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| 1 | 尿钠排泄、血压、心血管病与死亡率的关系:社区前瞻性流行病学队列研究显示文摘WHO建议人群钠摄人<2 g/d作为预防心血管病的措施之一,但这一目标在任何国家都没有实现。该建议主要基于短期血压试验的个体水平数据,没有来自随机试验或观察性研究的关于低钠摄入与降低心血管事件的数据。前瞻性城市农村流行病学研究目前正在21个国家进行。该文对其中18个国家的数据进行分析,其中包含了临床结果数据。 | Mente A O'Donnell M Rangarajan S McQueen M Dagenais G Wielgosz A Lear S Ah STL Wei L Diaz R Avezum A Lopez-Jaramillo P Lanas F Mony P Szuba A Iqbal R Yusuf R Mohammadifard N Khatib R Yusoff K Ismail N Gulec S Rosengren A Yusufali A Kruger L Tsolekile LP Chifamba J Dans A Alhabib KF Yeates K Teo K Yusuf S 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 29 |
| 2 | 肽酰基精氨酸脱亚氨酶4和中性粒细胞胞外诱捕网形成在实验性动脉粥样硬化和动脉损伤中的作用:浅表糜烂的影响显示文摘中性粒细胞可能促进人类动脉粥样硬化的血栓并发症的发生。特别是中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)可加剧局部炎症,并放大和加剧动脉内膜损伤和血栓形成。肽酰基精氨酸脱亚氨酶4(peptidyl arginine deiminase 4,PAD4)参与NET的形成,但对该酶在动脉粥样硬化血栓形成中的作用的认识仍然不足。 | 刘青 叶鹏 Franck G Mawson TL Folco EJ Molinaro R Ruvkun V Engelbertsen D Liu X Tesmenitsky Y Shvartz F Sukhova GK Michel JB Nicoletti A Lichtman AH Wagner DD Croce KJ Libby P | 2018 | 中华高血压杂志2018，26，5： | 13 |
| 3 | Cytochrome P450 levels are altered in patients with esophageal squamous-cell carcinoma显示文摘AIM: To investigate the role of cytochrome P450 (CYP) in the carcinogenesis of squamous-cell carcinoma (SCC) in human esophagus by determining expression patterns and protein levels of representative CYPs in esophageal tissue of patients with SCC and controls. METHODS: mRNA expression of CYP2E1, CYP2C, CYP3A4, and CYP3A5 was determined using RT-PCR in both normal and malignant esophageal tissues of patients with untreated esophageal SCC (n = 21) and in controls (n = 10). Protein levels of CYP2E1, CYP2C8, CYP3A4, and CYP3A5 were measured by Western blot. RESULTS: Within the group of SCC patients, mRNA expression of CYP 3A4 and CYP2C was significantly lower in malignant tissue (-39% and -74%, respectively, P < 0.05) than in normal tissue. Similar results were found in CYP3A4 protein levels. Between groups, CYP3A4, CYP3A5, and CYP2C8 protein concentration was significantly higher in non-malignant tissue of SCC patients (4.8-, 2.9-, and 1.9-fold elevation, P < 0.05) than in controls. In contrast, CYP2E1 protein levels were significantly higher in controls than in SCC patients (+46%, P < 0.05). CONCLUSION: Significant differences exist in protein levels of certain CYPs in non-malignant esophageal tissue (e.g. CYP2C8, CYP3A4, CYP3A5, and CYP2E1) between SCC patients and healthy subjects and may contribute to the development of SCC in the esophagus. | I Bergheim E Wolfgarten E Bollschweiler AH Hlscher C Bode A Parlesak | 2007 | World Journal of Gastroenterology2007，13，7： | 6 |
| 4 | 茶叶摄入与中国成年人高密度脂蛋白胆固醇浓度纵向变化的关系显示文摘茶叶摄入与高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)浓度的年龄相关变化之间的关系仍不清楚。该研究目的是探索茶摄入量与HDL-C浓度纵向变化之间的关系。研究人员通过调查问卷评估基线(2006年)的茶叶消费量,并在2006、2008、2010和2012年测量了未患有心血管病或癌症. | 刘莉 叶鹏 Huang S Li J Wu Y Ranjbar S Xing A Zhao H Wang Y Shearer GC Bao L Lichtenstein AH Wu S Gao X | 2018 | 中华高血压杂志2018，26，8： | 5 |
| 5 | 一种解列车控制问题的新算法显示文摘本文提出一种解列车控制问题的新算法。该算法基于遗传算法、罚函数法和RungaKuta法。 | CHENG JinSong (Dept. of Computer, Anhui University, Hefei AH,230039) In this paper, we present a new algorithm for solving train control problem. The algorithm is based on genetic algorithm, penalty function method and the RungaKutta method. | 1999 | 微机发展1999，9，4： | 4 |
| 6 | Immunohistochenucal evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast显示文摘 | Perren A Weng LP Boag AH | 1999 | AmJ Path1999，155，4： | 2 |
| 7 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 8 | 术前检测患者血液中总蛋白、白蛋白与白细胞介素-1受体拮抗剂作为切口疝修补术后是否出现血清肿的预测指标显示文摘患者切口疝修补术后出现血清肿是非常常见的,约占20%~30%,其中10%的患者渗液量超过50ml。出现血清肿并不一定出现并发症,但血清肿患者术后容易出现疼痛不适,尤其是补片感染导致修补手术失败,切口疝复发。对某些患者及时使用细针抽液,甚至是手术治疗都是必要的。 | Klink CD Binnebosel M Lucas AH Schachtrupp A Grommes J Conze J Klinge U Neumann U Junge K 宗振(译) 陈双(校) | 2012 | 中华疝和腹壁外科杂志(电子版)2012，6，2： | 2 |
| 9 | Origins of breast cancer subtypes and therapeutic implications 显示文摘 | Sims AH Howell A Howell S J Clarke R B | 2007 | Nature Clin Pract Oncol2007，4，12： | 1 |
| 10 | Recovery of radiologically functionless obstructed kidneys显示文摘 | Ibrahim A Fahal AH | 1984 | Br J Urol1984，56，2： | 1 |
| 11 | Imact and total proinsulin : new aspects for diagnosis and treatment of type 2 diabetes mellitus and insulin resistance 显示文摘 | Pftitzner A Kann PH Pftltzner AH | 2004 | Clin Lab2004，50，910： | 1 |
| 12 | Rational treatment of empyema in children显示文摘 | Meier AH Smith B Baghavan A | 2000 | pediatr surg2000，135，8： | 1 |
| 13 | Thioredoxin-interacting pro tein is stimulated by glucose through a carbohydrate response element and induces β-cell apoptosis显示文摘 | Minn AH Hafele C Shalev A | 2005 | Endocrinology2005，146，5： | 1 |
| 14 | XBP1links ER stress to in-testinal inflammation and confers genetic risk for human inflam-matory bowel disease显示文摘 | Kaser A Lee AH Franke A | 2008 | Cell2008，134，5： | 1 |
| 15 | Diagnostic und Therapies Magenkarzinoms-Workflow显示文摘 | Grundmann RT Hlscher AH Bembenek A | 2009 | Zentralbl Chir2009，134，： | 1 |
| 16 | Parkinson's disease,stroke,and related epidemiology显示文摘 | Nataraj A Rajput AH | 2005 | Mov Disord2005，20，11： | 1 |
| 17 | Effect of fermentation on the in vitro protein digestibility of pearl millet显示文摘 | Ali MAM Tinay A H E Abdalla AH | 2003 | Food Chemistry2003，80，1： | 1 |
| 18 | Neuroendocrine differentiation and prognosis in breast adenocarcinoma 显示文摘 | Miremadi A Pinder SE Lee AH | 2002 | Histopathology2002，40，3： | 1 |
| 19 | percutrancous nephro- lithotomy urithultrasonography-gulded renel access in the lateral decubitus 显示文摘 | Karami H Arbab AH Rezaei A | 2009 | Flank position J Endourol2009，23，： | 1 |
| 20 | Cytokines as media-tors of depression: what can we learn from animal studies? 显示文摘 | Dunn A J Swiergiel AH Beaurepaire RD | 2005 | Biobehav Rev2005，29，45： | 1 |
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