly occurring cancer in women worldwide,breast cancer poses a formidable public health challenge on a global scale.Breast cancer consists of a group of biologically and molecularly heterogeneous diseases originated from the breast.While the risk factors associated with this cancer varies with respect to other cancers,genetic predisposition,most notably mutations in BRCA1 or BRCA2 gene,is an important causative factor for this malignancy.Breast cancers can begin in different areas of the breast,such as the ducts,the lobules,or the tissue in between.Within the large group of diverse breast carcinomas,there are various denoted types of breast cancer based on their invasiveness relative to the primary tumor sites.It is important to distinguish between the various subtypes because they have different prognoses and treatment implications.As there are remarkable parallels between normal development and breast cancer progression at the molecular level,it has been postulated that breast cancer may be derived from mammary cancer stem cells.Normal breast development and mammary stem cells are regulated by several signaling pathways,such as estrogen receptors(ERs),HER2,and Wnt/b-catenin signaling pathways,which control stem cell proliferation,cell death,cell differentiation,and cell motility.Furthermore,emerging evidence indicates that epigenetic regulations and noncoding RNAs may play important roles in breast cancer development and may contribute to the heterogeneity and metastatic aspects of breast cancer,especially for triple-negative breast cancer.This review provides a comprehensive survey of the molecular,cellular and genetic aspects of breast cancer. | Yixiao Feng Mia Spezia Shifeng Huang Chengfu Yuan Zongyue Zeng Linghuan Zhang Xiaojuan Ji Wei Liu Bo Huang Wenping Luo Bo Liu Yan Lei Scott Du Akhila Vuppalapati Hue H.Luu Rex C.Haydon Tong-Chuan He Guosheng Ren | 2018 | Genes & Diseases2018，5，3： | 0 |
| 20 | Precipitation-dissolution behaviors of rare earth ions in H_3PO_4-Ca(H_2PO_4)_2 solutions显示文摘In order to achieve deeper understanding of rare earth elements(REEs) behaviors during phosphate rock processing with H_3PO_4. The solubility of REEs in Ca(H_2PO_4)_2-H_3PO_4 solutions with various concentrations of Ca(H_2PO_4)_2 at different temperatures were tested. The results demonstrate that REEs solubility decreases sharply with the increasing concentration of Ca(H_2PO_4)_2. Equations between [REE^(3+)] and [H^+],[H^+] and [Ca^(2+)] in Ca(H_2PO_4)_2-H_3PO_4 solutions were built based on the precipitation-dissolution equilibrium of rare earth phosphates and the ionization equilibrium of H_3PO_4. According to the equations, the decreasing mechanism of REEs solubility caused by elevated concentration of Ca(H_2PO_4)_2 was determined. The mechanism can be illustrated as that the elevated concentration of [H_2 PO_4^-] decreases the concentration of hydrogen ion by retarding the ionization process of H_3PO_4 and directly promotes the precipitation of rare earth phosphates. Furthermore, it can be easy deduced that similar effect would be caused by the other cation impurities(Fe^(3+), Al^(3+), etc.) on REEs solubility based on the mechanism. In addition, superimposed reduction effect on REEs solubility caused by the elevated concentration of Ca(H_2PO_4)_2 and the elevated temperature is found. This superimposed effect leads to a super low solubility of REEs in Ca(H_2PO_4)_2-H_3PO_4 solution. On the basis of the experimental study, outlooks and suggestions for further development of REEs recovery method are given. | Shengxi Wu Longsheng Zhao Liangshi Wang Xiaowei Huang Yunhan Zhang Zongyu Feng Dali Cui | 2019 | Journal of Rare Earths2019，37，5： | 0 |
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