|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by α-lipoic acid in humans显示文摘AIM: To evaluate the protective effects of precondition- ing by α-lipoic acid (LA) in patients undergoing hepatic resection under inflow occlusion of the liver. METHODS: Twenty-four patients undergoing liver re- section for various reasons either received 600 mg LA or NaCl 15 min before transection performed under inflow occlusion of the liver. Blood samples and liver wedge bi- opsy samples were obtained after opening of the abdo- men immediately after inflow occlusion of the liver, and 30 min after the end of inflow occlusion of the liver. RESULTS: Serum levels of aspartate transferase and alanine transferase were reduced at all time points in patients who received LA in comparison to those who received NaCL. This was accompanied by reduced histo- morphological features of oncosis. We observed TUNEL- positive hepatocytes in the livers of the untreated patients, especially after 30 min of ischemia. LA attenu- ated this increase of TUNEL-positive hepatocytes. Under preconditioning with LA, ATP content was significantly enhanced after 30 min of ischemia and after 30 min of reperfusion. CONCLUSION: This is the first report on the poten- tial for LA reducing ischemia/reperfusion injury (IRI) of the liver in humans who were undergoing liver surgery. Beside its simple and rapid application, side effects did not occur. LA might therefore represent a new strategy against hepatic IRI in humans. | Fritz Dünschede Kirsten Erbes Achim Kircher Stefanie Westermann Joachim Seifert Arno Schad Kempski Oliver Alexandra K Kiemer Junginger Theodor | 2006 | World Journal of Gastroenterology2006，12，42： | 6 |
| 2 | Efficacy of SpyGlass^(TM)-directed biopsy compared to brush cytology in obtaining adequate tissue for diagnosis in patients with biliary strictures显示文摘AIM: To evaluate the diagnostic yield(inflammatory activity) and efficiency(size of the biopsy specimen) of SpyGlassTM-guided biopsy vs standard brush cytology in patients with and without primary sclerosing cholangitis(PSC).METHODS: At the University Medical Center Mainz, Germany, 35 consecutive patients with unclear biliarylesions(16 patients) or long-standing PSC(19 patients) were screened for the study. All patients underwent a physical examination, lab analyses, and abdominal ultrasound. Thirty-one patients with non-PSC strictures or with PSC were scheduled to undergo endoscopic retrograde cholangiography(ERC) and subsequent per-oral cholangioscopy(POC). Standard ERC was initially performed, and any lesions or strictures were localized. POC was performed later during the same session. The Boston Scientific SpyGlass SystemTM(Natick, MA, United States) was used for choledochoscopy. The biliary tree was visualized, and suspected lesions or strictures were biopsied, followed by brush cytology of the same area. The study endpoints(for both techniques) were the degree of inflammation, tissue specimen size, and the patient populations(PSC vs non-PSC). Inflammatory changes were divided into three categories: none, low activity, and high activity. The specimen quantity was rated as low, moderate, or sufficient.RESULTS: SpyGlassTM imaging and brush cytology with material retrieval were performed in 29 of 31(93.5%) patients(23 of the 29 patients were male). The median patient age was 45 years(min, 20 years; max, 76 years). Nineteen patients had known PSC, and 10 showed non-PSC strictures. No procedure-related complications were encountered. However, for both methods, tissues could only be retrieved from 29 pa-tients. In cases of inflammation of the biliary tract, the diagnostic yield of the SpyGlassTM-directed biopsies was greater than that using brush cytology. More tissue material was obtained for the biopsy method than for the brush cytology method(P = 0.021). The biopsies showed significantly more inflammatory characteristics and greater inflammatory activity compared to the cy-tological investigation(P = 0.014). The greater quantity of tissue samples proved useful for both PSC and non-PSC patients.CONCLUSION: SpyGlassTM imaging can be recom-mended for proper inflammatory diagnosis in PSC pa-tients. However, its value in diagnosing dysplasia wasnot addressed in this study and requires further investi-gation. | Johannes Wilhelm Rey Torsten Hansen Sebastian Dümcke Achim Tresch Katja Kramer Peter Robert Galle Martin Goetz Marcus Schuchmann Ralf Kiesslich Arthur Hoffman | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，4： | 2 |
| 3 | Tumorigenicity of human breast cancer is associated with loss of the Ca^2+-activated chloride channel CLCA2 显示文摘 | Achim D Gruber AD Pauli BU | 1999 | Cancer Res1999，59，： | 1 |
| 4 | A verification approach to applied system security显示文摘 | Achim D Brncker Burkhart Wolff | 2005 | International Journal on Soft-ware Tools for Technology Transfer2005，，： | 1 |
| 5 | Phosphorus fertilizer effects on soil phosphorus pools in acid upland soils 显示文摘 | Achim D Thomas G Niels T | 2002 | Soil Science Society of America Journal2002，66，： | 1 |
| 6 | Neural transplantation for stroke显示文摘 | Kondziolka D Wechsler L Achim C | 2002 | J Clin Neurosci2002，9，3： | 1 |
| 7 | Neural transplantation for stroke 显示文摘 | Kondziolka D Wechsler L Achim C | 2002 | J Clin Neurosci2002，9，3： | 1 |
| 8 | Neural Transplantation for stroke显示文摘 | Kondziolka D Wechsler L Achim C | 2002 | J Clin Neurosci2002，9，3： | 1 |
| 9 | 显示文摘 | Achim G Thomas D Rerinhard K | 1986 | Proc Nati Acad Sci USA1986，83，： | 1 |
| 10 | Phosphorus fertilizer effect s on Soil Phosphorus Pools in Acid Upland Soils 显示文摘 | Achim D Thomas G Niels T | 2002 | Soil Science Society of America Journal2002，66，2： | 1 |
| 11 | Rectal Cancer: Mucinous Carcinoma on Magnetic Resonance Imaging Indicates Poor Response to Neoadjuvant Chemoradiation显示文摘 | Katja Oberholzer Matthias Menig Andreas Kreft Astrid Schneider Theodor Junginger Achim Heintz Karl-Friedrich Kreitner Andreas M. H?tker Torsten Hansen Christoph Düber Heinz Schmidberger | 2012 | International Journal of Radiation Oncology Biology Physics2012，，2： | 1 |
| 12 | A method for the determination of acrylamide in bakery products using ion trap LC-ESI-MS/MS显示文摘 | Claus Achim Weisz Georg M Kammerer D R | 2005 | Mol Nutr Food Res2005，49，10： | 1 |
| 13 | Dendritic cell-based tumor vaccine for cervical cancer II: results of a clinical pilot study in 15 individual patients显示文摘 | Alfonso Ferrara Marion Nonn Peter Sehr Carola Schreckenberger Michael Pawlita Matthias Dürst Achim Schneider Andreas M. Kaufmann | 2003 | Journal of Cancer Research and Clinical Oncology2003，，9： | 1 |
| 14 | Unsupervised video anomaly detection using feature clustering 显示文摘 | LI H ACHIM A BULL D | 2012 | IET Signal Processing2012，6，5： | 1 |
| 15 | Unsupervised video anomaly detection using feature clustering显示文摘 | Li H Achim A Bull D | 2012 | IET signal processing2012，6，5： | 1 |
| 16 | Agroecosystems, nitrogen-use efficiency, and nitrogen management 显示文摘 | Cassman K G Achim D Waiters D T | 2003 | Ambio2003，31，： | 1 |
| 17 | Current therapies in hepatorenal syndrome显示文摘 | ACHIM C ZGURAA ZGURA D | 2014 | Rom J Intern Med2014，52，4： | 1 |
| 18 | Targeting pathophysiological rhythms:prednisone chronotherapy shows sustained efficacy in rheu- matoid arthritis显示文摘 | Frank B Gisela D Achim S | 2010 | Ann Rheum Dis2010，69，7： | 1 |
| 19 | A novel system for robust lane detection and tracking显示文摘 | WANG Y F NAIM D ACHIM A | 2012 | Signal Processing2012，92，2： | 1 |
| 20 | The significance of spinal canal dimensionsin discriminating symptomatic from asymptomatic disc herniations显示文摘 | Claudio D Beat W Achim E | 2002 | Euro Spine2002，11，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员