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7篇 您的检索式:作者名="Abraham Domb"
    题名 作者 年代 出处 被引量
1Biodegradable Injectable in situ Depot -forming Drug Delivery Systems- Macromo显示文摘Deepak Chitkara Ariella Shikanov Neeraj Kumar Abraham J Domb 2006Biosc2006,6,:1
2Poly (sebacie acid-co-rieinoleic acid) biodegradable carrier for paelitaxel-effect of additives显示文摘Shikanov Ariella Ezra Aviva Domb Abraham J 2005J Control Release2005,105,12:1
3Antibacterial effect of composite resins containing quaternary ammonium polyethyleneimine nanoparticles显示文摘Ira Yudovin-Farber Nurit Beyth Ervin I. Weiss Abraham J. Domb 2010Journal of Nanoparticle Research2010,,2:1
4Streptococcus mutans biofilm changes surface-topography of resin composites显示文摘Nurit Beyth Ran Bahir Shlomo Matalon Abraham J. Domb Ervin I. Weiss 2007Dental Materials2007,,6:1
5Antibacterial effect of composite resins containing quaternary ammonium polyethyleneimine nanoparticles显示文摘Ira Yudovin-Farber Nurit Beyth Ervin I. Weiss Abraham J. Domb 2010Journal of Nanoparticle Research2010,,2:1
6Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting, penetrating and nuclear accumulation显示文摘Gene therapy has drawn great attention in the treatments of many diseases,especially for cardiovascular diseases.However,the development of gene carriers with low cytotoxicity and multitargeting function is still a challenge.Herein,the multitargeting REDV-G-TATG-NLS peptide was conjugated to amphiphilic cationic copolymer poly(e-caprolactone-co-3(S)-methyl-morpho-line-2,5-dione)-g-polyethyleneimine(PCLMD-g-PEI)via a heterobifunctional orthopyridyl disulfde-poly(ethylene glycol)-N-hydroxysuccinimide(OPSS-PEG-NHS)linker to prepare PCLMD-g-PEI-PEG-REDV-G-TAT-G-NLS copolymers with the aim to develop the gene carriers with low cytotoxicity and high transfection efficiency.The multitargeting micelles were prepared from PCLMD-g-PEI-PEG-REDV-G-TAT-G-NLS copolymers by self-assembly method and used to load pEGFP-ZNF580 plasmids(pDNA)to form gene complexes for enhancing the proliferation and migration of endothelial cells(ECs).The loading pDNA capacity was proved by agarose gel electrophoresis assay.These multitargeting gene com-plexes exhibited low cytotoxicity by 3-(4,-dimethylthia-zol-2-yl)-2,5-diphenyltetrazolium bromide assay.The high internalization efficiency of these gene complexes was confirmed by flow cytometry.The results of in vitro transfection demonstrated that these multitargeting gene complexes possessed relatively high transfection effi-ciency.The rapid migration of ECs transfected by these gene complexes was verified by wound healing assay.Owing to ECs-targeting ability,cell-penetrating ability and nuclear targeting capacity of REDV-G-TAT-G-NLS pep-tide,the multitargeting polycationic gene carrier with low cytotoxicity and high transfection efficiency has great potential in gene therapy.Xinghong Duo Lingchuang Bai Jun Wang Jintang Guo Xiangkui Ren Shihai Xia Wencheng Zhang Abraham Domb Yakai Feng 2020Frontiers of Chemical Science and Engineering2020,14,5:0
7Erratum to: Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting, penetrating and nuclear accumulation显示文摘The authors regret that there was an error in our publication.Considering Lingchuang Bai made great contributions to this work,Xinghong Duo and Lingchuang Bai should be co-first authors,but there was no statement that“Xinghong Duo and Lingchuang Bai contributed equally to this work”.The authors would like to apologize for any inconvenience caused.Xinghong Duo Lingchuang Bai Jun Wang Jintang Guo Xiangkui Ren Shihai Xia Wencheng Zhang Abraham Domb Yakai Feng 2021Frontiers of Chemical Science and Engineering2021,15,1:0
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