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Local icariin application enhanced periodontal tissue regeneration and relieved local inflammation in a minipig model of periodontitis

查看全文 作　　者：Xiuli [1,2]Zhang;Nannan [1,2]Han;Guoqing [2,3]Li;Haoqing [2]Yang;Yangyang [2]Cao;Zhipeng [2]Fan;Fengqiu [1]Zhang 高影响力作者 机构地区：[1]Department of Periodontology, Capital Medical University School of Stomatology;[2]Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology;[3]Molecular Laboratory for Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology高影响力机构 出　　处：《International Journal of Oral Science》索引2018年第10卷第3期,共6页高影响力期刊 基　　金：supported by grants from the National Natural Science Foundation of China (grant number 81625005 to Z.F.);High-level Talents of the Beijing Health System (grant number 2014-3-080 to F.Z.);the program for Beijing Science and Technology of Chinese Medicine (grant number JJ2013-11 to F.Z.) 摘　　要：Periodontitis is an inflammatory autoimmune disease. Treatment should alleviate inflammation, regulate the immune reaction and promote periodontal tissue regeneration. Icariin is the main active ingredient of Epimedii Folium, and it is a promising compound for the enhancement of mesenchymal stem cell function, promotion of bone formation, inhibition of bone resorption, alleviation of inflammation and regulation of immunity. The study investigated the effect of icariin on periodontal tissue regeneration in a minipig model of periodontitis. The minipig model of periodontitis was established. Icariin was injected locally. The periodontal clinical assessment index, a computed tomography(CT) scan, histopathology and enzyme-linked immune sorbent assay(ELISA)were used to evaluate the effects of icariin. Quantitative analysis results 12 weeks post-injection demonstrated that probing depth,gingival recession, attachment loss and alveolar bone regeneration values were(3.72 ± 1.18) mm vs.(6.56 ± 1.47) mm,(1.67 ± 0.59)mm vs.(2.38 ± 0.61) mm,(5.56 ± 1.29) mm vs.(8.61 ± 1.72) mm, and(25.65 ± 5.13) mm3 vs.(9.48 ± 1.78) mm3 in the icariin group and0.9% NaCl group, respectively. The clinical assessment, CT scan, and histopathology results demonstrated significant enhancement of periodontal tissue regeneration in the icariin group compared to the 0.9% NaCl group. The ELISA results suggested that the concentration of interleukin-1 beta(IL-1β) in the icariin group was downregulated compared to the 0.9% NaCl group, which indicates that local injection of icariin relieved local inflammation in a minipig model of periodontitis. Local injection of icariin promoted periodontal tissue regeneration and exerted anti-inflammatory and immunomodulatory function. These results support the application of icariin for the clinical treatment of periodontitis. 关 键 词：ELISA Treatment SHOULD ALLEVIATE
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