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| 1 | Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin,TGF-β1,IL-13 and oxidative stress显示文摘AIM To evaluate the therapeutic effects of bone marrowderived CD11b+CD14+ monocytes in a murine model of chronic liver damage. METHODS Chronic liver damage was induced in C57BL/6 mice by administration of carbon tetrachloride and ethanol for 6 mo. Bone marrow-derived monocytes isolated by immunomagnetic separation were used for therapy. The cell transplantation effects were evaluated by morphometry,biochemical assessment,immunohistochemistry and enzyme-linked immunosorbent assay. RESULTS CD11b+CD14+ monocyte therapy significantly reduced liver fibrosis and increased hepatic glutathione levels. Levels of pro-inflammatory cytokines,including tumor necrosis factor-α,interleukin(IL)-6 and IL-1β,in addition to pro-fibrotic factors,such as IL-13,transforming growth factor-β1 and tissue inhibitor of metalloproteinase-1 also decreased,while IL-10 and matrix metalloproteinase-9 increased in the monocytetreated group. CD11b+CD14+ monocyte transplantation caused significant changes in the hepatic expression of α-smooth muscle actin and osteopontin. CONCLUSION Monocyte therapy is capable of bringing about improvement of liver fibrosis by reducing oxidative stress and inflammation,as well as increasing antifibrogenic factors. | Veruska Cintia Alexandrino de Souza Thiago Almeida Pereira Valéria Wanderley Teixeira Helotonio Carvalho Maria Carolina Accioly Brelaz de Castro Carolline Guimaraes D’assuncao Andreia Ferreira de Barros Camila Lima Carvalho Virgínia Maria Barros de Lorena Vláudia Maria Assis Costa Alvaro Aguiar Coelho Teixeira Regina Celia Bressan Queiroz Figueiredo Sheilla Andrade de Oliveira | 2017 | World Journal of Gastroenterology2017，23，28： | 6 |
| 2 | Measurement of blood pressure may be affected by an interaction between subject and observer based on gender显示文摘 | Accioly JM | 1996 | J Hum Hypertens1996，10，： | 1 |
| 3 | The anatomical basis of the osteo-musculo-cutaneous trapezius flap in mandibular reconstruction显示文摘 | C. Vacher J.-J. Accioli Vasconcellos | 2005 | Surgical and Radiologic Anatomy2005，，1： | 1 |
| 4 | Photon mass and gravitational deflection显示文摘 | Accioly A Paszko R | 2004 | Phys Rev D2004，69，10： | 1 |
| 5 | Traditional Uses, Chemical Constituents, and Biological Activities of Bixa orellana L.: A Review显示文摘 | Daniela de Araújo Vilar Marina Suênia de Araujo Vilar Túlio Flávio Accioly de Lima e Moura Fernanda Nervo Raffin Márcia Rosa de Oliveira Camilo Flamarion de Oliveira Franco Petr?nio Filgueiras de Athayde-Filho Margareth de Fátima Formiga Melo Diniz José M | 2014 | The Scientific World Journal2014，，： | 1 |
| 6 | Endocrine and testicular changes induced by olanzapine in adult Wistar rats显示文摘 | Simone Siqueira Bringel Adelmar Afonso Amorim Júnior Marleyne José Afonso Accioly Lins Amorim Lorena Tavares Brito Rosana Nogueira Morais Sandra Maria Torres Bruno Mendes Tenorio Valdemiro Amaro Silva Junior | 2011 | J. Appl. Toxicol2011，，1： | 1 |
| 7 | The mRNAs associated to a zinc finger protein from Trypanosoma cruzi shift during stress conditions显示文摘 | Lysangela Ronalte Alves Camila Oliveira Patrícia Alves M?rking Rafael Luis Kessler Sharon Toledo Martins Bruno Accioly Alves Romagnoli Fabricio Kerrynton Marchini Samuel Goldenberg | 2014 | RNA Biology2014，，： | 1 |
| 8 | On the dependence structure of realized volatilities 显示文摘 | Mendes B V M Accioly V B | 2012 | International Review of Financial Analysis2012，22，： | 1 |
| 9 | Cytogenetic studies in Brazilian marine Sciaenidae and Sparidae fishes (Perciformes) 显示文摘 | ACCIOLY IV MOLINA WF | 2008 | Genet Mol Res2008，7，2： | 1 |
| 10 | Both osteopontin‐c and osteopontin‐b splicing isoforms exert pro‐tumorigenic roles in prostate cancer cells显示文摘 | Tatiana M. Tilli Kivvi D. Mello Luciana B. Ferreira Aline R. Matos Maria Thereza S. Accioly Paulo A.S. Faria Akeila Bellahcène Vincent Castronovo Etel R. Gimba | 2012 | Prostate2012，，15： | 1 |
| 11 | Performances of Brazilian IPOs Backed by Private Equity显示文摘 | Andrea Maria Accioly Fonseca Minardi Guilherme Lopes Ferrari Pedro Carvalho ArafijoTavares | 2012 | Journal of Business Research2012，66，： | 1 |
| 12 | Medial plantar flap based distally on the lateral planter artery to cover a forefoot skin defect显示文摘 | Accioli de Vasconcellos Z Touam C | 2000 | Plast Reconstr Surg2000，106，： | 1 |
| 13 | On the dependence structure of realized volatilities显示文摘 | Mendes B V M Accioly V B | | International Review of Financial Analysis0，22，1： | 1 |
| 14 | Hypartonic solutions in the treatment of hyporolemic shock:a prospective,randomized study in patients admitted to the emergency room显示文摘 | Younes RN Au F Accioly CQ | 1992 | Surgery1992，111，： | 1 |
| 15 | The fascial planes of the temple and face:an en-bloc anatomical study and a plea for consistency显示文摘 | ACCIOLI D E VASCONCELLOS J J BRITTO J A HENIN D | 2003 | Br J Hast Surg2003，56，7： | 1 |
| 16 | Cytogenetic studies in Brazilian marine Sciaenidae and Sparidae fishes (Perciformes)显示文摘 | Accioly I V Molina W F | 2008 | Genetics and Molecular Research2008，7，2： | 1 |
| 17 | Regression of Barrett's Esophagus: Is There a Difference between Clinical and Surgical Treatment?显示文摘 | Ramon Rawache Barbosa Moreira de Lima Fernando Antonio Siqueira Pinheiro Joao Odilo Goncalves Pinto Marcos Andre Araujo Accioly Filho Mateus Alves de Araujo Paulo Henrique Araujo Parente | 2017 | Journal of Pharmacy and Pharmacology2017，5，12： | 0 |
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