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| 1 | Flexible polyimide-based hybrid optoelectric neural interface with 16 channels of micro-LEDs and electrodes显示文摘In this paper,a polyimide-based flexible device that integrates 16 micro-LEDs and 16 IrO_(x)-modified microelectrodes for synchronous photostimulation and neural signal recording is presented.The 4×4 micro-LEDs(dimensions of 220×270×50μm^(3),700μm pitch)are fixed in the SU-8 fence structure on a polyimide substrate and connected to the leads via a wire-bonding method.The recording electrodes share a similar fabrication process on the polyimide with 16 microelectrode sites(200μm in diameter and 700μm in pitch)modified by iridium oxide(IrO_(x)).These two subparts can be aligned with alignment holes and glued back-to-back by epoxy,which ensures that the light from the LEDs passes through the corresponding holes that are evenly distributed around the recording sites.The long-term electrical and optical stabilities of the device are verified using a soaking test for 3 months,and the thermal property is specifically studied with different duty cycles,voltages,and frequencies.Additionally,the electrochemical results prove the reliability of the IrO_(x)-modified microelectrodes after repeated pressing or friction.To evaluate the tradeoff between flexibility and strength,two microelectrode arrays with thicknesses of 5 and 10μm are evaluated through simulation and experiment.The proposed device can be a useful mapping optogenetics tool for neuroscience studies in small(rats and mice)and large animal subjects and ultimately in nonhuman primates. | Bowen Ji Zhejun Guo Minghao Wang Bin Yang Xiaolin Wang Wen Li Jingquan Liu | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 2 | Recent advances in wireless epicortical and intracortical neuronal recording systems显示文摘An implantable brain-computer interface(BCI)has proven to be effective in the field of sensory and motor function restoration and in the treatment of neurological disorders.Using a BCI recording system,we can transform current methods of human interaction with machines and the environment,especially to help those with cognitive and mobility disabilities regain mobility and reintegrate into society.However,most reported work has focused on a simple aspect of the whole system,such as electrodes,circuits,or data transmission,and only a very small percentage of systems are wireless.A miniature,lightweight,wireless,implantable microsystem is key to realizing long-term,real-time,and stable monitoring on freely moving animals or humans in their natural conditions.Here,we summarize typical wireless recording systems,from recording electrodes,processing chips and controllers,wireless data transmission,and power supply to the system-level package for either epicortical electrocorticogram(ECoG)or intracortical local field potentials(LFPs)/spike acquisition,developed in recent years.Finally,we conclude with our vision of challenges in next-generation wireless neuronal recording systems for chronic and safe applications. | Bowen JI Zekai LIANG Xichen YUAN Honglai XU Minghao WANG Erwei YIN Zhejun GUO Longchun WANG Yuhao ZHOU Huicheng FENG Honglong CHANG Jingquan LIU | 2022 | Science China(Information Sciences)2022，65，4： | 2 |
| 3 | Stretchable Parylene-C electrodes enabled by serpentine structures on arbitrary elastomers by silicone rubber adhesive显示文摘The delicate serpentine structures are widely used in high-performance stretchable electronics over the past decade.The metal interconnects encapsulated in biocompatible polymer Parylene-C film is a superior choice for long-term implantation in vivo,especially as neural interface to acquire electrophysiological signals or apply electrical stimulation.To avoid the physical contact damages from the neural tissues such as the brain or peripheral nerves,serpentine interconnects are utilized as stretchable electrodes and usually bonded to the soft elastomer substrate.The adhesion strength between the serpentine interconnects and the elastomer substrate becomes a considerable issue to ensure reliability and structural integrity.In this paper,the stretchable Parylene-C electrodes can be transfer printed onto arbitrary elastomer substrates by a thin layer of silicone rubber adhesive with low modulus for electrocorticogram(ECoG)recording.Mechanical simulation of serpentine structures consisting of same periodic arcs and different straight segments is investigated by uniaxial stretching.Then,the elastic stretchability of serpentine electrodes is further studied by simulation and experiments.After 5000 repetitive stretching cycles,the electrochemical impedance of microelectrodes remains in steady states.These results prove that the silicone rubber adhesive facilitates the interfacial bonding in the structure of stretchable electrodes as the compliant and reliable neural interface. | Bowen Ji Zhaoqian Xie Wen Hong Chunpeng Jiang Zhejun Guo Longchun Wang Xiaolin Wang Bin Yang Jingquan Liu | 2020 | Journal of Materiomics2020，6，2： | 1 |
| 4 | A flexible neural implant with ultrathin substrate for low-invasive brain–computer interface applications显示文摘Implantable brain–computer interface(BCI)devices are an effective tool to decipher fundamental brain mechanisms and treat neural diseases.However,traditional neural implants with rigid or bulky cross-sections cause trauma and decrease the quality of the neuronal signal.Here,we propose a MEMS-fabricated flexible interface device for BCI applications.The microdevice with a thin film substrate can be readily reduced to submicron scale for low-invasive implantation.An elaborate silicon shuttle with an improved structure is designed to reliably implant the flexible device into brain tissue.The flexible substrate is temporarily bonded to the silicon shuttle by polyethylene glycol.On the flexible substrate,eight electrodes with different diameters are distributed evenly for local field potential and neural spike recording,both of which are modified by Pt-black to enhance the charge storage capacity and reduce the impedance.The mechanical and electrochemical characteristics of this interface were investigated in vitro.In vivo,the small cross-section of the device promises reduced trauma,and the neuronal signals can still be recorded one month after implantation,demonstrating the promise of this kind of flexible BCI device as a low-invasive tool for brain–computer communication. | Zhejun Guo Fang Wang Longchun Wang Kejun Tu Chunpeng Jiang Ye Xi Wen Hong Qingda Xu Xiaolin Wang Bin Yang Bomin Sun Zude Lin Jingquan Liu | 2022 | Microsystems & Nanoengineering2022，8，6： | 1 |
| 5 | Evaluation of coalbed methane potential of different reservoirs in western Guizhou and eastern Yunnan, China显示文摘 | Li Song Tang Dazhen Pan Zhejun Xu Hao Guo Lele | 2015 | Fuel2015，139，： | 1 |
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