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| 1 | Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘 | Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F | 2005 | 中国神经肿瘤杂志2005，3，3： | 53 |
| 2 | 世界胃肠病学组织全球指南——发展中国家幽门螺杆菌感染显示文摘世界上有一半人口感染幽门螺杆菌(H.pylori),其感染率因地理位置、种族、年龄和社会经济状况不同而存在很大差异.在发展中国家较高.发达国家较低。但总体而言,近年世界许多地区的H.pylori感染率均呈下降趋势。 | Hunt RH Xiao SD Megraud F Leon-Barua R Bazzoli F van der Merwe S Vaz Coelho LG Fock M Fedail S Cohen H Malfertheiner P Vakil N Hamid S Goh KL Wong BCY Krabshuis J Le Mair A 杜颖 戴宁 | 2011 | 胃肠病学2011，16，7： | 27 |
| 3 | IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treat- ment of Cancer Brain Tumor Group显示文摘 | van den Bent M J Dubbink HJ Marie Y Brandes AA Taphoorn MJ Wesseling P Frenay M Tijssen CC Lacombe D ldbaih A van Marion R Kros JM Dinjens WN Gorlia T. Sanson M. | 2010 | 中国神经肿瘤杂志2010，8，1： | 22 |
| 4 | 糖尿病膀胱的尿动力学及病理学改变(附动物实验与临床观察)显示文摘目的:观察糖尿病膀胱(DCP)的尿动力学及病理学改变,探讨发病机制及病理演绎过程。方法:建立DCP wistar大鼠模型(30只),正常wistar大鼠作对照(30只),进行膀胱储尿期压、最大容量、最大膀胱压等测定,进行膀胱湿重、膀胱壁厚度及光镜、电镜的病理学观察。早期DCP患者(32例),晚期DCP(28例)及非DM人群(22例)进行尿流率、压力-流率尿道分布压及括约肌肌电图等测定,作相关统计学处理。结果:①60天后,DCP鼠组与对照组:膀胱储尿期压(0.45±0.08)kPa,(0.60±0.03)kPa(P<0.05);最大膀胱容量(3.49±0.40)ml,(1.82±0.12)ml(P<0.01);最大膀胱压(3.09±0.10)kPa,(4.91±0.30)kPa(P<0.01);膀胱顺应性(1.39±0.11)ml.kPa-1,(0.68±0.07)ml.kPa-1(P<0.01);湿重增加(P<0.01);逼尿肌细胞连接纤维化,成纤维细胞变性及胶原纤维排列紊乱。②相对于对照组,早期DCP患者最大尿流率偏低,为(15.97±5.71)ml.s-1(P<0.05),逼尿肌活动亢进(占59%),逼尿肌/括约肌协同失调(占37.5%);而晚期DCP患者最大尿流率明显下降,为(8.75±4.20)ml.s-1(P<0.01),膀胱容量增加,为(472.5±32.9)ml(P<0.01),剩余尿量增多,为(62.59±19.87)ml(P<0.01),逼尿肌收缩功能减弱。结论:DCP早期就有膀胱的动力学及病理学改变,以逼尿肌活动功能亢进,逼尿肌/括约肌协同失调较常见,晚期以逼尿肌收缩功能减弱为主,建议对DCP患者早期就应给予干预,控制病情的进一步恶化。 | 卫中庆 van Koeveringe G A 田成功 王昱 于洪波 易超然 孙则禹 陈炜 van Kerrebroeck P E | 2005 | 临床泌尿外科杂志2005，20，11： | 11 |
| 5 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 6 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 7 | WONCA研究论文摘要汇编——初级医疗中普里西特治疗模式对2型糖尿病患者的干预效果:整群随机对照试验显示文摘背景性功能障碍在2型糖尿病患者中较为普遍,也是糖尿病护理中最易被忽视的并发症之一。患者和医务工作者在糖尿病护理中对讨论性问题感到困难。普里西特治疗(PLISSIT)模式中的性咨询模型可能是有效工具,可以帮助医务工作者与2型糖尿病患者对性问题进行探讨。PLISSIT的含义是许可(Permission)、有限信息(Limited Information)、特别建议(Specific Suggestions)和强化治疗(Intensive Therapy)。尽管在糖尿病护理中经常建议使用PLISSIT模式,但是并没有证据证明其对2型糖尿病患者的有效性。本研究采用整群随机对照试验,评估PLISSIT模式在初级医疗中对2型糖尿病患者的干预效果。方法 /设计招募年龄40~75岁、表示对性功能不满意且愿意与全科医生讨论性问题的2型糖尿病患者。护士向所有参与者发放相关知识传单。干预组中,每例患者依据PLISSIT模式对全科医生进行性问题咨询;认为知识传单信息不足的患者可以预约全科医生进行常规护理。主要结局指标包括性功能、性功能满意度和生活质量;次要结局指标包括抑郁症状、性痛苦、情绪安康、治疗满意度。在研究开始前及研究3、12个月后,通过自我报告问卷对结局指标进行评估。通过电话采访对治疗满意度进行评估。讨论本研究介绍了整群随机对照试验的设计,对初级护理中使用PLISSIT模式对2型糖尿病患者干预的有效性进行研究。针对男性和女性2型糖尿病患者重要指标结果,提出了关于PLISSIT模式有效性的重要和缺失观点。 | Rutte A van Oppen P Nijpels G | 2015 | 中国全科医学2015，18，20： | 5 |
| 8 | Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial显示文摘 | Roger Stupp Monika E Hegi Warren P Mason Martin J van den Bent Martin JB Taphoorn Robert C Janzer Samuel K Ludwin Anouk Allgeier Barbara Fisher Karl Belanger Peter Hau Alba A Brandes Johanna Gijtenbeek Christine Marosi Charles J Vecht Karima Mokhtari Piet | 2009 | Lancet Oncology2009，，5： | 4 |
| 9 | A numerical model of gas-fluidized beds显示文摘 | Kuipers J A M Van Duin K J Van Beckum F P H | 1992 | Chem Eng Sci1992，47，5： | 4 |
| 10 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 11 | Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication显示文摘 | Hilde M van der Schaar Lonneke van der Linden Kjerstin H W Lanke Jeroen R P M Strating Gerhard Purstinger Erik de Vries Cornelis A M de Haan Johan Neyts Frank J M van Kuppeveld | 2012 | Cell Research2012，22，11： | 3 |
| 12 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 13 | New class of materials: half-metallic ferromagnets 显示文摘 | de Groot R A Muller F M van Engen P P M | 1983 | Phys Rev Lett1983，50，： | 2 |
| 14 | Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study显示文摘 | JT Moller P Cluitmans LS Rasmussen P Houx H Rasmussen J Canet P Rabbitt J Jolles K Larsen CD Hanning O Langeron T Johnson PM Lauven PA Kristensen A Biedler H van Beem O Fraidakis JH Silverstein JEW Beneken JS Gravenstein | 1998 | The Lancet . 1998 (9106)1998，，9106： | 2 |
| 15 | Autotrophlic growth of anaerobic ammonium-oxidizing microorganisms in a fluidized bed reactor 显示文摘 | Van de Graaf A A De Bruijn P Robertson L A | 1996 | Microbiology1996，142，8： | 2 |
| 16 | Medical image matching-a review with classification 显示文摘 | VAN DEN ELSEN P A POL E J D VIERGEVER M A | 1993 | IEEE Eng in Med & Biol1993，12，1： | 2 |
| 17 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 18 | Geometric ergodicity and quasi-stationarity in discrtet-time birth-death processes显示文摘 | Van Doorn E A Schrijner P | 1995 | J Austral Math Soc: Ser B1995，37，： | 2 |
| 19 | Durable Asphalt Pavements Are Self Healing显示文摘The traffic volume and the number of heavy vehicles are growing continuously. Considering the continuous traffic flow and the limited time available for road maintenance,it is very important to design a durable pavement system. Asphalt pavements with a healing capability are believed to be very useful since they can extend the pavement service life thanks to rest periods and hot summers. In order to design durable asphalt pavements,research in understanding and upgrading the self-healing capability of bituminous materials in time is of major importance. The self healing capability of bituminous mastic was evaluated in this research with a direct tension healing test. In the test program,different healing times,crack status and modifications were applied. The results indicate that elastic recovery and flow capacity are important factors for the self healing capability of bituminous materials at different crack phases as simulated with the direct tension test. | QIU J VAN DE VEN M F C WU S P YU J Y MOLENAAR A A A | 2010 | 武汉理工大学学报2010，32，17： | 2 |
| 20 | Exosome-medlated recognition and degradation of mRNAs lacking a termination codon 显示文摘 | van Hoof A Frischmeyer P A Dietz H C | 2002 | Science2002，295，5563： | 1 |
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