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| 1 | Relevance of an in vitro osteoclastogenesis system to study receptor activator of NF-kB ligand and osteoprotegerin biological activities显示文摘 | Y Wittrant S Theoleyre S Couillaud C Dunstan D Heymann F Rédini | 2003 | Experimental Cell Research2003，，2： | 2 |
| 2 | Neutrophile-to-lymphocyte,lymphocyte-to-monocyte,and platelet-tolymphocyte ratios as prognostic and response biomarkers for resectable locally advanced gastric cancer显示文摘BACKGROUND Perioperative fluorouracil plus leucovorin,oxaliplatin,and docetaxel(FLOT)improves prognosis in locally advanced gastric cancer(LAGC).Neutrophil-to-lymphocyte(NLR),lymphocyte-tomonocyte(LMR),and platelet-to-lymphocyte(PLR)ratios are prognostic biomarkers but not predictive factors.AIM To assess blood ratios’(NLR,LMR and PLR)potential predictive response to FLOT and survival outcomes in resectable LAGC patients.METHODS This was a multicentric retrospective study investigating the clinical potential of NLR,LMR,and PLR in resectable LAGC patients,treated with at least one preoperative FLOT cycle,from 12 Portuguese hospitals.Means were compared through non-parametric Mann-Whitney tests.Receiver operating characteristic curve analysis defined the cut-off values as:High PLR>141 for progression and>144 for mortality;high LMR>3.56 for T stage regression(TSR).Poisson and Cox regression models the calculated relative risks/hazard ratios,using NLR,pathologic complete response,TSR,and tumor regression grade(TRG)as independent variables,and overall survival(OS)as the dependent variable.RESULTS This study included 295 patients(mean age,63.7 years;59.7% males).NLR was correlated with survival time(r=0.143,P=0.014).PLR was associated with systemic progression during FLOT(P=0.022)and mortality(P=0.013),with high PLR patients having a 2.2-times higher risk of progression[95% confidence interval(CI):0.89-5.26]and 1.5-times higher risk of mortality(95%CI:0.92-2.55).LMR was associated with TSR,and high LMR patients had a 1.4-times higher risk of achieving TSR(95%CI:1.01-1.99).OS benefit was found with TSR(P=0.015)and partial/complete TRG(P<0.001).Patients without TSR and with no evidence of pathological response had 2.1-times(95%CI:1.14-3.96)and 2.8-times(95%CI:1.6-5)higher risk of death.CONCLUSION Higher NLR is correlated with longer survival time.High LMR patients have a higher risk of decreasing T stage,whereas high PLR patients have higher odds of progressing under FLOT and dying.Patients with TSR and a pathological response have better OS and lower risk of dying. | Tiago Cruz Tomás Ines Eiriz Marina Vitorino Rodrigo Vicente Joao Gramaca Alicia Guadalupe Oliveira Paulo Luz Mafalda Baleiras Ana Sofia Spencer Luísa Leal Costa Patrícia Liu Joana Mendonca Magno Dinis Teresa Padrao Marisol Correia Goncalo Atalaia Michelle Silva Teresa Fiúza | 2022 | World Journal of Gastrointestinal Oncology2022，14，7： | 2 |
| 3 | Helicobacter pylori Induces Increased Expression of Toll‐Like Receptors and Decreased Toll‐Interacting Protein in Gastric Mucosa that Persists Throughout Gastric Carcinogenesis显示文摘 | Pedro Pimentel‐Nunes Nádia Gon?alves Inês Boal‐Carvalho Luís Afonso Paula Lopes Roberto Roncon‐Albuquerque Rui Henrique Luís Moreira‐Dias Adelino F. Leite‐Moreira Mário Dinis‐Ribeiro | 2012 | Helicobacter2012，，1： | 2 |
| 4 | The immediate effects of endovenous diode 808-nm laser in the greater saphenous vein:morphologic study and clinical imp lications显示文摘 | Corcos L Dini S De Anna D | | 0，，： | 1 |
| 5 | The immediate effects of endovenous diode 808-nm laser in the greater saphenous vein:morphologic syudy and clinical implication显示文摘 | Corcos L Dini S De anna D | 2005 | J Vasc Surg2005，41，6： | 1 |
| 6 | Nonlinear analysis of plates and laminates using the element free Galerkin method显示文摘 | BELLINHA J DINIS L M J S | 2007 | Composite Structures2007，78，3： | 1 |
| 7 | The immediate effects of endovenousdiode 808-nm laser in the greaters aphenousvein:morphologic study and clinical implications显示文摘 | Corcos L Dini S DeAnna D | 2005 | J Vasc Surg2005，41，6： | 1 |
| 8 | Experimental determination of the TG-43 dosimetric characteristics of EechoSeedTM model 6733 ^125I brachytherapy 显示文摘 | Meigooni A S Dini S A Sowards K T | 2002 | Medical Physics2002，29，： | 1 |
| 9 | N-terminal protype-B natriuretic peptide and Doppler diastolic variables are incremental for risk strati- fication of patients with NYHA class I-II systolic heart failure 显示文摘 | Dini FL Fontanive P Buralli S | 2009 | Int J Cardio12009，136，2： | 1 |
| 10 | Modification of wheat straw lignin by solid state fermentation with white-rot fungi显示文摘 | Maria J. Dinis Rui M.F. Bezerra Fernando Nunes Albino A. Dias Cristina V. Guedes Luís M.M. Ferreira John W. Cone Guilhermina S.M. Marques Ana R.N. Barros Miguel A.M. Rodrigues | 2009 | Bioresource Technology2009，，20： | 1 |
| 11 | Predicting of mechanical properties of Fe-Mn-(Al, Si) TRIP/TWIP steels using neural network model- ing显示文摘 | Dini G Najafizadeh A Monir-Vaghefi S M | 2009 | Computational Materials Science2009，45，4： | 1 |
| 12 | Regulation of osteoclast protease expression by RANKL显示文摘 | Y Wittrant S Theoleyre S Couillaud C Dunstan D Heymann F Rédini | 2003 | Biochemical and Biophysical Research Communications2003，，3： | 1 |
| 13 | An easy route for the synthesis of new axially substituted titanium ( Ⅳ ) phthaloeyanines 显示文摘 | M Barthel D Dini S Vagin | 2002 | Eur J Org Chem2002，22，： | 1 |
| 14 | Effect of height and geometry on local heat transfer and pressure drop in a channel with corrugated walls显示文摘 | SANIEI N DINI S | 1993 | Heat Transfer Engineering1993，14，： | 1 |
| 15 | The immediate effects of endovenous diode 808nm laser in the greater saphenous vein:morphologic study and clinical implications显示文摘 | Corcos L Dini S De Anna D | | 0，，06： | 1 |
| 16 | Evaluation of the effi- cacy and tolerability of a solution containing propyl betaine and polihexanide for wound irrigation 显示文摘 | Romanelli M Dini V Barbanera S | 2010 | Skin Pharmaeol Physiol2010，23，： | 1 |
| 17 | The right ventricle: role of Doppler echocardiography in clinical practice显示文摘 | Dini FL Galderisi M Mondillo S | 2004 | Ital Heart J Suppl2004，5，10： | 1 |
| 18 | Cutaneous ulcers associated with hydroxyurea therapy显示文摘 | Quattrone F Dini V Barbanera S | 2013 | J Tissue Viability2013，22，4： | 1 |
| 19 | Limitedcholesterol depletion causes aggregation of plasma membrane lipid rafts inducing T cell activation 显示文摘 | Mahammad S Dinie J Adler J | 2010 | BBA-Mol Cell Biol2010，1801，6： | 1 |
| 20 | N-terminal protype-B natriuretic peptide and Doppler diastolic variables are incremental for risk stratification of patients with NYHA class I-II systolic heart failure显示文摘 | Dini FL Fontanive P Buralli S | 2009 | International Journal of Cardiology2009，136，2： | 1 |
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