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| 1 | gastrointestinal symptom prevalence depends on disease duration and gastrointestinal region in type 2 diabetes mellitus显示文摘AIM To unravel relationships between gastrointestinal(GI)symptoms impairing quality of life(QOL)and clinical profiles of diabetes mellitus(DM)patients. METHODS We enrolled 134 outpatients with type 2 DM.Mean age was 64.7 years,mean body mass index was 24.7 RESULTS Lower abdominal symptoms were found to be more frequent than those affecting the upper abdomen.Diabetic duration and medications showed associations with GI symptoms.We identified differences in peak prevalences of the five symptoms.Gastralgia(P=0.02vs 10-14 years)and total GI symptoms(P=0.01 and P=0.02 vs 5-9 years and 10-14 years,respectively)peaked at a diabetes duration of 15-19 years.Heartburn(P=0.004)and postprandial fullness(P=0.03)tended to increase with disease duration.Constipation and diarrhea showed bimodal peaks,with the first early and the second late(e.g.,P=0.03 at 15-19 years vs 10-14years for diarrhea)in the disease course.Finally,GI symptoms showed clustering that reflected the region of the GI tract affected,i.e.,constipation and diarrhea had similar frequencies(P<0.0001). CONCLUSION Our study highlights the importance of questioning patients about QOL impairment due to abdominal symptoms,especially in the early and the late periods of diabetes. | Midori Fujishiro Akifumi Kushiyama Hiroki Yamazaki Sunao Kaneko Yuko Koketsu Takeshi Yamamotoya Takako Kikuchi Hideyuki Sakoda Ryo Suzuki Takashi Kadowaki | 2017 | World Journal of Gastroenterology2017，23，36： | 4 |
| 2 | C-reactive protein induces high-mobility group box-1 protein release through activation of p38MAPK in macrophage RAW264.7 cells显示文摘 | Ko-ichi Kawahara Kamal Krishna Biswas Masako Unoshima Takashi Ito Kiyoshi Kikuchi Yoko Morimoto Masahiro Iwata Salunya Tancharoen Yoko Oyama Kazunori Takenouchi Yuko Nawa Noboru Arimura Meng Xiao Jie Binita Shrestha Naoki Miura Toshiaki Shimizu Kentaro Me | 2008 | Cardiovascular Pathology2008，，3： | 3 |
| 3 | Ocean Mixing with Lead-Dependent Subgrid Scale Brine Rejection Parameterization in a Climate Model显示文摘Sea ice thickness is highly spatially variable and can cause uneven ocean heat and salt flux on subgrid scales in climate models.Previous studies have demonstrated improvements in ocean mixing simulation using parameterization schemes that distribute brine rejection directly in the upper ocean mixed layer.In this study,idealized ocean model experiments were conducted to examine modeled ocean mixing errors as a function of the lead fraction in a climate model grid.When the lead is resolved by the grid,the added salt at the sea surface will sink to the base of the mixed layer and then spread horizontally.When averaged at a climate-model grid size,this vertical distribution of added salt is lead-fraction dependent.When the lead is unresolved,the model errors were systematic leading to greater surface salinity and deeper mixed-layer depth(MLD).An empirical function was developed to revise the added-salt-related parameter n from being fixed to lead-fraction dependent.Application of this new scheme in a climate model showed significant improvement in modeled wintertime salinity and MLD as compared to series of CTD data sets in 1997/1998 and 2006/2007.The results showed the most evident improvement in modeled MLD in the Arctic Basin,similar to that using a fixed n=5,as recommended by the previous Arctic regional model study,in which the parameter n obtained is close to 5 due to the small lead fraction in the Arctic Basin in winter. | Meibing Jin Jennifer Hutchings Yusuke Kawaguchi Takashi Kikuchi | 2012 | Journal of Ocean University of China2012，11，4： | 1 |
| 4 | Nuclear and cytoplasmic maturation in vitro of porcine oocytes显示文摘 | Takashi Nagai Nobuhiko Yamauehi Kazuhiro Kikuchi | 2001 | Journal of Reproduction and Development2001，，147： | 1 |
| 5 | Mesenteric Phlebosclerosis显示文摘 | Akinori Iwashita M.D. Ph.D. Tsuneyoshi Yao M.D. Ph.D. Ronald J. Schlemper M.D. Ph.D. Yasuyuki Kuwano M.D. Takashi Yao M.D. Ph.D. Mitsuo Iida M.D. Ph.D. Takayuki Matsumoto M.D. Ph.D. Masahiro Kikuchi M.D. Ph.D | 2003 | Diseases of the Colon & Rectum2003，，2： | 1 |
| 6 | Periodontal disease and type 2 diabetes mellitus: Is the HMGB1–RAGE axis the missing link?显示文摘 | Yoko Morimoto-Yamashita Takashi Ito Ko-ichi Kawahara Kiyoshi Kikuchi Shoko Tatsuyama-Nagayama Yoshiko Kawakami-Morizono Mari Fijisawa Keiko Miyashita Makiko Emoto Mitsuo Torii Masayuki Tokuda | 2012 | Medical Hypotheses2012，，4： | 1 |
| 7 | Hypertrophic growth of cultured neonatal rat heart cells mediated by vasopressin V 1A receptor显示文摘 | Yasuhiro Nakamura Takashi Haneda Junzo Osaki Setsuya Miyata Kenjiro Kikuchi | 2000 | European Journal of Pharmacology2000，，1： | 1 |
| 8 | ALK Gene Translocation in Inflammatory Myofibroblastic Tumor of the Urinary Bladder: A Case Report显示文摘 | Kimiaki Takagi Manabu Takai Koji Kameyama Kengo Horie Mina Kikuchi Taku Kato Kosuke Mizutani Kensaku Seike Tomohiro Tsuchiya Mitsuru Yasuda Shigeaki Yokoi Natsuko Suzui Masahiro Nakano Takashi Deguchi | 2015 | Urology Case Reports2015，，5： | 1 |
| 9 | Secretional expression of a Bacillus subtilis xylanase gene in the Basidiomycete Coprinus cinereus 显示文摘 | Madoka Kikuchi Kei-ichiro Ogawa Takashi Yamazaki | 1999 | FEMS Microbiology Letters1999，178，： | 1 |
| 10 | Arginine vasopressin increases the rate of protein synthesis in isolated perfused adult rat heart via the V1 receptor显示文摘 | Jun Fukuzawa Takashi Haneda Kenjiro Kikuchi | 1999 | Molecular and Cellular Biochemistry (-)1999，，1： | 1 |
| 11 | Successful piglet production by IVF of oocytes matured in vitro using NCSU-37 supplemented with fetal bovine serum显示文摘 | Misae Suzuki Koji Misumi Manabu Ozawa Junko Noguchi Hiroyuki Kaneko Katsuhiko Ohnuma Dai-ichiro Fuchimoto Akira Onishi Masaki Iwamoto Norio Saito Takashi Nagai Kazuhiro Kikuchi | 2005 | Theriogenology2005，，2： | 1 |
| 12 | The practical synthesis of a uterine relaxant,bis(2- ethyl] amino) -1,2,3,4-tetrahydronaphthalen-7-yl] oxy] -N,N-dimethylacetamide)sulfate (KUR-1246)显示文摘 | Ken Kikuchi Hideki Takeuchi | 2001 | Chem Pharm Bull2001，49，8： | 1 |
| 13 | Phase II study of S-1 as first-line treatment for elderly patients over 75 years of age with advanced gastric cancer: the Tokyo Cooperative Oncology Group study显示文摘 | Wasaburo Koizumi Toshikazu Akiya Atsushi Sato Toshikazu Sakuyama Eisaku Sasaki Takashi Tomidokoro Tsutomu Hamada Mototsugu Fujimori Yoshinori Kikuchi Ken Shimada Tetsuya Mine Kensei Yamaguchi Tsuneo Sasaki Minoru Kurihara | 2010 | Cancer Chemotherapy and Pharmacology2010，，： | 1 |
| 14 | Intrauterine sonography for preoperative assessment of cervical invasion in endometrial carcinoma显示文摘 | Jafreen Sultana Takashi Okai | 1997 | Gynecol Oncol1997，65，3： | 1 |
| 15 | Transbronchial human interleukin-10 gene transfer reduces acute inflammation associated with allograft rejection and intragraft interleukin-2 and tumor necrosis factor-α gene expression in a rat model of lung transplantation显示文摘 | Hisashi Oishi Yoshinori Okada Toshiaki Kikuchi Yasushi Hoshikawa Tetsu Sado Masafumi Noda Chiaki Endo Akira Sakurada Yuji Matsumura Takashi Kondo | 2010 | Journal of Heart and Lung Transplantation2010，，3： | 1 |
| 16 | Differentiating primary CNS lymphoma from glioblastoma multiforme: assessment using arterial spin labeling, diffusion-weighted imaging, and 18 F-fluorodeoxyglucose positron emission tomography显示文摘 | Koji Yamashita Takashi Yoshiura Akio Hiwatashi Osamu Togao Koji Yoshimoto Satoshi O. Suzuki Koichiro Abe Kazufumi Kikuchi Yasuhiro Maruoka Masahiro Mizoguchi Toru Iwaki Hiroshi Honda | 2013 | Neuroradiology2013，，2： | 1 |
| 17 | Characteristics of the Pressure Wave Radiated from an Entrance Portal When a Train Enters a Tunnel 显示文摘 | Masanobu Iida Yasuyuki Tanaka Katsuhiro Kikuchi Takashi Fukuda | 2001 | Theoretical and Applied Mechanics2001，50，： | 1 |
| 18 | Phase II study of S-1 as first-line treatment for elderly patients over 75?years of age with advanced gastric cancer: the Tokyo Cooperative Oncology Group study显示文摘 | Wasaburo Koizumi Toshikazu Akiya Atsushi Sato Toshikazu Sakuyama Eisaku Sasaki Takashi Tomidokoro Tsutomu Hamada Mototsugu Fujimori Yoshinori Kikuchi Ken Shimada Tetsuya Mine Kensei Yamaguchi Tsuneo Sasaki Minoru Kurihara | 2010 | Cancer Chemotherapy and Pharmacology2010，，6： | 1 |
| 19 | 4-Hydroxud- erricin from Angelica keiskei Roots Induces Caspase-dependent Apoptotic Cell Death in HL60 Human Leukemia Cells显示文摘 | Toshihiro Akihisa Takashi Kikuchi Hisashi Nagai | 2011 | J Oleo Sci2011，60，2： | 1 |
| 20 | 4-Hydroxuderricin from Angelica keiskei Roots Induces Caspase-dependent Apoptotic Cell Death in HL60 Human Leukemia CeU显示文摘 | TOSHIHIRO AKIHISA TAKASHI KIKUCHI HISASHI NAGAI | 2011 | J Oleo Sci2011，60，2： | 1 |
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