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| 1 | Th e role of ferroptosis in ionizing radiation-induced cell death and tumor suppression显示文摘Ferroptosis,a form of regulated cell death caused by lipid peroxidation,was recently identified as a natural tumor suppression mechanism.Here,we show that ionizing radiation(IR)induces ferroptosis in cancer cells.Mechanistically,IR induces not only reactive oxygen species(ROS)but also the expression of ACSL4,a lipid metabolism enzyme required for ferroptosis,resulting in elevated lipid peroxidation and ferroptosis.ACSL4 ablation largely abolishes IR-induced ferroptosis and promotes radioresistance.IR also induces the expression of ferroptosis inhibitors,including SLC7A11 and GPX4;as an adaptive response.IR-or KEAP1 deficiencyinduced SLC7A11 expression promotes radioresistance through inhibiting ferroptosis.Inactivating SLC7A11 or GPX4 with ferroptosis inducers(FINs)sensitizes radioresistant cancer cells and xenograft tumors to IR.Furthermore,radiotherapy induces ferroptosis in cancer patients,and increased ferroptosis correlates with better response and longer survival to radiotherapy in cancer patients.Our study reveals a previously unrecognized link between IR and ferroptosis and indicates that further exploration of the combination of radiotherapy and FINs in cancer treatment is warranted. | Guang Lei Yilei Zhang Pranavi Koppula Xiaoguang Liu Jie Zhang Steven HLin Jaffer AAjani Qin Xiao Zhongxing Liao Hui Wang Boyi Gan | 2020 | Cell Research2020，30，2： | 88 |
| 2 | ME-C:Hcoatings in motor vehicles显示文摘 | G 8130 8 A 3 2 hlin R Larsson M Hedenqvist P | 2001 | Wear2001，249，： | 1 |
| 3 | Chnonic granulomatous disease:the European experience显示文摘 | van den Berg JM van Koppen E hlin A Belohradsky BH | 2009 | PLoS One2009，4，4： | 1 |
| 4 | DNA methylation of the p14ARF,RASSF1A and APC1A genes as an independent prognostic factor incolorectal cancer patients显示文摘 | Nilsson TK L(o)f-(o)hlin ZM Sun XF | | 0，，1： | 1 |
| 5 | DNA methylation of the p14ARF, RASSF1A and APC1A genes as an independentprognostic factor in colorectal cancer patients显示文摘 | Torbj?rn Nilsson Zarah L?f-?hlin Xiao-Feng Sun | 2013 | International Journal of Oncology2013，，1： | 1 |
| 6 | Venous and cerebrospinal fluid flow in multiple sclerosis:a case-control study显示文摘 | Sundsr(o)m P W(a)hlin A Ambarki K | 2010 | Ann Neurol2010，68，2： | 1 |
| 7 | Determination carotenoids in tomato juice by liquid chromatography显示文摘 | Hlin C Chen B H | 2003 | Chrornatogr A2003，，1012： | 1 |
| 8 | 水文山流域土壤水δ18O空间分布异质性研究显示文摘流域非饱和带和土壤层的空间异质性是构成水文过程非线性的主要根源,也是水文实验研究中的薄弱环节,特别是其空间分布,传统研究集中于等值线类型的定性描述。研究通过实验流域土壤水δ18O这一非饱和带的主要空间变量,结合传统统计和地统计方法分析不同深度土层δ18O的变化机制和分布空间的分布变异情况,为地统计学方法对水文参数空间变异定量的应用提供数据基础。研究结果显示:15 cm土层土壤水δ18O半方差函数空间模型从纯金模型到高斯和指数模型,再回到纯块金模型,变化剧烈。通过蒸发分馏估算其蒸发强度,得到45cm土层最强(11%),且有关离散性质的极差、标准差和偏度差绝对值也都以45cm土层为最大。说明了在这非饱和带过程中,起关键作用的不是所想象的表面土层,而是中部土层,在水文山实验流域则是地面下的45cm土层;45cm土层的δ18O符合高斯模型和指数模型,且高斯模型中块金与基台值之比C0/(C0+C1)接近于零,说明在下渗、蒸发、迁移以及和土壤中原有δ18O融合后,形成更强的空间自相关性。80cm深度参与'混合'机制的是46d前降雨的'老水',其δ18O的空间自相关性变化则呈现明显滞后性,48 h后才呈现出空间的相关性。可见,经典统计学点参数变量和地统计学区域化变量方法在流域水文参数空间定量方面的有效性,同时在流域水文机制方面出现有意外的、特别是与传统概念相悖的现象。 | 蔡钊 刘九夫 HLIN 顾慰祖 廖爱民 王妞 王欢 | 2019 | 水文2019，39，6： | 1 |
| 9 | Oxiracetam pre-but not post-treatment pre-vented social recognition deficits produced with trimethyltin in rats显示文摘 | Hlinák Z KrejcíI | | Behav Brain Res0，161，2： | 1 |
| 10 | 基于VRML和VTK的医学教育虚拟学习环境[J]显示文摘 | JLu ZPan HLin MZhang等 | | 计算机与图像学0，，： | 1 |
| 11 | ST analysis as an adjunct to electronicfetal monitoring:an overview显示文摘 | Amer-Whlin I Miller LA | 2010 | J Perinat Neonatal Nurs2010，24，3： | 1 |
| 12 | Characterisation of traffic-generated particulate matter in Copenhagen显示文摘 | Peter W?hlin Ruwim Berkowicz Finn Palmgren | 2005 | Atmospheric Environment2005，，12： | 1 |
| 13 | The human carotid body releases acetylcholine, ATP and cyto- kines during hypoxia显示文摘 | K~hlin J Mkrtehian S Ebberyd A | 2014 | Exp Physiol2014，99，8： | 1 |
| 14 | Particle size distribution and particle mass measurements at urban,near-city and rural level in the Copenhagen area and Southern Sweden显示文摘 | Ketzel M W?hlin P Kristensson A | 2004 | Atmosphere Chemistry and Physics2004，4，1： | 1 |
| 15 | Hypermethylation of promoter regions of the APC1A and p16INK4a genes in relation to prognosis and tumor characteristics in cervical cancer patients显示文摘 | L(o)f-(o)hlin ZM Sorbe B Wingren S | | 0，，： | 1 |
| 16 | Source apportionment of particulate matter in Europe: A review of methods and results显示文摘 | M. Viana T.A.J. Kuhlbusch X. Querol A. Alastuey R.M. Harrison P.K. Hopke W. Winiwarter M. Vallius S. Szidat A.S.H. Prév?t C. Hueglin H. Bloemen P. W?hlin R. Vecchi A.I. Miranda A. Kasper-Giebl W. Maenhaut R. Hitzenberger | 2008 | Journal of Aerosol Science2008，，10： | 1 |
| 17 | Source apportionment of particulate matter in Europe: A review of methods and results显示文摘 | M. Viana T.A.J. Kuhlbusch X. Querol A. Alastuey R.M. Harrison P.K. Hopke W. Winiwarter M. Vallius S. Szidat A.S.H. Prév?t C. Hueglin H. Bloemen P. W?hlin R. Vecchi A.I. Miranda A. Kasper-Giebl W. Maenhaut R. Hitzenberger | 2008 | Journal of Aerosol Science2008，，10： | 1 |
| 18 | Modulation of multidrug resistance gene expression in human breast cancer cells by (-)-gossypol-enriched cottonseed oil 显示文摘 | YE W CHANG HLIN WANG LISHU | 2007 | Antieaneer research2007，27，1： | 1 |
| 19 | Peak CKMB and cTnT accurately estimates myocardial infarct size after reperfusion显示文摘 | Erik Hedstr?m Karin ?str?m-Olsson Hans ?hlin Fredrik Frogner Marcus Carlsson Therese Billgren Stefan Jovinge Peter Cain Galen S. Wagner H?kan Arheden | 2007 | Scandinavian Cardiovascular Journal2007，，1： | 1 |
| 20 | Glider Observations of the Dotson Ice Shelf Outflow 显示文摘 | Miles Travis Lee Sang Hoon W/~hlin Anna | 2016 | Deep Sea Research Part II Topical Studies in Oceanography2016，123，： | 1 |
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