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| 1 | Vitellaria paradoxa nutshells from seven sub-Saharan countries as potential herbal medicines for treating diabetes based on chemical compositions, HPLC fingerprints and bioactivity evaluation显示文摘The aim of the study was to determine the feasibility of the Vitellaria paradoxa nutshell as a new medicinal resource for treating diabetes. A total of forty-one compounds were identified by HPLC-DAD-Q-TOF-MS and phytochemical methods in V. paradoxa nutshell methanol extract. Based on HPLC fingerprints, four characteristic constituents were quantified and the origin of twenty-eight V. paradoxa nutshells from seven sub-Saharan countries was compared, which were classified into three groups with chemometric method. Twenty-eight samples contained high total phenolic content, and exhibited moderate-higher antioxidant activity and strong α-glucosidase inhibitory activity. Furthermore, all fractions and isolated compounds were evaluated for their antioxidant and α-glucosidase inhibitory activities, and α-glucosidase inhibitory action mechanism of four characteristic constituents including protocatechuic acid, 3, 5, 7-trihydroxycoumarin,(2 R, 3 R)-(+)-taxifolin and quercetin was investigated via molecular docking method, which were all stabilized by hydrogen bonds with α-glucosidase. The study provided an effective approach to waste utilization of V. paradoxa nutshell, which would help to resolve waste environmental pollution and provide a basis for developing potential herbal resource for treating diabetes. | LI Da XIAO Jian-Qi LIU Wen-Yuan ZHANG Chao-Feng AKIHISA Toshihiro ABE Masahiko MASTERS Eliot-T. ZHAI Wei-Wei FENG Feng ZHANG Jie | 2019 | Chinese Journal of Natural Medicines2019，17，6： | 2 |
| 2 | Inhibitory effect of di - and trihy - droxy tirterpenes from the flowers of composition 12 - O - tetradacanoylphorbol - 13 - acetate - induced in - flammation in mice 显示文摘 | Yasukawa Ken Akihisa Toshihiro | 1996 | Biol Pharm Bull1996，19，10： | 1 |
| 3 | Oxy - genated lanostane - type triterpenoids from the fungus Ganoderma lu- cidum显示文摘 | Toshihiro Akihisa Masaaki Tagata Motohiko Ukiya | 2005 | J Nat Prod2005，68，： | 1 |
| 4 | Melanogenesis inhibitory activities of iridoid-,hemiterpene-,and fatty acid-glycosides from the fruits of Morinda citrifolia(Noni)显示文摘 | Toshihiro Akihisa Ken-ichi Seino Etsuyo Kaneko | 2010 | Journal of Oleo Science2010，59，1： | 1 |
| 5 | Anti - tumor- initiating effects of monascin, an azaphilonoid pigment from the extract of Monasctts pilosus fermented rice(red- mold rice ) 显示文摘 | Toshihiro Akihisa Harukuni Tokudab Motohiko Ukiyaa | 2005 | Chemistry & Biodiversity2005，，2： | 1 |
| 6 | Inhibitory effect of di-and trihy-droxy tirterpenes from the flowers of composition 12-O-tetradacanoylphorbol-13-acetate-induced inflammation in mice显示文摘 | Yasukawa Ken Akihisa Toshihiro | 1996 | Biol Pharm Bull1996，19，10： | 1 |
| 7 | Melanogenesis inhibitory activities of iridoid-, hemiter- pene-, and fatty acid-glycosides from the fruits of Morinda citrifolia (Noni)显示文摘 | Toshihiro Akihisa Ken-ichi Seino Etsuyo Kaneko | 2010 | Journal of Oleo Science2010，59，1： | 1 |
| 8 | Eupha-7,9 ( 11 ) , 24-trien-3β-ol ( 'Antiquol C' ) and other triterpenes from euphorbia antiquorum latex and their inhibitory effects on epstein-barr virus activation 显示文摘 | Toshihiro Akihisa E M Kithsiri Wijeratne Harukuni Tokuda | 2002 | J Nat Prod2002，65，2： | 1 |
| 9 | Triterpenoid ketones from Lingnania chuungii Mcclure:Arborinone and Glutinone显示文摘 | Toshihiro Akihisa Kazuhiro Yamamoto Toshitake Tamura | 1992 | Chem Pharm Bull1992，40，3： | 1 |
| 10 | 4-Hydroxud- erricin from Angelica keiskei Roots Induces Caspase-dependent Apoptotic Cell Death in HL60 Human Leukemia Cells显示文摘 | Toshihiro Akihisa Takashi Kikuchi Hisashi Nagai | 2011 | J Oleo Sci2011，60，2： | 1 |
| 11 | Anti-inflammatory activities of the triterpene acids from the resin of Boswellia carteri显示文摘 | Norihiro Banno Toshihiro Akihisa Ken Yasukawa Harukuni Tokuda Keiichi Tabata Yuji Nakamura Reiko Nishimura Yumiko Kimura Takashi Suzuki | 2006 | Journal of Ethnopharmacology2006，，2： | 1 |
| 12 | Oxygenated lanostane-type triterpenoids from the Fungus Gan- oderma lucidum显示文摘 | Toshihiro Akihisa Masaaki Tagata Motohiko Ukiya | 2005 | J Nat Prod2005，68，4： | 1 |
| 13 | 4-Hydroxuderricin from Angelica keiskei Roots Induces Caspase-dependent Apoptotic Cell Death in HL60 Human Leukemia CeU显示文摘 | TOSHIHIRO AKIHISA TAKASHI KIKUCHI HISASHI NAGAI | 2011 | J Oleo Sci2011，60，2： | 1 |
| 14 | Inhibitory effect of euphol, a triterpvne alcohol from the roots of Euphorbia kansui显示文摘 | Ken Yasukawa Toshihiro Akihisa ZY Yoshida | 2000 | J Pharm Pharmacol2000，52，1： | 1 |
| 15 | Triterpene alcohol and sterol ferulates from rice bran and their anti-inflammatory effects显示文摘 | Akihisa Toshihiro Yasukawa Ken Yamaura Miho | 2000 | Journal of Agricultural and Food Chemistry2000，48，6： | 1 |
| 16 | Sterols of cucurbitaceae: The configurations at C-24 of 24-Alkyl-Δ5-,Δ7- and Δ8-sterols显示文摘 | Toshihiro Akihisa Swapnadip Thakur Fumiko U. Rosenstein Taro Matsumoto | 1986 | Lipids1986，，1： | 1 |
| 17 | Inhib itory effect of heliantriol C; a component of edible Chrysanthemum,on tumor p romotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin显示文摘 | Ken Yasukawa Toshihiro Akihisa Yoshimasa Kasahara | 1998 | Phytomedicine1998，5，： | 1 |
| 18 | Inhibitory Effect of Di - and Trihydroxy Triterpenes from the flowers of Compositaeon 12 - O - Tetradacanoylphorbol - 13 - acetate - induced inflammation in Mice显示文摘 | Yasukaua Ken Akihisa Toshihiro | 1996 | Biol Pharm Bull1996，19，10： | 1 |
| 19 | Triterpenoid ketones from Lingnania chungii meclure:arborinone,friedelin and glutinone显示文摘 | Toshihiro Akihisa Kazuhiro Yamamoto Toshitake Tamura | 1992 | Chem Pharm Bull1992，40，3： | 1 |
| 20 | Cytotoxic and Nitric Oxide Production‐Inhibitory Activities of Limonoids and Other Compounds from the Leaves and Bark of Melia azedarach显示文摘 | Xin Pan Masahiro Matsumoto Yuki Nishimoto Eri Ogihara Jie Zhang Motohiko Ukiya Harukuni Tokuda Kazuo Koike Momoko Akihisa Toshihiro Akihisa | 2014 | Chemistry & Biodiversity2014，，8： | 1 |
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