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| 1 | 急性肾损伤诊断与分类专家共识显示文摘近几十来.临床和基础的研究工作者们针对急性肾功能衰竭(ARF)进行了广泛的研究,尽管我们在该疾病的生理和发病机制方面都取得了长足的进步,但如何将这些知识用于临床,改进ARF患者预后方面的工作却做得十分有限。ARF是由多种病因导致、可发生在各种临床情况之下(儿童或成人、门诊或住院、ICU或非ICU患者)的一种复杂的肾功能紊乱,其临床表现既可以是血肌酐水平的轻微升高,也可以是无尿性肾功能衰竭。 | RL Mehta JA Kellum S Shah B Molitoris C Ronco D Warnock A Levin 王欣 | 2006 | 中华肾脏病杂志2006，22，11： | 348 |
| 2 | BCLC策略:预后预测和治疗推荐2022版更新显示文摘2018版BCLC预后和治疗推荐策略发布后,肝细胞癌(简称HCC)的研究又取得了重大进展。本次更新基于肝癌各领域的研究进展结果。重点关注影响策略的重要研究进展。虽然近年的研究结果成绩斐然,但将其引入为临床医生和研究者提供行动依据的循证模型指南来说证据效力依然不够确切。本文对该问题进行分析,阐述了为HCC患者制定个体化治疗临床决策所需的批判性思维和专业知识。 | Reig M Forner A Rimola J Ferrer-Fabrega J Burrel M Garcia-Criado A Kelley RK Galle PR Mazzaferro V Salem R Sangro B Singal AG Vogel A Fuster J Ayuso C Bruix J 刘永凡(摘译) 崔笑(摘译) 耿小平(审校) | 2022 | 肝胆外科杂志2022，30，5： | 80 |
| 3 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 4 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 5 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 6 | The precipitation strengthening behavior of Cu-rich phase in Nb contained advanced Fe-Cr-Ni type austenitic heat resistant steel for USC power plant application | Cheng-yu Chi a, Hong-yao Yu b, Jian-xin Dong b, Wen-qing Liu c, Shi-chang Cheng d, Zheng-dong Liu d, Xi-shan Xie b a School of Metallurgical and Ecological Engineering, University of Science & Technology Beijing, Beijing 100083, China b School of Materials Science and Engineering, University of Science & Technology Beijing, Beijing 100083, China c Instrumental Analysis & Research Center, Shanghai University, Shanghai 200444, China d Central Iron and Steel Research Institute, Beijing 100081, China | 2012 | Progress in Natural Science:Materials International2012，22，3： | 20 |
| 7 | 龙门山断裂带沉积岩和天然断层泥的摩擦滑动性质与启示显示文摘对采自四川龙门山断裂带(LFZ)地震发生区段的样品进行摩擦滑动实验研究,得到一系列实验结果。实验样品包括用富含黏土的完整泥岩和砂岩制备的模拟断层泥、由富含方解石的灰岩制备的模拟断层泥和一种天然断层泥。其中,天然断层泥是通过人工探槽方法采自于穿过泥岩和砂岩层的地表破裂中。富含黏土矿物的样品主要由伊利石和石英组成。在实验中,将1 mm厚的断层泥夹于具有倾斜锯切面的围岩之间,在三轴实验系统中对其进行剪切变形实验,实验条件与龙门山断裂带2 km深处的条件相一致。实验温度范围为25℃~150℃,同时为了研究摩擦强度的速度依赖性,对剪切位移的速度实施1.22~0.122μm/s的阶跃式变化。分析结果表明,天然断层泥比原岩的泥岩和砂岩更富含伊利石,而且强度比原岩弱得多。天然断层泥的稳态摩擦系数约为0.4,而原岩则约为0.6。另外,灰岩断层泥的摩擦系数为0.6~0.7。除了灰岩,所有样品均表现为稳定、速度强化的滑动行为。灰岩在25℃~50℃表现为速度强化,但是在100℃~150℃时表现为准静态的振荡,在150℃时显示速度弱化行为。运用此次实验结果讨论沉积岩在类似于汶川地震这样的地震事件中所起的作用,指出该区域富含黏土的沉积层可能对从深部扩展而来的破裂扩展有阻尼作用,而灰岩则有可能会加速破裂的传播,同时产生明显的应力降。 | 何昌荣 VERBERNE B A SPIERS C J | 2011 | 岩石力学与工程学报2011，30，1： | 20 |
| 8 | 广东龙窝花岗闪长质岩体的年代学、地球化学及岩石成因显示文摘龙窝岩体是南岭地区燕山早期具幔源组分贡献的花岗岩的典型代表,其主体岩性为花岗闪长岩,岩体中含有深色闪长质包体,锆石ELA-ICP-MS定年结果表明花岗闪长岩的形成年龄为169.1±2.5Ma,属中侏罗世岩浆活动的产物。地球化学特征上,该岩体铝弱过饱和(A/NKC=1.0~1.1),相对贫碱,富钾(K_2O/Na_2O=1.15~1.45),富轻稀土和大离子亲石元素(如Rb、Cs、Th、U),贫高场强元素(如Nb、Ti)。闪长质包体具有与寄主岩相似的矿物组合,但铁镁矿物含量及过渡族元素(V、CR、Co、Ni)丰度相对偏高,二者的主量和微量元素表现出混合成因的演化趋势。寄主岩与包体具有相近的Sr、Nd同位素组成,I_(Sr)和ε_(Nd)(t)值分别为0.70843~0.70995、-6.53~-8.89和0.70797~0.70882、-4.71~-9.24,均表现出壳幔混源花岗岩类岩石的特点。二元混合模拟计算显示寄主岩与包体成岩过程中地幔物质的混入比例分别为32.9%~40.4%和 31.8%~46.4%。通过对岩石产出构造背景及地质地球化学特征的综合分析,表明龙窝花岗闪长岩及其中的闪长质包体是在伸展-引张环境下,由幔源基性岩浆及其诱发的壳源长英质岩浆混合作用的产物。 | 邱检生 胡建 McInnes B I A 蒋少涌 徐夕生 Allen C M | 2004 | 岩石学报2004，20，6： | 19 |
| 9 | Clostridium difficile infections in China显示文摘Clostridium difficile (C. difficile) infection has become one of the major hospital-associated infections in West-ern countries in the last two decades. However, there is limited information on the status of C. difficile infection inChinese healthcare settings. Given the large and increasing elderly population and the well-recognized problem ofover-prescribing of broad spectrum antibiotics in China, it is critical to understand the epidemiology and potentialrisk factors that may contribute to C. difficile infection in China. A literature review of available published studies,including those in Chinese language-based journals, was conducted. A review of the currently available literaturesuggested the presence of C. difficile infections in China, but also suggested that these infections were not particu-larly endemic. This finding should lead to better designed and greatly expanded studies to provide a more reliableepidemiologically-based conclusion on the actual status of C. difficile infection in China, including the identifica-tion of any associated risk factors. Such information is ultimately valuable to develop appropriate strategies to pre-vent C. difficile infection and the vast negative impact of such infections in China and other developing countries. | Ke Jin a,b,c,Shixia Wang c,d,Zuhu Huang a,b,c,Shan Lu b,c,daDepartment of Infectious Diseases,bJiangsu Province Key Laboratory in Infectious Diseases,cChina-US Vaccine ResearchCenter,the First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China d Department of Medicine,University of Massachusetts Medical School,Worcester,MA 01655,USA. | 2010 | The Journal of Biomedical Research2010，24，6： | 14 |
| 10 | 酒精摄入、心脏生物标志物和心房颤动风险与不良结局显示文摘酒精摄入和新发心房颤动相关性证据不一,尤其是在低剂量下。该研究评估欧洲队列在整个饮酒范围内酒精摄入、生物标志物和新发心房颤动的关系。方法和结果:在一个以社区为基础的汇集队列中,研究者随访107845人,以评估酒精摄入(酒精种类和饮酒方式)与新发心房颤动的关系。研究者收集经典心血管病危险因素和新发心力衰竭的信息,并检测生物标记物氨基末端脑钠肽前体和高敏肌钙蛋白I。 | 陈嘉睿(译) 练桂丽((审校) Csengeri D Sprünker NA Di Castelnuovo A Niiranen T Vishram-Nielsen JK Costanzo S S derberg S Jensen SM Vartiainen E Donati MB Magnussen C Camen S Gianfagna F L chen ML Kee F Kontto J Mathiesen EB Koenig W Stefan B de Gaetano G J rgensen T Kuulasmaa K Zeller T Salomaa V Iacoviello L Schnabel RB | 2021 | 中华高血压杂志2021，29，2： | 9 |
| 11 | 热处理豆粕饲喂生长猪的氨基酸消化率显示文摘为测定热处理对豆粕(SBM)表观回肠消化率和标准回肠消化率(SID)的影响,本试验将常规去壳豆粕(48.5%蛋白)分成4组,一份未经额外热处理,一份在125℃下高压蒸汽处理15 min,一份在125℃下高压蒸汽处理30 min,另一份在125℃下烘箱烘干30 min。制定四种豆粕-玉米淀粉型日粮配方,且每个配方只能使用上述四种豆粕中的一种,作为每种日粮中唯一氨基酸来源。用无氮日粮配方来估算基础内源性氨基酸损失。分别在初始体重为(25.3±2.0)kg的10头阉公猪回肠末端安装一个T-型瘘管。采用5×5拉丁方设计法,将试验猪分成5个日粮处理组,5个重复处理周期。每个处理周期持续7 d,在第6天和第7天收集回肠食糜。试验结果表明,随着高压蒸汽处理时间(0~30 min)的延长,蛋白质和所有氨基酸的表观回肠消化率和标准回肠消化率呈线性降低(P<0.01)。糠氨酸含量和豆粕样品的颜色表明高压蒸汽处理导致豆粕产生美拉德反应。然而,125℃烘箱干燥30min并未改变豆粕中蛋白和氨基酸标准回肠消化率,也没有改变SBM的糠氨酸含量(P>0.10),且烘箱处理的样品颜色表明该样品并未受到热处理破坏。总之,热蒸汽处理时间从0 min增至30 min,高压蒸汽处理豆粕的氨基酸消化率呈线性降低,降低原因很可能是由于125℃高压蒸汽处理导致豆粕产生美拉德反应。 | González-Vega J C Kim B G Htoo J K Lemme A Stein H H | 2015 | 中国饲料2015，，24： | 8 |
| 12 | 男性迟发性性腺功能减退症的检查、治疗和监测:国际男科学会(ISA)、国际老年男性研究会(ISSAM)、欧洲泌尿外科学会(EAU)、欧洲泌尿外科学院(EAA)和美国男科学会(ASA)联合推荐显示文摘简介
人口学资料明确显示:老年人口占总人口的百分率正逐年增加。当前,有关老年男性雄激素缺乏的问题逐渐成为令人感兴趣、但又充满争议的世界性话题。已经有横向和纵向的研究资料表明,随着年龄增大,成年男子的雄激素水平逐渐降低, | Wang C Nieschlage E Swerdloff R Behre HM Hellstrom WJ Gooren LJ Kaufman JM Legros JJ Lunenfeld B Morales A Morley JE Schulman C Thompson IM Weidner W Wu FCW 伍学焱(翻译) | 2011 | 国际生殖健康/计划生育杂志2011，30，1： | 8 |
| 13 | Preparation of nano-sized Bi_2Te_3 thermoelectric material powders by cryogenic grinding | Xiaozong Chen a, Leifeng Liu b, Yuan Dong a, Lianjun Wang a, Lidong Chen c, Wan Jiang a, a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, 2999 people of North Road, Shanghai 201620, PR China b Department of Materials and Environmental Chemistry, Stockholm University, SE-106 91 Stockholm, Sweden c Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, PR China | 2012 | Progress in Natural Science:Materials International2012，22，3： | 8 |
| 14 | 维生素D对心力衰竭患者全因死亡率的影响:4000U/d维生素D口服3年随机临床试验结果显示文摘循环25-羟基维生素D[25-hydroxyvitamin D,25(OH)D]〈75nmol/L与死亡率风险的非线性增加相关。这种低25(OH)D水平在心力衰竭患者中很常见。因此,Zittermann等进行研究检查口服维生素D补充剂能否降低晚期心力衰竭患者的死亡率。 | 刘莉 叶鹏 Zittermann A Ernst JB Prokop S Fuchs U Dreier J Kuhn J Knabbe C Birschmann I Schulz U Berthold HK Pilz S Gouni-Berthold I Gummert JF Dittrich M Brgermann J | 2017 | 中华高血压杂志2017，25，10： | 7 |
| 15 | Leukemia:研究鉴定出与34种AML白血病亚群相关联的基因突变显示文摘针对成年急性髓细胞白血病(acute myeloid leukemia,AML)患者的一项新的大型研究将80种癌症相关基因突变与5种AML亚型相关联。这5种AML亚型可通过特异性的染色体异常加以确定。在未来,这些发现可能有助指导基因突变测试和治疗决策。 | A-K Eisfeld K Mrózek J Kohlschmidt D Nicolet S Orwick C J Walker K W Kroll J S Blachly A J Carroll J E Kolitz B L Powell E S Wang R M Stone A de la Chapelle J C Byrd C D Bloomfield | 2017 | 现代生物医学进展2017，17，15： | 7 |
| 16 | Corrosion behavior of Mg-Y alloy in NaCl aqueous solution | Xin Zhang a,b,c,Kui Zhang a,Xia Deng a,Hongwei Li b,c,Yongjun Li a,Minglong Ma a,Ning Li b,c,Yanlong Wang b,c a State Key Laboratory for Fabrication and Processing of Nonferrous Metals,Beijing General Research Institute for Nonferrous Metals,Beijing 100088,China b Beijing Engineering Research Center for Advanced Manufacturing and Evaluation of Special Vehicle Parts,Beijing 100072,China c Center of Technology,Beijing North Vehicle Group Corporation,Beijing 100072,China | 2012 | Progress in Natural Science:Materials International2012，22，2： | 7 |
| 17 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 18 | 全球溺水负担:GBD 2017全球疾病负担死亡率的估计研究显示文摘世界卫生组织已将溺水确定为公共卫生优先事项。溺水指因淹没或者浸没于液体中而出现呼吸障碍的过程,其结果分为死亡、受伤和不受伤。致命性溺水是世界范围内导致非故意伤害相关死亡的主要原因,全球每年约有30万人溺水死亡。中低收入国家非故意溺水发生尤为严重。此外,男性和儿童是非故意溺水的高危人群。伤害预防工作者掌握准确和及时的数据将有助于合理分配公共卫生资源和评价干预措施的效果。 | 黄锦裕 佘宇航(摘译) 李丽萍(审校) Franklin R C Peden A E Hamilton E B | 2020 | 伤害医学(电子版)2020，9，4： | 6 |
| 19 | Impact of laparoscopic surgery training laboratory on surgeon's performance显示文摘Minimally invasive surgery has been replacing the open standard technique in several procedures. Similar or even better postoperative outcomes have been described in laparoscopic or robot-assisted procedures when compared to open surgery. Moreover, minimally invasive surgery has been providing less postoperative pain, shorter hospitalization, and thus a faster return to daily activities. However, the learning curve required to obtain laparoscopic expertise has been a barrier in laparoscopic spreading. Laparoscopic surgery training laboratory has been developed to aid surgeons to overcome the challenging learning curve. It may include tutorials, inanimate model skills training(box models and virtual reality simulators), animal laboratory, and operating room observation. Several different laparoscopic courses are available with specific characteristics and goals. Herein, we aim to describe the activities performed in a dry and animal-model training laboratory and to evaluate the impact of different kinds of laparoscopic surgery training courses on surgeon's performance. Several tasks are performed in dry and animal laboratory to reproduce a real surgery. A short period of training can improve laparoscopic surgical skills, although most of times it is not enough to confer laparoscopic expertise for participants. Nevertheless, this short period of training is able to increase the laparoscopic practice of surgeons in their communities. Full laparoscopic training in medical residence or fellowship programs is the best way of stimulating laparoscopic dissemination. | Fabio C M Torricelli Joao Arthur B A Barbosa Giovanni S Marchini | 2016 | World Journal of Gastrointestinal Surgery2016，8，11： | 6 |
| 20 | Effects of disinhibition on spatiotemporal pattern of neuronal first recruitment in neuronal networks显示文摘The propagation of neuronal activities is a key feature to understanding information processing in networks. The analysis based on first-spikes of bursts in turn plays an important role in the research of neuronal activity propagation. Our focus here is to investigate how spatiotemporal patterns of neuronal first-spikes are affected by disinhibition. Multi-electrode arrays were used to record stimulation-evoked bursts of multiple neurons in randomly cultured neuronal networks. Both the precise timing of and the rank relationships between first-spikes were analyzed. Compared with evoked bursts in the network's native state, the precise first-spike latencies in its dis-inhibited state are more consistent and the propagation of its bursting activities is much faster. Additional points of interest are that disinhibited neuronal networks can be evoked to generate stable and distinguishable neuronal first recruitment spatiotemporal patterns specific to the stimulation site, and that the disinhibition may cause the original spatiotemporal patterns to change in a heterogeneous manner with regards to different propagation pathways. | Liangbin Pana,b,c,1, Xindong Songa,b,c,1, Guangxin Xiang a,b,c, Jing Zhua,b,c, Jing Cheng a,b,c,d,a Medical Systems Biology Research Center, Tsinghua University School of Medicine, Beijing 100084, China b Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China c National Engineering Research Center for Beijing Biochip Technology, 18 Life Science Parkway, Beijing 102206, China d State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China | 2009 | Progress in Natural Science:Materials International2009，19，5： | 6 |
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