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| 1 | Recent advances in wireless epicortical and intracortical neuronal recording systems显示文摘An implantable brain-computer interface(BCI)has proven to be effective in the field of sensory and motor function restoration and in the treatment of neurological disorders.Using a BCI recording system,we can transform current methods of human interaction with machines and the environment,especially to help those with cognitive and mobility disabilities regain mobility and reintegrate into society.However,most reported work has focused on a simple aspect of the whole system,such as electrodes,circuits,or data transmission,and only a very small percentage of systems are wireless.A miniature,lightweight,wireless,implantable microsystem is key to realizing long-term,real-time,and stable monitoring on freely moving animals or humans in their natural conditions.Here,we summarize typical wireless recording systems,from recording electrodes,processing chips and controllers,wireless data transmission,and power supply to the system-level package for either epicortical electrocorticogram(ECoG)or intracortical local field potentials(LFPs)/spike acquisition,developed in recent years.Finally,we conclude with our vision of challenges in next-generation wireless neuronal recording systems for chronic and safe applications. | Bowen JI Zekai LIANG Xichen YUAN Honglai XU Minghao WANG Erwei YIN Zhejun GUO Longchun WANG Yuhao ZHOU Huicheng FENG Honglong CHANG Jingquan LIU | 2022 | Science China(Information Sciences)2022，65，4： | 2 |
| 2 | 可植入无线Micro LED光遗传学硬件设计显示文摘为将光遗传技术用于自由移动生物体的体内视觉神经调控,文中提出一种新的无线能量传输、可植入、光源参数可调、多通道的光遗传硬件结构。该硬件结构主要包括Micro LED阵列多通道光源、nRF52832控制器、光驱动电路、无线能量传输电路,硬件整体尺寸为18 mm×18 mm×2 mm,质量为1.54 g,满足轻量化植入的要求。其次,设计并流片Micro LED光源阵列,单颗光源的尺寸为60μm×60μm;并在此基础上为每颗光源设计光导,实现光导直径在10μm左右,能够完成神经元级的光刺激。最后,将光源阵列的参数与光源阵列组合,运用深度学习的方法进行优化,实现光源的最优刺激。实验结果表明,光源满足光遗传的要求。 | 吉彦平 王文思 郑梦沂 | 2023 | 现代电子技术2023，46，8： | 0 |
| 3 | 脑机接口技术的基础研究:神经元与二极管显示文摘随着微电子学与光电子学进入“后摩尔时代”,高性能光电器件与生物系统的融合逐渐成为一个重要的发展方向。采用高性能半导体光电器件和系统解决神经科学领域面临的技术难题,尤其是借助光学、电学等手段对神经信号进行调控和传感,受到了越来越广泛的关注。本综述论文以电子工程领域的基本单元之一——二极管与神经科学领域的基本单元——神经元之间的相互作用为切入点,总结了本课题组近年来的代表性研究工作。通过对材料器件进行设计和加工,实现了生物相容的植入式光电器件。这些光电器件通过光电信号的转换与神经信号相互作用,可以实现对生物细胞、组织和活体系统的光遗传学调控、无线光电刺激、原位荧光检测和光电传感等功能。这些新型的光电器件技术对于基础神经科学研究和神经疾病诊疗都具有重要意义。 | 盛兴 赵汶鑫 李丽珠 黄云翔 丁贺 | 2023 | 中国激光2023，50，9： | 0 |
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