|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Serum thymosin β4 levels in patients with hepatitis B virus-related liver failure显示文摘AIM:To investigate whether serum thymosinβ4 can provide diagnostic or prognostic information in liver failure patients caused by chronic hepatitis B virus(HBV) infection. METHODS:Serum thymosinβ4 levels were measured in 30 patients with acute-on-chronic liver failure(ACLF), 31 patients with chronic liver failure(CLF),30 patients with compensated liver cirrhosis(CR)and 32 patients with chronic hepatitis B and 30 healthy controls.Serum thymosinβ4 levels were measured by enzyme-linked immunosorbent assay and Child-Pugh and model for end-stage liver disease(MELD)scores were calculated for each patient on admission.RESULTS:Compared with healthy controls,serum thymosinβ4 levels in ACLF,CLF,CR and chronic hepatitis B patients were significantly lower,6.5047 (4.7879-10.5314)μg/mL vs 0.4632(0.2759-0.8768) μg/mL,0.6981(0.5209-1.2008)μg/mL,1.8053 (0.8110-2.3397)μg/mL,3.7803(1.8570-6.4722)μg/mL, respectively(P<0.001).The levels of thymosinβ4 in liver failure(ACLF or CLF)patients were markedly lower than that in CR(P<0.001),and a difference was also found between CLF and ACLF patients(P=0.038).In patients with chronic liver disease,there was a positive relationship between thymosinβ4 levels and albumin, choline esterase,and platelet(P<0.001),and negative relationship with alanine aminotransferase(P=0.020), aspartate aminotransferase,total bilirubin,international normalized ratio of prothrombin time,and Child-Pugh and MELD scores(P<0.001).Of the 61 liver failure patients,the thymosinβ4 levels of non-survivors were significantly lower than that of survivors(P=0.007). Receiver operating characteristics analysis identified a thymosinβ4 cutoff level of 0.5708μg/mL for predicting poor prognosis in all liver failure patients.The serial thymosinβ4 values were observed in 13 liver failure inpatients.Lower initial values were observed in the death.While greater improvement in thymosinβ4 value was found in those who recovered from the disease. CONCLUSION:Serum thymosinβ4 can be used as an important potential predictor for liver failure caused by chronic HBV infection. | Tao Han,Ying Liu,Huan Liu,Zheng-Yan Zhu,Yan Li,Shi-Xiang Xiao,Zhen Guo,Zhen-Gang Zhao,Department of Hepatology,Tianjin Institute of Hepatobiliary Disease,Tianjin Key Laboratory of Artificial Cells,Tianjin Third Central Hospital,Tianjin Medical University,83 Jintang Road,Tianjin 300170, China | 2010 | World Journal of Gastroenterology2010，16，5： | 20 |
| 2 | Improving the Performance of Oilwell Cement by Graft-modifi ed PB Latex显示文摘Graft-modified polybutadiene(PB) latex was synthesized and used as an admixture to improve the performance of oilwell cement. Results showed that the addition of latex to pure cement slurry can significantly reduce the fluid loss of the cement slurry. When the dosage was 8%, the fluid loss was only 38 mL, and the fluidity of the cement slurry was improved. With an increasing amount of latex, the fluidity of the cement slurry increased continuously. The toughness of cement was significantly enhanced, whose average elastic modulus was 4.2 GPa. Scanning electron microscopy revealed that the filter cake of the cement slurry with latex was thin and dense, and the surface was coated with a layer of latex film. The microstructure of the cement stone showed a high density, and an interweaving mesh network formed in the cement. The results of cement hydration heat analysis and X-ray diffraction showed that latex inhibited the hydration of cement; the effect was stronger under a larger amount of latex. It is indicated that the graft-modified PB latex has great potential to replace the conventional styrene-butadiene rubber(SBR) latex for cementing in the future. | Jintang Guo Wenjie Pan Jinjie Fan Yongjin Yu | 2018 | Transactions of Tianjin University2018，24，5： | 2 |
| 3 | Biodegradable polydepsipeptides显示文摘 | YAKAI FENG JINTANG GUO | 2009 | Molecular Sciences2009，10，： | 1 |
| 4 | Fabrication and characterization of electrospun biocompatible PU/PEGMA hybrid nanofibers by in-situ UV photopolymerization显示文摘Poly(ethylene glycol) methacrylate (PEGMA) was introduced into a polyurethane (PU) solution in order to prepare hemocompatible electrospun membranes for potential application as small diameter vascular scaffolds. Crosslinked PU/PEGMA hybrid nanofibers were fabricated by a reactive electrospinning process with N,N′-methylenebisacrylamide (MBAm) as crosslinker and benzophenone (BP) as photoinitiator. The photoinduced polymerization and crosslinking reaction took place simultaneously during the electrospinning process. No significant difference in the membrane morphology was found by SEM when PEGMA content was less than 20 wt%. The crosslinked fibrous membranes of PU/PEGMA exhibit higher hydrophilicity and mechanical strength than PU membrane. These nanofibrous membranes are potential substitutes for artificial vascular scaffolds. | WANG HeYun FENG YaKai YUAN WenJie ZHAO HaiYang FANG ZiChen KHAN Musammir GUO JinTang | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，7： | 1 |
| 5 | Study on structure and performance of polycarbonate ure- thane synthesized via different copolymerization methods显示文摘 | Guo Jintang Zhao Meihua Ti Yan | 2007 | J Mater Sci2007，42，： | 1 |
| 6 | Thermothickening behavior of graft copolymerscontaining poly (N-isopropyl acrylamide-co-N , Ndimethylacrylamide)side chains in aqueous solution显示文摘 | Fan Guoqiang Guo Jintang Dong Meimei | 2014 | Journal of Macromolecular Science Part A:Pure andApplied Chemistry2014，51，11： | 1 |
| 7 | Biodegradable polydepsipep- tides显示文摘 | Feng Yakai Guo Jintang | 2009 | International Journal of Molecular Sciences2009，10，58： | 1 |
| 8 | The use of ion exchange resins in the recycle of palladium catalysts for the synthesis of polyketones显示文摘 | Guo Jintang Liu Bing Wang Xinying | 2004 | Reactive and Functional Polymers2004，61，2： | 1 |
| 9 | Synthesis of poly (1-oxo-2-phenyltrimethylene)catalyzed by palladium- rare earth catalyst 显示文摘 | Tian Jing Guo Jintang Zhu Chengcai | 2007 | Fibers and Polymers2007，8，6： | 1 |
| 10 | N-glucosyltransferase GbNGT1 from ginkgo complements the auxin metabolic pathway显示文摘As auxins are among the most important phytohormones,the regulation of auxin homeostasis is complex.Generally,auxin conjugates,especially IAA glucosides,are predominant at high auxin levels.Previous research on terminal glucosylation focused mainly on the O-position,while IAA-N-glucoside and IAA-Asp-N-glucoside have been neglected since their discovery in 2001.In our study,IAA-Asp-N-glucoside was found to be specifically abundant(as high as 4.13 mg/g)in the seeds of 58 ginkgo cultivars.Furthermore,a novel N-glucosyltransferase,termed GbNGT1,was identified via differential transcriptome analysis and in vitro enzymatic testing.It was found that GbNGT1 could catalyze IAA-Asp and IAA to form their corresponding N-glucosides.The enzyme was demonstrated to possess a specific catalytic capacity toward the N-position of the IAA-amino acid or IAA from 52 substrates.Docking and site-directed mutagenesis of this enzyme confirmed that the E15G mutant could almost completely abolish its N-glucosylation ability toward IAA-Asp and IAA in vitro and in vivo.The IAA modification of GbNGT1 and GbGH3.5 was verified by transient expression assay in Nicotiana benthamiana.The effect of GbNGT1 on IAA distribution promotes root growth in Arabidopsis thaliana. | Qinggang Yin Jing Zhang Shuhui Wang Jintang Cheng Han Gao Cong Guo Lianbao Ma Limin Sun Xiaoyan Han Shilin Chen An Liu | 2021 | Horticulture Research2021，8，1： | 1 |
| 11 | Synthesis and characterization of poly(carbonate urethane)networks with shape-memory properties 显示文摘 | Feng Yakai Xue Yan Guo Jintang | 2009 | Journal of Applied Polymer Science2009，112，1： | 1 |
| 12 | Surface modification of biomaterials by photochemical immobilization and photograft polymerization to improve hemocompatibility显示文摘Thrombus formation and blood coagulation are serious problems associated with blood contacting products,such as catheters,vascular grafts,artificial hearts,and heart valves.Recent progresses and strategies to improve the hemocompatibility of biomaterials by surface modification using photochemical immobilization and photograft polymerization are reviewed in this paper.Three approaches to modify biomaterial surfaces for improving the hemocompatibility,i.e.,bioinert surfaces,immobilization of anticoagulative substances and biomimetic surfaces,are introduced.The biomimetic amphiphilic phosphorylcholine and Arg-Gly-Asp(RGD)sequence are the most effective and most often employed biomolecules and peptide sequence for improving hemocompatibility of material surfaces.The RGD sequence can enhance adhesion and growth of endothelial cells(ECs)on material surfaces and increase the retention of ECs under flow shear stress conditions.This surface modification is a promising strategy for biomaterials especially for cardiovascular grafts and functional tissue engineered blood vessels. | Yakai FENG Haiyang ZHAO Li ZHANG Jintang GUO | 2010 | Frontiers of Chemical Science and Engineering2010，4，3： | 1 |
| 13 | 查看详情显示文摘 | Feng Yakai Guan Wenli Zhao Haiyang Guo Jintang Chen Qingliang Liu Jianshi | | 0，，06： | 1 |
| 14 | Biodegradable Polydepsipeptides显示文摘 | Yakai Feng Jintang Guo | 2009 | Molecular Sciences2009，10，： | 1 |
| 15 | Preparation and Investigation of High-Efficiency Antibacterial Liquid Dishwashing Detergent显示文摘A high-effi ciency liquid dishwashing detergent was prepared by using oregano essential oil as an antibacterial agent. The surface cleaning and antibacterial property of the detergent resolved its unifunctionality problem. The antibacterial activities of the detergent were demonstrated through a disk diff usion assay and wipe experiments with Escherichia coli and Staphylococcus aureus . Results showed that the prepared detergent was highly eff ective against E. coli and S. aureus . The results of chemical accelerated tests indicated that the detergent would be eff ective for at least 1 year. The antibacterial property and detergency performance of the high-effi ciency antibacterial liquid dishwashing detergent were compared with those of a commercial antibacterial detergent containing 0.02% o -phenylphenol. The detergency performance of the high-effi ciency detergent reached 97.8% and was superior to that of the commercial antibacterial detergent. | Mingxue Dai Jintang Guo Xuexue Xue Yakai Feng | 2019 | Transactions of Tianjin University2019，25，4： | 0 |
| 16 | Copolymerization of polyketones catalyzed by polyacrylonitrile resin-supported palladium acetate显示文摘The crosslinked polyacrylonitrile (PAN) wassynthesized by suspension polymerization using acrylonitrile(ANT) and divinylbenzene (DVB). Effects of a varietyof conditions on the polymerization of PAN particle sizeand stiffness were investigated. Polyketone was preparedby the copolymerization of carbon monoxide (CO) andstyrene (ST) catalyzed by PAN resin-supported palladiumacetate. The resin-supported catalyst and the copolymerizationproduct were characterized by infrared spectroscopy(IR) and Scanning Electron Microscopy (SEM). Effects ofthe components of a catalytic system and reaction time onthe catalytic activity were studied. The reusability of theresin-supported catalyst was also investigated.Results indicatedthat the resin-supported catalyst has excellent catalyticproperty. The yield of polyketone was 6.2348 g whenusing 1 g of resin and 22.4 mg of palladium acetate. | Jintang GUO Hongxin ZHANG Bo WANG Yaqin YE | 2008 | Frontiers of Chemical Science and Engineering2008，2，2： | 0 |
| 17 | Comprehensive reutilization of herbal waste:Coproduction of magnolol,honokiol,and β-amyrin from Magnolia officinalis residue显示文摘Herbal extraction residues(HERs)cause serious environmental pollution and resource waste.In this study,a novel green route was designed for the comprehensive reutilization of all components in HERs,taking Magnolia officinalis residues(MOR)as an example.The reluctant structure of MOR was first destroyed by alkali pretreatment to release the functional ingredients(magnolol and honokiol)originally remaining in MOR and to make MOR more accessible for hydrolysis.A metal–organic frame material MIL-101(Cr)with a maximum absorption capacity of 255.64 mg g^(-1)was synthesized to absorb the released honokiol and magnolol from the pretreated MOR solutions,and 40 g L^(-1)reducing sugars were obtained with 81.8%enzymatic hydrolysis rate at 10%MOR solid loading.Finally,382 mg L-1β-amyrin was produced from MOR hydrolysates by an engineered yeast strain.In total,1 kg honokiol,8 kg magnolol,and 7.64 kg β-amyrin could produce from 1 ton MOR by this cleaner process with a total economic output of 170,700 RMB. | Lukun Xiao Anyi Zhao Jie Qiu An Liu Sha Chen Jinzhu Jiang Jun Zhang Cong Guo Jipeng Di Jintang Cheng Chang Chen Kangxin Hou Aiping Zhang Yan Liu Caixia Wang | 2024 | Green Energy & Environment2024，9，2： | 0 |
| 18 | Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting, penetrating and nuclear accumulation显示文摘Gene therapy has drawn great attention in the treatments of many diseases,especially for cardiovascular diseases.However,the development of gene carriers with low cytotoxicity and multitargeting function is still a challenge.Herein,the multitargeting REDV-G-TATG-NLS peptide was conjugated to amphiphilic cationic copolymer poly(e-caprolactone-co-3(S)-methyl-morpho-line-2,5-dione)-g-polyethyleneimine(PCLMD-g-PEI)via a heterobifunctional orthopyridyl disulfde-poly(ethylene glycol)-N-hydroxysuccinimide(OPSS-PEG-NHS)linker to prepare PCLMD-g-PEI-PEG-REDV-G-TAT-G-NLS copolymers with the aim to develop the gene carriers with low cytotoxicity and high transfection efficiency.The multitargeting micelles were prepared from PCLMD-g-PEI-PEG-REDV-G-TAT-G-NLS copolymers by self-assembly method and used to load pEGFP-ZNF580 plasmids(pDNA)to form gene complexes for enhancing the proliferation and migration of endothelial cells(ECs).The loading pDNA capacity was proved by agarose gel electrophoresis assay.These multitargeting gene com-plexes exhibited low cytotoxicity by 3-(4,-dimethylthia-zol-2-yl)-2,5-diphenyltetrazolium bromide assay.The high internalization efficiency of these gene complexes was confirmed by flow cytometry.The results of in vitro transfection demonstrated that these multitargeting gene complexes possessed relatively high transfection effi-ciency.The rapid migration of ECs transfected by these gene complexes was verified by wound healing assay.Owing to ECs-targeting ability,cell-penetrating ability and nuclear targeting capacity of REDV-G-TAT-G-NLS pep-tide,the multitargeting polycationic gene carrier with low cytotoxicity and high transfection efficiency has great potential in gene therapy. | Xinghong Duo Lingchuang Bai Jun Wang Jintang Guo Xiangkui Ren Shihai Xia Wencheng Zhang Abraham Domb Yakai Feng | 2020 | Frontiers of Chemical Science and Engineering2020，14，5： | 0 |
| 19 | Erratum to: Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting, penetrating and nuclear accumulation显示文摘The authors regret that there was an error in our publication.Considering Lingchuang Bai made great contributions to this work,Xinghong Duo and Lingchuang Bai should be co-first authors,but there was no statement that“Xinghong Duo and Lingchuang Bai contributed equally to this work”.The authors would like to apologize for any inconvenience caused. | Xinghong Duo Lingchuang Bai Jun Wang Jintang Guo Xiangkui Ren Shihai Xia Wencheng Zhang Abraham Domb Yakai Feng | 2021 | Frontiers of Chemical Science and Engineering2021，15，1： | 0 |
| 20 | Modification of polycarbonateurethane surface with poly (ethylene glycol) monoacrylate and phosphorylcholine glyceraldehyde for anti-platelet adhesion显示文摘 | Jing YANG Juan LV Bin GAO Li ZHANG Dazhi YANG Changcan SHI Jintang GUO Wenzhong LI Yakai FENG | 2014 | Frontiers of Chemical Science and Engineering2014，8，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员