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| 1 | Mechanical and cellular processes driving cervical myelopathy显示文摘Cervical myelopathy is a well-described clinical syndrome that may evolve from a combination of etiological mechanisms. It is traditionally classified by cervical spinal cord and/or nerve root compression which varies in severity and number of levels involved. The vast array of clinical manifestations of cervical myelopathy cannot fully be explained by the simple concept that a narrowed spinal canal causes compression of the cord, local tissue ischemia, injury and neurological impairment. Despite advances in surgical technology and treatment innovations, there are limited neuro-protective treatments for cervical myelopathy, which reflects an incomplete understanding of the pathophysiological processes involved in this disease. The aim of this review is to provide a comprehensive overview of the key pathophysiological processes at play in the development of cervical myelopathy. | Roisin T Dolan Joseph S Butler John M O'Byrne Ashley R Poynton | 2016 | World Journal of Orthopedics2016，7，1： | 5 |
| 2 | Small artery structure and hypertension: adaptive changes and target organ damage显示文摘 | Ashley S Izzard Damiano Rizzoni Enrico Agabiti-Rosei Anthony M Heagerty | 2005 | Journal of Hypertension2005，，2： | 5 |
| 3 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 4 | The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria显示文摘 | Elizabeth MH Wellington Alistair BA Boxall Paul Cross Edward J Feil William H Gaze Peter M Hawkey Ashley S Johnson-Rollings Davey L Jones Nicholas M Lee Wilfred Otten Christopher M Thomas A Prysor Williams | 2013 | The Lancet Infectious Diseases2013，，2： | 1 |
| 5 | Nutrient adequacy during weight loss interventions: a randomized study in women comparing the dietary intake in a meal replacement group with a traditional food group 显示文摘 | ASHLEY J M HERZOG H CLODFELTER S | 2007 | Nutr J2007，6，： | 1 |
| 6 | Bone marrow-generated den dritic cells pulsed with tumor extracts or tunor RNA induce antitumor immunity against central nervous system tumors显示文摘 | Ashley D M Faiola B Nair S | 1997 | J Exp Med1997，186，7： | 1 |
| 7 | Inventory, channel coordination and bargaining in a manufacturer-retailer system显示文摘 | Li S X Huang Z M Ashley A | 1996 | The Annals of Operations Research1996，68，1： | 1 |
| 8 | Ghrelin promotesintestinal epithelial cell proliferation through PI3K/Aktpathway and EGFR transactivation both converging to ERK1/2phosphorylation显示文摘 | WASEEM T DUXBURY M ASHLEY S W | 2014 | Peptides2014，52，： | 1 |
| 9 | Stereotactic radiotherapy ( SABR )for the treatment of primary non-small cell lung cancer; systematic review and comparison with a surgical cohort显示文摘 | Sold t F Lodge M Ashley S | 2013 | Radiother Oncol2013，109，1： | 1 |
| 10 | Fluid sediment in combined sewers显示文摘 | ASHLEY R M ARTHUR S COGHLAN B P | 1994 | Water Science & Technology1994，29，12： | 1 |
| 11 | Estimation of mor- tality and morbidity risk in vascular surgery using POS- SUM and the Portsmouth predictor equation显示文摘 | Midwinter MJ Tytherleigh M Ashley S | 1999 | Br J Surg1999，86，4： | 1 |
| 12 | Rates and patterns of Late Cenozoic denudation in the northernmost Atlantic Coastal Plain and Piedmont显示文摘 | STANFORD S D ASHLEY G M RUSSELL E W B | 2002 | Geological Society of American Bulletin2002，114，： | 1 |
| 13 | Executive Compensation and Earnings Persistence显示文摘 | ASHLEY A S YANG S S M | 2004 | Journal of Business Ethics2004，50，4： | 1 |
| 14 | High incidence of HER- 2 positivity in inflammatory breast cancer显示文摘 | Parton M Dowsett M Ashley S | 2004 | Breast2004，13，2： | 1 |
| 15 | Interleukin 10 reduces the severity of acute pancreatitis in rat显示文摘 | KUSSKE A M ASHLEY S W | 1997 | Gastroenterology1997，112，： | 1 |
| 16 | Bone marrow-generated dendritic cells pulsed ith tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors显示文摘 | Ashley D M Faiola B Nair S | 1997 | J Exp Med1997，186，7： | 1 |
| 17 | Improving Buyer-seller system cooperation through inventory control显示文摘 | Li S X Huang Z M Ashley A | 1996 | International Journal of Production Economics1996，43，： | 1 |
| 18 | Quantitative detection of trichloroacetic acid in human urine using isotope dilution HPLC-Electrospray Ionization Tandem mass spectrometry显示文摘 | Kuklenyik Z S Ashley D L Calafat A M | 2002 | Analytical Chemistry2002，74，9： | 1 |
| 19 | Seller-Buyer co-operation in a monopolistic market显示文摘 | Li S X Huang Z M Ashley A | 1995 | Journal of the Operations Research Society1995，46，： | 1 |
| 20 | Late Quatermary sequence stratigraphy of a slowly subsiding passive margin, New Jersey Continental Shelf显示文摘 | Carey J S Sheridan R E Ashley G M | 1998 | AAPG Bulletin1998，82，5： | 1 |
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