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| 1 | LncRNA Nron regulates osteoclastogenesis during orthodontic bone resorption显示文摘Activation of osteoclasts during orthodontic tooth treatment is a prerequisite for alveolar bone resorption and tooth movement.However,the key regulatory molecules involved in osteoclastogenesis during this process remain unclear.Long noncoding RNAs(lnc RNAs)are a newly identified class of functional RNAs that regulate cellular processes,such as gene expression and translation regulation.Recently,lnc RNAs have been reported to be involved in osteogenesis and bone formation.However,as the most abundant noncoding RNAs in vivo,the potential regulatory role of lnc RNAs in osteoclast formation and bone resorption urgently needs to be clarified.We recently found that the lnc RNA Nron(long noncoding RNA repressor of the nuclear factor of activated T cells)is highly expressed in osteoclast precursors.Nron is downregulated during osteoclastogenesis and bone ageing.To further determine whether Nron regulates osteoclast activity during orthodontic treatment,osteoclastic Nron transgenic(Nron c TG)and osteoclastic knockout(Nron CKO)mouse models were generated.When Nron was overexpressed,the orthodontic tooth movement rate was reduced.In addition,the number of osteoclasts decreased,and the activity of osteoclasts was inhibited.Mechanistically,Nron controlled the maturation of osteoclasts by regulating NFATc1 nuclear translocation.In contrast,by deleting Nron specifically in osteoclasts,tooth movement speed increased in Nron CKO mice.These results indicate that lnc RNAs could be potential targets to regulate osteoclastogenesis and orthodontic tooth movement speed in the clinic in the future. | Ruilin Zhang Junhui Li Gongchen Li Fujun Jin Zuolin Wang Rui Yue Yibin Wang Xiaogang Wang Yao Sun | 2020 | International Journal of Oral Science2020，12，2： | 9 |
| 2 | Organic photovoltaic cells:Novel organic semiconducting materials and molecular arrangement engineering显示文摘Organic photovoltaic cells(OPVs) have attracted more and more attention due to its highly potential application to solve the energy crisis considering its advantages,such as low cost and ease of large area production.The power conversion efficiency(PCE) of OPVs has undergone a more than nine-fold increase from ~1.0% by Tang in 1986 to 9.2% in 2010 announced by Mitsubishi Chemical.The major challenges of obtaining high efficiency OPVs are the synthesis of new narrow band gap materials,controlling molecular arrangement,designing novel configuration cells for better photon harvesting in the active layer.In the article,we summarized the recent progress of novel narrow band gap photovoltaic materials and the effective methods to control the morphology of donor and acceptor in the blend films for high performance of OPVs. | WANG ZiXuan ZHANG FuJun WANG Jin XU XiaoWei WANG Jian LIU Yang XU Zheng | 2012 | Chinese Science Bulletin2012，57，32： | 2 |
| 3 | Fossil Liverworts from the Lower Cretaceous Huolinhe Formation in Inner Mongolia, China显示文摘A new genus and species, Rebouliothallus huolinhensis sp. nov., and two uncertain species, Ricciopsis sp. and Hepaticites sp., are described. The fossils were collected from the Lower Cretaceous Huolinhe Formation of Huolinhe Basin, northeastern China. The new genus Rebouliothallus was established in the Aytoniaceae family of Marchantiales. Rebouliothallus huolinhensis appears to be quite similar to species of the extant genus Reboulia Raddi. The species is characterized by the relatively large ventral scales. Ventral scales are large, imbricate and arranged in two rows on the ventral surface. Rhizoids are either pegged or smooth. Ricciopsis sp. is characterized by the rosetteforming thallus. Hepaticites sp. shows some similarities to liverworts. Of the forty-nine Early Cretaceous floras of China, only two floras, one from the Huolinhe basin, Inner Mongolia and the other from the Jixi Basin, Heilongjiang Province, contain fossil liverworts. The rare fossil liverwort records in the Early Cretaceous floras of China may be the result of taphonomic bias. | LI Ruiyun WANG Xuelian JIN Peihong MA Fujun YAN Defei LIN Zhicheng SUN Bainian | 2016 | Acta Geologica Sinica(English Edition)2016，90，3： | 2 |
| 4 | Luminescent and photovoltaic properties of poly(9,9-dioctylfluorene-co-bithiophene) in organic electronic devices显示文摘We studied the luminescent and photovoltaic properties of poly(9,9-dioctylfluorene-co-bithiophene)(F8T2) based on ITO/PEDOT:PSS/F8T2/Bphen/LiF(0 or 1 nm)/Al and ITO/PEDOT:PSS/F8T2:PCBM/Bphen/Al.A stable and bright yellow emission was obtained from polymer F8T2,and the electroluminescence power reached 45 ?W at a 15 V driving voltage.Polymer F8T2 shows a broad absorption band from 400 to 500 nm,and has a shorter absorption edge at about 560 nm compared to that of the typical electron donor P3HT(650 nm).The photoluminescence quenching of F8T2 occurs with only a small fraction of blended PCBM due to the effective exciton dissociation at the interface between F8T2 and PCBM.Polymer solar cells(PSCs) using F8T2:PCBM as the active layer show a low power conversion efficiency(PCE) of 0.10% with an open circuit voltage(Voc) of 0.91 V and short circuit current density(Jsc) of 0.23 mA/cm2.The PSCs using F8T2:P3HT:PCBM as the active layer have a Voc of 0.85 V and Jsc of 3.02 mA/cm2,improving the PCE by about 0.90%.We attribute the improved cell performance to the higher number of photons harvested by P3HT molecules. | XU XiaoWei ZHU EnWei BIAN LinYi WANG ZiXuan WANG Jin ZHUO ZuLiang WANG Jian ZHANG FuJun TANG WeiHua | 2012 | Chinese Science Bulletin2012，57，9： | 2 |
| 5 | Current developments of research on permafrost engineering and cold region environment:a report of the 8^(th) International Symposium on Permafrost Engineering显示文摘The Eighth International Symposium on Permafrost Engineering was held in Xi'an,China,October 2009.The major topics discussed in the symposium included:permafrost engineering (involving design,construction and evaluation);mitigation of frost hazards in the regions affected by seasonally frozen ground;properties of frozen soils,model development and their applications;frost hazards and periglacial environments in mountain and plateau regions;climatic,environmental and cryospheric changes;and permafrost hydrology,cold regions water resources and land uses.The papers submitted to the symposium and lectures during the meeting represented some new developments of research on cold region engineering and environment.Here we summarized the works of the symposium in topics including:Permafrost engineering;General geocryology;Properties of frozen soils:model development and their applications;And climatic,environmental and cryospheric changes.During the symposium,the attendees pointed out that future studies should pay more attention to theoretical study and engineering mechanism study,and also on interaction between climate change and cold region environments and their engineering affects. | FuJun Niu 1,2,GuoYu Li 1,ShuPing Zhao 1,ShuJuan Zhang 1,YongGuo Zhao 2,HuiJun Jin 1 1.State Key Laboratory of Frozen Soil Engineering,Cold and Arid Regions Environmental and Engineering Research Institute,Chinese Academy of Sciences,Lanzhou,Gansu Province 730000,China 2.Key Laboratory of Highway Construction and Maintenance Technology for Permafrost Regions of Ministry of Communications,CCCC First Highway Consultants Co.,Ltd.,Xi’an,Shaanxi Province 710068,China | 2010 | Research in Cold and Arid Regions2010，2，2： | 1 |
| 6 | Precisely engineering a dual-drug cooperative nanoassembly for proteasome inhibition-potentiated photodynamic therapy显示文摘Photodynamic therapy(PDT) has been widely investigated for cancer therapy. The intracellular accumulation of reactive oxygen species(ROS)-damaged protein facilitates tumor cell apoptosis. However, there is growing evidence that the ubiquitin-proteasome pathway(UPP) significantly impedes PDT by preventing the enrichment of ROS-damaged proteins in tumor cells. To tackle this challenge, we report a facile dual-drug nanoassembly based on the discovery of an interesting co-assembly of bortezomib(BTZ, a proteasome inhibitor) and pyropheophorbide a(PPa) for proteasome inhibition-mediated PDT sensitization.The precisely engineered nanoassembly with the optimal dose ratio of BTZ and PPa demonstrates multiple advantages, including simple fabrication, high drug co-loading efficiency, flexible dose adjustment,good colloidal stability, long systemic circulation, favorable tumor-specific accumulation, as well as significant enrichment of ROS-damaged proteins in tumor cells. As a result, the cooperative nanoassembly exhibits potent synergistic antitumor activity in vivo. This study provides a novel dual-drug engineering modality for multimodal cancer treatment. | Fujun Yang Qingyu Ji Rui Liao Shumeng Li Yuequan Wang Xuanbo Zhang Shenwu Zhang Haotian Zhang Qiming Kan Jin Sun Zhonggui He Bingjun Sun Cong Luo | 2022 | Chinese Chemical Letters2022，33，4： | 1 |
| 7 | Atomic-scale insight into the epitaxial growth mechanism and interfacial coupling of BNT film prepared by hydrothermal synthesis显示文摘Revealing the epitaxial growth mechanism and the interfacial coupling effect between oxide films will help to build a“structure-property”bridge for the design of microelectronic devices.Here,the epitaxial growth mechanism and the interfacial coupling in Bi_(0.5)Na_(0.5)TiO_(3)/SrTiO_(3)(BNT/STO)heterointerfaces are investigated by the aberration-corrected scanning transmission electron microscopy,which is synthesized by a hydrothermal method.The results illustrate that 4 mol/L NaOH leads to not only the epitaxial growth of the BNT film but also the mutual diffusion of elements.The uneven distribution of local elements in BNT films is observed and confirmed to impact the cation displacements of B-site and lattice distortion.However,the overall trend of B-site cation displacement at the BNT/STO heterointerfaces is dominated by the interfacial strain.Additionally,the oxygen octahedral tilt exhibits continuous tilt patterns of a^(0)a^(0)a^(0)-a−b^(0)c−-a^(0)a^(0)c−-a^(0)b−c−-a−b−c−from the substrate to BNT film due to the constraint of the substrate and presents a strong correlation with cation displacement.These results are helpful to understand the underlying atomic structures and physical properties of BNT epitaxial thin films. | Fujun Chen Hao Qian Xiaoyuan Sun Tianyang Zheng Yunfei Liu Jin Luo Yinong Lyu | 2023 | Journal of Materials Science & Technology2023，，33： | 0 |
| 8 | Chinese Nightlife Nouveau显示文摘UPON a fellow entrepreneur from Shenzhen coming to the capital, that evening his Beijing associate took him out to dinner, followed by drinks at the famous Sanlitun Bar Street and an hour or so of Karaoke at the Cash Box Party World. At midnight, when the sleepy host intimated it might be time to go home, his guest replied in genuine astonishment, 'But it's at this hour that Shenzhen nightlife really gets going!' | JIN FUJUN & TAN ZHEN | 2004 | China Today2004，53，10： | 0 |
| 9 | Finite element simulation of Rayleigh surface acoustic wave in(100)AlN/(100)ZnO/diamond layered structure显示文摘With the rapid development of the fifth-generation(5G)wireless system,the explosive growth of transmitted data raises higher requirements for high-performance surface acoustic wave(SAW)devices as filters and duplexers.(100)AlN/(100)ZnO/diamond layered structures are theoretically simulated by finite element method(FEM)to investigate the Rayleigh SAW propagation properties,including phase velocity,electromechanical coupling coefficient K^(2),and temperature coefficient of frequency(TCF).Three types of layered structures with different interdigital transducers(IDTs)arrangements,which are IDTs/(100)AlN/(100)ZnO/diamond,(100)AlN/IDTs/(100)ZnO/diamond,and(100)AlN/(100)ZnO/IDTs/diamond structures,are considered in the simulations.The results show that the Sezawa mode exhibits larger K^(2)than the other modes.We found that the(100)AlN/IDTs/(100)ZnO/diamond structure exhibited better SAW properties,including high K^(2)and appropriate phase velocity. | ZHANG Zeyu QIAN Jin QIAN Lirong WEN Fujun WANG Litian LI Cuiping | 2023 | Optoelectronics Letters2023，19，12： | 0 |
| 10 | Loss of NEIL3 activates radiotherapy resistance in the progression of prostate cancer显示文摘Objective:To explore the genetic changes in the progression of castration-resistant prostate cancer(CRPC)and neuroendocrine prostate cancer(NEPC)and the reason why these cancers resist existing therapies.Methods:We employed our CRPC cell line microarray and other CRPC or NEPC datasets to screen the target gene NEIL3.Lentiviral transfection and RNA interference were used to construct overexpression and knockdown cell lines.Cell and animal models of radiotherapy were established by using a medical electron linear accelerator.Flow cytometry was used to detect apoptosis or cell cycle progression.Western blot and qPCR were used to detect changes in the protein and RNA levels.Results:TCGA and clinical patient datasets indicated that NEIL3 was downregulated in CRPC and NEPC cell lines,and NEIL3 was correlated with a high Gleason score but a good prognosis.Further functional studies demonstrated that NEIL3 had no effect on the proliferation and migration of PCa cells.However,cell and animal radiotherapy models revealed that NEIL3 could facilitate the radiotherapy sensitivity of PCa cells,while loss of NEIL3 activated radiotherapy resistance.Mechanistically,we found that NEIL3 negatively regulated the expression of ATR,and higher NEIL3 expression repressed the ATR/CHK1 pathway,thus regulating the cell cycle.Conclusions:We demonstrated that NEIL3 may serve as a diagnostic or therapeutic target for therapy-resistant patients. | Qiong Wang Zean Li Jin Yang Shirong Peng Qianghua Zhou Kai Yao Wenli Cai Zhongqiu Xie Fujun Qin Hui Li Xu Chen Kaiwen Li Hai Huang | 2022 | Cancer Biology & Medicine2022，19，8： | 0 |
| 11 | Translational perspective on bone-derived cytokines in inter-organ communications显示文摘OSTEOKINES IN INTER-ORGAN COMMUNICATIONS The concept of“organic wholeness”permeates all the fields of traditional Chinese medicine,which is also widely accepted by modern medicine.The wealth of knowledge regarding inter-organ communications generated in the latest decades provided solid evidence that human physiology and pathophysiology involve systematic interactions between multiple organs or tissues.Therefore,advancing our understanding of the inter-organ communication process is believed to provide a new perspective for treating various human diseases. | Fujun Jin Meijing Liu Dake Zhang Xiaogang Wang | 2023 | The Innovation2023，4，1： | 0 |
| 12 | Generation of functional oligopeptides that promote osteogenesis based on unsupervised deep learning of protein IDRs显示文摘Deep learning(DL)is currently revolutionizing peptide drug development due to both computational advances and the substantial recent expansion of digitized biological data.However,progress in oligopeptide drug development has been limited,likely due to the lack of suitable datasets and difficulty in identifying informative features to use as inputs for DL models.Here,we utilized an unsupervised deep learning model to learn a semantic pattern based on the intrinsically disordered regions of~171 known osteogenic proteins.Subsequently,oligopeptides were generated from this semantic pattern based on Monte Carlo simulation,followed by in vivo functional characterization.A five amino acid oligopeptide(AIB5P)had strong bone-formation-promoting effects,as determined in multiple mouse models(e.g.,osteoporosis,fracture,and osseointegration of implants).Mechanistically,we showed that AIB5P promotes osteogenesis by binding to the integrinα5 subunit and thereby activating FAK signaling.In summary,we successfully established an oligopeptide discovery strategy based on a DL model and demonstrated its utility from cytological screening to animal experimental verification. | Mingxiang Cai Baichuan Xiao Fujun Jin Xiaopeng Xu Yuwei Hua Junhui Li Pingping Niu Meijing Liu Jiaqi Wu Rui Yue Yong Zhang Zuolin Wang Yongbiao Zhang Xiaogang Wang Yao Sun | 2022 | Bone Research2022，10，2： | 0 |
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