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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Inhibitory effects of antagonists of bombesin/gastrin releasing peptide ( GRP ) and somatostatin analog ( RC160) on growth of HT-29 human colon cancers in nude mice显示文摘 | Radulovic S Schally AV | 1994 | Acta oncologicd1994，33，6： | 2 |
| 3 | Widespread occurrence of the JAK2V617F mutation in chronic myeloproliferative disorders 显示文摘 | Jones AV Kreil S Zoi K | 2005 | Blood2005，106，6： | 1 |
| 4 | Tomato lycopene and low density lipoprotein oxidation: a human dietary intervention study显示文摘 | Agarwal S Rao AV | 1998 | Lipids1998，33，10： | 1 |
| 5 | Left atrial size after cardioversion for atrial fibrillation:effect of external direct current shock显示文摘 | Mattioli AV Bonatti S Bonetti L | 2003 | J Am Soc Echocardiogr2003，16，： | 1 |
| 6 | Supermarkets, other food stores, and obesity: the atherosclerosis risk in communities study 显示文摘 | Morland K Diez Roux AV Wing S | 2006 | Am J Prev Meal2006，30，： | 1 |
| 7 | Tomato lyeopene and low density lipoprotein oxidation: a human dietary intervention study 显示文摘 | Agarwal S Rao AV | 1998 | Lipids1998，33，： | 1 |
| 8 | Nuclear export of microRNA precursors显示文摘 | Lund El Giittinger S Calado Av | 2004 | Science2004，303，5654： | 1 |
| 9 | Neuropsychiatric symptoms in dementia-frequency, relationship to dementia severity and comparison in Alzheimer's disease, vascular de- mentia and frontotemporat dementia显示文摘 | Srikanth S Nagaraja AV Ratnavalli E | 2005 | J Neurol Sci2005，236，12： | 1 |
| 10 | The role of vitamin D in reducing cancer risk and progression 显示文摘 | Feldman D Krishnan AV Swami S | 2014 | Nat Rev Cancer2014，14，5： | 1 |
| 11 | Polymorphisms in NEIL-2, APE-1, CYP2E1 and MDM2 genes are independent pre- dictors of gastric cancer risk in a northern Jiangsu population ( Chi- na ) 显示文摘 | Elingarami S Liu H Kalinjuma AV | 2015 | J Nanosci Nanotechnol2015，15，7： | 1 |
| 12 | The role of vitmin Din reducing cancer risk and progression显示文摘 | Feldma D Krishnan AV Swami S | 2014 | Nat Rev Cancer2014，14，5： | 1 |
| 13 | Carotenoids and chronic diseases 显示文摘 | Agarwal S Rao AV | 2000 | Drug Metabol Drug Interact2000，17，14： | 1 |
| 14 | Individual variation in the ac tivation and inactivation of metabolic pathways of cyclophosphamide显示文摘 | Boddy AV Furtun Y Sardas S | 1992 | J Natl Cancer Inst1992，84，： | 1 |
| 15 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 16 | Beneficial endo- crine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: in- teractions with metformin显示文摘 | MATVEYENKO AV DRY S COX HI | 2009 | Diabetes2009，58，7： | 1 |
| 17 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 18 | Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence path- ways显示文摘 | Molofsky AV He S Bydon M | 2005 | Genes Dev2005，19，12： | 1 |
| 19 | Delivery of the posterior arm reduces shoulder dimensions in shoulder dystocia显示文摘 | Kung J Swan AV Arulkumaran S | 2006 | Inter J Gy- necol Obstet2006，93，： | 1 |
| 20 | The role of vitamin D inreducing cancer risk and progression显示文摘 | Feldman D Krishnan AV Swami S | 2014 | Nature Reviews Cancer2014，14，5： | 1 |
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