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| 1 | Functional properties, phenolic constituents and antioxidant potential of industrial apple pomace for utilization as active food ingredient显示文摘Apple pomace is a waste biomass generated after apple fruit processing.In present investigation,efforts were made to comprehend influence of differently dried pomace on cell wall properties and phenolic profile.Different drying techniques were employed to remove moisture content from fresh apple pomace.Total dietary fiber yield(74%)and array of functional properties such as density,water and oil holding capacity,swelling capacity and glucose dialysis retardation index(36.91%)was found better in freeze dried fraction.The higher total phenolics(5.78±0.08 mg GAE/g dry weight)content was also recorded in freeze dried fraction followed by oven and sun drying.The 50%aqueous acetone was found as more efficient solvent for extraction of phenolic constituents.RP-HPLC analysis has revealed presence of quercetin,phloridzin and phloretin as major phenolics.Thus,it is evident from the results that pomace generated at industrial scale can be utilized as a source of dietary food ingredient. | Shalika Ranaa Sakshi Gupta Ajay Rana Shashi Bhushan | 2015 | Food Science and Human Wellness2015，4，4： | 8 |
| 2 | Acanthus ilicifolius plant extract prevents DNA alterations in a transplantable Ehrlich ascites carcinoma-bearing murine model显示文摘AIM: To investigate the chemopreventive efficacy of the Indian medicinal plant Acanthus ilicifolius L Acanthaceae in a transplantable Ehrlich ascites carcinoma (EAC)- bearing murine model. METHODS: Male Swiss albino mice were divided into four groups: Group A was the untreated normal control; Group B was the EAC control mice group that received serial, intraperitoneal (ip) inoculations of rapidly proliferating 2 x 105 viable EAC cells in 0.2 mL of sterile phosphate buffered saline; Group C was the plant extract-treated group that received the aqueous leaf extract (ALE) of the plant at a dose of 2.5 mg/kg body weight by single ip injections, once daily for 10, 20 and 30 consecutive days following tumour inoculation (ALE control); and Group D was the EAC + ALE- treatment group. The chemopreventive potential of the ALE was evaluated in a murine model by studying various biological parameters and genotoxic markers, such as tumour cell count, mean survival of the animals, haematological indices, hepatocellular histology, immunohistochemical expression of liver metallothionein (MT) protein, sister-chromatid exchanges (SCEs), and DNA alterations.RESULTS: Treatment of the EAC-bearing mice with the ALE significantly (P < 0.001) reduced viable tumour cell count by 68.34% (228.7 x 106 ± 0.53) when compared to EAC control mice (72.4 x 106 ± 0.49), and restored body and organ weights almost to the normal values. ALE administration also increased (P < 0.001) mean survival of the hosts from 35 ± 3.46 d in EAC control mice to 83 ± 2.69 d in EAC + ALE-treated mice. Haematological indices also showed marked improvement with administration of ALE in EAC-bearing animals. There was a significant increase in RBC count (P < 0.001), hemoglobin percent (P < 0.001), and haematocrit value (P < 0.001) from 4.3 ± 0.12, 6.4 ± 0.93, and 17.63 ± 0.72 respectively in EAC control mice to 7.1 ± 0.13, 12.1 ± 0.77, and 30.23 ± 0.57 respectively in EAC + ALE-treated group, along with concurrent decrement (P < 0.001) in WBC count from 18.8 ± 0.54 in EAC control to 8.4 ± 0.71 in EAC + ALE. Furthermore, treatment with ALE substantially improved hepatocellular architecture and no noticeable neoplastic lesions or foci of cellular alteration were observed. Daily administration of the ALE was found to limit liver MT expression, an important marker of cell proliferation with concomitant reduction in MT immunoreactivity (62.25 ± 2.58 vs 86.24 ± 5.69, P < 0.01). ALE was also potentially effective in reducing (P < 0.001) the frequency of SCEs from 14.94 ± 2.14 in EAC control to 5.12 ± 1.16 in EAC + ALE-treated group. Finally, in comparison to the EAC control, ALE was able to suppress in vivo DNA damage by abating the generations of ‘tailed’ DNA by 53.59% (98.65 ± 2.31 vs 45.06 ± 1.14, P < 0.001), and DNA single-strand breaks (SSBs) by 38.53% (3.14 ± 0.31 vs 1.93 ± 0.23, P < 0.01) in EAC-bearing murine liver. CONCLUSION: Our data indicate that, ALE is beneficial in restoring haematological and hepatic histological profiles and in lengthening the survival of the animals against the proliferation of ascites tumour in vivo. Finally, the chemopreventive efficacy of the ALE is manifested in limiting MT expression and in preventing DNA alterations in murine liver. The promising results of this study suggest further investigation into the chemopreventive mechanisms of the medicinal plant A. ilicifolius in vivo and in vitro. | Tridib Chakraborty Dipak Bhuniya Mary Chatterjee Mosiur Rahaman Dipak Singha Baidya Nath Chatterjee Subrata Datta Ajay Rana Kartick Samanta Sunil Srivastawa Sankar K Maitra Malay Chatterjee | 2007 | World Journal of Gastroenterology2007，13，48： | 2 |
| 3 | Functional reconstitution of defective myeloid dendritic cells in chronic hepatitis C infection on successful antiviral treatment显示文摘 | Deepa Rana Yogesh K. Chawla Ajay Duseja Radhakrishan Dhiman Sunil K. Arora | 2012 | Liver Int2012，，7： | 1 |
| 4 | A novel strategy for automatic test data generation using soft computing technique显示文摘 | Priyanka CHAWLA Inderveer CHANA Ajay RANA | 2015 | Frontiers of Computer Science2015，9，3： | 1 |
| 5 | Role of small intestinal bacterial overgrowth and delayed gastrointestinal transit time in cirrhotic patients with minimal hepatic encephalopathy显示文摘 | Ankur Gupta Radha K Dhiman Savita Kumari Satyavati Rana Ritesh Agarwal Ajay Duseja Yogesh Chawla | 2010 | Journal of Hepatology2010，，5： | 1 |
| 6 | Functional reconstitution of defective myeloid dendritic cells in chronic hepatitis C infection on successful antiviral treatment显示文摘 | Deepa Rana Yogesh K. Chawla Ajay Duseja Radhakrishan Dhiman Sunil K. Arora | 2012 | Liver Int2012，，7： | 1 |
| 7 | Role of small intestinal bacterial overgrowth and delayed gastrointestinal transit time in cirrhotic patients with minimal hepatic encephalopathy显示文摘 | Ankur Gupta Radha K Dhiman Savita Kumari Satyavati Rana Ritesh Agarwal Ajay Duseja Yogesh Chawla | 2010 | Journal of Hepatology2010，，5： | 1 |
| 8 | Animal models of inflammatory bowel disease: a review显示文摘 | Nidhi Goyal Ajay Rana Abhilasha Ahlawat Krishna Reddy V. Bijjem Puneet Kumar | 2014 | Inflammopharmacology2014，，4： | 1 |
| 9 | Comparative evaluation for catalytic gasification of petroleum coke and asphaltene in subcritical and supercritical water显示文摘Subcritical and supercritical water gasification of petroleum coke and asphaltene was performed at variable temperatures(350–650°C),feed concentrations(15–30 wt%)and reaction times(15–60 min).Nickel-impregnated activated carbon(Ni/AC)was synthesized as a catalyst for enhancing syngas yields at optimal gasification conditions(650°C,15 wt%and 60 min).Structural chemistry of precursors and chars developed at different gasification temperatures was studied using physicochemical and synchrotronbased approaches such as carbon–hydrogen–nitrogen–sulfur(CHNS)analysis,thermogravimetric and differential thermogravimetric analysis(TGA/DTA),scanning electron microscopy(SEM),Fourier-Transform Infrared spectroscopy(FTIR),Raman spectroscopy,X-ray diffraction(XRD)and X-ray absorption spectroscopy(XAS).Asphaltene testified to be a better precursor for catalytic hydrothermal gasification leading to 11.97 mmol/g of total gas yield compared to petroleum coke(8.04 mmol/g).In particular,supercritical water gasification using 5 wt%Ni/AC at 650°C with 15 wt%feed concentration for 60 min resulted in 4.17 and 2.98 mmol/g of H_2from asphaltene and petroleum coke,respectively.Under the same conditions,the respective CH_4yields from catalytic gasification of asphaltene and petroleum coke were 2.54and 1.07 mmol/g.Nonetheless,asphaltene also seemed to an attractive feedstock for the production of highly aromatic chars through hydrothermal gasification. | Rachita Rana Sonil Nanda Aimee Maclennan Yongfeng Hu Janusz A.Kozinski Ajay K.Dalai | 2019 | Journal of Energy Chemistry2019，28，4： | 1 |
| 10 | Diversity of Sodium Transporter HKT1;5 in Genus Oryza显示文摘Asian cultivated rice shows allelic variation in sodium transporter,OsHKT1;5,correlating with shoot sodium exclusion(salinity tolerance).These changes map to intra/extracellularly-oriented loops that occur between four transmembrane-P loop-transmembrane(MPM)motifs in OsHKT1;5.HKT1;5 sequences from more recently evolved Oryza species(O.sativa/O.officinalis complex species)contain two expansions that involve two intracellularly oriented loops/helical regions between MPM domains,potentially governing transport characteristics,while more ancestral HKT1;5 sequences have shorter intracellular loops.We compared homology models for homoeologous OcHKT 1;5-K and OcHKT1;5-L from halophytic O.coarctata to identify complementary amino acid residues in OcHKT1;5-L that potentially enhance affinity for Na+.Using haplotyping,we showed that Asian cultivated rice accessions only have a fraction of HKT1;5 diversity available in progenitor wild rice species(O.nivara and O.rufipogon).Progenitor HKT1;5 haplotypes can thus be used as novel potential donors for enhancing cultivated rice salinity tolerance.Within Asian rice accessions,10 non-synonymous HKT1;5 haplotypic groups occur.More HKT1;5 haplotypic diversities occur in cultivated indica gene pool compared to japonica.Predominant Haplotypes 2 and 10 occur in mutually exclusive japonica and indica groups,corresponding to haplotypes in O.sativa salt-sensitive and salt-tolerant landraces,respectively.This distinct haplotype partitioning may have originated in separate ancestral gene pools of indica and japonica,or from different haplotypes selected during domestication.Predominance of specific HKT1;5 haplotypes within the 3000 rice dataset may relate to eco-physiological fitness in specific geo-climatic and/or edaphic contexts. | Shalini PULIPATI Suji SOMASUNDARAM Nitika RANA Kavitha KUMARESAN Mohamed SHAFI Peter CIVÁŇ Gothandapani SELLAMUTHU Deepa JAGANATHAN Prasanna Venkatesan RAMARAVI S.PUNITHA Kalaimani RAJU Shrikant S.MANTRI R.SOWDHAMINI Ajay PARIDA Gayatri VENKATARAMAN | 2022 | Rice science2022，29，1： | 0 |
| 11 | TRAF2-MLK3 interaction is essential for TNF-α-induced MLK3 activation显示文摘混合的系 kinase (MLK3 ) 3 是被肿瘤坏死因素激活的激活 mitogen 的蛋白质 kinase kinase kinase -- 伪(TNF- 伪) 并且明确地在 TNF- 伪刺激上激活 c6 月 N 终端 kinase (JNK ) 。TNF- 伪由激活 MLK3 的机制不被知道。TNF 联系受体的因素(TRAF ) 是被招募到 TNF 受体的细胞质的结束并且调停的改编者分子,包括 JNK 的激活下游的发信号。这里,我们报导 MLK3 与 TRAF2, TRAF5 和 TRAF6 联系;然而,仅仅 TRAF2 能显著地导致 MLK3 的 kinase 活动。到 TRAF 领域并且为到它的 C 终端一半(氨基酸 511-847 ) 的 MLK3 的 TRAF2 地图的相互作用领域。与对方一起的内长的 TRAF2 和响应以一种时间依赖者方式的 TNF- 伪处理的 MLK3 伙伴。在 MLK3 和 TRAF2 之间的协会调停有绑在 MLK3 的 TRAF2 删除异种的 MLK3 激活和竞争以一种剂量依赖者方式稀释 MLK3 kinase 活动,在 TNF- 伪处理上。而且 MLK3 的下游的目标, JNK 被 TNF- 伪以一种 TRAF2 依赖的方式激活。因此,我们在 TRAF2 和 MLK3 之间的直接相互作用为 TNF- 伪 - 被要求的数据表演导致了 MLK3 和它的下游的目标的激活, JNK。 | Gautam Sondarva Chanakya N Kundu Suneet Mehrotra Rajakishore Mishra Velusamy Rangasamy Pradeep Sathyanarayana Rajarshi S Ray Basabi Rana Ajay Rana | 2010 | Cell Research2010，20，1： | 0 |
| 12 | Fungal diversity notes 1387-1511:taxonomic and phylogenetic contributions on genera and species of fungal taxa显示文摘This article is the 13th contribution in the Fungal Diversity Notes series,wherein 125 taxa from four phyla,ten classes,31 orders,69 families,92 genera and three genera incertae sedis are treated,demonstrating worldwide and geographic distri-bution.Fungal taxa described and illustrated in the present study include three new genera,69 new species,one new com-bination,one reference specimen and 51 new records on new hosts and new geographical distributions.Three new genera,Cylindrotorula(Torulaceae),Scolecoleotia(Leotiales genus incertae sedis)and Xenovaginatispora(Lindomycetaceae)are introduced based on distinct phylogenetic lineages and unique morphologies.Newly described species are Aspergillus lan-naensis,Cercophora dulciaquae,Cladophialophora aquatica,Coprinellus punjabensis,Cortinarius alutarius,C.mammil-latus,C.quercoflocculosus,Coryneum fagi,Cruentomycena uttarakhandina,Cryptocoryneum rosae,Cyathus uniperidiolus,Cylindrotorula indica,Diaporthe chamaeropicola,Didymella azollae,Diplodia alanphillipsii,Dothiora coronicola,Efibula rodriguezarmasiae,Erysiphe salicicola,Fusarium queenslandicum,Geastrum gorgonicum,G.hansagiense,Helicosporium sexualis,Helminthosporium chiangraiensis,Hongkongmyces kokensis,Hydrophilomyces hydraenae,Hygrocybe boertmannii,Hyphoderma australosetigerum,Hyphodontia yunnanensis,Khaleijomyces umikazeana,Laboulbenia divisa,Laboulbenia triarthronis,Laccaria populina,Lactarius pallidozonarius,Lepidosphaeria strobelii,Longipedicellata megafusiformis,Lophiotrema lincangensis,Marasmius benghalensis,M.jinfoshanensis,M.subtropicus,Mariannaea camelliae,Mel-anographium smilaxii,Microbotryum polycnemoides,Mimeomyces digitatus,Minutisphaera thailandensis,Mortierella solitaria,Mucor harpali,Nigrograna jinghongensis,Odontia huanrenensis,O.parvispina,Paraconiothyrium ajrekarii,Par-afuscosporella niloticus,Phaeocytostroma yomensis,Phaeoisaria synnematicus,Phanerochaete hainanensis,Pleopunctum thailandicum,Pleurotheciella dimorphospora,Pseudochaetosphaeronema chiangraiense,Pseudodactylaria albicolonia,Rhexoacrodictys nigrospora,Russula paravioleipes,Scolecoleotia eriocamporesi,Seriascoma honghense,Synandromyces makranczyi,Thyridaria aureobrunnea,Torula lancangjiangensis,Tubeufia longihelicospora,Wicklowia fusiformispora,Xenovaginatispora phichaiensis and Xylaria apiospora.One new combination,Pseudobactrodesmium stilboideus is pro-posed.A reference specimen of Comoclathris permunda is designated.New host or distribution records are provided for Acrocalymma fici,Aliquandostipite khaoyaiensis,Camarosporidiella laburni,Canalisporium caribense,Chaetoscutula juniperi,Chlorophyllum demangei,C.globosum,C.hortense,Cladophialophora abundans,Dendryphion hydei,Diaporthe foeniculina,D.pseudophoenicicola,D.pyracanthae,Dictyosporium pandanicola,Dyfrolomyces distoseptatus,Ernakula-mia tanakae,Eutypa flavovirens,E.lata,Favolus septatus,Fusarium atrovinosum,F.clavum,Helicosporium luteosporum,Hermatomyces nabanheensis,Hermatomyces sphaericoides,Longipedicellata aquatica,Lophiostoma caudata,L.clematidis-vitalbae,Lophiotrema hydei,L.neoarundinaria,Marasmiellus palmivorus,Megacapitula villosa,Micropsalliota globocys-tis,M.gracilis,Montagnula thailandica,Neohelicosporium irregulare,N.parisporum,Paradictyoarthrinium diffractum,Phaeoisaria aquatica,Poaceascoma taiwanense,Saproamanita manicata,Spegazzinia camelliae,Submersispora variabi-lis,Thyronectria caudata,T.mackenziei,Tubeufia chiangmaiensis,T.roseohelicospora,Vaginatispora nypae,Wicklowia submersa,Xanthagaricus necopinatus and Xylaria haemorrhoidalis.The data presented herein are based on morphological examination of fresh specimens,coupled with analysis of phylogenetic sequence data to better integrate taxa into appropriate taxonomic ranks and infer their evolutionary relationships. | Saranyaphat Boonmee Dhanushka N.Wanasinghe Mark S.Calabon Naruemon Huanraluek Sajini K.U.Chandrasiri Gareth E.B.Jones Walter Rossi Marco Leonardi Sanjay K.Singh Shiwali Rana Paras N.Singh Deepak K.Maurya Ajay C.Lagashetti Deepika Choudhary Yu-Cheng Dai Chang-Lin Zhao Yan-Hong Mu Hai-Sheng Yuan Shuang-Hui He Rungtiwa Phookamsak Hong-Bo Jiang María P.Martín Margarita Dueñas MTeresa Telleria Izabela L.Kałucka Andrzej M.Jagodziński Kare Liimatainen Diana S.Pereira Alan J.L.Phillips Nakarin Suwannarach Jaturong Kumla Surapong Khuna Saisamorn Lumyong Tarynn B.Potter Roger G.Shivas Adam H.Sparks Niloofar Vaghefi Mohamed A.Abdel-Wahab Faten A.Abdel-Aziz Guo-Jie Li Wen-Fei Lin Upendra Singh Rajendra P.Bhatt Hyang Burm Lee Thuong T.T.Nguyen Paul M.Kirk Arun Kumar Dutta Krishnendu Acharya VVenkateswara Sarma M.Niranjan Kunhiraman C.Rajeshkumar Nikhil Ashtekar Sneha Lad Nalin N.Wijayawardene Darbe J.Bhat Rong-Ju Xu Subodini N.Wijesinghe Hong-Wei Shen Zong-Long Luo Jing-Yi Zhang Phongeun Sysouphanthong Naritsada Thongklang Dan-Feng Bao Janith V.S.Aluthmuhandiram Jafar Abdollahzadeh Alireza Javadi Francesco Dovana Muhammad Usman Abdul Nasir Khalid Asha J.Dissanayake Anusha Telagathoti Maraike Probst Ursula Peintner Isaac Garrido-Benavent Lilla Bóna Zsolt Merényi Lajos Boros Bratek Zoltán JBenjamin Stielow Ning Jiang Cheng-Ming Tian Esmaeil Shams Farzaneh Dehghanizadeh Adel Pordel Mohammad Javan-Nikkhah Teodor T.Denchev Cvetomir M.Denchev Martin Kemler Dominik Begerow Chun-Ying Deng Emma Harrower Tohir Bozorov Tutigul Kholmuradova Yusufjon Gafforov Aziz Abdurazakov Jian-Chu Xu Peter E.Mortimer Guang-Cong Ren Rajesh Jeewon Sajeewa S.N.Maharachchikumbura Chayanard Phukhamsakda Ausana Mapook Kevin D.Hyde | 2021 | Fungal Diversity2021，，6： | 0 |
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