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| 1 | Value of a newly sequenced bacterial genome显示文摘Next-generation sequencing(NGS) technologies have made high-throughput sequencing available to medium- and small-size laboratories, culminating in a tidal wave of genomic information. The quantity of sequenced bacterial genomes has not only brought excitement to the field of genomics but also heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has had consequences for genome quality, resulting in an exponential increase in draft(partial data) genome deposits in public databases. If no further interests are expressed for a particular bacterial genome, it is more likely that the sequencing of its genome will be limited to a draft stage, and the painstaking tasks of completing the sequencing of its genome and annotation will not be undertaken. It is important to know what is lost when we settle for a draft genome and to determine the 'scientific value' of a newly sequenced genome. This review addresses the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology. Also, it discusses the factors that could be leading to the increase in the number of draft deposits and the consequent loss of relevant biological information. | Eudes GV Barbosa Flavia F Aburjaile Rommel TJ Ramos Adriana R Carneiro Yves Le Loir Jan Baumbach Anderson Miyoshi Artur Silva Vasco Azevedo | 2014 | World Journal of Biological Chemistry2014，5，2： | 7 |
| 2 | Anodic treatment of aluminum in nitric acid containing aniline, previous to deposition of polyaniline and its role on corrosion显示文摘 | Huerta-Vilca D Moraes S R Artur J M | 2004 | synth met2004，，140： | 1 |
| 3 | Biogenic amines in meat inoculated with Lactobacillus sake starter strains and an aminepositive lactic acid bacterium显示文摘 | Artur R S Susanna E | 1997 | Z Lebensm Unters Forsch A1997，205，2： | 1 |
| 4 | Fault diagnosis of analog piecewise linear circuits based on homotopy显示文摘 | ARTUR R ROMUALD Z | 2002 | IEEE Transactions onInstruments and Measurement2002，51，4： | 1 |
| 5 | Organization Design显示文摘 | Miition H Artur R | 2002 | Management Science2002，48，： | 1 |
| 6 | The influence ofmyoglobin on the colour of minced pork loin显示文摘 | Tadeusz K Malgorzata J Artur R | 2013 | Meat Science2013，94，2： | 1 |
| 7 | Estrogen receptorα andβExpression in theca and granulosa cells from women with polycystic ovary syndrome显示文摘 | Artur J J Stacy R W Denis A N | 2002 | J Clin Endocrinol Metab2002，87，： | 1 |
| 8 | Molecular mechanisms of primary and secondary mucosal immunity using avian infectious bronchitis virus as a model system显示文摘 | Guo X S Artur R Chen J M | 2008 | Vet Immunol Immunopathol2008，121，34： | 1 |
| 9 | Aromatase mRNA expression in individual follicles from polycystic ovaries显示文摘 | Artur J Jakimiuk L Stacy R | 1998 | Mol Hum Reprod1998，4，1： | 1 |
| 10 | Orthostatic hypotension epidemi- ology, prognosis, and treatment 显示文摘 | Fabrizio R Raffaele DC Artur F | 2015 | J Am Coil Cardiol2015，66，7： | 1 |
| 11 | The theory of optimal capital structure显示文摘 | Harris M Artur R | 1991 | Journal of Finance1991，44，： | 1 |
| 12 | Protein degradation in C3 and C4 plants with particular reference to ribulose bisphosphate carboxylase and glycolate oxidase显示文摘 | MARIA G E RICARDO B F ARTUR R T | 1998 | Journal of Experimental Botany1998，49，： | 1 |
| 13 | Organization design显示文摘 | MILTON H ARTUR R | 2002 | Management Science2002，48，7： | 1 |
| 14 | Bacterial cel- lulose membranes as transdermal delivery systems for di- clofenac: In vitro dissolution and permeation studies 显示文摘 | Nuno H C S S Artur F R Isabel F A | 2014 | Carbohydr Polym2014，106，： | 1 |
| 15 | The influence of myoglobin on the colour of minced pork loin显示文摘 | TADEUSZ K MALGORZATA J ARTUR R | 2013 | Meat Science2013，94，2： | 1 |
| 16 | Effects of valeryl salicylate, a COX-1 inhibitor, on models of acute inflammation in mice显示文摘 | Jarbas M Siqueira-Junior Rodrigo R Peters Artur J.de Brum-Fernandes Rosa M Ribeiro-do-Valle | 2003 | Pharmacological Research2003，，5： | 1 |
| 17 | 显示文摘 | Ana I R N A B Artur M S S | 2003 | Tetrahedron Letters2003，44，： | 1 |
| 18 | ^1H and ^13C NMR spectroscopy of mono-, di-, tri- and tetrasubstituted xanthones 显示文摘 | Eduarda G R F Artur M S S Jose A S C | 1998 | Magn Reson Chem1998，36，4： | 1 |
| 19 | Influence of ultra-high pressure homogenisation on antioxidant capacity, polyphenol and vitamin content of clear apple juice显示文摘 | ángela Suárez-Jacobo Corinna E. Rüfer Ramón Gervilla Buenaventura Guamis Artur X. Roig-Sagués Jordi Saldo | 2011 | Food Chemistry2011，，2： | 1 |
| 20 | The Theory of Capital Structure显示文摘 | MILTON H ARTUR R | 1991 | Journal of Finance1991，46，1： | 1 |
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