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| 1 | CSF total and oligomeric α-Synuclein along with TNF-α as risk biomarkers for Parkinson’s disease: a study in LRRK2 mutation carriers显示文摘Background Asymptomatic carriers of leucine-rich repeat kinase 2(LRRK2)gene mutations constitute an ideal population for discovering prodromal biomarkers of Parkinson’s disease(PD).In this study,we aim to identify CSF candidate risk biomarkers of PD in individuals with LRRK2 mutation carriers.Methods We measured the levels of CSF total-(t-),oligomeric(o-)and phosphorylated S129(pS129-)α-syn,total-tau(tTau),phosphorylated threonine 181 tau(pTau),amyloid-beta 40(Aβ-40),amyloid-beta-42(Aβ-42)and 40 inflammatory chemokines in symptomatic(n=23)and asymptomatic(n=51)LRRK2 mutation carriers,subjects with a clinical diagnosis of PD(n=60)and age-matched healthy controls(n=34).General linear models corrected for age and gender were performed to assess differences in CSF biomarkers between the groups.Markers that varied significantly between the groups were then analyzed using backward-elimination logistic regression analysis to identify an ideal biomarkers panel of prodromal PD.Results Discriminant function analysis revealed low levels of CSF t-α-syn,high levels of CSF o-α-syn and TNF-αbest discriminated asymptomatic LRRK2 mutation carriers from both symptomatic PD and healthy controls.Assessing the discriminative power using receiver operating curve analysis,an area under the curve>0.80 was generated.Conclusions The current study suggests that CSF t-,o-α-syn and TNF-αare candidate risk biomarkers for the detection of PD at the prodromal stage.Our findings also highlight the dynamic interrelationships between CSF proteins and the importance of using a biomarkers’panel approach for an accurate and timely diagnosis of PD. | Nour K.Majbour Jan O.Aasly Eldbjørg Hustad Mercy A.Thomas Nishant N.Vaikath Naser Elkum Wilma D.Jvan de Berg Takahiko Tokuda Brit Mollenhauer Henk W.Berendse Omar M.A.El-Agnaf | 2020 | Translational Neurodegeneration2020，9，2： | 2 |
| 2 | 生物质能源生产的生态环境影响(英文)显示文摘生物质能源生产是能源发展领域的重大挑战,在解决新的替代能源中扮演着重要角色。本文着重论述了美国生物能源生产的生态环境问题。从经济、环境和战略方面考虑,生物能源有望提高国家安全,因而受政策驱动的美国生物能源生产技术备受注目。尽管生物能源具有诸多潜在效益,但是在北美,生物原料供应、高强度经营的土地上农药使用及其对陆地野生动物的潜在影响等令人担忧,我们分析了其中的原因。通常认为,未来生物能源的环境、经济效应是正面的;然而,谨慎地审视和发展生物能源经济以保护生态系统的可持续性显得至关重要。 | John W.Bickham Mark A.Thomas | 2010 | Journal of Resources and Ecology2010，1，2： | 2 |
| 3 | The prognostic significance of p16INK4a/p14ARF locus deletion and MDM‐2 protein expression in adult acute myelogenous leukemia显示文摘 | StefanFaderl Hagop M.Kantarjian ElihuEstey TaghiManshouri Ching‐YangChan AbdelRahman Elsaied Steven M.Kornblau JorgeCortes Deborah A.Thomas SherryPierce Michael J.Keating ZeevEstrov MaherAlbitar | 2000 | Cancer2000，，： | 1 |
| 4 | Emphysematous cystitis: a review of 135 cases显示文摘 | Anil A.Thomas Brian R.Lane Arun Z.Thomas Erick M.Remer Steven C.Campbell Daniel A.Shoskes | 2007 | BJU International2007，，1： | 1 |
| 5 | Toward the efficient use of Beauveria bassiana in integrated cotton insect pest management显示文摘Background:For controlling the resistance to insects,in particular carpophagous and phyllophagous caterpillars,using chemical pesticides has led to contamination of cotton area in Benin.Facing this problem,alternative methods including the use of entomopathogenic fungi as biopesticide could be a sound measure to preserve the environment,biodiversity and ensure good quality of crops.Previous studies have revealed the insecticidal potential of the entomopathogenic Beauveria bassiana on some insect pest species.However,little is known about its effectiveness on cotton Lepidopteran pests.This review is done to learn more about B.bassina for its application in controlling cotton insect pests,especially Lepidopteran species.Main body:Different sections of the current review deal with the related description and action modes of B.bassiana against insects,multi-trophic interactions between B.bassiana and plants,arthropods,soil and other microbes,and biological control programs including B.bassiana during last decade.Advantages and constraints in applying B.bassiana and challenges in commercialization of B.bassiana-based biopesticide have been addressed.In this review,emphasis is put on the application methods and targeted insects in various studies with regard to their applicability in cotton.Conclusion:This review helps us to identify the knowledge gaps related to application of B.bassiana on cotton pest in general and especially in Lepidopteran species in Benin.This work should be supported by complementary laboratory bioassays,station and/or fields experiments for effective management of cotton Lepidopteran pests in Benin. | DANNON H.Fabrice DANNON A.Elie DOURO-KPINDOU O.Kobi ZINSOU A.Valerien HOUNDETE A.Thomas TOFFA-MEHINTO Joëlle ELEGBEDE I.A.T.Maurille OLOU B.Dénis TAMÒ Manuele | 2020 | Journal of Cotton Research2020，3，3： | 1 |
| 6 | OCCURRENCE OF EARLIEST CYCADS IN THE PERMIAN OF CHINA AND ITS BEARING ON THEIR EVOLUTION显示文摘Living cycads show a range of archaic features which suggest that they are primitive plants. They have a long fossil record, but this unfortunately consists largely of vegetative leaves. Very few reproductive organs are preserved as fossils. However, | 高志峰 BARRY A.THOMAS | 1989 | Chinese Science Bulletin1989，34，9： | 1 |
| 7 | Interpreting the Significance of Drinking by Alcohol-Dependent Liver Transplant Patients: Fostering Candor Is the Key to Recovery显示文摘 | Robert M. Weinrieb Deborah H.A. Van Horn A.Thomas McLellan Michael R. Lucey | 2000 | Liver Transplantation2000，，6： | 1 |
| 8 | 标准——世界通用语言 ASTM国际标准组织总裁唐建思(James Thomas)显示文摘今年世界标准日的主题定为"标准——世界通用的语言",真是好极了!这一说法对有些人来说是全新的,但对于众多标准化业内人士来说,包括我本人在内,却并不陌生。在标准领域40多年的从业生涯中,我听闻许多技术专家、企业高管和政府官员都曾提起高品质技术标准的全球相关性问题。事实是清楚的,标准支撑起80%的国际贸易、 | Jamce A.Thomas | 2015 | 中国标准化2015，，10： | 1 |
| 9 | 血栓性血小板减少性紫癜溶血尿毒综合征血浆置换治疗的并发症:附加78例的一项研究显示文摘血栓性血小板减少性紫癜溶血尿毒综合征(TTP—HUS)血浆置换(PE)治疗的病例从1981年到1997年增加了7倍。因此,对于临床疑似TTD-HUS的病例来说,由于血浆置换引起的致病和致死率越来越成为重要的考虑因素。某些研究认为PE的并发症很少,但作者以前报告的连续71个临床疑似TTP—HUS病例,1996年至1999年,进行血浆置换治疗,发生严重并发症达到30%,包括2例死亡。 | J.R.McMinn A.Thomas Deirdra R.Terrell 宋任浩 | 2003 | 国外医学(输血及血液学分册)2003，26，6： | 1 |
| 10 | Prognostic significance of immunophenotypic and karyotypic features of Philadelphia positive B‐lymphoblastic leukemia in the era of tyrosine kinase inhibitors显示文摘 | JesseJaso Deborah A.Thomas KristaCunningham Jeffrey L.Jorgensen Hagop M.Kantarjian L. JeffreyMedeiros Sa A.Wang | 2011 | Cancer2011，，： | 1 |
| 11 | The Epstein-Barr Virus G-Protein-Coupled Receptor Contributes to Immune Evasion by Targeting MHC Class Ⅰ Molecules for Degradation显示文摘 | Jianmin Zuo Andrew Currin Bryan D.Griffin Claire Shannon-Lowe Wendy A.Thomas Maaike E.Ressing Emmanuel J.H.J.Wiertz Martin Rowe | | 0，，： | 1 |
| 12 | The Epstein-Barr Virus-Encoded BILF1 Protein Modulates Immune Recogmition of Endogenously Processed Antigen by Targeting Major Histocompatibility Complex Class Ⅰ Molecules Traf cking on both the Exocytic and Endocytic Pathways显示文摘 | Jianmin Zuo Laura L.Quinn Jennifer Tamblyn Wendy A.Thomas Regina Feederle Henri-Jacques Delecluse Andrew D.Hislop Martin Rowe | | 0，，： | 1 |
| 13 | Interpreting the Significance of Drinking by Alcohol-Dependent Liver Transplant Patients: Fostering Candor Is the Key to Recovery显示文摘 | Robert M. Weinrieb Deborah H.A. Van Horn A.Thomas McLellan Michael R. Lucey | 2000 | Liver Transplantation2000，，6： | 1 |
| 14 | Development of emotional facial recognition in late childhood and adolescence显示文摘 | Laura A.Thomas Michael D.De Bellis ReikoGraham Kevin S.LaBar | 2007 | Developmental Science2007，，5： | 1 |
| 15 | 高流行区进行社区调查发现肺结核病例的意义:南印度Tirrvallur地区的一项比较性研究报告显示文摘背景:在南印度的Tirrvallur地区,作为DOTS项目的一部分,肺结核病人的发现主要由卫生机构(HF)来完成;另外,作为正在进行的一项流行病学研究的组成部分,通过社区调查(CS)对成人进行筛检也可以发现一部分病例。目的:对一年内由HF和CS发现的所有病人的社会人口学、临床学、细菌学特征以及治疗结局进行比较。结果:在32663名受调查的成人患者中共发现100例涂阳以及 116例涂阴肺结核病人;在65例已经开始化疗的涂阳病例中,44例已治愈。与HF病人相比,CS病人一方面年龄偏大(AOR=1.9)、男性较多(AOR=2.7)、文化程度较低(AOR=1.7)、居住条件较差(AOR=2.0);另一方面CS病人咳嗽3周以上(AOR=3.4)的比例以及涂阳比例较低(AOR=4.2)。在61名新发现涂阳CS病人中,40人报告有胸痛症状;其中32人(80%)已经就诊过,但未确诊。结论:即使在结核病高流行地区,社区调查对于肺结核病例发现也价值甚微。通过社区调查所发现的病例症状轻、传染性小,而且不到一半的人已经治愈。诊断性检查应面向年长、文化程度低的男性。 | T.Santha Garg Renu T.R.Frieden R.Subramani P.G.Gopi V.Chandrasekaran N.Selvakumar A.Thomas R.Rajeswari R.Balasubramanian C.Kolappan P.R.Narayanan 贺晓新 | 2003 | 国际结核病与肺部疾病杂志2003，，3： | 0 |
| 16 | 保护ASTM知识产权版权、盗版和ASTM国际标准组织标准显示文摘ASTM国际标准组织的标准从未像今天这样容易获得,其获取既便宜又高效。由于互联网的存在,只需轻点鼠标,无论在世界任何地方,都可在您的电脑桌面上轻松获得ASTM标准。 | James A.Thomas | 2011 | 中国标准化2011，，2： | 0 |
| 17 | 助推中国建立公平竞争平台显示文摘我很高兴有这个机会在全球欢庆世界标准日之时,对中国和中国国家标准化管理委员会表达我良好的祝愿。今年世界标准日主题为“标准营造公平竞争环境”,就ASTM国际标准组织而言,其标准在全球广为使用,中国在法规和企业标准中也广泛采纳了ASTM标准,我们始终坚持标准制定过程的一致性,注重产品质量和市场相关性。 | James A.Thomas | 2014 | 中国标准化2014，，10： | 0 |
| 18 | 森林生态学概述、动态和多样性显示文摘本书集中当前的一些研究结果,介绍森林和林地生态系统的结构,通过从极地到萨瓦那再到热带雨林生态系统的大量实例,对林地和森林生态系统的一般过程进行描述,并在种群和区域尺度上讨论动植物多样性的重要性。本书着重介绍林地生态系统过程, | Peter A.Thomas 盛文萍 | 2008 | 国外科技新书评介2008，，8： | 0 |
| 19 | 退休感言:最后的寄语显示文摘自1999年2月开始,我撰写"寄语"这一专栏,多年来已撰写了许多精彩且有趣的文章,涉及各不相同的主题。然而就在我即将于明年一月底退休之际,告别寄语——成为我至今为止遇到过的最难言说的话题。 | James A.Thomas | 2016 | 中国标准化2016，，12： | 0 |
| 20 | 创新的移动业务满足低端用户的需求和预算显示文摘目前全球有20亿人使用移动电话来满足自己的沟通需要。然而地球上还有接近40亿人没有手机,无法使用通信手段进行沟通。在很多国家,移动网络的覆盖仍然远远未达到完善水平,一般来说,运营商会优先覆盖城市人口。但覆盖并非唯一理由:实际上有75%的全球人口都在移动网络的覆盖范围之内,但是今天只有25%的人口是移动电话用户。 | A.Thomas | 2006 | 网络电信2006，8，12： | 0 |
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