|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Glutamate and depression: Reflecting a deepening knowledge of the gut and brain effects of a ubiquitous molecule显示文摘The versatility of glutamate as the brain’s foremost excitatory neurotransmitter and modulator of neurotransmission and function is considered common knowledge.Years of research have continued to uncover glutamate’s effects and roles in several neurological and neuropsychiatric disorders,including depression.It had been considered that a deeper understanding of the roles of glutamate in depression might open a new door to understanding the pathological basis of the disorder,improve the approach to patient management,and lead to the development of newer drugs that may benefit more patients.This review examines our current understanding of the roles of endogenous and exogenous sources of glutamate and the glutamatergic system in the aetiology,progression and management of depression.It also examines the relationships that link the gut-brain axis,glutamate and depression;as it emphasizes how the gut-brain axis could impact depression pathogenesis and management via changes in glutamate homeostasis.Finally,we consider what the likely future of glutamate-based therapies and glutamate-based therapeutic manipulations in depression are,and if with them,we are now on the final chapter of understanding the neurochemical milieu of depressive disorders. | Adejoke Yetunde Onaolapo Olakunle James Onaolapo | 2021 | World Journal of Psychiatry2021，11，7： | 3 |
| 2 | Melatonin in drug addiction and addiction management: Exploring an evolving multidimensional relationship显示文摘Melatonin is a pleiotropic signalling molecule that regulates several physiological functions, and synchronises biological rhythms. Recent evidences are beginning to reveal that a dysregulation of endogenous melatonin rhythm or action may play a larger role in the aetiology and behavioural expression of drug addiction, than was previously considered. Also, the findings from a number of animal studies suggest that exogenous melatonin supplementation and therapeutic manipulation of melatonin/melatonin receptor interactions may be beneficial in the management of behavioural manifestations of drug addiction. However, repeated exogenous melatonin administration may cause a disruption of its endogenous rhythm and be associated with potential drawbacks that might limit its usefulness. In this review, we examine the roles of melatonin and its receptors in addictive behaviours; discussing how our understanding of melatonin's modulatory effects on the brain rewards system and crucial neurotransmitters such as dopamine has evolved over the years. Possible indications(s) for melatonergic agents in addiction management, and how manipulations of the endogenous melatonin system may be of benefit are also discussed. Finally, the potential impediments to application of melatonin in the management of addictive behaviours are considered. | Olakunle J Onaolapo Adejoke Y Onaolapo | 2018 | World Journal of Psychiatry2018，8，2： | 2 |
| 3 | Circadian dysrhythmia-linked diabetes mellitus: Examining melatonin's roles in prophylaxis and management显示文摘Diabetes mellitus is a chronic, life-threatening metabolic disorder that occurs worldwide. Despite an increase in the knowledge of the risk factors that are associated with diabetes mellitus, its worldwide prevalence has continued to rise; thus, necessitating more research into its aetiology. Recent researches are beginning to link a dysregulation of the circadian rhythm to impairment of intermediary metabolism; with evidences that circadian rhythm dysfunction might play an important role in the aetiology, course or prognosis of some cases of diabetes mellitus. These evidences thereby suggest possible relationships between the circadian rhythm regulator melatonin, and diabetes mellitus. In this review, we discuss the roles of the circadian rhythm in the regulation of the metabolism of carbohydrates and other macronutrients; with emphasis on the importance of melatonin and the impacts of its deficiency on car-bohydrate homeostasis. Also, the possibility of using melatonin and its analogs for the 'prophylaxis' or management of diabetes mellitus is also considered. | Adejoke Y Onaolapo Olakunle J Onaolapo | 2018 | World Journal of Diabetes2018，9，7： | 2 |
| 4 | Nutrition,nutritional deficiencies,and schizophrenia:An association worthy of constant reassessment显示文摘Schizophrenia is a mental health disorder that occurs worldwide,cutting across cultures,socioeconomic groups,and geographical barriers.Understanding the details of the neurochemical basis of schizophrenia,factors that contribute to it and possible measures for intervention are areas of ongoing research.However,what has become more evident is the fact that in targeting the neurochemical imbalances that may underlie schizophrenia,the type of response seen with currently available phamacotherapeutic agents does not provide all the answers that are needed.Therefore,the possible contribution of non-pharmacological approaches to schizophrenia management is worthy of consideration.In recent times,research is beginning to show nutrition may play a possibly significant role in schizophrenia,affecting its development,progression and management;however,while attempts had been made to examine this possible relationship from different angles,articles addressing it from a holistic point of view are not common.In this review,we examine existing scientific literature dealing with the possible relationship between nutrition and schizophrenia,with a view to elucidating the impact of diet,nutritional deficiencies and excesses on the aetiology,progression,management and outcome of schizophrenia.Secondly,the effect of nutritional supplements in prevention,as sole therapy,or adjuncts in schizophrenia management are examined. | Olakunle James Onaolapo Adejoke Yetunde Onaolapo | 2021 | World Journal of Clinical Cases2021，9，28： | 1 |
| 5 | Antibacterial Susceptibility of Klebsiella pneumoniae Isolates from Respiratory Tract Infections to Honey and Lemon显示文摘 | G. O. Adeshina B. M. Mshelia J. A. Onaolapo | 2014 | Annual Research & Review in Biology2014，，4： | 1 |
| 6 | Antidepressant-like potential of silymarin and silymarin-sertraline combination in mice:Highlighting effects on behaviour,oxidative stress,and neuroinflammation显示文摘BACKGROUND Currently,there is increasing advocacy for the use of diet,dietary supplements,and herbal remedies in depression management.AIM To determine the antidepressant effects of standardized silymarin(SILY)extract either as a sole agent or as an adjunct in depression therapy.METHODS Adult mice were assigned into three main groups based on the neurobehavioural models;and each main group had ten treatment groups of 10 mice each.Treatment groups were:Vehicle control group,oral sertraline(SERT)group,two groups fed SILY)-supplemented diet(SILY at 140 and 280 mg/kg of feed,respectively),dexamethasone(DEX;i.p.)group,DEX/SERT group,two groups of DEX/SILY(SILY at 140 and 280 mg/kg of feed,respectively),and another two groups of(SERT/DEX/SILY)(SILY at 140 and 280 mg/kg of feed,respectively,plus i.p.DEX plus SERT).Duration of the study was 7 wk,and treatments were administered daily.RESULTS SILY(alone)increased body weight,open field locomotor activity,rearing,and grooming;it also enhanced spatial working memory while decreasing anxietyrelated behaviours and behavioural despair.SILY also improved antioxidant status while decreasing lipid peroxidation,acetylcholinesterase activity,and inflammatory markers.Neuronal integrity of the cerebral cortex and hippocampus was preserved.Overall,when administered alone or with SERT,SILY counteracted DEX-induced behavioural and biochemical changes while preserving neuromorphological integrity.CONCLUSION In conclusion,SILY is beneficial in mitigating DEX-induced central nervous system and other related changes in mice. | Adejoke Yetunde Onaolapo Hameed Sulaiman Anthony Tope Olofinnade Olakunle James Onaolapo | 2022 | World Journal of Pharmacology2022，11，3： | 0 |
| 7 | Substance use and substance use disorders in Africa:An epidemiological approach to the review of existing literature显示文摘The relationship between man and substances that have abuse potentials,and whose use has been associated with the development or progression of substance use disorders has continued to evolve in terms of geography,economic implications,and time.History shows that local plants with psychoactive constituents can get exported worldwide through global travel,commerce,or even conquest.Time and globalization also change people’s relationship with substances of abuse;hence,an area that was initially alien to certain substances might evolve to becoming a trafficking hub,and then a destination.A case in point is Africa where a rapidly increasing prevalence of substance use/abuse and substance use disorder among adolescents and young adults is putting enormous strain on the economy,healthcare system,and society at large.However,there appears to be a paucity of scientific literature and data on the epidemiology,risk assessment,and contributing factors to substance use and the development of substance use disorders across Africa.In this narrative review,we examine extant literature(PubMed,Google scholar,Medline)for information on the prevalence,trends,and influencers of substance use and the development of substance use disorders.This is with a view of understanding the determinants of substance use and factors that influence the development of substance use disorders in the region,and how this information can be channeled towards developing a comprehensive intervention and treatment program. | Olakunle James Onaolapo Anthony Tope Olofinnade Foluso Olamide Ojo Olufunto Adeleye Joshua Falade Adejoke Yetunde Onaolapo | 2022 | World Journal of Psychiatry2022，12，10： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员