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| 1 | Holocene vegetation cover in Qin’an area of western Chinese Loess Plateau revealed by n-alkane显示文摘Previous studies have found that wetlands prevailed in western Chinese Loess Plateau and pine pollen could reach up to 80% in Qin’an area of the plateau during middle Holocene. It was then deduced that forest vegetation covered Qin’an area in a warm and wet climate during middle Holocene. The proxies of molecule biomarkers from two Holocene sections, a swamp-alluvial loess section and a typical loess-paleosol section are used to reconstruct regional vegetation history. It is found that the heavy-molecular-weight (HMW) homologues of the n-alkanes in all samples exhibit a pronounced odd-over-even predominance, maximizing at C31 and the abundance of the nC27-alkanes is the lowest in nC27, nC29, nC31, i.e. C27 | ZHONG YanXia CHEN FaHu AN ChengBang XIE ShuCheng HUANG XianYu | 2007 | Chinese Science Bulletin2007，52，12： | 10 |
| 2 | Changes in Physicochemical,Cooking and Sensory Characteristics of Rice Shifted from Low-temperature Storage显示文摘The physicochemical, cooking, and sensory characteristics of stored rice were measured in order to investigate the quality changes in it after low-temperature storage. The quality of the stored rice was compared to that of the rice stored at ambient temperature(20℃, 30%–70% RH) at a 25 d interval during 200 d of storage. The rice was stored in a temperature controller at 4℃ for 3 months and later under a simulated condition similar to that of the main rice consumption areas in China(35℃, 80% RH and 30℃, 70% RH). The results showed that the fatty acid value, b value, and moisture content of rice stored at 35℃, 80% RH and 30℃, 70% RH had increased significantly, whereas its L value had decreased as compared to the rice stored at ambient temperature. Higher temperature storage caused a greater water uptake, whereas the dry mass in the residual cooking water notably reduced under the storage at 35℃ as compared to that at 20℃. Hardness increased and adhesiveness reduced under the storage at 35℃ as compared to that at 20℃. The shelf life of the stored rice which was shifted from a low temperature to three storage conditions used in this study was 75 d, 100 d and 150 d, respectively, in the main rice consumption areas of China. | AN Yanxia ZHOU Xianqing ZHANG Yurong | 2018 | Grain & Oil Science and Technology2018，1，1： | 6 |
| 3 | Service allocation based on QoS evaluation in military organization cloud cooperation显示文摘The problem of cloud cooperation of military service providers(MSPs) is addressed for allocating limited resources to military service users(MSUs) that are geographically distributed. The MSPs, also called military organization clouds, are virtualized and encapsulated by the services they can offer and each of them contains different kinds of resources that MSU needs. The MSPs are also geographically dispersed. They are required to allocate their resources to the MSU complying with the corresponding quality of service(Qo S), so that each MSU gathers the services it needs to guarantee its task to be implemented. The outline of military organization cloud cooperation is discussed and the method of service optimal selection is proposed based on Qo S evaluation. The Qo S evaluation method based on exponential approximation is put forward to include the users' will. Simulation results verify the effectiveness of the proposed algorithm. | An Zhang Haiyang Sun Yanxia Zhang | 2016 | Journal of Systems Engineering and Electronics2016，27，2： | 3 |
| 4 | Safety,tolerability,and pharmacokinetics of BAT8001 in patients with HER2-positive breast cancer:An open-label,dose-escalation,phase I study显示文摘Background:The introductions of anti-human epidermal growth factor receptor-2(HER2)agents have significantly improved the treatment outcome of patients with HER2-positive breast cancer.BAT8001 is a novel antibodydrug conjugate targeting human epidermal growth factor receptor-2(HER2)-expressing cells composed of a trastuzumab biosimilar linked to the drug-linker Batansine.This dose-escalation,phase I study was designed to assess the safety,tolerability,pharmacokinetics,and preliminary anti-tumor activity of BAT8001 in patients with HER2-positive locally advanced or metastatic breast cancer.Methods:This trial was conducted in subjects with histologically confirmed HER2-positive breast cancer(having evaluable lesions and an Eastern Cooperative Oncology Group performance status of 0 or 1)using a 3+3 design of escalating BAT8001 doses.Patients received BAT8001 intravenously in a 21-day cycle,with dose escalation in 5 cohorts:1.2,2.4,3.6,4.8,and 6.0 mg/kg.The primary objective was to evaluate the safety and tolerability of BAT8001.Preliminary activity of BAT8001 was also assessed as a secondary objective.Results:Between March 2017 to May 2018,29 HER2-positive breast cancer patients were enrolled.The observed dose-limiting toxicities were grade 4 thrombocytopenia and grade 3 elevated transaminase.The maximum tolerated dose was determined to be 3.6 mg/kg.Grade 3 or greater adverse events(AEs)occurred in 14(48.3%)of 29 patients,including thrombocytopenia in 12(41.4%)patients,aspartate aminotransferase increased in 4(13.8%)patients,γ-glutamyl transferase increased in 2(6.9%)patients,alanine aminotransferase increased in 2(6.9%)patients,diarrhea in 2(6.9%)patients.Objective response was observed in 12(41.4%,95%confidence interval[CI]=23.5%-61.1%)and disease control(including patients achieving objective response and stable disease)was observed in 24(82.8%,95%CI=64.2%-94.2%)patients.Conclusions:BAT8001 demonstrated favorable safety profiles,with promising anti-tumor activity in patients with HER2-positive locally advanced or metastatic breast cancer.BAT8001 has the potential to provide a new therapeutic option in patients with metastatic HER2-positive breast cancer. | Ruoxi Hong Wen Xia Liye Wang Kaping Lee Qianyi Lu Kuikui Jiang Shengfeng Li Jinquan Yu Jin Wei Weijia Tang Danyang Zhou Xin An Jiajia Huang Cong Xue Xiwen Bi Yanxia Shi Zhongyu Yuan Fei Xu Shusen Wang | 2021 | Cancer Communications2021，41，2： | 2 |
| 5 | Current management of chemotherapy-induced neutropenia in adults:key points and new challenges显示文摘Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive chemotherapy.The timing and grade of CIN may play prognostic and predictive roles in cancer therapy.CIN is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined therapies.There are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain unclear.However,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological emergency.No consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with FN.However,current tools have limitations.The CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of FN.In view of the current reports,our group discusses the key points,new challenges,and management of CIN. | Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang Jifeng Feng Ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei Zhou | 2020 | Cancer Biology & Medicine2020，17，4： | 2 |
| 6 | Mass change of the Antarctic ice sheet inferred from ICESat and CryoSat-2显示文摘This study examined the mass change of the Antarctic ice sheet(AIS) based on ICESat and CryoSat-2 observations. We estimated the AIS exhibited mass losses of-101±15 Gt·a^(-1) during the ICESat period(Sept–Nov 2003 to Sept–Oct 2009) and-186±55 Gt·a^(-1) during the CryoSat-2 period(Jan 2011 to Dec 2015). Mass losses occurred mainly in the sectors of the Amundsen and Bellingshausen seas. Benefitting from the 30-d subcycle of CryoSat-2, we obtained monthly estimates of mass evolution. Considerable annual variations were observed in the mass evolution sequences and the climatological monthly mass evolution. Seasonal mass evolutions in the sectors of the Bellingshausen and Amundsen seas were found most representative of the annual variation. The geographical distribution characteristics of interannual AIS mass evolution were revealed by the annual average mass evolution sequences. During Jan 2011 to Dec 2015, the ice sheets in the sectors of the Bellingshausen and Amundsen seas, and the Totten Glacier, experienced increasingly rapid areal mass loss. An area of mass gain with a moderate rate of increase was found between Dronning Maud Land and Enderby Land. Rapid mass accumulation has occurred in a limited area of the Kamb Ice Stream. | ZHANG Baojun WANG Zemin AN Jiachun LIU Yanxia | 2017 | Advances in Polar Science2017，28，3： | 1 |
| 7 | Enantioseparation by HPLC Using an Inorganic Chiral Mesoporous Silica with Highly-ordered Structure显示文摘Highly-ordered inorganic chiral mesoporous silica(HOCMS)has attracted substantial interest in recent decades.High performance liquid chromatography(HPLC)is the most important approach for the separation of enantiomers and herein reported an HPLC chiral stationary phase composed of HOCMS.The column was fabricated by conventional high pressure slurry packing.Eighteen racemates,including alcohols,ketones,amines,aldehydes and organic acids,were resolved on the column.Good chiral separations of hydrobenzoin,metoprolol,propranolol hydrochloride,4-methyl-2-pentanol,omeprazole,2,2′-furoin and ketoprofen were obtained.The relative standard devi-ations for five replicate separations of racemates were 0.1%–0.16%for retention time and 1.73%–2.64%for peak areas.The results suggest that HOCMS is a promising candidate for preparation of chiral stationary phases for HPLC. | PENG Bo FU Shiguo LI Yanxia ZHANG Junhui XIE Shengming LI Li LYU Yun DU AN Aihong CHEN Xuexian YUAN Liming | 2019 | Chemical Research in Chinese Universities2019，35，6： | 1 |
| 8 | Continuous cropping of alfalfa (Medicago sativa L.) reduces bacterial diversity and simplifies cooccurrence networks in aeolian sandy soil显示文摘Alfalfa is a perennial herbaceous forage legume that is remarkably and negatively affected by monocropping.However,the contribution of the changes in bacterial communities to soil sickness in alfalfa have not been elucidated.Therefore,we investigated bacterial community structures in response to monocropped alfalfa along the chronosequence.Continuous cropping remarkably reduced bacterial alpha diversity and altered community structures,and soil pH,total P and available P were strongly associated with the changes of bacterial diversity and community structures.Intriguingly,10 years of monocropped alfalfa might be a demarcation point separating soil bacterial community structures into two obvious groups that containing soil samples collected in less and more than 10 years.The relative abundances of copiotrophic bacteria of Actinobacteria and Gammaproteobacteria significantly increased with the extension of continuous cropping years,while the oligotrophic bacteria of Armatimonadetes,Chloroflexi,Firmicutes and Gemmatimonadetes showed the opposite changing patterns.Among those altered phyla,Actinobacteria,Chloroflexi,Alphaproteobacteria and Acidobacteria were the most important bacteria which contributed 50.86%of the community variations. Additionally, the relative abundances of nitrogen fixation bacteria ofBradyrhizobium and Mesorhizobium obviously increased with continuous cropping years, while theabundances of Arthrobacter, Bacillus, Burkholderiaceae and Microbacterium with potential functionsof solubilizing phosphorus and potassium remarkably decreased after long-term continuouscropping. Furthermore, bacterial cooccurrence patterns were significantly influenced by continuouscropping years, with long-term monocropped alfalfa simplifying the complexity of the cooccurrencenetworks. These findings enhanced our understandings and provided references for forecasting howsoil bacterial communities responds to monocropped alfalfa. | Yanxia Xu Junjie Liu Xuefeng Liu Hong Li Zhao Yang Hongbao Wang Xinyu Huang Lan Lan Yutong An Lujun Li Qin Yao Guanghua Wang | 2022 | Soil Ecology Letters2022，4，2： | 0 |
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