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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Hepatitis C virus resistance to new specifically-targeted antiviral therapy: A public health perspective显示文摘Until very recently, treatment for chronic hepatitis C virus(HCV) infection has been based on the combination of two non-viral specific drugs: pegylated interferon-α and ribavirin, which is effective in, overall, about 40%-50% of cases. To improve the response to treatment, novel drugs have been designed to specifically block viral proteins. Multiple compounds are under development, and the approval for clinical use of the first of such direct-acting antivirals in 2011(Telaprevir and Boceprevir), represents a milestone in HCV treatment. HCV therapeutics is entering a new expanding era, and a highly-effective cure is envisioned for the first timesince the discovery of the virus in 1989. However, any antiviral treatment may be limited by the capacity of the virus to overcome the selective pressure of new drugs, generating antiviral resistance. Here, we try to provide a basic overview of new treatments, HCV resistance to new antivirals and some considerations derived from a Public Health perspective, using HCV resistance to protease and polymerase inhibitors as examples. | Karina Salvatierra Sabrina Fareleski Alicia Forcada F Xavier López-Labrador | 2013 | World Journal of Virology2013，2，1： | 2 |
| 3 | A method for estima- ting vaccine-preventable pediatric influenza pneumonia hospitaliza- tions in developing countries: Thailand as a case study 显示文摘 | Fatimah S D Alicia M F Charung M | 2011 | Vac- cine2011，29，26： | 1 |
| 4 | Numerical analysis of slider bearing with a heterogeneous slip/no-slip surface 显示文摘 | RICHARD F S ALICIA E F | 2004 | Tribology Transactions2004，47，3： | 1 |
| 5 | New Dimeric Surfactants from Alkyl Glucosides显示文摘 | Mariano J L Jos K Alicia F | 1999 | Tetrahedron1999，55，12： | 1 |
| 6 | Trace elements distribution in soil,pore wa- ter and groundwater in Buenos Aires,Argentina 显示文摘 | olga s H Alicia F c | 2009 | Geoderma2009，149，： | 1 |
| 7 | Biodeinking of flexographic inks by fungal laccases using synthetic and natural mediators显示文摘 | Ursula F Alicia P Susana C | 2012 | Biochemical Engineering Journal2012，67，： | 1 |
| 8 | Effects of soil resistivity on currents induced on pipelines 显示文摘 | ANA O ALICIA F | 2000 | Journal of Applied Geophysics2000，44，4： | 1 |
| 9 | Phospholipase C and sphingomyelinase activities of the Clostridium perfringens α-toxin显示文摘 | Patricia Urbina Marietta Flores-Díaz Alberto Alape-Girón Alicia Alonso Félix M. Goni | 2009 | Chemistry and Physics of Lipids2009，，1： | 1 |
| 10 | Subcellular localisation of VEGF in different pituitary cells. Changes of its expression in oestrogen induced prolactinomas显示文摘 | Jorge Humberto Mukdsi Ana Lucía De Paul Silvina Gutiérrez Félix Daniel Roth Agustín Aoki Alicia Inés Torres | 2005 | Journal of Molecular Histology (-)2005，，8： | 1 |
| 11 | Establishment of the contribution of volatile compounds to the aroma of fermented sausages at different stages of processing and storage显示文摘 | ALICIA O JOSELUIS N MONICA F | 2009 | Food Chemistry2009，115，4： | 1 |
| 12 | Nonparametric model comparison and uncertainty evaluation for signal strength indoor location显示文摘 | Carlos K F Inmaculada M J Alicia G C | 2009 | IEEE Transactions on Mobile Computing2009，8，9： | 1 |
| 13 | Aquatic macrophytes potential for the simultaneous removal of heavy metals (Buenos Aires,Argentina)显示文摘 | PATRICIA M ANDREA S ALICIA F C | 2004 | Chemosphere2004，57，： | 1 |
| 14 | Factor associated with seeking medical care and submitting a stool sample in estimating the burden of foodborne illness 显示文摘 | Elaine ScaUan Timothy F Jones Alicia Cronquist | 2006 | Foodborne Pathog Dis2006，3，4： | 1 |
| 15 | Retrospective cohort study of granisetron administration for PONV prophylaxis and treatment显示文摘 | Alicia S PhDP Anne F | 2005 | Hospital Pharmacy2005，40，： | 1 |
| 16 | Gemini (dimerie)surfactants from alkyl glucosides显示文摘 | MARIANO J JOSE K ALICIA F C | 1997 | Tetrahedron Letters1997，38，23： | 1 |
| 17 | Fast detection of Salmonella Infantis with carbon nanotube field effect transistors显示文摘 | Raquel A Villamizar Alicia Maroto Xavier Rius F | | 0，，2： | 1 |
| 18 | Isolation of soluble collagen from Hake skin显示文摘 | Alica S C Maria E P Alicia N F | 1997 | Journal of Aquatic Food Product Technology1997，61，1： | 1 |
| 19 | New family of nonionic gemini surfactants, determination and analysis of interfacial properties 显示文摘 | MARIANO J L C JOSE K ALICIA F C | 2002 | Langmuir2002，18，7： | 1 |
| 20 | Glioblastoma in adults 显示文摘 | Alba AB Alicia T Enrico F | 2008 | Crit Rev Oncol Hematol2008，67，2： | 1 |
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