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| 1 | Effectiveness of an intervention for reducing social stigma towards mental illness in adolescents显示文摘AIM: To evaluate the effectiveness of an intervention for reducing social stigma towards mental illness in adolescents. The effect of gender and knowledge of someone with mental illness was measured. METHODS: Two hundred and eighty secondary school students were evaluated using the Community Attitudes towards Mental Illness(CAMI) questionnaire. The schools were randomized and some received the intervention and others acted as the control group. The programme consisted of providing information via a documentary film and of contact with healthcare staff in order to reduce the social stigma within the school environment. RESULTS: The intervention was effective in reducing the CAMI authoritarianism and social restrictiveness subscales. The intervention showed significant changes in girls in terms of authoritarianism and social restrictiveness, while boys only showed significant changes in authoritarianism. Following the intervention, a significant reduction was found in authoritarianism and social restrictiveness in those who knew someone with mental illness, and only in authoritarianism in those who did not know anyone with mental illness. CONCLUSION: The intervention was effective to reduce social stigma towards people with mental illness, especially in the area of authoritarianism. Some differences were found depending on gender and whether or not the subjects knew someone with mental illness. | Regina Vila-Badia Francisco Martínez-Zambrano Otilia Arenas Emma Casas-Anguera Esther García-Morales Raúl Villellas José Ramón Martín María Belén Pérez-Franco Tamara Valduciel Diana Casellas Mar García-Franco Jose Miguel Joaquim Balsera Gemma Pascual Eugènia Julia Susana Ochoa | 2016 | World Journal of Psychiatry2016，6，2： | 4 |
| 2 | Translational pancreatic cancer research:a comparative study on patient-derived xenograft models显示文摘AIM To assess the viability of orthotopic and heterotopic patient-derived pancreatic cancer xenografts implanted into nude mice.METHODS This study presents a prospective experimental analytical follow-up of the development of tumours in mice upon implantation of human pancreatic adenocarcinoma samples. Specimens were obtained surgically from patients with a pathological diagnosis of pancreatic adenocarcinoma. Tumour samples from pancreatic cancer patients were transplanted into nude mice in three different locations(intraperitoneal, subcutaneous and pancreatic). Histological analysis(haematoxylin-eosin and Masson's trichrome staining) and immunohistochemical assessment of apoptosis(TUNEL), proliferation(Ki-67), angiogenesis(CD31) and fibrogenesis(α-SMA) were performed. When a tumour xenograft reached the target size, it was reimplanted in a new nude mouse. Three sequential tumour xenograft generations were generated(F1, F2 and F3).RESULTS The overall tumour engraftment rate was 61.1%. The subcutaneous model was most effective in terms of tissue growth(69.9%), followed by intraperitoneal(57.6%) and pancreatic(55%) models. Tumour development was faster in the subcutaneous model(17.7 ± 2.6 wk) compared with the pancreatic(23.1 ± 2.3 wk) and intraperitoneal(25.0 ± 2.7 wk) models(P = 0.064). There was a progressive increase in the tumour engraftment rate over successive generations for all three models(F1 28.1% vs F2 71.4% vs F3 80.9%, P < 0.001). There were no significant differences in tumour xenograft differentiation and cell proliferation between human samples and the three experimental models among the sequential generations of tumour xenografts. However, a progressive decrease in fibrosis, fibrogenesis, tumour vascularisation and apoptosis was observed in the three experimental models compared with the human samples. All three pancreatic patient-derived xenograft models presented similar histological and immunohistochemical characteristics.CONCLUSION In our experience, the faster development andgreatest number of viable xenografts could make the subcutaneous model the best option for experimentation in pancreatic cancer. | Mercedes Rubio-Manzanares Dorado Luis Miguel Marín Gómez Daniel Aparicio Sánchez Sheila Pereira Arenas Juan Manuel Praena-Fernández Juan Jose Borrero Martín Francisco Farfán López Miguel ángel Gómez Bravo Jordi Muntané Relat Javier Padillo Ruiz | 2018 | World Journal of Gastroenterology2018，24，7： | 2 |
| 3 | Flow cytometric characterization of human umbilical cord blood lymphocytes: immunophenotypic features 显示文摘 | D' Arena G Musto P Cascavilla N | 1998 | Haematologica1998，83，3： | 1 |
| 4 | GSK-3beta inhibition/beta-catenin stabilization in ventral midbrain precursors increases differentiation into dopamine neurons显示文摘 | Castelo-Branco G Rawal N Arenas E | | 0，，24： | 1 |
| 5 | Comparison of odour active compounds detected by gas-chromatography-olfactometry between hand-squeezed juices from different orange varieties显示文摘 | ARENA E GUARRERA N CAMPIS1 S | 2006 | Food Chemistry2006，98，1： | 1 |
| 6 | Comparison of odour active compounds detected by gas-chromatography- olfactometry between hand-squeezed juices from different orange varieties 显示文摘 | Arena E Guarrera N Campisi S | 2006 | Food Chemistry2006，98，： | 1 |
| 7 | Photovoltaic properties of multi-walled carbon nanotubes deposited on n-doped silicon 显示文摘 | Arena A Donato N Saitta G | 2008 | Microelectron J2008，39，12： | 1 |
| 8 | Mitochondrial respiratory chain dysfunction: Implications in neurodegeneration显示文摘 | María Morán David Moreno-Lastres Lorena Marín-Buera Joaquín Arenas Miguel A. Martín Cristina Ugalde | 2012 | Free Radical Biology and Medicine2012，，3： | 1 |
| 9 | Comparison of odour active compounds detected by gas-cbromatography-olfactometry between hand-squeezed juices from different orange varieties显示文摘 | ARENA E GUARRERA N CAMPISI S | 2006 | Food Chemistry2006，98，： | 1 |
| 10 | The Vila de Cruces Ophiolite:a remnant of the early Rheic Ocean in the Variscan suture of Galicia (Northwest Iberian Massif)显示文摘 | Arenas R Martínez Catalán J.R Sánchez Martínez S Fernández-Suárez J Andonaegui P Pearce J.A Coffu F | | 0，，： | 1 |
| 11 | Temperature response of photosynthesis, excitation energy dissipation and alternative electron sinks to carbon assimilation in Beta vulgaris L显示文摘 | D'AMBROSIO N ARENA C DE SANTO A V | 2006 | Environmental and Experimental Botany2006，55，： | 1 |
| 12 | MET overexpression confers HGF-dependent invasive phenotype to human thyroid carcinoma cells in vitro显示文摘 | De Luca A Arena N Sena LM | 1999 | J Cell Physiol1999，180，9： | 1 |
| 13 | Minimally differentiated acute myeloid leukemia (AML M0): clinico-biological findings of 29 cases显示文摘 | Cascavilla N Melillo L D'Arena G | 2000 | Leuk Lymphoma2000，37，12： | 1 |
| 14 | Cardiac Rehabilitation and Cardiovascular Disability:role in assessment and improving functional capacity,a position statement from the American Association of Cardiovascular and Pulmonary Rehabilitation显示文摘 | Hamm L F Wenger N K Arena R | | 0，，01： | 1 |
| 15 | Phase Ⅲ,randomized,double-blind,placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and vinorelbine in trastuzumab-resistant,advanced breast cancer (BOLERO-3)显示文摘 | O' Regan R Ozguroglu M Andre F Toi M Jerusalem G Wilks S Isaacs C Xu B Masuda N Arena FP Yardley D Yap YS Mukhopadhyay P Douma S El-Hashimy M Taran T Sahmoud T Lebwohl D Gianni L | | 0，，15： | 1 |
| 16 | Met over-expression confers HGF-dependent invasive pheno-type to human thyroid carcinoma cells invitro显示文摘 | De LUCA A ARENA N SENA L M | 1999 | J Cell Physiol1999，180，3： | 1 |
| 17 | Analytical procedure to obtain internal parameters from performance curves of commercial thermoelectric modules显示文摘 | Palaeios R Arenas A Pecharromán R R | | 0，，3： | 1 |
| 18 | Flow cytometric characterization of human umbilical cord blood lymphocytes: immunophenotypic features显示文摘 | Musto P Cascavilla N | 1998 | Haematologica1998，83，： | 1 |
| 19 | GSK-3β inhibition/β- catenin stabilization in ventral midbrain precursors increases differentiation into dopamine neurons显示文摘 | Castelo-Branco G Rawal N Arenas E | 2004 | J Cell Sci2004，117，24： | 1 |
| 20 | Intracellular trafficking of Brucella abortus in J774 macrophages显示文摘 | Arenas G N Staskevich A S Ahallay A | 2000 | Infect Immun2000，68，7： | 1 |
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