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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Keep up the pace: declines in simple repetitive timing differentiate healthy aging from the earliest stages of Alzheimer's disease显示文摘 | Ashley S Bangert David A Balota | 2012 | J Int Neuropsychol Soc2012，18，6： | 1 |
| 3 | The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria显示文摘 | Elizabeth MH Wellington Alistair BA Boxall Paul Cross Edward J Feil William H Gaze Peter M Hawkey Ashley S Johnson-Rollings Davey L Jones Nicholas M Lee Wilfred Otten Christopher M Thomas A Prysor Williams | 2013 | The Lancet Infectious Diseases2013，，2： | 1 |
| 4 | Early response to platinum-based first-line chemotherapy in non-small cell lung cancer may predict survival显示文摘 | Sirohi B Ashley S Norton A | 2007 | J Thorac Oncol2007，2，8： | 1 |
| 5 | Good clinical response of breast cancers to neoadjuvant chemoendocfine therapy is associatedwith improved overall survival显示文摘 | Cleator S J Makris A Ashley S E | 2005 | Ann Oncol2005，16，2： | 1 |
| 6 | Population dynamics of a meiotic/mitotic expansion model for the fr-agile X syndrome显示文摘 | Ashley A E Sherman S L | 1995 | Am J Hum Genet1995，57，6： | 1 |
| 7 | Good clinical response of breast cancer to neoadjuvant chemoendocrine therapy is associated with improved overall survival显示文摘 | Cleator S J Makris A Ashley S E | 2005 | Aan Oncol2005，16，2： | 1 |
| 8 | Inventory, channel coordination and bargaining in a manufacturer-retailer system显示文摘 | Li S X Huang Z M Ashley A | 1996 | The Annals of Operations Research1996，68，1： | 1 |
| 9 | The pathway study: results of a pilot feasibility study in patients suspected of having lung carcinoma investigated in a conventional chest clinic setting compared to a centralised two-stop pathway显示文摘 | P.V Murray M.E.R O’Brien R Sayer N Cooke G Knowles A.C Miller V Varney N.P Rowell A.R Padhani D MacVicar A Norton S Ashley I.E Smith | 2003 | Lung Cancer2003，，3： | 1 |
| 10 | Heritability of canopy apparent photosynthesis and its relationship to seed yield in soybeans显示文摘 | Harrison S A Boerma H R Ashley D A | 1981 | Crop Science1981，21，： | 1 |
| 11 | Leaf photosynthetic characteristics of determinate soybean cuhivars 显示文摘 | Bhagsari A S Ashley D A Brown R H | 1977 | Crop Science1977，17，6： | 1 |
| 12 | Executive Compensation and Earnings Persistence显示文摘 | ASHLEY A S YANG S S M | 2004 | Journal of Business Ethics2004，50，4： | 1 |
| 13 | Seller-buyer system cooperation in a monopolistic market 显示文摘 | Li S X Huang Z Ashley A | 1995 | Journal of Operational Research Society1995，46，： | 1 |
| 14 | Subtotal hepatectomy: a porcine model for the study of liver regeneration显示文摘 | Fiona G Court Peter E Laws Charles P Morrison Benjamin D Teague Matthew S Metcalfe Simon A Wemyss-Holden Ashley R Dennison Guy J Maddern | 2004 | Journal of Surgical Research2004，，1： | 1 |
| 15 | Updated effieacy and toxicity analysis of irinotecan and oxaliplatin (IROX) : intergroup trial N9741 in first-line treatment of metastatic colorectal cancer显示文摘 | Ashley A C Sargent D J Alberts S R | 2007 | Cancer2007，110，3： | 1 |
| 16 | Interleukin 10 reduces the severity of acute pancreatitis in rat显示文摘 | KUSSKE A M ASHLEY S W | 1997 | Gastroenterology1997，112，： | 1 |
| 17 | Improving Buyer-seller system cooperation through inventory control显示文摘 | Li S X Huang Z M Ashley A | 1996 | International Journal of Production Economics1996，43，： | 1 |
| 18 | Twenty-year follow-up of the Royal Marsden randomized, double-blinded tamoxifen breast cancer prevention trial 显示文摘 | Powles TJ Ashley S Tidy A | 2007 | J Natl Cancer Inst2007，99，4： | 1 |
| 19 | Is surgery necessary after complete clinical remission following neoadjuvant chemotherapy for early breast cancer? 显示文摘 | Ring A Webb A Ashley S | 2003 | J Clin Oncol2003，21，24： | 1 |
| 20 | Quantitative detection of trichloroacetic acid in human urine using isotope dilution HPLC-Electrospray Ionization Tandem mass spectrometry显示文摘 | Kuklenyik Z S Ashley D L Calafat A M | 2002 | Analytical Chemistry2002，74，9： | 1 |
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