Laser flash photolysis and pulse radiolysis study on chemical activity of VP-16 and podophyllotoxin

查看全文 作　　者：孙晓宇;汪世龙;倪亚明;张超杰;王玫;姚思德

出　　处：《Science China Chemistry》索引2002年第45卷第2期,共9页

基　　金：This work was supported by the National Natural Science Foundation of China (Grant No. 39700029). 摘　　要：Time-resolved laser flash photolysis and pulse radiolysis have been used to study the chemical activity of podophyllotoxin(PPT) and etoposide(VP-16). The mechanism of photoionization of etoposide and podophyllotoxin has been confirmed and illustrated. It is demonstrated that VP-16 and PPT in aqueous solution can be photoionized at 248 nm to give hydrated electron and neutral radical resulting from rapid deprotonation of radical cation of VP-16 and PPT. The quantum yield for the photoionization of VP-16 and PPT with single-photo is 0.21 and 0.61, respectively. In addition, they can react with hydrated electron, hydrogen radical and hydroxyl radical. This will give chemists some advice on synthesizing new derivatives of podophyllotoxin in cancer treatment. 关键词：podophyllotoxin, VP-16, laser flash photolysis, PULSE radiolysis, ANTITUMOR activity.

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Laser flash photolysis and pulse radiolysis study on chemical activity of VP-16 and podophyllotoxin

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