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| 1 | Active tectonic blocks and strong earthquakes in the continent of China显示文摘The primary pattern of the late Cenozoic to the present tectonic deformation of China is characterized by relative movements and interactions of tectonic blocks. Active tectonic blocks are geological units that have been separated from each other by active tectonic zones. Boundaries between blocks are the highest gradient of differential movement. Most of tectonic activity occurs on boundaries of the blocks. Earthquakes are results of abrupt releases of accumulated strain energy that reaches the threshold of strength of the earth's crust. Boundaries of tectonic blocks are the locations of most discontinuous deformation and highest gradient of stress accumulation, thus are the most likely places for strain energy accumulation and releases, and in turn, devastating earthquakes. Almost all earthquakes of magnitude greater than 8 and 80%-90% of earthquakes of magnitude over 7 occur along boundaries of active tectonic blocks. This fact indicates that differential movements and interactions of active tectonic blocks are the primary mechanism for the occurrences of devastating earthquakes. | ZHANG Peizhen (张培震) DENG Qidong (邓起东) ZHANG Guomin (张国民) MA Jin (马 瑾) GAN Weijun (甘卫军) MIN Wei (闵 伟) MAO Fengying (毛凤英) WANG Qi (王 琪) | 2003 | Science China Earth Sciences2003，46，z2： | 239 |
| 2 | Antioxidant and Anti-inflammatory Capacity of Ferulic Acid Released from Wheat Bran by Solid-state Fermentation of Aspergillus niger显示文摘Objective A strain of Aspergillus niger(A. niger), capable of releasing bound phenolic acids from wheat bran, was isolated. This strain was identified by gene sequence identification. The antioxidant and anti-inflammatory capacity of ferulic acid released from wheat bran by this A. niger strain(FA-WB) were evaluated. Methods Molecular identification techniques based on PCR analysis of specific genomic sequences were conducted; antioxidant ability was examined using oxygen radical absorbance capacity(ORAC), cellular antioxidant activity(CAA) assays, and erythrocyte hemolysis assays. RAW264.7 cells were used as a model to detect anti-inflammatory activity. Results The filamentous fungal isolate was identified to be A. niger. ORAC and CAA assay showed that FA-WB had better antioxidant activity than that of the ferulic acid standard. The erythrocyte hemolysis assay results suggested that FA-WB could attenuate AAPH-induced oxidative stress through inhibition of reactive oxy gen species(ROS) generation. FA-WB could significantly restore the AAPH-induced increase in intracellular antioxidant enzyme activities to normal levels as well as inhibit the intracellular malondialdehyde formation. TNF-?, IL-6, and NO levels indicated that FA-WB can inhibit the inflammation induced by lipopolysaccharide(LPS). Conclusion Ferulic acid released from wheat bran by a new strain of A. niger had good anti-inflammatory activity and better antioxidant ability than standard ferulic acid. | YIN Zhi Na WU Wen Jia SUN Chong Zhen LIU Hui Fan CHEN Wen Bo ZHAN Qi Ping LEI Zhuo Gui XIN Xuan MA Juan Juan YAO Kun MIN Tian ZHANG Meng Meng WU Hui | 2019 | Biomedical and Environmental Sciences2019，32，1： | 14 |
| 3 | Regulatory mechanisms for abnormal expression of the human breast cancer specific gene 1 in breast cancer cells显示文摘Breast cancer-specific gene 1 (BCSG1), also referred as synuclein γ, was originally iso-lated from a human breast cancer cDNA library and the protein is mainly localized to presynaptic terminals in the nervous system. BCSG1 is not expressed in normal or benign breast lesions, but expressed at an extremely high level in the vast majority of the advanced staged breast carcinomas and ovarian carcinomas. Overexpression of BCSG1 in cancer cells led to significant increase in cell proliferation, motility and invasiveness, and metastasis. To elucidate the molecular mechanism and regulation for abnormal transcription of BCSG1, a variety of BCSG1 promoter luciferase reporters were constructed including 3′ end deleted sequences, Sp1 deleted, and activator protein-1 (AP1) domains mutated. Transient transfection assay was used to detect the transcriptional activation of BCSG1 promoters. Results showed that the Sp1 sequence in 5′-flanking region was involved in the basal transcriptional activities of BCSG1 without cell-type specificity. In comparison to pGL3-1249, the reporter activities of pGL3-1553 in BCSG1-negative MCF-7 cells and pGL3-1759 in HepG2 cells were notably decreased. Mutations at AP1 sites in BCSG1 intron 1 significantly reduced the promoter ac-tivity in all cell lines. Transcription factors, c-jun, c-fos and cyclin AMP-responsive element binding (CREB) protein, could markedly enhance the promoter activities. Thus, our results suggest that the abnormal expression of BCSG1 in breast cancer cells is likely regulated by multiple mechanisms. The 5′ flanking region of BCSG1 provides the basal transcriptional activity without cell type specificity. A critical promoter element involved in abnormal expression of BCSG1 presents in the first exon. The cell type specificity of BCSG1 transcription is probably affected through intronic cis-regulatory se-quences. AP1 domains in the first intron play an important role in control of BCSG1 transcription. | LU Aiping1, LI Qing1, LIU Jingwen2 1. Department of Pathology, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100036, China 2. VA Palo alto Health Care System, Palo Alto, California, CA 94304, USA | 2006 | Science China(Life Sciences)2006，49，4： | 8 |
| 4 | Accumulation in Dasuopu ice core in Qinghai-Tibet Plateau and solar activity显示文摘The time series of accumulation in recent 300 years correlated well with solar activity in Dasuopu ice core. Results of spectrum analysis on the accumulation time series of the Dasuopu ice core shows that there are some periods that coincide with the periods of solar activity. By comparing the long-time change trend of the accumulation in the Dasuopu ice core with various kinds of indexes of solar activity intensity, a negative correlation is found between the trend and solar activity. | Keqin Duan Ninglian Wang Yuefang Li Weizheng Sun | 2000 | Chinese Science Bulletin2000，45，11： | 8 |
| 5 | Geochemical characteristics of organic matter-rich strata of lower Cambrian in Tarim Basin and its origin显示文摘The organic matter-rich strata of the Yurtusi Formation of Lower Cambrian are wildly spread and steady in the Tarim Basin, in which cherts are developed, companied with phos-phorite. Al/(Al+Fe+Mn) ratio and Si/(Si+Al+Fe) ratio of cherts range from 0.0023 to 0.0046 and 0.965 to 0.98, respectively, suggesting that cherts are formed in submarine hydrothermal activity and far away from terrestrial. Trace elements, such as As, Hg, Pb, Zn, Cu, Co, P, V, Ba, etc., are markedly rich in organic matter-rich sedimentary rocks of which Ba/Sr ratios are between 21.2 and 158.1. Compared with modern hydrothermal sediments, their Ba/Sr ratios are similar, it in-dicates that the organic matter-rich strata have the geochemical feature of submarine hydro-thermal sediments. The total content of rare earth elements (SREE) in cherts is from 8.81 to 56.682 mg/g, on average 31.41 mg/g and the SREE of cherts is between continental margin cherts and abyssal cherts. The LREE/HREE ratio of cherts varies from 1.01 to 3.56, which re-veals the characteristics of hydrothermal sediments. There is positive correlation between the total organic content (TOC) and Ba/Sr ratio which is geochemical index of submarine hydro-thermal activity, which indicates that the submarine hydrothermal activity obviously influences the richness of organic matter in the Yurtusi Formation. | CHEN Jianfa1, SUN Shengli2, LIU Wenhui3 & ZHENG Jianjing3 1. Petroleum University, Beijing 102249, China 2. Zhanjiang Ocean University, Zhanjiang 524025, China 3. Lanzhou Institute of Geology, Chinese Academy of Sciences, Lanzhou 730000, China | 2004 | Science China Earth Sciences2004，47，z2： | 6 |
| 6 | Active blocks and strong seismic activity in North China region显示文摘The active North China block consists of three second-order blocks: Ordos, North China Plain, and East Shandong-Huanghai Sea blocks. Two active tectonic zones, the Anyang-Heze- Linyi and Tangshan-Cixian zones, exist in the active North China Plain block and have separated the active block into 3 third-order active blocks, Taihangshan, Hebei-Shandong, and Henan-Huai blocks. The 3 third-order active blocks are characterized by their entire motion and are clearly different in their Cenozoic structures and deep structures. The active boundary tectonic zones between the third-order active blocks are less than those between the first- and second-order active blocks in their movement strength, extent, and seismic activity. The density of M ≥ 6 earthquakes in the boundary zones between active blocks is higher than that within the blocks by 9-22 times in the North China region, up to one order of magnitude on average. M ≥ 7 earthquakes occurred basically in the boundary zones between active blocks. The difference is not occasional, but reflects the nature of intraplate movement and the characteristics of strong seismic activity and is the powerful evidence for hypothesis of active blocks. | HAN Zhujun (韩竹军) XU Jie (徐 杰) RAN Yongkang (冉勇康) CHEN Lichun (陈立春) YANG Xiaoping (杨晓平) | 2003 | Science China Earth Sciences2003，46，z2： | 6 |
| 7 | Concentration of nitrate in the Guliya ice core from theQinghai-Xizang Plateau and the solar activity显示文摘The variations of NO\+-\-3 concentration in the Guliya ice core are reconstructed for recent about 1 000 a. Spectrum analysis of NO\+-\-3 indicates significant periodicities in the variations of NO\+-\-3 concentration, which coincide with the periodicities of the solar activity. Therefore, a positive correlation between the variations of NO\+-\-3 concentration and the solar activity is found. | Ninglian Wang Tandong Yao L. G. Thompson | 1998 | Chinese Science Bulletin1998，43，10： | 5 |
| 8 | Inter-annual variation of the earth rotation and El Nio显示文摘The relationship between the inter-annual variations of the earth rotation, atmospheric angular momentum (AAM), sunspot number and El Ni(?)o is analyzed. The result shows that the inter-annual variation of the earth rotation responds to the variation of AAM and the preg-nancy of El Ni(?)o timely. Generally, the inter-annual compo-nent of the earth rotation will reach zero in a changing proc-ess that increases from the negative to the positive extreme before El Ni(?)o occurs about half year or more. And the solar activity may have certain influence on the appearance of El Ni(?)o. We consider that El Ni(?)o will possibly appear around the end of 2001. | HAN Yanben ZHAO Juan LI Zhian | 2002 | Chinese Science Bulletin2002，47，2： | 4 |
| 9 | Mechanism for chronic pain generation显示文摘Neuropathic pain and the other abnormalities of sensation induced by axon injury or by peripheral nerve inflammation should result from functional compensations of the injured neurons during their regeneration. Ectopic distribution of proteins related to Na+, K+ and Ca2+ channels as well as of receptors on both membranes of injured axon and its cell body becomes a main pacemaker from which spontaneous ectopic afferent of primary sensatory neurons and crosstalk between neurons occur. Abnormal ectopic afferent activities lead to disorders of the sensation, such as hyperalgesia, allodynia, spontaneous pain and paraesthesia. Administration of some ion channel agents and/or α2-adrenergic blockers has shown efficiency in preventing neuropathic pain development and in relieving neuropathic pain. | XIE YikuanInstitute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005. | 2000 | Chinese Science Bulletin2000，45，9： | 4 |
| 10 | Submerged culture of Magnetospirillum gryphiswaldense under N_2-fixing condition and regulation of activity of nitrogen fixation显示文摘A submerged culture technique for Magneto-spirillum gryphiswaldense under the nitrogen-fixing condition (microaerobic and N-limited) was set up. In N-limited medium with Na-lactate as a sole carbon source, the optical density (A600 nm) and activity of nitrogen fixation of cells were 1.3 and 217 nmol of ethylene produced per hour per A600nm respectively within 21 h by three times of feeds. The pH and temperature were controlled at 7.2 and 30℃ respectively, and the oxygen concentration was controlled by sparging with N2 containing 0.4%-0.8% of O2. The activity of nitrogen fixation of cells was obviously inhibited by oxygen and ammonium. It indicated that the posttranslational regulation of nitrogenase existed in M. gryphiswaldense. | JIANG Wei, ZHAO Dehua, LI Ying, TIAN Jiesheng, WANG Zhenfang & LI JilunDepartment of Microbiology, College of Biological Sciences, China Agricultural University, Beijing 100094, China | 2002 | Chinese Science Bulletin2002，47，24： | 4 |
| 11 | A New Enolate Furostanoside from Asparagus Filicinus显示文摘A new enolate derivative of furostanol glycoside, named asparagusin A, was isolated from the roots of Asparagus filicinus and established as 3 - O- 6 - D- xylopyranosyl (l →4)- β - Dglucopyranosyl (25S)-furost-20(22)-ene-3β, 26-diol 26-O-0-D-glucopyranoside (l) by spectroscopic and chemical methods. Asparagusin A (l) exhibited a cytotoxic activity effect on PC12 cells. | Xiao Dong CONG Wen Cai YE Chun Tao CHE Department of Pharmacohnosy China Pharmaceutical University Nanjing 210009 Department of Phytochemistry China Pharmaceutical University Nanjing 210009 School of Chinese Medicine The Chinese University of Hong Kon | 2000 | Chinese Chemical Letters2000，11，9： | 4 |
| 12 | THE HISTORICAL CLIMATIC RECORDS IN ICE CORES FROM THE SURFACE LAYER OF WILKES LAND, ANTARCTICA显示文摘The information preserved in the surface layer of the Antarctic ice sheet is so abundant and detailed that in the areas with a high accumulation rate the annual climatic changes in the past can be distinguished. After conducting an investigation into the stratigraphical features of ice cores from two typical shallow boreholes in the Wilkes Land, one inland and another near the margin, analyzing δ(18)O and the gross β radioactivity in the cores, as well as anslyzing the power spectra of δ18O, the authors present some important assessments on the climatic information in the past several decades therein such as the annual mean temperature and precipitation, and suggest that there is a period of 11 years with which the climate changes cyclically in East Antactica. Such a studying method will be of value in both theory and practice to the inland Antarctica, where direct meteorological observation is deficient. | 秦大河 王文悌 | 1990 | Science China Chemistry1990，33，4： | 3 |
| 13 | Synthesis and catalytic activity of novel heteronuclear Ln(Ⅲ)-Cu(Ⅱ) complexes with noncyclic polyether-amino acid Schiff base显示文摘A series of novel heteronuclear Ln(Ⅲ)-Cu(Ⅱ) complexes with noncyclic polyether-amino acid Schiff base were synthesized. The general formula is [LnCu2(H2TALY)(NO3)5](NO3)2’ nH2O(Ln=La, Nd, Sm, Gd, n= 4; Ln=Yb, Y, n=3), where H2TALY = tetraglycol aldehyde bis-lysine Schiff base. It is the first time to report the synthetic method for this new Cu(Ⅱ) complexes and Ln(Ⅲ)-Cu(Ⅱ) heteronuclear complexes. The complexes were characterized by elemental analysis, IR spectra, TG-DTA, magnetic susceptibility, and especially by a 500 MHz NMR spectrometer for 2D-COSY NMR. Coordination mechanism and structures of complexes have been suggested as well. Of particular interest is the potential that the novel complexes obtained may be used as a catalyst, which prompted us to investigate them. It shows 100% conversion with the viscosity-average molecular weight 120 000 for the polymerization of methyl methacrylate (MMA) without addition of any cocatalyst. Furthermore, the complexes with such aliphatic Schiff | 姚克敏 李宁 黄巧虹 沈联芳 袁汉珍 | 1999 | Science China Chemistry1999，42，1： | 3 |
| 14 | Discovery of Cu-Zn,Cu-Sn intermetallic minerals and its significance for genesis of the Mianning-Dechang REE Metallogenic Belt,Sichuan Province,China显示文摘Mianning-Dechang Himalayan REE Metallogenetic Belt in Sichuan Province lies along the western margin of the Yangtze Craton. We have conducted detailed mineralogical studies on ore minerals collected from Maoniuping and Dalucao, the two largest deposits in the belt. With optical microscope, SEM/EDS, and EPMA, three rare intermetallic minerals, i.e., zinccopperite (Cu2Zn), Sn- bearing native copper, and Cu-bearing jupiter were found to occur in the main ore along with barite, fluorite, apatite, sulfide and bastnaesite. Since the conditions under which zinccopperite and Sn- bearing native copper formed are quite unique, finding of these minerals, for the first time in domestic REE deposits, has significant implications for the genesis of the ore deposits in which they occur. In comparison with Cu-Zn intermetallic minerals in other occurrences, we propose that the formation of this REE metallogenetic belt is associated with fast upwelling of the Himalayan magma from deep source. | XIE Yuling1, HOU Zengqian2, XU Jiuhua1, YUAN Zhongxin2, BAI Ge2 & LI Xiaoyu3 1. Civil and Environmental Engineering School, University of Science and Technology Beijing, Beijing 100083, China 2. Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, China 3. The 109th Geological Team, Sichuan Bureau of Mineral Exploration, Chengdu 610100, China | 2006 | Science China Earth Sciences2006，49，6： | 2 |
| 15 | A Cytotoxic Saponin with Two Monoterpenoids from Albizia julibrissin显示文摘A new cytotoxic saponin(1). Julibrosides J27 was isolated from the stem barks of Alibizia. julibrissin by chromatography. and the structure was elucidated as 3--O-0- Dxylopyranosyl-(1 -2)-β -D- fucopyranosyl- (1 -6) -β - D-glucopyranosyl - 21 -O-l(6S)-2 -tuans- 2-hyduoxymethyl-6-methyl-6-O-[4-O-((6S)-2-trans-2-trans-2-hydroxylmethy 6- methyl - 6- hydroxy)-2.7 octadienoyl-β-D-quinovopy -ranosyl]2.7-octadienoyl}- acacic acid- 28 -O-β-D-glucopranosyl-(l→3)-l(a-L-arabinofuranosyl (l →4)l-a-L.rhamnopyranosyl-(l →2)-6-D-glucopyrnosyl ester based on spectral and chemical | Kun ZOU Jing Rong CUI Yu Ying ZHAO Ru Yi ZHANG Jun Hua ZHENG( Department of Natural Medicines. Beijing Medical University. Beijing 100083 National Research Laboratories of Natural and Biominetic Drug. Beijing Medical University. Beijing 100083) | 2000 | Chinese Chemical Letters2000，11，1： | 2 |
| 16 | Laser flash photolysis and pulse radiolysis study on chemical activity of VP-16 and podophyllotoxin显示文摘Time-resolved laser flash photolysis and pulse radiolysis have been used to study the chemical activity of podophyllotoxin(PPT) and etoposide(VP-16). The mechanism of photoionization of etoposide and podophyllotoxin has been confirmed and illustrated. It is demonstrated that VP-16 and PPT in aqueous solution can be photoionized at 248 nm to give hydrated electron and neutral radical resulting from rapid deprotonation of radical cation of VP-16 and PPT. The quantum yield for the photoionization of VP-16 and PPT with single-photo is 0.21 and 0.61, respectively. In addition, they can react with hydrated electron, hydrogen radical and hydroxyl radical. This will give chemists some advice on synthesizing new derivatives of podophyllotoxin in cancer treatment. | 孙晓宇 汪世龙 倪亚明 张超杰 王玫 姚思德 | 2002 | Science China Chemistry2002，45，2： | 2 |
| 17 | Effect of ceria on copper/γ-alumina catalysts for carbon monoxide and n-hexane oxidation显示文摘Effectofceriaoncopper/γ-aluminacatalystsforcarbonmonoxideandn-hexaneoxidation￥JiangXiaoyuan;ZhouRenxian;YuanXianxin;ZhengXiao... | Jiang Xiaoyuan Zhou Renxian Yuan Xianxin Zheng Xiaoming Jin Songshou (Institute of Catalysis, Hangzhou University, Hangzhou 310028, China) | 1996 | Journal of Environmental Sciences1996，8，2： | 1 |
| 18 | Synthesis, characterization and oxidative activity of heteropolyanion pillared layered compound显示文摘TRANSITION element trisubstituted and Ln bi-(1:11)series heteropolyanion with Keggin struc-ture are excellent catalyst with oxidizing properties.But they have some shortcomingssuch as poor stability and impossible recycle use when they are used in homogeneous oxidation.Anions(An-),among hydroxides(LDHS)-like layers,having a general formula[M1-x2+Mx3+- | He, QL Gao, J Hu, CW Wang, EB | 1997 | Chinese Science Bulletin1997，42，11： | 1 |
| 19 | Molecular cloning,in vitro expression and enzyme activity analysis of violaxan-thin de-epoxidase from Oryza sativa L.显示文摘The violaxanthin de-epoxidase gene was cloned from rice (Oryza sativa subsp. japonica). The full length of the cDNA is 1887 bp, encoding a 446-amino acids protein with the transit peptide of 98 amino acids. The bacterial expression vector pET-Rvde was constructed and the expression quantity of the exogenous protein increased with the induction time by 0.4 mmol/L IPTG. Its molecular weight was similar with that of the native VDE. Western blotting indicated that the expressed protein has immu-nological reaction with the VDE polyclonal antibody. The absorbance spectrum together with xanthophyll pigments quantification by HPLC demonstrated that the expressed VDE has its enzyme activity, which can de-epoxidate violaxanthin into antheraxanthin and zeaxanthin in vitro. | Lin, RC Li, LB Kuang, TY | 2002 | Chinese Science Bulletin2002，47，11： | 1 |
| 20 | ISOLATION AND IDENTIFICATION OF CYTOTOXIC COMPONENTS FROM BRYOPHYLLUM PINNATUM显示文摘A potent cytotoxic bufadienolide orthoacetate has been Isolated from Bryophyllum pinnatum. Baaed on spectral study methods, its structure was identified as bersaldegenin 1,3, 5-orthoacetate. | 严秀珍 李国雄 Yamagishi Takashi | 1992 | Chinese Journal of Cancer Research1992，4，4： | 1 |
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