|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Bicuspid aortic valve hemodynamics does not promote remodeling in porcine aortic wall concavity显示文摘AIM: To investigate the role of type-I left-right bicuspid aortic valve(LR-BAV) hemodynamic stresses in the remodeling of the thoracic ascending aorta(AA) concavity, in the absence of underlying genetic or structural defects.METHODS: Transient wall shear stress(WSS) profiles in the concavity of tricuspid aortic valve(TAV) and LR-BAV AAs were obtained computationally. Tissue specimens excised from the concavity of normal(nondilated) porcine AAs were subjected for 48 h to those stress environments using a shear stress bioreactor. Tissue remodeling was characterized in terms of matrix metalloproteinase(MMP) expression and activity via immunostaining and gelatin zymography.RESULTS: Immunostaining semi-quantification results indicated no significant difference in MMP-2 and MMP-9 expression between the tissue groups exposed to TAV and LR-BAV AA WSS(P = 0.80 and P = 0.19, respectively). Zymography densitometry revealed no difference in MMP-2 activity(total activity, active form and latent form) between the groups subjected to TAV AA and LR-BAV AA WSS(P = 0.08, P = 0.15 and P = 0.59, respectively).CONCLUSION: The hemodynamic stress environment present in the concavity of type-I LR-BAV AA does not cause any significant change in proteolytic enzyme expression and activity as compared to that present in the TAV AA. | Samantha K Atkins Alison N Moore Philippe Sucosky | 2016 | World Journal of Cardiology2016，8，1： | 3 |
| 2 | Use of superoxide dismutase and catalase producing lactic acid bacteria in TNBS induced Crohn’s disease in mice显示文摘 | Jean Guy LeBlanc Silvina del Carmen Anderson Miyoshi Vasco Azevedo Fernando Sesma Philippe Langella Luis G. Bermúdez-Humarán Laurie Watterlot Gabriela Perdigon Alejandra de Moreno de LeBlanc | 2010 | Journal of Biotechnology2010，，3： | 2 |
| 3 | 通过新型轻量化参数优化方法比较激光选区熔化部件设计的不同细胞结构(英文)显示文摘目的:1.提出一种在外型不变的部件内模拟不同细胞结构的方法;2.发展激光选区熔化(SLM)部件轻量化参数设计的新方法;3.利用这一方案实现优化设计并比较不同细胞结构的质量。创新点:1.提出基于拉丁超立方实验设计、遗传算法、克里金元模型和有限元方法的轻量化优化方案;2.该方法可通过较少的采样获得良好的结果并能克服几何奇点(内部网格细化算法)的问题。方法:1.进行内部细胞结构的生成和参数化;2.根据输入数据(设计变量和约束条件等)采用拉丁超立方实验设计模拟所选样本;3.利用先前的数据创建克里金元模型并利用预测的元模型来计算遗传算法演化过程中的适应函数;4.将模拟实现的优化结果添加到数据中更新元模型,并通过数次重复迭代提高元模型的准确度直至误差小于5%;5.将这一概念应用于不同的几何结构,然后通过SLM加工制造优化后的几何结构,并在弯曲载荷下进行测试。结论:1.该优化算法通过适当的参数化克服了SLM技术的相关限制,可适用于SLM部件的优化;2.立方单元格在计算机辅助设计定义、参数化和时间优化等方面有一些优势,但和有限元分析的估计结果相比,其存在的缺乏坚实支撑的水平条(悬挂结构)会造成机械性能损失;3.将立方单元结构与用户自定义的参数化增强相结合可以得到更有效的设计结果(更高的比刚度),但更多的设计变量也延长了所需要的优化时间。 | Rubén PAZ Mario D.MONZóN Philippe BERTRAND Alexey SOVA | 2019 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2019，20，2： | 2 |
| 4 | The functional complex network approach to foster forest resilience to global changes显示文摘Human impacts on Earth's ecosystems have greatly intensified in the last decades. This is reflected in unexpected disturbance events, as well as new and increasing socio-economic demands, all of which are affecting the resilience of forest ecosystems worldwide and the provision of important ecosystem services. This Anthropocene era is forcing us to reconsider past and current forest management and silvicultural practices, and search for new ones that are more flexible and better at dealing with the increasing uncertainty brought about by these accelerating and cumulative global changes. Here, we briefly review the focus and limitations of past and current forest management and silvicultural practices mainly as developed in Europe and North America. We then discuss some recent promising concepts, such as managing forests as complex adaptive systems, and approaches based on resilience, functional diversity, assisted migration and multi-species plantations, to propose a novel approach to integrate the functionality of species-traits into a functional complex network approach as a flexible and multi-scale way to manage forests for the Anthropocene. This approach takes into consideration the high level of uncertainty associated with future environmental and societal changes. It relies on the quantification and dynamic monitoring of functional diversity and complex network indices to manage forests as a functional complex network. Using this novel approach, the most efficient forest management and silvicultural practices can be determined, as well as where, at what scale, and at what intensity landscape-scale resistance, resilience and adaptive capacity of forests to global changes can be improved. | Christian Messier Jürgen Bauhus Frederik Doyon Fanny Maure Rita Sousa-Silva Philippe Nolet Marco Mina Núria Aquilué Marie-Josée Fortin Klaus Puettmann | 2019 | Forest Ecosystems2019，6，3： | 2 |
| 5 | Helieobacter pylori sero- prevalence in patients with chronic obstructive pulmonary disease 显示文摘 | Roussos A Philippou N Krietsepi V | 2005 | Rcsp Meal2005，99，： | 1 |
| 6 | 16s rRNA and 16s to 23s internal transcribed spacer sequence analyses reveal inter- and intraspecific bifidobacterium phylogeny显示文摘 | Leblond-Bourget N Philippe H Mangin I | 1996 | Int J Syst Bacteriol1996，46，1： | 1 |
| 7 | Surface wettability control by nanocoating: The effects on pool boiling heat transfer and nucleation mechanism显示文摘 | Phan H T Caney N Marry Philippe | 2009 | International Journal of Heat and Mass Transfer2009，52，2324： | 1 |
| 8 | High-Dose Split-Course Radiation Therapy for Anal Cancer: Outcome Analysis Regarding the Boost Strategy (CORS-03 Study)显示文摘 | Jean-Michel Hannoun-Levi Cécile Ortholan Michel Resbeut Eric Teissier Philippe Ronchin Didier Cowen Audrey Zaccariotto Karen Bénézery Eric Fran?ois Naji Salem Steve Ellis David Azria Jean-Pierre Gerard | 2011 | International Journal of Radiation Oncology Biology Physics2011，，3： | 1 |
| 9 | Optimizing therapy of sei- zures in stroke patients显示文摘 | Philippe R Alexandra M Norbert N | 2006 | Neurology2006，67，： | 1 |
| 10 | Isolation and genetic characterization of H5N2 influenza viruses from pigs in korea显示文摘 | Jun H L Philippe N Q P Min Suk S | 2009 | Journal of Virology2009，83，9： | 1 |
| 11 | Optimal decoding for watermarks subject to geometrical attacks显示文摘 | Philippe N Henri M | 2003 | Signal Processing:Image Communication2003，18，4： | 1 |
| 12 | Assessment of ethanol consumption and water drinking by NPY Y2 receptor knockout mice 显示文摘 | Todd ET Philippe N Patrik E | 2004 | Peptide2004，25，： | 1 |
| 13 | Value of high-dose cytarabine during interval therapy of a Berlin-Frankfurt-Munster-based protocol in increased-risk children with acute lymphoblastic leukemia and lymphoblastic lymphoma: results of the European Organization for Research and Treatment of Cancer 58881 randomized phase Ⅲ trial 显示文摘 | Millot F Suciu S Philippe N | 2001 | J Clin Oncol2001，19，7： | 1 |
| 14 | The evaluation of psoriasis therapy with biologics leads to a revision of the current view of the pathogenesis of this disorder 显示文摘 | Philipp S Wolk K Kreutzer S Wallace E Ludwig N Roewert J | 2006 | Expert Opia Ther Targets2006，10，6： | 1 |
| 15 | Outcomes in diabetic patients undergoing primary percutaneous coronary intervention for acute anterior myocardial infarction: Results from the INFUSE‐AMI study显示文摘 | Elias A. Sanidas Sorin J. Brener Akiko Maehara Philippe Généreux Bernhard Witzenbichler Magdi El‐Omar Martin Fahy Roxana Mehran C. Michael Gibson Gregg W. Stone | 2014 | Cathet Cardiovasc Intervent2014，，5： | 1 |
| 16 | Magnetically levitated slice motors-an overview 显示文摘 | THOMAS N PHILIPP K FRANZ Z | 2011 | IEEE Transactions on Industrial Applications2011，47，2： | 1 |
| 17 | Optimising monitoring in the management of Crohn’s disease: A physician’s perspective显示文摘 | Pavol Papay Ana Ignjatovic Konstantinos Karmiris Heda Amarante Pal Milheller Brian Feagan Geert D’Haens Philippe Marteau Walter Reinisch Andreas Sturm Flavio Steinwurz Laurence Egan Julián Panés Edouard Louis Jean-Frédéric Colombel Remo Panaccione | 2013 | Journal of Crohn’s and Colitis2013，，： | 1 |
| 18 | Isolation and genetic characterization of H5N2 influenza viruses from pigs in korea显示文摘 | Jun H L Philippe N Q P Min Su k S | 2009 | Journal of Virology2009，83，9： | 1 |
| 19 | Nodal-staging surgery for locally advanced cervical cancer in the era of PET显示文摘 | Sebastein G Philippe M Fabrice N | 2012 | Lancet Oncol2012，13，： | 1 |
| 20 | Respiratory diseases and Helicobacter pylori infection:is there a link显示文摘 | Roussos A Philippou N Mantzaris GJ | 2006 | Respiration2006，73，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员