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| 1 | Glycosylation of dentin matrix protein 1 is a novel key element for astrocyte maturation and BBB integrity显示文摘血大脑障碍(BBB ) 是在 endothelial 房间和星形细胞之间形成的一条紧密的边界,它在循环把大脑与大多数病原体以及神经毒素分开并且保护。然而,详细说明了涉及 BBB 的形成的分子的播放器完全不被知道。牙质矩阵蛋白质 1 (DMP1 )-proteoglycan (PG ) 被知道涉及骨头和牙质的矿化作用,也与未知功能包括大脑在软纸巾被表示。在现在的学习,我们报导 DMP1-PG 在大脑星形细胞被表示并且在 BBB 充实单位。DMP1 的唯一的 glycosylation 地点在在鼠标的蛋白质的 N 终端域是 serine89 (S89 ) 。有 DMP1 的变异的老鼠削尖把 S89 改变到 glycine (S89G ) 的变化,它蛋白质的完全根除的 glycosylation,表明的严重 BBB 混乱。DMP1 变异的鼠标的另一个品种,缺乏 DMP1 的 C 终端域,表明了正常 BBB 功能。S89G-DMP1 星形细胞的极性被破坏,房间房间粘附被松开。通过一组分析,我们发现 DMP1 glycosylation 极其在 vitro 并且在 vivo 为星形细胞成熟被要求。S89G-DMP1 变异的星形细胞没能表示 aquaporin 4 并且减少了 laminin 和 ZO1 表示,它导致了 BBB 的混乱。有趣地,在 nestin 倡导者驾驶的老鼠大脑的野类型的 DMP1-PG 的 overexpression 在野类型层次以外提高了 laminin 和 ZO1 表示并且能有效地抵抗的静脉内的导致甘露糖醇的 BBB 可逆的洞。一起拿,我们的学习不仅揭示了一个新奇元素,即, DMP1-PG,调整了 BBB 形成,而且把新功能分到 DMP1-PG。 | Bo Jing Chunxue Zhang Xianjun Liu Liqiang Zhou Jiping Liu Yinan Yao Juehua Yu Yuteng Weng Min Pan Jie Liu Zuolin Wang Yao Sun Yi Eve Sun | 2018 | Protein & Cell2018，9，3： | 5 |
| 2 | Cyclic stretch induced miR-146a upregulation delays C2C12 myogenic differentiation through inhibition of Numb显示文摘 | Wei Kuang Jiali Tan Yinzhong Duan Jianmin Duan Weijian Wang Fang Jin Zuolin Jin Xiao Yuan Yanpu Liu | 2008 | Biochemical and Biophysical Research Communications2008，，： | 1 |
| 3 | Biosorption of Cd from Aqueous Solution by Live and Dead Biomass of Fusarium oxysporum Isolated from the Sludge of Abandoned Mine显示文摘Owing to exploring the biosorption mechanism of Fusarium oxysporum to Cd,the adsorption capacities of live and dead biomass of F.oxysporum strain KF2 were detected.The result showed both the live and dead biomass of strain KF2 could tolerate the Cd concentration up to 200 mg/L,and had the largest adsorption capacities for Cd,at 2.21 and 1.86 mg/g,respectively,with the inoculation amount of 3 g,the pH at 6,and the initial Cd concentration of 100 mg/L.The pseudo-second-order kinetic model(live biomass r^(2)>0.99,dead biomass r^(2)>0.90)was more suitable for describing the adsorption process of strain KF2.It indicated that the physicochemical adsorption on the cell surface might be the main pattern for Cd removal.Furthermore,the FTIR results showed that the main functional groups for cell wall to bind Cd were carboxyl,hydroxyl,amino,and phosphate. | Chongju WANG Xiaolu YUAN Xuejiao JIA Jingtao FAN Yue LI Lin MEI Zuolin LIU | 2022 | Meteorological and Environmental Research2022，13，5： | 0 |
| 4 | The Garnet Exsolution Texture and Petrological Investigations on a Typical Pelitic Granulite from Eastern Himalaya Syntaxis显示文摘The ultrahigh pressure(UHP)metamorphism has been documented in the Western Synataxis(Mukherjee et al.,2003)and central part of the high Himalayan(Wang et al.,2015).However,high pressure granulite facies but | ZHANG Cong TIAN Zuolin LIU Xiaoyu LI Peng YANG Jingsui | 2016 | Acta Geologica Sinica(English Edition)2016，90，S1： | 0 |
| 5 | Generation of functional oligopeptides that promote osteogenesis based on unsupervised deep learning of protein IDRs显示文摘Deep learning(DL)is currently revolutionizing peptide drug development due to both computational advances and the substantial recent expansion of digitized biological data.However,progress in oligopeptide drug development has been limited,likely due to the lack of suitable datasets and difficulty in identifying informative features to use as inputs for DL models.Here,we utilized an unsupervised deep learning model to learn a semantic pattern based on the intrinsically disordered regions of~171 known osteogenic proteins.Subsequently,oligopeptides were generated from this semantic pattern based on Monte Carlo simulation,followed by in vivo functional characterization.A five amino acid oligopeptide(AIB5P)had strong bone-formation-promoting effects,as determined in multiple mouse models(e.g.,osteoporosis,fracture,and osseointegration of implants).Mechanistically,we showed that AIB5P promotes osteogenesis by binding to the integrinα5 subunit and thereby activating FAK signaling.In summary,we successfully established an oligopeptide discovery strategy based on a DL model and demonstrated its utility from cytological screening to animal experimental verification. | Mingxiang Cai Baichuan Xiao Fujun Jin Xiaopeng Xu Yuwei Hua Junhui Li Pingping Niu Meijing Liu Jiaqi Wu Rui Yue Yong Zhang Zuolin Wang Yongbiao Zhang Xiaogang Wang Yao Sun | 2022 | Bone Research2022，10，2： | 0 |
| 6 | Perovskite solar cells with NiO_(x) hole-transport layer显示文摘Inverted perovskite solar cells(PSCs)have attracted interest due to their simple fabrication,long-term stability,and small hysteresis[1-3].It is noteworthy that the quality of the hole-transport layer(HTL)largely determines the device performance.Nickel oxide(NiO_(x))has been paid great attention as a hole-transport material in PSCs because of its natural p-type property,low cost,good stability,and high transmittance[4,5]. | Mengjia Li Zuolin Zhang Jie Sun Fan Liu Jiangzhao Chen Liming Ding Cong Chen | 2023 | Journal of Semiconductors2023，44，10： | 0 |
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