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| 1 | Abortifacient Potential of Aqueous Extract of Senna alata Leaves in Rats显示文摘Objective To study the abortifacient activity of aqueous extract of Senna alata leaves in female Wistar rats.Methods Pregnant rats weighing 143.65 ± 13.11 g were completely randomized into 5 groups(A-E).Rats in group A(negative control) were orally administered,once daily with 0.5 ml of distilled water on days 10-18 post-coitum while those in groups B,C,D,and E were treated exactly like the negative control except they received the same volume containing 2.85 mg/kg body weight of mifepristone(group B,reference drug),250,500 and 1 000 mg/kg body weight of the extract respectively(groups C-E).Results Phytochemical screening of the extract showed positive results for saponins(1.22%),flavonoids(1.06%),cardiac glycosides(0.20%),cardenolides and dienolides(0.18%),phenolics(0.44%) and alkaloids(0.52%).Respiratory distress,salivation,diarrhoea,changes in the appearance of hair as well as maternal mortality were not observed at any time during the exposure period except in the mifepristone-treated animals where there was episode of diarrhoea and tiredness.The extract significantly reduced(P<0.05) the number of life foetus,weight and survival ratio of the foetus,numbers of implantations and Corpora lutea,implantation index,progesterone,prolactin,estradiol,follicle stimulating and luteinizing hormones whereas the number of dead foetus,number and percentage of rats that aborted,percentage vaginal opening,resorption index,pre-and post-implantation losses increased significantly.In addition,mifepristone-treated animals produced resorption index that compared well with the distilled water control.There was also no dead or life foetus and serum progesterone concentration was increased in the animals treated with mifepristone.All cases of abortion were accompanied with vaginal bleeding.Although,the final weight of the rats increased significantly,the feed and water intake were not significantly altered in all the treatment groups.The weight of the uterus,uterine-body weight ratio,length of the right uterus horn and uterine cholesterol decreased significantly in all the treatment groups.The uterine alkaline phosphatase activity and glucose concentration increased in only the extract-treated animals whereas mifepristone decreased the uterine alkaline phosphatase activity and glucose content of the animals.Conclusion This study has provided evidence to the age-long claim of S.alata leaves in 'washing the uterus'.The abortifacient properties were most pronounced at 500 and 1 000 mg/kg body weight of the extract and were similar to the animals treated with 2.85 mg/kg body weight of mifepristone.Hormonal influence,changes in implantation site,estrogenicity and uterogenicity are suggested as possible mechanism of abortifacient activity of aqueous extract of S.alata leaves.Overall,the extract may be used as an abortifacient especially at 500 and 1 000 mg/kg body weight and therefore not safe for consumption as oral remedy during pregnancy. | Yakubu MT Adeshina AO Oladiji AT Akanji MA Oloyede OB Jimoh GA Olatinwo AWO Afolayan AJ | 2010 | Journal of Reproduction and Contraception2010，21，3： | 2 |
| 2 | Application of biological data in cancer risk estimations of chlordane and heptachlor 显示文摘 | ADESHINA F TODD E L | 1991 | Regul Toxicol Pharmacol1991，14，1： | 1 |
| 3 | Effect of Lactobacillus acidophilus as a Dietary Supplement on Nonspecific Immune Response and Disease Resistance in Juvenile Common carp, Cyprinos carpio显示文摘Effects of diet fortified with Lactobacillus acidophilus at 0.0%, 0.2%, 0.4% and 0.6% on nonspecific immune response and disease resistant common carp juvenile infected with Pseudomonas aeruginosa and Aeromonas hydrophilla were examined. Immune response parameters(the total protein, albumin, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, urea, creatinine and immunoglobulin), percentage mortality and relative protection level were determined on day 1 and days 14, 28, 42 and 56. Fish fed Lactobacilus acidophilus fortified diet significantly improved nonspecific immune parameters especially group treated with 0.4% inclusion with lower mortality rate indicating a better relative protection level against Pseudomonas aeruginosa and Aeromonas hydrophilla. | Adeshina Ibrahim Sani Abdulkareem Ramatu Adewale Yusuf Adewale | 2018 | Journal of Northeast Agricultural University(English Edition)2018，25，2： | 1 |
| 4 | Antibacterial Susceptibility of Klebsiella pneumoniae Isolates from Respiratory Tract Infections to Honey and Lemon显示文摘 | G. O. Adeshina B. M. Mshelia J. A. Onaolapo | 2014 | Annual Research & Review in Biology2014，，4： | 1 |
| 5 | Pesticide mixtures potentiate the toxicity in murine thymocytes显示文摘 | Olgun S Gogal RM Adeshina F | 2004 | Toxicology2004，196，： | 1 |
| 6 | Polymorphisms in the glutathione S-transferase mu cluster are associatedwith tumour progression and patient outcome in colorectal cancer显示文摘 | Sarah Holley Ramesh Rajagopal Paul Hoban Mark Deakin Adeshina Fawole James Elder Jackie Elder Victoria Smith Richard Strange Anthony Fryer | 2006 | International Journal of Oncology2006，，1： | 1 |
| 7 | Mathematical analysis of a Wolbachia invasive model with imperfect maternal transmission and loss of Wolbachia infection显示文摘Arboviral infections,especially dengue,continue to cause significant health burden in their endemic regions.One of the strategies to tackle these infections is to replace the main vector agent,Ae.aegypti,with the ones incapable of transmitting the virus.Wolbachia,an intracellular bacterium,has shown promise in achieving this goal.However,key factors such as imperfect maternal transmission,loss of Wolbachia infection,reduced reproductive capacity and shortened life-span affect the dynamics of Wolbachia in different forms in the Ae.aegypti population.In this study,we developed a Wolbachia transmission dynamic model adjusting for imperfect maternal transmission and loss ofWolbachia infection.The invasive reproductive number that determines the likelihood of replacement of the Wolbachia-uninfected(WU)population is derived and with it,we established the local and global stability of the equilibrium points.This analysis clearly shows that cytoplasmic incompatibility(CI)does not guarantee establishment of the Wolbachia-infected(WI)mosquitoes as imperfect maternal transmission and loss of Wolbachia infection could outweigh the gains from CI.Optimal release programs depending on the level of imperfect maternal transmission and loss of Wolbachia infection are shown.Hence,it is left to decision makers to either aim for replacement or co-existence of both populations. | Adeshina I.Adekunle Michael T.Meehan Emma S.McBryde | 2019 | Infectious Disease Modelling2019，4，1： | 1 |
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