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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 3 | Impaired swallowing mechanics of post radiation therapy head and neck cancer patients: A retrospective videofluoroscopic study显示文摘AIM: To determine swallowing outcomes and hyolaryngeal mechanics associated with post radiation therapy head and neck cancer(rt HNC) patients using videofluoroscopic swallow studies. METHODS: In this retrospective cohort study, video-fluoroscopic images of rt HNC patients(n = 21) were compared with age and gender matched controls(n = 21). Penetration-aspiration of the bolus and bolus residue were measured as swallowing outcome variables. Timing and displacement measurements of the anterior and posterior muscular slings elevating the hyolaryngeal complex were acquired. Coordinate data of anatomical landmarks mapping the action of the anterior muscles(suprahyoid muscles) and posterior muscles(long pharyngeal muscles) were used to calculate the distance measurements, and slice numbers were used to calculate time intervals. Canonical variate analysis with post-hoc discriminant function analysis was performed on coordinate data to determine multivariate mechanics of swallowing associated with treatment. Pharyngeal constriction ratio(PCR) was also measured to determine if weak pharyngeal constriction is associated with post radiation therapy.RESULTS: The rt HNC group was characterized by poor swallowing outcomes compared to the control group in regards to: Penetration-aspiration scale(P < 0.0001), normalized residue ratio scale(NRRS) for the valleculae(P = 0.002) and NRRS for the piriform sinuses(P = 0.003). Timing and distance measurements of the anterior muscular sling were not significantly different in the two groups, whereas for the PMS time of displacement was abbreviated(P = 0.002) and distance of excursion was reduced(P = 0.02) in the rt HNC group. A canonical variate analysis shows a significant reduction in pharyngeal mechanics in the rt HNC group(P < 0.0001). The PCR was significantly higher in the test group than the control group(P = 0.0001) indicating reduced efficiency in pharyngeal clearance. CONCLUSION: Using videofluoroscopy, this study shows rt HNC patients have worse swallowing outcomes associated with reduced hyolaryngeal mechanics and pharyngeal constriction compared with controls. | William G Pearson Jr Alisa A Davidoff Zachary M Smith Dorothy E Adams Susan E Langmore | 2016 | World Journal of Radiology2016，8，2： | 2 |
| 4 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 5 | 显示文摘 | Takai T Halicioglu T | 1984 | J Cryst Growth1984，70，： | 1 |
| 6 | The chemical bond in semiconductors显示文摘 | Pearson W B | 1960 | Progress in Semiconductors1960，5，： | 1 |
| 7 | Potential of somatic cell concentration in milk as a sire selection criterion to reduce mastitis in dairy cattle 显示文摘 | Coffey E M Vinson W E Pearson R E | 1986 | J Dairy Sci1986，69，： | 1 |
| 8 | Development of a tool for measuring and analyzing computer user satisfaction 显示文摘 | Bailey J E Pearson S W | 1983 | Management science1983，，53： | 1 |
| 9 | A phase I study of docetaxel as a radio-sensitizer for locally advanced squamous cell cervical cancer显示文摘 | Alvarez E A Wolfson A H Pearson J M | 2009 | Gynecol Oncol2009，113，2： | 1 |
| 10 | A Social History of the Mobile Telephone with a View of its Future显示文摘 | H Lacohée N Wakeford I Pearson | 2003 | BT Technology Journal2003，，3： | 1 |
| 11 | Feedback stabilization of linear autonomous time lag systems显示文摘 | FIAGBEDZI Y A PEARSON A E | | 0，，09： | 1 |
| 12 | The applica- tion of laser ablation-inductively coupled plasma-mass spectrometry to in situ U-Pb zircon geochronology显示文摘 | Jackson S E Pearson N J Griffin W L | 2004 | Chemical Geology2004，211，1： | 1 |
| 13 | Progress in semiconductors显示文摘 | MOOSER E PEARSON W B GIBSON A F | 1960 | Johniley & Sons1960，，5： | 1 |
| 14 | Transform coding of images using interleaved blocks 显示文摘 | Pearson D E Whybray M W | 1984 | Communications Radar and Signal Processing of IEE Proceedings1984，131，5： | 1 |
| 15 | Bubble interactions near a free surface 显示文摘 | Pearson A Cox E Blake J R | 2004 | Engineering Analysis with Boundary Elements2004，28，： | 1 |
| 16 | Food as a form of destination identity: A tourism destination brand perspective 显示文摘 | Lin Y C Pearson T E Cai L P | 2011 | Tourism and Hospitality Research2011，1，1： | 1 |
| 17 | Chicken flavor: The identification of some chemical components and the importance of sulfur compounds in the cooked volatile fraction显示文摘 | Minor L J Pearson A M Dawson L E | 1965 | Journal of Food Science1965，30，4： | 1 |
| 18 | Treating type 2 diabetes in youth: a de- pressing pieture 显示文摘 | PEARSON E R | 2012 | J R Coil Physicians Edinb2012，42，3： | 1 |
| 19 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 20 | The Hf isotopecompositon of cratonic mantle: LA-MC-ICPMS analysis of zir-con megacrysts in kimberlites显示文摘 | Griffin W L Pearson N J * Belousova E A | 2000 | Geochemica et CosmochimicaActa2000，64，： | 1 |
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