|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 耐甲氧西林金黄色葡萄球菌感染防治专家共识2011年更新版显示文摘耐甲氧西林金黄色葡萄球菌(Methicillin-resistant staphylococcus aureus,MRSA)感染的流行是一个严重的临床医学及公共卫生问题。自1961年首次发现MRSA以来[1],MRSA分离率逐年增加,成为医院感染重要的革兰阳性细菌,多重耐药现象日益严重,国外部分地区已出现对万古霉素耐药或中介的金黄色葡萄球菌[2]。 | | 2011 | 中华实验和临床感染病杂志(电子版)2011，5，3： | 130 |
| 2 | 万古霉素个体化给药临床药师指引显示文摘卫生部全国细菌耐药监测网(Mohnarin)数据显示,耐甲氧西林金黄色葡萄球菌(Methicillin-resistant Staphylococcus aureus,MRSA)分离率逐年上升,已成为医院感染重要的革兰阳性细菌[1]。 | 何志超 伍俊妍 邱凯锋 | 2015 | 今日药学2015，0，2： | 93 |
| 3 | MRSA全基因结构及SCC mec分型的意义显示文摘耐甲氧西林金黄色葡萄球菌(methieillin-resistant S.aureus,NRSA)1961年首次在英国报导,因其耐药谱广、耐药性高、传播速度快而成为全世界关注的焦点,其鉴定、分型、基因结构、致病机理、耐药机制和耐药基因传递方式均成了研究的热门课题。 | 欧阳范献 鲍时翔 | 2006 | 中华微生物学和免疫学杂志2006，26，12： | 30 |
| 4 | Microcalorimetric investigation of the effect of berberine alkaloids from Coptis chinensis Franch on Staphylococcus aureus growth显示文摘The inhibitory effects of three berberine alkaloids (BAs) from rhizome of Coptis chinensis Franch, a traditional Chinese medicinal (TCM) herb, on Staphylococcus aureus growth were investigated by mi- crocalorimetry. The power–time curves of S. aureus with and without BAs were acquired; meanwhile the extent and duration of inhibitory effects on the metabolism were evaluated by studying the growth rate constant (k), half inhibitory ratio (IC50), maximum heat-output power (Pmax), peak time of maximum heat-output power (tp) and total heat production (Qt). The value of k of S. aureus in the presence of the three BAs decreased with the increasing concentrations of BAs. Moreover, Pmax was reduced and the value of tp increased with increasing concentrations of the three drugs. The inhibitory activity varied with different drugs. The values of IC50 of the three BAs are respectively, 101.4 μg/mL for berberine, 241.0 μg/mL for palmatine and 792.3 μg/mL for jateorrhizine. The sequence of antimicrobial activity of the three BAs is: berberine > palmatine > jateorrhizine. It is suggested that the functional group me- thylenedioxy or methoxyl at C2 on the phenyl ring could possibly improve antimicrobial activity more strongly than hydroxyl at C2 on the phenyl ring. | YAN Dan XIAO XiaoHe JIN Cheng DONG XiaoPing | 2008 | Science China Chemistry2008，51，7： | 27 |
| 5 | 耐甲氧西林金黄色葡萄球菌对消毒剂和常用抗菌药物的耐药性及相关基因的研究显示文摘耐甲氧西林金黄色葡萄球菌(methicillin-resistant Staphylococcus aureus ,MRSA)已成为医院感染的重要病原菌,流行、暴发常有报道,同时社区获得性感染亦逐年增多。金黄色葡萄球菌对甲氧西林耐药是由于获得了携带mec基因的葡萄球菌盒式染色体(staphylococcal cassette chromosome mec,SCCmec),并通过SCCmec不断积累抗生素耐药基因。近年来国内外学者已从金黄色葡萄球菌中检出耐消毒剂基因的菌株。因此,控制MRSA特别是对常用消毒剂如季铵盐类等消毒剂耐药菌株的传播具有实际意义。 | 黄支密 仵蕾 吴林松 糜祖煌 单浩 陈榆 吴晶 秦玲 | 2006 | 中华微生物学和免疫学杂志2006，26，12： | 21 |
| 6 | 上海地区儿童呼吸道感染致病菌耐药性研究显示文摘 | 车大钿 陆敏 张泓 李万华 陆权 | 2006 | 中国当代儿科杂志2006，8，4： | 16 |
| 7 | 常见肺部耐药菌感染治疗进展显示文摘 | 李东成 刘晓红 高元明 | 2006 | 临床肺科杂志2006，11，2： | 15 |
| 8 | 耐甲氧西林金黄色葡萄球菌的流行病学显示文摘 | 王婧 王超 阴赪宏 | 2007 | 中国医刊2007，42，3： | 12 |
| 9 | Synergistic activity of lawsone methyl ether in combination with some antibiotics and artocarpin against methicillin-resistant Staphylococcus aureus, Candida albicans, and Trychophyton rubrum显示文摘Objective: One appealing strategy to overcome and prevent resistant problem is the use of combined two or more antibacterial substances. Lawsone methyl ether(LME) is the naphthoquinone found in the leaves of Impatiens balsamina. The objective of this study is to determine the interaction of LME with some antibiotics(ampicillin, tetracycline, norfloxacin, and clotrimazole) and a natural compound, artocarpin against methicillin-resistant Staphylococcus aureus(MRSA), Candida albicans, and Trychophyton rubrum.Methods: A broth microdilution method was used to determine the minimum inhibition concentration(MIC). Synergistic effects were evaluated at their own MIC using the checkerboard method and time-kill assay.Results: LME showed moderate antibacterial activity against MRSA with MIC value of 15.6 μg/mL, and exhibited strong antifungal activities against T. rubrum and C. albicans with MIC values of 7.8 and 3.9 μg/m L,respectively. The interaction of LME with the natural compound artocarpin against MRSA produced a synergy with fractional inhibitory concentration index(FICI) value of 0.31, while the combination of LME and clotrimazole exhibited synergy against C. albicans and T. rubrum with FICI values of 0.38 and 0.24, respectively. The time-kill assays confirmed that the compounds in combination enhanced their antimicrobial activities against the resistant microorganisms with different degrees.Conclusion: LME in combination with clotrimazole exhibited synergy effect against C. albicans and T.rubrum. In combination with artocarpin, it showed synergy effect against MRSA. | Pharkphoom Panichayupakaranant Abdi Wira Septama Akarawat Sinviratpong | 2019 | Chinese Herbal Medicines2019，11，3： | 11 |
| 10 | 利奈唑胺和万古霉素治疗耐甲氧西林金黄色葡萄球菌感染疗效的Meta分析显示文摘自英国Jevons首次发现耐甲氧西林金黄色葡萄球菌(methicillin resistant Staphylococcus aureus,MRSA)以来,MRSA的感染率大大增加,已成为院内感染的重要病原菌之一。目前,糖肽类药物如万古霉素或替考拉宁仍是治疗MRSA感染患者的唯一选择。尽管大部分分离的致病菌对万古霉素敏感,但1997年日本报道了首例对万古霉素中介的金黄色葡萄球菌, | 林志青 黄延玲 黄萍 陈琪 | 2011 | 中华传染病杂志2011，39，6： | 11 |
| 11 | 耐甲氧西林金黄色葡萄球菌的SCCmec基因型及耐药谱研究显示文摘耐甲氧西林金黄色葡萄球菌(methicillin-resistant Staphylococcus aureus ,MRSA)常引起医院感染的暴发流行。MRSA由于获得了外源性甲氧西林耐药决定子A(methicillin resistance determinant A,mecA),该基因编码青霉素结合蛋白2a,造成对所有β内酰胺类药物耐药。mec基因存在于葡萄球菌盒式染色体(Staphylococcal cassene chromosome mec,SCCmec)中,SCCmec是一种新型的可移动元件,不同于噬菌体和转座子,而且该元件还携带除mecA基因外的其他抗生素耐药基因,造成多重耐药。 | 余方友 李美兰 林晓梅 周铁丽 陈增强 王薇薇 戴美杰 陈坚 刘桂胜 | 2006 | 中华微生物学和免疫学杂志2006，26，6： | 11 |
| 12 | 耐甲氧西林金黄色葡萄球菌的研究进展显示文摘 | 王占华 王晓红 宋先锋 王云芹 黄树立 李林林 郑遵成 刘厚庆 孙秀丽 | 2006 | 社区医学杂志2006，4，05S： | 11 |
| 13 | 耐甲氧西林金黄色葡萄球菌的流行状况及其起源进化显示文摘 | 张文双 沈叙庄 杨永弘 | 2008 | 中国当代儿科杂志2008，10，3： | 10 |
| 14 | Antimicrobial drug resistance of Staphylococcus aureus in dairy products显示文摘Objective:To evaluate the prevalence of multidrug resistant Staphylococcus aureus(S.aureus) in dairy products.Methods:Isolation and identification of S.aureus were performed in 3 dairybased food products.The isolates were tested for their susceptibility to 5 different common antimicrobial drugs.Results:Of 50 samples examined,5(10%) were contaminated with 5. aureus.Subsequently,the 5 isolates were subjected to antimicrobial resistance pattern using five antibiotic discs(methicillin,vancomycin,kanamycin,chloramphenicol and tetracycline).Sample 29 showed resistance to methicillin and vancomycin.Sample 18 showed intermediate response to tetracycline.The other samples were susceptible to all the antibiotics tested.Conclusions:The results provide preliminary data on sources of food contamination which may act as vehicles for the transmission of antimicrobial-resistant Staphylococcus.Therefore,it enables us to develop preventive strategies to avoid the emergence of new strains of resistant S.aureus. | Sasidharan S Prema B Yoga Latha L | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，2： | 10 |
| 15 | Methicillin-resistant Staphylococcus aureus pneumonia in diabetics: a single-center, retrospective analysis显示文摘Background: Methicillin-resistant Staphylococcus aureus (MRSA) pneumonia is an important issue with significant morbidity and mortality in clinical practice, especially in diabetes mellitus (DM). Studies focusing on S. aureus pneumonia in DM is limited, we sought to make a relatively comprehensive exploration of clinical characteristics, antimicrobial resistance, and risk factors for mortality of S. aureus pneumonia in DM and non-diabetics mellitus (non-DM). Methods: A retrospective study was conducted in Ruijin Hospital from 2014 to 2017. The characteristics of DM and non-DM patients were assessed, including demographics, comorbidities, using of invasive mechanical ventilation, Hemoglobin A1c (HbA1C), confusion, urea, respiratory rate, blood pressure, age ≥65 years (CURB-65) score, length of hospital stay, clinical outcomes, antimicrobial susceptibility. Independent risk factors for mortality were identified by univariate and multivariate logistic regression analysis. Results: A total of 365 patients with S. aureus pneumonia were included in our study, including 144 with DM and 221 non-DM. DM patients were more susceptible to MRSA infection (65.3% vs. 56.1%, P > 0.05), suffered from much severer pneumonia with a higher CURB-65 score, invasive mechanical ventilation rate (46.5% vs. 28.1%, P < 0.01) and mortality rates (30.6% vs. 23.1%, P > 0.05);almost all DM patients had higher antimicrobial resistance than non-DM patients, the DM group had a higher coinfection rate (47.2% vs. 45.7%, P > 0.05), and Acinetobacter baumannii was the most common bacterium in DM, while Klebsiella pneumoniae ranked first in patients with non-DM. Independent risk factors for pneumonia-related mortality were MRSA and CURB-65. Higher HbA1c levels were linked to a higher MRSA infection and co-infection rate and more severe pneumonia, leading to an increase in mortality. Conclusions: DM patients with poor glucose control are more susceptible to MRSA infection. They suffer from higher antimicrobial resistance, a higher co-infection rate, and much severer pneumonia than non-DM. MRSA itself is an independent risk factor for mortality in all patients. | Qiu-Rui Zhang Hong Chen Bing Liu Min Zhou | 2019 | Chinese Medical Journal2019，，12： | 9 |
| 16 | 头孢西丁纸片扩散法检测耐甲氧西林金黄色葡萄球菌显示文摘耐甲氧西林金黄色葡萄球菌(methicillin-resistant staphylococcus aureus,MRSA)不仅对甲氧西林耐药,且具有多重耐药性.目前由于某些菌株在甲氧西林耐药表型上出现不均一性,影响了临床常用的表型检测方法如苯唑西林纸片扩散法、MIC法的准确性,且这类菌株正逐渐增加,并由医院感染向社区感染发展.mecA基因和青霉素结合蛋白PBP2a的检测是目前公认的MRSA检测鉴定的金标准,但这两项技术要求高、试剂昂贵,不适合普通临床实验室大量开展[2].有报道使用30μg头孢西丁纸片扩散法检测耐甲氧西林金黄色葡萄球菌,可克服使用苯唑西林鉴定方法的局限性,具有较好的敏感性和特异性.本研究对该方法用于临床实验室快速筛选MRSA进行研究. | 鲁卫平 顾江 安琳 夏季 黎敏 | 2006 | 中华检验医学杂志2006，29，5： | 9 |
| 17 | 耐甲氧西林金黄色葡萄球菌肺炎的诊断与治疗显示文摘耐甲氧西林金黄色葡萄球菌(meticillin resistant Staphylococcus aureus,MRSA)因其对抗生素的高度耐药性及其诊治的复杂性令广大临床医生感到异常棘手,自发现至今已成为全球院内感染的重要病原菌之一.中国细菌耐药性监测(CHINET) 2013年的资料显示,金黄色葡萄球菌占分离总菌株数的9.61%,其中MRSA在金黄色葡萄球菌中的平均检出率为45.2%,MRSA分离率最高的医院达72.0%. | 刘斌 刘又宁 | 2015 | 中华内科杂志2015，54，1： | 8 |
| 18 | Prevalence and antibiogram study of Salmonella and Staphylococcus aureus in poultry meat显示文摘Objective:To evaluate the presence and antibiogram pattern of Salmonella and Staphylococcus aureus(S.aureus)in retail poultry meat products.Methods:Foodborne pathogens(Salmonella and S.aureus)were isolated from poultry meat and confirmed with the help of biochemical and immunological test.Antibiogram of the isolates were examined by following CLS1 methods.Results:A total number of 209 poultry meat samples were collected and studied in this study.Out of which,5.26%were found contaminated with Salmonella while 18.18%were found contaminated with S.aureus.All the Salmonella and S.aureus isolates were found resistant to at least one antibiotic.About 72.72%of the Salmonella isolates showed resistance to tetracycline,while S.aureus isolates were also found highly resistant to tetracycline equal to 44.73%.One of the Salmonella isolates showed multi-drug resistance to almost six antibiotics out of nine antibiotics used in the study.Multidrug resistant S.aureus isolates were also found in the study.Conclusions:The study confirmed the presence of Salmonella and S.aureus in retail poultry meat.It is a potential threat to consumer health.To reduce the risk of contamination,good hygiene practices are necessary from processing to storage. | Ali Akbar Anil Kumar Anal | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，2： | 8 |
| 19 | 万古霉素敏感性下降的金黄色葡萄球菌研究进展显示文摘金黄色葡萄球菌可以引起严重的社区和医院感染。近几年,甲氧西林耐药金黄色葡萄球菌(methicillin—resistant Staphylococcus aureus,MRSA)所致的感染在全球范围内呈上升趋势。 | 陈宏斌 王辉 | 2009 | 中华检验医学杂志2009，32，11： | 8 |
| 20 | 部分医院MRSA菌耐消毒剂qacA、qac A/B基因检测显示文摘 | 陆亚华 黄支密 糜祖煌 | 2005 | 中华微生物学和免疫学杂志2005，25，10： | 7 |
您所在的机构暂未开通此部分的功能，请联系管理员