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| 1 | Current approach to treatment of minimal hepatic encephalopathy in patients with liver cirrhosis显示文摘Minimal hepatic encephalopathy(MHE)corresponds to the earliest stage of hepatic encephalopathy(HE).MHE does not present clinically detectable neurological-psychiatric abnormalities but is characterized by imperceptible neurocognitive alterations detected during routine clinical examination via neuropsychological or psychometrical tests.MHE may affect daily activities and reduce job performance and quality of life.MHE can increase the risk of accidents and may develop into overt encephalopathy,worsening the prognosis of patients with liver cirrhosis.Despite a lack of consensus on the therapeutic indication,interest in finding novel strategies for prevention or reversion has led to numerous clinical trials;their results are the main objective of this review.Many studies address the treatment of MHE,which is mainly based on the strategies and previous management of overt HE.Current alternatives for the management of MHE include measures to maintain nutritional status while avoiding sarcopenia,and manipulation of intestinal microbiota with non-absorbable disaccharides such as lactulose,antibiotics such as rifaximin,and administration of different probiotics.This review analyzes the results of clinical studies that evaluated the effects of different treatments for MHE. | Segundo Moran Marlene López-Sánchez María del Pilar Milke-García Gustavo Rodríguez-Leal | 2021 | World Journal of Gastroenterology2021，27，22： | 5 |
| 2 | Role of ATG16L,NOD2 and IL23R in Crohn's disease pathogenesis显示文摘Inflammatory bowel disease is a group of diseases that includes Crohn's disease (CD) and ulcerative colitis.CD is characterized as a chronic inflammatory disease of the gastrointestinal tract,ranging from the mouth to the anus.Although there are gross pathological and histological similarities between CD and Johne's disease of cattle,the cause of CD remains controversial.It is vital to understand fully the cause of this disease because it affects approximately 500 000 people in North America and Europe.It ranges from 27 to 48 cases per 100 000 people.There are many theories on the cause of CD ranging from possible association with environmental factors including microorganisms to imbalance in the intestinal normal flora of the patients.Regardless of the environmental trigger,there is strong evidence that a genetic disposition is a major key in acquiring CD.Many studies have proven the link between mutations in the ATG16L,NOD2/CARD15,IBD5,CTLA4,TNFSF15 and IL23R genes,and CD.The purpose of this review is to examine all genetic aspects and theories of CD,including up to date multiple population studies performed worldwide. | Saleh A Naser Melissa Arce Anam Khaja Marlene Fernandez Najih Naser Sammer Elwasila Saisathya Thanigachalam | 2012 | World Journal of Gastroenterology2012，18，5： | 5 |
| 3 | Hepatic Expression of CXC Chemokines Predicts Portal Hypertension and Survival in Patients With Alcoholic Hepatitis显示文摘 | Marlene Dominguez Rosa Miquel Jordi Colmenero Montserrat Moreno Joan–Carles García–Pagán Jaime Bosch Vicente Arroyo Pere Ginès Juan Caballería Ramón Bataller | 2009 | Gastroenterology2009，，5： | 3 |
| 4 | Effect of calcium-based versus non-calcium-based phosphate binders on mortality in patients with chronic kidney disease: an updated systematic review and meta-analysis显示文摘 | Sophie A Jamal Ben Vandermeer Paolo Raggi David C Mendelssohn Trish Chatterley Marlene Dorgan Charmaine E Lok David Fitchett Ross T Tsuyuki | 2013 | The Lancet2013，，： | 2 |
| 5 | Aggressive surgery for metastatic liver neuroendocrine tumors显示文摘 | Jeffrey A Norton Robert S Warren Mary G Kelly Marlene B Zuraek Robert T Jensen | 2003 | Surgery2003，，： | 2 |
| 6 | Dynamics of aggregate stability influenced by soil management and crop residues显示文摘 | MERCDES T C MARLENE C A JOANN W | 2006 | Soil Science and Plant Analysis2006，37，： | 1 |
| 7 | Organizational Learning 显示文摘 | FIOL C MARLENE LYLES MARJORIE A | 1985 | Academy of Management Review1985，10，4： | 1 |
| 8 | Dose-response study of intrathecal morphine versus intrathecal neostigmine,their combination,or placebo for postoperative analgessia in patients undergoing anterior and posterior vaginoplasty显示文摘 | Gabriela R Marlene P Wiliam A | 1996 | Anesth Analg1996，82，： | 1 |
| 9 | Lack of association between intussusception and oral polio vaccine in Cuban children显示文摘 | Miguel A. Galindo Sardi?as Andrés Zambrano Cárdenas Gisele Coutin Marie Manuel Santin Pe?a Miriam Ali?o Santiago Marlen Valcárcel Sanchez C.P. Farrington | 2001 | European Journal of Epidemiology2001，，8： | 1 |
| 10 | Loss of folypoly-γ-glutamate synthetase activityis a dominant mechanism of resistance to polyglutamaylation-dependent novelantifolates in multiple human leukemia sublines显示文摘 | ESTI L LILAH R MARLENE A | 2003 | Inter J Cancer2003，103，5： | 1 |
| 11 | A re-examination of disclosure level and the expected cost of equity capital显示文摘 | Botosan Christine A and Plumlee Marlene A | 2002 | Journal of Accounting Research2002，40，1： | 1 |
| 12 | Remaval of facial soft tissue ptosis with secial threads显示文摘 | Marlen A Sulamanidze | 2002 | Dermatolosic Surgery2002，28，5： | 1 |
| 13 | Development of a disease -specific health - related quality of life questionnaire for sleep apnea显示文摘 | Flemom W Ward Reimer Marlene A | 1998 | American Journal of Respiratory and Critical Care Medicine1998，158，： | 1 |
| 14 | Vasodilatory response of border zones to Acetazolamide before and after endarterectomy 显示文摘 | Marlene W Yves B Patrice A | 2000 | Stroke2000，31，： | 1 |
| 15 | Assurance on XBRL for financial reporting 显示文摘 | David P R Marlene A P | 2008 | Accounting Horizons2008，22，3： | 1 |
| 16 | Effect of calcium-based versus non-calcium-based phosphate binders on mortality in patients with chronic kidney disease: an updated systematic review and meta-analysis显示文摘 | Sophie A Jamal Ben Vandermeer Paolo Raggi David C Mendelssohn Trish Chatterley Marlene Dorgan Charmaine E Lok David Fitchett Ross T Tsuyuki | 2013 | The Lancet2013，，： | 1 |
| 17 | Vasodilatory Response of Border Zones to Acetazolamide Before and After Endarterectomy显示文摘 | Marlene W Yves B Patrice A | 2000 | Stroke2000，31，： | 1 |
| 18 | Simple and fast HPLC method for simultaneous determination of retinol,tocopherols,coenzyme Q10 and carotenoids in complex samples显示文摘 | BEATRICE G MARLENE S MARC A | 2012 | Food Chemistry2012，134，： | 1 |
| 19 | Anemia and deficiencies of folate and vitamin B6 are common and vary with season in Chinese women of childbearing age显示文摘 | Alayne G R Marlene B G Lain W A | 2000 | J Nutr2000，130，11： | 1 |
| 20 | New perspectives concerning performance appraisals of inercolle- giate eoaches显示文摘 | GEORGE B CUNNINGHAM MARLENE A DIXON | 2003 | J Sport Manage2003，，5： | 1 |
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