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| 1 | Duodenal gangliocytic paraganglioma with lymph node metastases: a case report and comparative review of 31 cases显示文摘Gangliocytic paraganglioma(GP) is a rare tumor of uncertain origin most often located in the second portion of the duodenum. It is composed of three cellular components: Epithelioid endocrine cells, spindlelike/sustentacular cells, and ganglion-like cells. While this tumor most often behaves in a benign manner, cases with metastasis are reported. We describe the case of a 62-year-old male with a periampullary GP with metastases to two regional lymph nodes who was successfully treated with pancreaticoduodenectomy. Using Pub Med, EMBASE, EBSCOhost MEDLINE and CINAHL, and Google Scholar, we searched the literature for cases of GP with regional lymph node metastasis and evaluated the varying presentations, diagnostic workup, and disease management of identified cases. Thirty-one cases of GP with metastasis were compiled(30 with at least lymph node metastases and one with only distant metastasis to bone), with age at diagnosis ranging from 16 to 74 years. Ratio of males to females was 19:12. The most common presenting symptoms were abdominal pain(55%) and gastrointestinal bleeding or sequelae(42%). Twenty-five patients underwent pancreaticoduodenectomy. Five patients were treated with local resection alone. One patient died secondary to metastatic disease, and one died secondary to perioperative decompensation. The remainder did well, with no evidence of disease at follow-up from the most recent procedure(except two in which residual disease was deliberately left behind). Of the 26 cases with sufficient histological description, 16 described a primary tumor that infiltrated deep to the submucosa, and 3 described lymphovascular invasion. Of the specific immunohistochemistry staining patterns studied, synaptophysin(SYN) stained all epithelioid endocrine cells(18/18). Neuron specific enolase(NSE) and SYN stained most ganglion-like cells(7/8 and 13/18 respectively), and S-100 stained all spindle-like/sustentacular cells(21/21). Our literature review of published cases of GP with lymph node metastasis underscores the excellent prognosis of GP regardless of specific treatment modality. We question the necessity of aggressive surgical intervention in select patients, and argue that local resection of the mass and metastasis may be adequate. We also emphasize the importance of pre-surgical assessment with imaging studies, as well as post-surgical follow-up surveillance for disease recurrence. | Sahara J Cathcart Aaron R Sasson Jessica A Kozel Jennifer M Oliveto Quan P Ly | 2017 | World Journal of Clinical Cases2017，5，6： | 9 |
| 2 | Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction 显示文摘 | JAMES L JANUZZI JR MD SHAFIQ U REHMAN M D ASIM A MOHAMMED M D ANJU BHARDWAJ M D LINDA BARAJAS R N JUSTINE BARAJAS HAN-NA KIM M D MPH AARON L BAGGISH M D RORY B WEINER M D ANNABEL CHEN-TOURNOUX MD JANE E MARSHALL RDCS STEPHANIE A MOORE M D WILLIAM D CARLSON M D GREGORY D LEWIS M D JORDAN SHIN M D DOROTHY SULLIVAN ANP KIMBERLY PARKS D O THOMAS J WANG M D SHAWN A GREGORY M D SHANMUGAM UTHAMALINGAM M D MARC J SEMIGRAN M D | 2011 | J Am Coll Cardiol2011，58，18： | 1 |
| 3 | Structural and near-IR photophysical studies on ternary lanthanide complexes containing poly(pyrazolyl)borate and 1,3-diketonate ligands显示文摘 | DAVIES G M AARONS R J MOTSON G R | 2004 | Dalton Trans2004，8，： | 1 |
| 4 | The United Kingdom public health re- sponse to an imported laboratory confirmed case of a no- vel coronavirus in September 2012显示文摘 | Pebody R G Chand M A Thomas H L Green H K Boddington N L Carvalho C Brown C S Anderson S R Rooney C Crawley-Boevey E Irwin D J Aarons E Tong C Newsholme W Price N Langrish C Tucker D Zhao H Phin N Crofts J Bermingham A Gil- gunn-Jones E Brown K E Evans B Catchpole M Watson J M | 2012 | Euro Surveill2012，17，20： | 1 |
| 5 | Perfusion ab- normalities in subchondral bone associated with marrow edema, os- teoarthritis, and avascular necrosis 显示文摘 | AARON R K DYKE J P C1OMBOR D M | 2007 | Ann N Y Acad Sci2007，1117，： | 1 |
| 6 | Fluorescence resonance energy transfer between Ouantum Dotdonors dyelabeled protein accptors 显示文摘 | Aaron R C Medintz L L Matthew M | 2004 | Journal of Polymer Science Part A: Polymer Chemistry2004，126，： | 1 |
| 7 | Nanoparticleagglomeration in polymer-based solar cells显示文摘 | Jonathon W K Aaron P R Michael E M | 2010 | PhysicalReview Letters2010，105，16： | 1 |
| 8 | Sequential Exposure to Carbon Nanotubes and Bacteria Enhances Pulmonary Inflammation and Infectivity显示文摘 | Shvedova Anna A Fabisiak James P Kisin Elena R Murray Ashley R Roberts Jenny R Tyurina Yulia Y Antonini James M Feng Wei Hong Kommineni Choudari Reynolds Jeffrey Barchowsky Aaron Castranova Vince Kagan Valerian E | 2008 | American Journal of Respiratory Cell and Molecular Biology2008，，5： | 1 |
| 9 | Effect of high altitude on laser assisted in situ keratomileusis(LASIK)eyes显示文摘 | Aaron M Gooch J Harvey R | 2010 | Aviat Space Environ Med2010，81，3： | 1 |
| 10 | Maximum entropy method for magnetoencephalography显示文摘 | Huang M Aaron R Shiffman CA | 1997 | IEEE Trans BME1997，44，1： | 1 |
| 11 | The epidemiology of leisure physical activity in an adolescent population显示文摘 | Aaron D J Kriska A M Dearwater S R | 1993 | Medicine and Science in Sport and Exercise1993，25，7： | 1 |
| 12 | Potentiation of pa- clitaxel cytotoxicity in lung and esophageal cancer cells by pharmacologic inhibition of the phosphoinositide 3-kinase/ protein kinase B (Akt)-mediated signaling pathway 显示文摘 | Dao M N Aaron G C Rishindra R | 2004 | The Journal of Thoracic and Cardiovascular Surgery2004，，127： | 1 |
| 13 | Branch surface and its vertical distribution in coastal Douglas -fir显示文摘 | Aaron R W Douglas A M | 2006 | Trees2006，20，： | 1 |
| 14 | Dopamine and serotonin receptor binding and antipsychotic efficacy显示文摘 | Neil M R Jeffrey A W Aaron D L | 2007 | Neuropsy chopharmacology2007，32，： | 1 |
| 15 | Production of α-1,3-galactosyltransferase knockout Pigs by nuclear transfer cloning显示文摘 | Donna K S Kwang W P Hee T C Julia L G Gi S I Melissa S Aaron B August R Billy N D Clifton N M David B C Robert J H Randall S P | 2002 | Science2002，295，5557： | 1 |
| 16 | Branch surface area and its ver-tical distribution in coastal Douglas-fir显示文摘 | AARON R W DOUGLAS A M | 2006 | Trees2006，20，6： | 1 |
| 17 | The interaction of cytokinin withother signals 显示文摘 | Aaron M R Hyun S C Bridey B | 2005 | Physiologia Plantarum2005，123，2： | 1 |
| 18 | The geochemical effects of benzene,toluene,and xylene (BTX) biodegradation显示文摘 | Walton R K Janet S H Aaron L M | 1997 | Applied geochemistry1997，12，： | 1 |
| 19 | Contrasting microanatomy of idiopathic and corticosteroid-induced osteoporosis显示文摘 | AARON J E FRANCIS R M PEACOCK M | 2002 | Clin Orthop2002，143，： | 1 |
| 20 | Effect of high altitude on laser assisted in situ keratomileusis (LASIK) eyes 显示文摘 | Aaron M Gooch J Harvey R | 2010 | Aviat Space Environ Med2010，81，3： | 1 |
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