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212篇 您的检索式:作者名="pearson M L"
    题名 作者 年代 出处 被引量
1NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease显示文摘AIM:To assess whether polymorphisms in NOD2 and ATG16L1 affect cytokine responses and mycobacterium avium subspecies paratuberculosis (MAP) survival in monocytes from Crohn's disease (CD) patients.METHODS:Monocytes were isolated from peripheral blood of CD patients of known genotype for common single nucleotide polymorphisms of NOD2 and ATG16L1.Monocytes were challenged with MAP and bacterial persistence assessed at subsequent time-points.Cytokine responses were assayed using a Milliplex multi-analyte profiling assay for 13 cytokines.RESULTS:Monocytes heterozygous for a NOD2 polymorphism (R702W,P268S,or 1007fs) were more permissive for growth of MAP (P=0.045) than those without.There was no effect of NOD2 genotype on subsequent cytokine expression.The T300A polymorphism ofATG16L1 did not affect growth of MAP in our model (P=0.175),but did increase expression of cytokines interleukin (IL)-10 (P=0.047) and IL-6 (P=0.019).CONCLUSION:CD-associated polymorphisms affected the elimination of MAP fromex vivo monocytes (NOD2),or expression of certain cytokines (ATG16L1),implying independent but contributory roles in the pathogenesis of CD.Dylan M Glubb Richard B Gearry Murray L Barclay Rebecca L Roberts John Pearson Jacqui I Keenan Judy McKenzie Robert W Bentley 2011World Journal of Gastroenterology2011,17,23:2
2The role of the purchasing function: toward team participation显示文摘 Pearson J N 1994International Journal of Distribution of Purchasing a nd Materials Management1994,29,3:1
3Natural gas hydrate deposits: a review of in-situ properties显示文摘Pearson C F Halleck P M McGuire P L 1983Journal of geophysical research1983,87,:1
4On the Nature, Consequences and Remedies of Workplace Incivility: No Time for Nice? Think Again显示文摘PEARSON C M PORATH C L 2005Academy of Management Executive2005,19,1:1
5Chicken flavor: The identification of some chemical components and the importance of sulfur compounds in the cooked volatile fraction显示文摘Minor L J Pearson A M Dawson L E 1965Journal of Food Science1965,30,4:1
6The state of pediatric interfacility transport: consensus of the second National Pediatric and Neonatal Interfacility Transport Medicine Leadership Conference 显示文摘Woodward G A Insoft R M Pearson Shaver A L 2002Pediatr E- merg Care2002,18,1:1
7The Cost of Bad Behavior显示文摘PORATH C L PEARSON C M 2010Organizational Dynamics2010,39,1:1
8Emergence ofvancomycin resistance in Staphylococcus aureus显示文摘Smith T L pearson M L Wilcox K R et a1 1999New Eng-land Journal of Medicine1999,340,7:1
9A new silicon p-n junction photocell for converting solar radiation into electri-cal power 显示文摘Chapin D M Fuller C S Pearson G L 1954J Appl Phys1954,25,5:1
10Arm edema in breast cancer patients显示文摘ERICKSON V S PEARSON M L GANZ P A 2001J Natt Cancer Inst2001,93,2:1
11Assessing and Attacking Workplace Incivility 显示文摘PEARSON C M ANDERSSON L M PORATH C L 2000Organizational Dynamics2000,29,2:1
12A new silicon pn junction photocell for converting solar radiation into electrical power显示文摘Chapin D M Fuller C S Pearson G L 1954Appl Phys1954,25,5:1
13Animal models of schizophrenia: a critical review 显示文摘Marcotte E R Pearson D M Srivastava L K 2001J Psy- chiatry Neurosci2001,26,5:1
14Some further observations on the TBA test as an index of lipid oxidation in meats显示文摘CRACKEL R L GRAY J L PEARSON A M 1988Food Chemistry1988,28,3:1
15Chemical-mechanical polishing for fabricating patterned W metal features as chip interconnects显示文摘 Thompson D B Broabie R E Jaso M A Guthrie W L Pearson D J and Small M B 1991J electrochem soc1991,138,11:1
16Nitrate alternatives and the control of Clostridium botulinum incurred meat 显示文摘PEARSON M J SMOOT L A 1982CRC Critical Reviews in Food Science and Nutrition1982,,10:1
17Sex-dependent metabolic, neuroendocrine, and cognitive responses to dietary energy restriction and excess显示文摘Martin B Pearson M Kebejian L 2007Endocrinology2007,148,9:1
18A new silicon p-n junction photocell for converting solar radiation into electrical power electrical power 显示文摘Chapin D M Fuller C S Pearson G L 1954Journal of Applied Physics1954,5,:1
19Observations on the contributions of fat and lean to the aroma of cooked beef and lamb显示文摘Pearson A M Wenham L M Carse W A 1973J Anim Sci1973,36,:1
20Natural gas hydrate deposits: a review of in situ properties 显示文摘Pearson C F Halleck P M McGuire P L 1983Journal of Physical Chemistry1983,87,21:1
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