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| 1 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 2 | Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease显示文摘 | Vasa M Fichtlscherer S Adler K | 2001 | Circulation2001，103，24： | 1 |
| 3 | Prevention of chronic fibrillation by pacing in the region of bachmann's bundle:Results of a multicenter randomized trial显示文摘 | Bailin SJ Adler S Giudici M | 2001 | J Cardivasc Electrophys2001，12，8： | 1 |
| 4 | Possible participation of nitric oxide in the increase of norepinephrine release caused by angiotensin peptides in rat atria显示文摘 | HIRONACCI M M LOVENZO P S ADLER GRASCHINSKY E | 1997 | Hypertension1997，29，6： | 1 |
| 5 | S3-Leitlinie ?Exokrines Pankreaskarzinom” 2007显示文摘 | G Adler T Seufferlein S Bischoff H.-J Brambs S Feuerbach G Grabenbauer S Hahn V Heinemann W Hohenberger J Langrehr M Lutz O Micke H Neuhaus P Neuhaus H Oettle P Schlag R Schmid W Schmiegel K Schlottmann J Werner B Wiedenmann I Kopp | 2007 | Z Gastroenterol2007，，06： | 1 |
| 6 | Increase in circulating endothelial progenitor ceils by statin therapy in patients with stable coronary artery disease显示文摘 | Vasa M Fichtlscherer S Adler K | 2001 | Circulation2001，103，： | 1 |
| 7 | Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease显示文摘 | Vasa M Fichtlscherer S Adler K | 2001 | Cireulation2001，103，： | 1 |
| 8 | Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease 显示文摘 | Vasa M Fichtlscherer S Adler K | 2001 | Circulation2001，103，24： | 1 |
| 9 | Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coro nary artery disease显示文摘 | Vasa M Fichtlscherer S Aicher A Adler K Urbich C Martin H | 2001 | Cire Res2001，89，： | 1 |
| 10 | Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease显示文摘 | Vasa M Fichtlscherer S Adler K Aicher A Martin H Zeiher A M | 2001 | Circulation2001，103，： | 1 |
| 11 | Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease显示文摘 | Vasa M Fichtlscherer S Adler K | 2001 | Circulation2001，103，24： | 1 |
| 12 | Using mech-anistic and computational studies to explain ligand effectsin the palladium-catalyzed aerobic oxidation of alcohols显示文摘 | Schultz M J Adler R S Zierkiewicz W | 2005 | Journal of the American Chemical Society2005，127，23： | 1 |
| 13 | Familial transmission of risk factors in the first-degree relatives of schizophrenic people显示文摘 | WALDO M C ADLER L E LEONARD S | 2000 | Biol Psychiatry2000，47，： | 1 |
| 14 | Hemagglutinin activation of pathogenic avian influenza viruses of sero type H7 requires the protease recognition motif R-X-K// R-R显示文摘 | Vey M Orlich M Adler S | 1992 | Virology1992，188，1： | 1 |
| 15 | The CyberKnife: a frame- less robotic system for radiosurgery显示文摘 | Adler J R Chang S D Murphy M J et ol | 1997 | Stereotactic and Functional Neurosurgery1997，69，1： | 1 |
| 16 | A joint model forvehicle type and fuel type choice: Evidence from across-nested logit study显示文摘 | HESS S FOWLER M ADLER T | 2012 | Transportation2012，39，3： | 1 |
| 17 | Aquacultures sludge removal and stabilization within created wetlands 显示文摘 | SUMMERFELT S T ADLER P R GLENN D M | 1999 | Aquacuhural Engineering1999，19，2： | 1 |
| 18 | Image-guided robotic radiosurgery显示文摘 | Adler J R Jr Murphy M J Chang S D et O1 | 1999 | Neurosurgery1999，4，6： | 1 |
| 19 | Structural characterization of carbon-supported platinum-ruthenium nanoparticles from the molecular cluster precursor PtRusC(Co)16 显示文摘 | Nashner M S Frenkel A I Adler D L | 1997 | J Am Chem Soc1997，119，： | 1 |
| 20 | Haemagglutinin activation of pathogenic avian influenza virus of serotype H7 requires the recognition motif R-X-R/K-R显示文摘 | Vey M Orlich M Adler S | 1991 | Virology1991，188，： | 1 |
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