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| 1 | Lipopolysaccharide Enhances the Production of Nicotine-Induced Prostaglandin E2 by an Increase in Cyclooxygenase-2 Expression in Osteoblasts显示文摘以前的研究显示了那脂肪的多糖(LPS ) 在匾的 fromGram 否定的细菌导致前列腺素 E_2 (PGE_2 ) 的版本,它在吸烟的 periodontitis,和那棵烟草支持牙槽的骨头再吞可能是为 periodontitis 的发展和严厉的一个重要风险因素。我们在碱性磷酸酶(ALPase ) 上决定了烟碱 andLPS 的效果活动, PGE_2 生产,和表示 ofcyclooxygenase (COX-1, COX-2 ) , PGE_2 受体 Ep1-4,和在人的 osteoblastic Saos-2 房间的巨噬细胞殖民地刺激因素(M-CSF ) 。房间与 10 ~ 是有教养的(-3) M 烟碱面对 0, 1,或 10 μ g /ml LPS,或与 LPS 独自一个。ALPase 活动独自在与烟碱或 LPS 有教养的房间减少了,并且在与烟碱和 LPS 有教养的那些进一步减少了,而 PGE_2 生产显著地在前者增加了并且在后者进一步增加了。由自己,烟碱没影响 COX-1, COX-2,任何 PGE_2 受体,或 M-CSF 的表示,但是烟碱和 LPS 什么时候是现在, COX-2 的表示, Ep3, Ep4,和 M-CSF,显著地增加。10 ~ 的同时的增加(-4) M 消炎痛在 ALPase 活动, PGE_2 生产,和 M-CSF 表示消除了烟碱和 LPS 的效果。proteinkinase A 的 Phosphorylation 在与烟碱和 LPS 有教养的房间高。这些结果建议 LPS 由造骨细胞的 COX-2 表示的增加提高导致烟碱的 PGE_2 的生产, thatnicotine-LPS-induced PGE_2 首先在 autocrine orparacnne 模式与造骨细胞 Ep4 受体交往,并且 nicotine-LPS-induced PGE_2 然后减少 ALPase 活动和 increasesM-CSF 表示。 | Maiko SHOJI Natsuko TANABE Narihiro MITSUI Naoto SUZUKI Osamu TAKEICHI Tomoko KATONO Akira MOROZUMI Masao MAENO | 2007 | Acta Biochimica et Biophysica Sinica2007，39，3： | 9 |
| 2 | Feasibility of initial endoscopic common bile duct stone removal in patients with acute cholangitis显示文摘AIM To investigate the feasibility of initial endoscopic common bile duct(CBD) stone removal in patients with acute cholangitis(AC).METHODS A single-center,retrospective study was conducted between April 2013 and December 2014 and was approved by the Medical Ethics Committee at our institution.Written informed consent was obtained from each patient prior to the procedure.The cohort comprised 31 AC patients with CBD stones who underwent endoscopic biliary drainage(EBD) for na?ve papilla within 48 h after AC onset.We retrospectively divided the participants into two groups: 19 patients with initial endoscopic CBD stone removal(initial group) and 12 patients with delayed endoscopic CBD stone removal(delayed group).We evaluated the feasibility of initial endoscopic CBD stone removal in patients with AC.RESULTS We observed no significant differences between the groups regarding patient characteristics.According to the assessments based on the Tokyo Guidelines,the AC severity of patients with initial endoscopic CBD stone removal was mild to moderate.The use of antithrombotic agents before EBD was less frequent in the initial group than in the delayed group(11% vs 58%,respectively; P = 0.004).All the patients underwent successful endoscopic CBD stone removaland adverse events did not differ significantly between the groups.The number of endoscopic retrograde cholangiopancreatography procedures was significantly lower in the initial group than in the delayed group [median(interquartile range) 1(1-1) vs 2(2-2),respectively; P < 0.001].The length of hospital stay was significantly shorter for the initial group than for the delayed group [10(9-15) vs 17(14-20),respectively; P = 0.010].CONCLUSION Initial endoscopic CBD stone removal in patients with AC may be feasible when AC severity and the use of antithrombotic agents are carefully considered. | Akira Yamamiya Katsuya Kitamura Yu Ishii Yuta Mitsui Tomohiro Nomoto Hitoshi Yoshida | 2017 | World Journal of Clinical Cases2017，5，7： | 5 |
| 3 | Clinical outcomes of endoscopic ultrasonography-guided transmural drainage using plastic stent and nasocystic drain for pancreatic and peripancreatic collections显示文摘To the Editor:Pancreatic and peripancreatic collections(PCs)develop from acute pancreatitis(AP),chronic pancreatitis,surgery,or trauma.The 2012 revised Atlanta classification[1]of AP classified local complications into the following 4 PC types:acute peripancreatic fluid collection(<4 weeks after the onset of acute interstitial edematous pancreatitis),acute necrotic collection(<4 weeks after the onset of acute necrotizing pancreatitis),pancreatic pseudocyst(PPC;≥4 weeks after the onset of acute interstitial edematous pancreatitis),and walled-off necrosis(WON;≥4 weeks after the onset of acute necrotizing pancreatitis).Endoscopic ultrasonographyguided transmural drainage(EUS-TD)has been reported to be a minimally invasive procedure for patients with PCs[2–4].This study aimed to investigate the clinical outcomes of EUS-TD for PCs. | Katsuya Kitamura Akira Yamamiya Yu Ishii Yuta Mitsui Hitoshi Yoshida | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，1： | 2 |
| 4 | Expression of ECRG4 is an independent prognostic factor for poor survivalin patients with esophageal squamous cell carcinoma显示文摘 | Yoichiro Mori Hideyuki Ishiguro Yoshiyuki Kuwabara Masahiro Kimura Akira Mitsui Horoki Kurehara Ryota Mori Keisuke Tomoda Ryo Ogawa Takeyasu Katada Koshiro Harata Yoshitaka Fujii | 2007 | Oncology Reports2007，，： | 1 |
| 5 | Sandwich ELISAs for quantification of Xenopus laevis vitellogenin and albumin and their application to measurement of estradiol-17β effects on whole animals and primary-cultured hepatocytes显示文摘 | Naoko Mitsui Osamu Tooi Akira Kawahara | 2003 | Comparative Biochemistry and Physiology:Part C2003，135，： | 1 |
| 6 | Total Hip Arthroplasty Using a Cylindrical Cementless Stem in Patients With a Small Physique显示文摘 | Yoshihide Nakamura Hiromasa Mitsui Akira Kikuchi Satoshi Toh Hiroshi Katano | 2011 | The Journal of Arthroplasty2011，，1： | 1 |
| 7 | TiO2-x sputter for high rate deposition of TiO2显示文摘 | Yuko Tachibana Hisashi Ohsaki Akira Mitsui | 2000 | Vacuum2000，59，23： | 1 |
| 8 | Expression profiling of micro-RNAs in human esophageal squamous cell carcinoma using RT-PCR显示文摘 | Ryo Ogawa Hideyuki Ishiguro Yoshiyuki Kuwabara Masahiro Kimura Akira Mitsui Takeyasu Katada Koshiro Harata Tatsuya Tanaka Yoshitaka Fujii | 2009 | Medical Molecular Morphology2009，，2： | 1 |
| 9 | Effect of a zirconium oxide undercoat on microstructure and properties of tin-doped indium oxide films for organic light emitting devices显示文摘 | Akira Mitsui Kunio Masumo | 2003 | Thin Solid Films2003，442，： | 1 |
| 10 | Studies on the prevalence of human papillomavirus in pregnant women in Japan显示文摘 | Koichi Takakuwa Takuya Mitsui Mitsutoshi Iwashita Iwao Kobayashi Akira Suzuki Takaaki Oda Yuichi Torii Masahiko Matsumoto Goki Yahata Kenichi Tanaka | 2006 | Journal of Perinatal Medicine2006，，1： | 1 |
| 11 | MicroRNA-21 induces cell proliferation and invasion in esophageal squamouscell carcinoma显示文摘 | Yoichiro Mori Hideyuki Ishiguro Yoshiyuki Kuwabara Masahiro Kimura Akira Mitsui Ryo Ogawa Takeyasu Katada Koshiro Harata Tatsuya Tanaka Midori Shiozaki Yoshitaka Fujii | 2009 | Molecular Medicine Reports2009，，2： | 1 |
| 12 | Expression profiling of micro-RNAs in human esophageal squamous cell carcinoma using RT-PCR显示文摘 | Ryo Ogawa Hideyuki Ishiguro Yoshiyuki Kuwabara Masahiro Kimura Akira Mitsui Takeyasu Katada Koshiro Harata Tatsuya Tanaka Yoshitaka Fujii | 2009 | Medical Molecular Morphology2009，，2： | 1 |
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