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| 1 | 尿钠排泄、血压、心血管病与死亡率的关系:社区前瞻性流行病学队列研究显示文摘WHO建议人群钠摄人<2 g/d作为预防心血管病的措施之一,但这一目标在任何国家都没有实现。该建议主要基于短期血压试验的个体水平数据,没有来自随机试验或观察性研究的关于低钠摄入与降低心血管事件的数据。前瞻性城市农村流行病学研究目前正在21个国家进行。该文对其中18个国家的数据进行分析,其中包含了临床结果数据。 | Mente A O'Donnell M Rangarajan S McQueen M Dagenais G Wielgosz A Lear S Ah STL Wei L Diaz R Avezum A Lopez-Jaramillo P Lanas F Mony P Szuba A Iqbal R Yusuf R Mohammadifard N Khatib R Yusoff K Ismail N Gulec S Rosengren A Yusufali A Kruger L Tsolekile LP Chifamba J Dans A Alhabib KF Yeates K Teo K Yusuf S 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 29 |
| 2 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 3 | 术前检测患者血液中总蛋白、白蛋白与白细胞介素-1受体拮抗剂作为切口疝修补术后是否出现血清肿的预测指标显示文摘患者切口疝修补术后出现血清肿是非常常见的,约占20%~30%,其中10%的患者渗液量超过50ml。出现血清肿并不一定出现并发症,但血清肿患者术后容易出现疼痛不适,尤其是补片感染导致修补手术失败,切口疝复发。对某些患者及时使用细针抽液,甚至是手术治疗都是必要的。 | Klink CD Binnebosel M Lucas AH Schachtrupp A Grommes J Conze J Klinge U Neumann U Junge K 宗振(译) 陈双(校) | 2012 | 中华疝和腹壁外科杂志(电子版)2012，6，2： | 2 |
| 4 | Two-photon-excited fluorescence imaging of human RPE cells with a femtosecond Ti: Sapphire laser显示文摘 | Bindewald-Wittich A Han M Schmitz-Valckenberg S Snyder Sar- ah R Giese G Bille Josef F | 2006 | Invest Ophthalmol Vis Sci2006，47，10： | 1 |
| 5 | The diarylquinoline TMC207 for multidrug-resistant tuberculosis显示文摘 | Diacon AH Pym A Grobusch M | 2009 | N Engl J Med2009，360，23： | 1 |
| 6 | Cognitive dysfunction and its relationship to quality of life in breast cancer survivors显示文摘 | Von Ah D Russell K M Storniolo A M | 2009 | Oncol Nurs Forum2009，36，3： | 1 |
| 7 | Tensile properties of engineered cartilage formed from chondrocyte- and MSC-laden hydrogels 显示文摘 | Huang AH Yeger-McKeever M Steiny A | 2008 | Osteoarthritis and Cartilage2008，16，： | 1 |
| 8 | Molecular distinction between alternative oxidase from monocots and dicots显示文摘 | Considine M J Holzapffe R C Day D A Whelan J Millar AH | 2002 | Plant Physiol2002，129，： | 1 |
| 9 | Sarcomatoid renal cell carcinoma:the chromophobe connection显示文摘 | AKHTAR M TULBAH A KARDAR AH | 1997 | Am J Surg Pathol1997，21，10： | 1 |
| 10 | psis phosphate transporter PHT1 ; 1 displays enhanced arsenic accumulation显示文摘 | CATARECHA P SEGURA M D FRANCO-ZORRILLA J M et ah A mutant of the Arabido | 2007 | plant Cell2007，19，： | 1 |
| 11 | Treatment of hemophagocytic lymphohistiocytosis with HLH-94 immunochemotherapy and bone marrow transplantation显示文摘 | Henter JI Samuelsson-Horne A Arico M Egeler RM Elinder G Filiporich AH | 2002 | Blood2002，100，7： | 1 |
| 12 | Migrainous vertigo pres- enting as episodicposition galvertigo 显示文摘 | von Brevern M Radtke A Clarke AH | 2004 | Neurology2004，62，3： | 1 |
| 13 | Mithramycin downregulates proinflammatory cytokine-induced matrixmetal op roteinase gene expression in articular chondrocytes显示文摘 | Liacini A Sylvester J Zafarul ah M | | 0，，： | 1 |
| 14 | plantations in the Horqin sandy land of Northeast China显示文摘 | Cao C Y Jiang D M Teng X H et ah Soil chemical and microbiological properties along a chronosequence o{ Caragana microphylla Lain | 2008 | Applied Soil Ecolo- gy2008，40，1： | 1 |
| 15 | Inhibition of transcription factor NF - kappa B reduces matrix metalloproteinase -1, - 3 and - 9 production by vascular smooth muscle cells显示文摘 | Bond M Chase A J Baker AH | 2001 | Cardiovasc Res2001，50，3： | 1 |
| 16 | DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis显示文摘 | Lorenz-Depiereux B Bastepe M Benet-Pages A Amyere M Wagenstaller J Muller-Barth U Badenhoop K Kaiser SM Rittmaster RS Shlossberg AH Olivares JL Loris C Ramos FJ Glorieux F Vikkula M Juppner H Strom TM | | 0，，11： | 1 |
| 17 | Long-termelectrophysiologicalactivityand pharmacological response of a human induced pluripotent stem cell-derived neuron and astrocyte co-culture显示文摘 | Odawara A Saitoh Y Alhebshi AH Gotoh M Suzuki I | 2014 | Biochem Biophys Res Commun2014，443，4： | 1 |
| 18 | Adherence patterns in patients with type 2 diabetes on basal insulin analogues:missed,mistimed and reduced doses显示文摘 | Brod M Rana A Barnett AH | | 0，，： | 1 |
| 19 | The neurobiology ofmodafinil as an enhancer of cognitive performance and a poten-tial treatment for substance use disorders显示文摘 | Mereu M Bonci A Newman AH | 2013 | Psychopharma-cology (Berl)2013，229，3： | 1 |
| 20 | Complications of colostomy in infants and children显示文摘 | Saqi Z Shaikh AH Malik N Imran A Shaukat M | 1998 | Ann KE Med Col1998，4，： | 1 |
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