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| 1 | Fabrication and Thermal Structural Characteristics of Ultra-high Temperature Ceramic Struts in Scramjets显示文摘ZrB_2-SiC based ultra-high temperature ceramic(UHTC) struts were firstly proposed and fabricated with the potential application in the combustor of scramjets for fuel injection and flame-holding for their machinability and excellent oxidation/ablation resistance in the extreme harsh environment. The struts were machined with electrospark wire-electrode cutting techniques to form UHTC into the desired shape, and with laser drilling to drill tiny holes providing the channels for fuel injection. The integrated thermal-structural characteristic of the struts was evaluated in high-temperature combustion environment by the propane-oxygen free jet facility, subject to the heat flux of 1.5 MW/m^2 lasting for 300 seconds, and the struts maintained integrity during and after the first experiment. The experiments were repeated for verifying the reusability of the struts. Fracture occurred during the second repeated experiment with the crack propagating through the hole. Finite element analysis(FEA) was carried out to study the thermal stress distribution in the UHTC strut. The simulation results show a high thermal stress concentration occurs at the hole which is the crack initiation position. The phenomenon is in good agreement with the experimental results. The study shows that the thermal stress concentration is a practical key issue in the applications of the reusable UHTC strut for fuel injection structure in scramjets. | 解维华 PENG Zujun 金华 孟松鹤 PAN Yu | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，2： | 2 |
| 2 | Development of powdery mildew resistant derivatives of wheat variety Fielder for use in genetic transformation显示文摘Genetic transformation is widely used to improve target traits and to study gene function in wheat.However,transformation efficiency depends on the physiological status of the recipient genotype and that is affected by several factors including powdery mildew(PM)infection.The widely used recipient variety Fielder is very susceptible to PM.Therefore,it would be beneficial to develop PM resistant derivatives with high regeneration ability for use in genetic transformation.In the present study PM resistant lines CB037 and Pm97033 carrying genes Pm21 and PmV,respectively,were backcrossed to Fielder with selection for PM resistance.Five lines,NT89,NT90,NT154,and WT48 with Pm21 and line FL347 with PmV were developed,identified by molecular markers and genomic in situ hybridization(GISH)or fluorescent in situ hybridization(FISH),and further subjected to detailed assessment of agronomic traits and regeneration ability following genetic transformation capacity.Lines FL347,WT48,NT89 and NT154 assessed as being equal to,or superior,to Fielder in regeneration and transformation ability are recommended as suitable materials for the replacement of Fielder for wheat gene transfer and genome editing study. | Xiaona Liang Xiaomin Bie Yuliang Qiu Ke Wang Zujun Yang Yuqi Jia Zhiying Xu Mei Yu Lipu Du Zhishan Lin Xingguo Ye | 2023 | The Crop Journal2023，11，2： | 2 |
| 3 | NK cell depletion promotes liver metastasis of lung cancer cells显示文摘Lung cancer is the malignant tumor with the highest morbidity and mortality in the world[1].Metastasis is the main cause of death in lung cancer patients[2].Cancer cells that are shed from the primary tumor tissue and enter the peripheral circulation are called circulating tumor cells(CTCs)[3].Among them,tumor cells that reach and colonize distant target organs are named disseminated tumor cells(DTCs)[4].Influenced by the microenvironment,immune surveillance,angiogenesis and other factors,DTCs have a weak ability to proliferate or even enter a dormant state[5].Therefore,reducing proliferative activity or maintaining the dormancy of DTCs has emerged as a novel strategy to prevent lung cancer metastasis. | Pan Yu Long Zhang Jianhui Tian Jiajun Liu Zujun Que Ge Li Yiyang Zhou | 2024 | Acta Biochimica et Biophysica Sinica2024，56，2： | 0 |
| 4 | Paclitaxel-loaded and folic acid-modified PLGA nanomedicine with glutathione response for the treatment of lung cancer显示文摘Targeted delivery and smart response of nanomedicine hold great promise for improving the therapeutic efficacy and alleviating the side effects of chemotherapy agents in cancer treatment.However,availability of only a few studies that discuss organic nanomedicines with these properties limits the development prospects of nanomedicines.In the present study,folic acid(FA)-targeted delivery and glutathione(GSH)smart responsive nanomedicine were rationally designed for pacli-taxel(PTX)delivery for the treatment of lung cancer.Compared with other stimuli-responsive nanomedicines,this nanocarrier was not only sensitive to biologically relevant GSH for on-demand drug release but also biodegradable into biocompatible products after fulfilling its delivery task.The nanomedicine first entered tumor cells via FA and its receptor-mediated endocytosis.After the lysosomal escape,poly(lactic-co-glycolic acid)(PLGA)nanomedicine was triggered by a higher level of GSH and released its cargo into the tumor microenvironment.In vitro and in vivo results revealed that the PLGA nanomedicine not only inhibited the proliferation and promoted the apoptosis of lung cancer cells significantly but also possessed less toxic side effects when compared with free PTX.Therefore,the proposed drug delivery system demonstrates the potential of a multifunctional nano-platform to enhance bioavailability and reduce the side effects of chemotherapy agents. | Wang Yao Jialiang Yao Fangfang Qian Zujun Que Pan Yu Tianle Luo Dan Zheng Zhanxia Zhang Jianhui Tian | 2021 | Acta Biochimica et Biophysica Sinica2021，53，8： | 0 |
| 5 | Security of railway control systems:A survey,research issues and challenges显示文摘With the rapid development of railway transportation,higher requirements for capacity are increasing and amount of communication,computer and control technologies are applied in train control systems which is the popular method for train control.The application of 3 C brings the enhancement of railway transportation performance.However,the number of internal and external cyber security threats is rising,which could lead to some railway accidents.On the other hand,safety is the core of the design process for railway but security is rarely considered due to the closure of traditional railway systems.As cyber security is threatening the normal operation of industrial control systems and the critical infrastructure,security ssues of train control systems should be paid more attention as railway transportation play an important role for society and economy.However,due to the safety-critical characteristics,safety assessment and analysis works have been performed for a long time,but cyber security related works are rarely considered.In the paper,we demonstrate the security situation of train control systems based on the inherent features and the experience of other industrial control systems,where the technical defects and potential threats are summarized.According to the practical engineering experience,the current security protection strategies are illustrated,which shows the popular security protection methods are limited and cannot realize the defense-in-depth.Finally,some research challenges of security issues of train control systems are identified. | Zujun Yu Hongwei Wang Feng Chen | 2023 | High-Speed Railway2023，1，1： | 0 |
| 6 | Jinfukang inhibits clustering and invasion of circulating lung tumor cells by regulating the EGFR signaling pathway显示文摘Lung cancer is the leading cause of cancer-related death in China and worldwide[1].Although the popularization and application of PET-CT have improved the detection rate of patients with early lung cancer,there is still a lack of effective drugs to prevent and treat lung cancer metastasis and prolong the survival of patients[2,3].Circulating tumor cells(CTCs),as seeds of tumor metastasis,play an important role in the metastasis of lung cancer. | Yun Yang Lihua Zhu Jiajun Liu Pan Yu Zujun Que Yan Li Hegen Li Jianhui Tian | 2023 | Acta Biochimica et Biophysica Sinica2023，55，11： | 0 |
| 7 | Haploidentical transplantation has a superior graft-versus-leukemia effect than HLA-matched sibling transplantation for Ph- high-risk B-cell acute lymphoblastic leukemia显示文摘Background: Compared with human leukocyte antigen (HLA)-matched sibling donor (MSD) transplantation, it remains unclear whether haploidentical donor (HID) transplantation has a superior graft-versus-leukemia (GVL) effect for Philadelphia-negative (Ph-) high-risk B-cell acute lymphoblastic leukemia (B-ALL). This study aimed to compare the GVL effect between HID and MSD transplantation for Ph- high-risk B-ALL.Methods: This study population came from two prospective multicenter trials (NCT01883180, NCT02673008). Immunosuppressant withdrawal and prophylactic or pre-emptive donor lymphocyte infusion (DLI) were administered in patients without active graft-versus-host disease (GVHD) to prevent relapse. All patients with measurable residual disease (MRD) positivity posttransplantation (post-MRD+) or non-remission (NR) pre-transplantation received prophylactic/pre-emptive interventions. The primary endpoint was the incidence of post-MRD+.Results: A total of 335 patients with Ph- high-risk B-ALL were enrolled, including 145 and 190, respectively, in the HID and MSD groups. The 3-year cumulative incidence of post-MRD+ was 27.2% (95% confidence interval [CI]: 20.2%-34.7%) and 42.6% (35.5%-49.6%) in the HID and MSD groups(P = 0.003), respectively. A total of 156 patients received DLI, including 60 (41.4%) and 96 (50.5%), respectively, in the HID and MSD groups (P= 0.096). The 3-year cumulative incidence of relapse was 18.6% (95% CI: 12.7%-25.4%) and 25.9% (19.9%-32.3%;P = 0.116) in the two groups, respectively. The 3-year overall survival (OS) was 67.4% (95% CI: 59.1%-74.4%) and 61.6% (54.2%-68.1%;P = 0.382), leukemia-free survival (LFS) was 63.4% (95% CI: 55.0%-70.7%) and 58.2% (50.8%-64.9%;P= 0.429), and GVHD-free/relapse-free survival (GRFS) was 51.7% (95% CI: 43.3%-59.5%) and 37.8% (30.9%-44.6%;P= 0.041), respectively, in the HID and MSD groups.Conclusion: HID transplantation has a lower incidence of post-MRD+ than MSD transplantation, suggesting that HID transplantation might have a superior GVL effect than MSD transplantation for Ph- high-risk B-ALL patients.Trial registration: ClinicalTrials.gov: NCT01883180, NCT02673008. | Fan Menglin Wang Yu Lin Ren Lin Tong Huang Fen Fan Zhiping Xu Yajing Yang Ting Xu Na Shi Pengcheng Nie Danian Lin Dongjun Jiang Zujun Wang Shunqing Sun Jing Huang Xiaojun Liu Qifa Xuan Li | 2022 | Chinese Medical Journal2022，，8： | 0 |
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