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| 1 | Hedgehog signaling pathway as a new therapeutic target in pancreatic cancer显示文摘Pancreatic cancer is one of the most aggressive and difficult cancers to treat.Despite numerous research efforts,limited success has been achieved in the therapeutic management of patients with this disease.In the current review,we focus on one component of morphogenesis signaling,Hedgehog(Hh),with the aim of developing novel,effective therapies for the treatment of pancreatic cancer.Hh signaling contributes to the induction of a malignant phenotype in pancreatic cancer and is responsible for maintaining pancreatic cancer stem cells.In addition,we propose a novel concept linking Hh signaling and tumor hypoxic conditions,and discuss the effects of Hh inhibitors in clinical trials.The Hh signaling pathway may represent a potential therapeutic target for patients with refractory pancreatic cancer. | Hideya Onishi Mitsuo Katano | 2014 | World Journal of Gastroenterology2014，20，9： | 18 |
| 2 | Current advances in humanized mouse models显示文摘收到了人的房间或纸巾的人性化的老鼠模型移植在基本、适用的人的疾病研究是极其有用的。高度 immunodeficient 老鼠,不拒绝异种皮移植和支持细胞和织物区别和生长,为产生另外的适当模型是不可缺少的。自从 2000 年代初,为产生人性化的老鼠适当的一系列 immunodeficient 老鼠是连续地由介绍 IL-2Rγ 发展了; 空 基因(例如, NOD/SCID/γ c 空 和 Rag2 空 γc 空 老鼠) 。这些紧张显示出不仅高度人的房间嫁接评价,而且产生区分得好的 multilineage 在人的造血的干细胞(HSC ) 以后的人的造血的房间移植。这些人性化的老鼠在 vivo 便于人的血液学和免疫学的分析。然而,从 HSC 开发的人的造血的房间不与那些 phenotypically 并且机能上地总是相同在人。更最近, immunodeficient 老鼠的一个新系列补偿劣势这些。这些老鼠被遗传上介绍人的 cytokine 基因进 NOD/SCID/γ 产生; c 空 和 Rag2 空 γc 空 老鼠。在这评论,我们描述在这些老鼠开发的人的造血的房间的当前的知识。用这些人性化的老鼠的各种各样的人的疾病老鼠模型被总结。 | Ryoji Ito Takeshi Takahashi Ikumi Katano Mamoru Ito | 2012 | Cellular & Molecular Immunology2012，9，3： | 15 |
| 3 | Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses显示文摘Immunodeficient mice engrafted with human peripheral blood cells are promising tools for in vivo analysis of human patient individual immune responses.However,when human peripheral blood mononuclear cells(PBMCs)are transferred into NOG(NOD/Shi-scid,IL-2rg null)mice,severe graft versus host disease(GVHD)hinders long term detailed analysis.Administration of human PBMCs into newly developed murine MHC class I-and class II-deficient NOG(NOG-dKO;NOG-Iab,B2m-double-knockout)mice showed sufficient engraftment of human immune cells with little sign of GVHD.Immunization with influenza vaccine resulted in an increase in influenza-specific human IgG Ab,indicating induction of antigen-specific B cells in the NOG-dKO mice.Immunization with human dendritic cells pulsed with HLA-A2 restricted cytomegalovirus peptide induced specific cytotoxic T cells,indicating the induction of antigen-specific T cells in the NOG-dKO mice.Adoptive cell therapies(ACTs)using melanoma antigen recognized by T cells(MART-1)-specific TCR-transduced activated T cells showed strong tumor growth inhibition in NOG-dKO mice without any sign of GVHD accompanied by preferential expansion of the transferred MART-1-specific T cells.ACTs using cultured human melanoma infiltrating T cells also showed anti-tumor effects against autologous melanoma cells in NOG-dKO mice,in which changes in human cancer phenotypes by immune intervention,such as increased CD271 expression,could be evaluated.Therefore,NOG-dKO mice are useful tools for more detailed analysis of both the induction and effector phases of T-cell and B-cell responses for a longer period than regular NOG mice. | Tomonori Yaguchi Asuka Kobayashi Takashi Inozume Kenji Morii Haruna Nagumo Hiroshi Nishio Takashi Iwata Yuyo Ka Ikumi Katano Ryoji Ito Mamoru Ito Yutaka Kawakami | 2018 | Cellular & Molecular Immunology2018，15，11： | 6 |
| 4 | Mutations in carboxy-terminal part of E2 including PKR/eIF2αphosphorylation homology domain and interferon sensitivity determining region of nonstructural 5A of hepatitis C virus 1b:Their correlation with response to interferon monotherapy and viral load显示文摘AIM: To study the amino acid substitutions in the carboxy (C)-terminal part of E2 protein and in the interferon (IFN) sensitivity determining region (ISDR) and their correlation with response to IFN and viral load in 85 hepatitis C virus (HCV)-lb-infected patients treated with IFN. METHODS: The C-terminal part of E2 (codons 617-711) including PKR/eIF2a phosphorylation homology domain (PePHD) and ISDR was sequenced in 85 HCV-1b-infected patients treated by IFN monotherapy. RESULTS: The amino acid substitutions in PePHD detected only in 4 of 85 patients were not correlated either with response to IFN or with viral load. The presence of substitutions in a N-terminal variable region (codons 617-641) in the C-terminal part of E2 was significantly correlated with both small viral load (33.9% vs 13.8%, P = 0.0394) and sustained response to IFN (25.0% vs 6.9 %, P = 0.0429). Four or more substitutions in ISDR were significantly correlated with both small viral load (78.6% vs 16.2%, P < 0.0001) and sustained response to IFN (85.7% vs 2.9%, P < 0.0001). In multivariate analysis, ISDR in nonstructural (NS) 5A (OR = 0.39, P < 0.0001) and N-terminal variable region (OR = 0.51, P = 0.039) was selected as the independent predictors for small viral load, and ISDR (OR = 39.0, P < 0.0001) was selected as the only independent predictor for sustained response. CONCLUSION: The N-terminal variable region in the C-terminal part of E2 correlates with both response to IFN monotherapy and viral load and is one of the factors independently associated with a small viral load. | Koji Ukai Masatoshi Ishigami Kentaro Yoshioka Naoto Kawabe Yoshiaki Katano Kazuhiko Hayashi Takashi Honda Motoyoshi Yano Hidemi Goto | 2006 | World Journal of Gastroenterology2006，12，23： | 5 |
| 5 | Advances in refractory ulcerative colitis treatment: A new therapeutic target, Annexin A2显示文摘Medical treatment has progressed significantly over the past decade towards achieving and maintaining clinical remission in patients with refractory ulcerative colitis(UC). Proposed mediators of inflammation in UC include pro-inflammatory cytokines such as tumor necrosis factor-α(TNF-α) and interleukin-2, and the cellsurface adhesive molecule integrin α4β7. Conventional therapeutics for active UC include 5-aminosalicylic acid, corticosteroids and purine analogues(azathioprine and 6-mercaptopurine). Patients who fail to respond to conventional therapy are treated with agents such as the calicineurin inhibitors cyclosporine and tacrolimus, the TNF-α inhibitors infliximab or adalimumab, or a neutralizing antibody(vedolizumab) directed against integrin α4β7. These therapeutic agents are of benefit for patients with refractory UC, but are not universally effective. Our recent research on TNF-α shedding demonstrated that inhibition of annexin(ANX) A2 may be a new therapeutic strategy for the prevention of TNF-α shedding during inflammatory bowel disease(IBD) inflammation. In this review, we provide an overview of therapeutic treatments that are effective and currently available for UC patients, as well as some that are likely to be available in the near future. We also propose the potential of ANX A2 as a new molecular target for IBD treatment. | Satoshi Tanida Tsutomu Mizoshita Keiji Ozeki Takahito Katano Hiromi Kataoka Takeshi Kamiya Takashi Joh | 2015 | World Journal of Gastroenterology2015，21，29： | 4 |
| 6 | Pediatric living donor liver transplantation for congenital hepatic fibrosis using a mother's graft with von Meyenburg complex: A case report显示文摘This is the first report of living donor liver transplantation(LDLT) for congenital hepatic fibrosis(CHF) using a mother's graft with von Meyenburg complex. A 6-year-old girl with CHF, who suffered from recurrent gastrointestinal bleeding, was referred to our hospital for liver transplantation. Her 38-year-old mother was investigated as a living donor and multiple biliary hamartoma were seen on her computed tomography and magnetic resonance imaging scan. The mother's liver function tests were normal and she did not have any organ abnormality, including polycystic kidney disease. LDLT using the left lateral segment(LLS) graft from the donor was performed. The donor LLS graft weighed 250 g; the graft recipient weight ratio was 1.19%. The operation and post-operative course of the donor were uneventful and she was discharged on post-operative day(POD) 8. The graft liver function was good, and the recipient was discharged on POD 31. LDLT using a graft with von Meyenburg complex is safe and useful. Long-term follow-up is needed with respect to graft liver function and screening malignant tumors. | Naoya Yamada Yukihiro Sanada Takumi Katano Masahisa Tashiro Yuta Hirata Noriki Okada Yoshiyuki Ihara Atsushi Miki Hideki Sasanuma Taizen Urahashi Yasunaru Sakuma Koichi Mizuta | 2016 | World Journal of Gastroenterology2016，22，44： | 2 |
| 7 | Rescue case of low birth weight infant with acute hepatic failure显示文摘We report a case involving a rescued low birth weight infant(LBWI) with acute liver failure. Case: The patient was 1594 g and 32^(3/7) gestational wk at birth. At the age of 11 d, she developed acute liver failure due to gestational alloimmune liver disease. Exchange transfusion and high-dose gamma globulin therapy were initiated, and body weight increased with enteral nutrition. Exchange transfusion was performed a total of 33 times prior to living donor liver transplantation(LDLT). Her liver dysfunction could not be treated by medications alone. At 55 d old and a body weight of 2946 g, she underwent LDLT using an S2 monosegment graft from her mother. Three years have passed with no reports of intellectual disability or liver dysfunction. LBWIs with acute liver failure may be rescued by LDLT after body weight has increased to over 2500 g. | Noriki Okada Yukihiro Sanada Taizen Urahashi Yoshiyuki Ihara Naoya Yamada Yuta Hirata Takumi Katano Kentaro Ushijima Shinya Otomo Shujiro Fujita Koichi Mizuta | 2017 | World Journal of Gastroenterology2017，23，40： | 2 |
| 8 | Contrast-enhanced endoscopic ultrasonography in digestive diseases显示文摘 | Yoshiki Hirooka Akihiro Itoh Hiroki Kawashima Eizaburo Ohno Yuya Itoh Yosuke Nakamura Takeshi Hiramatsu Hiroyuki Sugimoto Hajime Sumi Daijiro Hayashi Naoki Ohmiya Ryoji Miyahara Masanao Nakamura Kohei Funasaka Masatoshi Ishigami Yoshiaki Katano Hidemi Got | 2012 | Journal of Gastroenterology2012，，10： | 2 |
| 9 | Contrast-enhanced endoscopic ultrasonography in digestive diseases显示文摘 | Yoshiki Hirooka Akihiro Itoh Hiroki Kawashima Eizaburo Ohno Yuya Itoh Yosuke Nakamura Takeshi Hiramatsu Hiroyuki Sugimoto Hajime Sumi Daijiro Hayashi Naoki Ohmiya Ryoji Miyahara Masanao Nakamura Kohei Funasaka Masatoshi Ishigami Yoshiaki Katano Hidemi Got | 2012 | Journal of Gastroenterology2012，，10： | 2 |
| 10 | Prognostic implication of DNA contents on long-term outcome of childhood acute lymphoblastic leukemia显示文摘 | Tsurusawa M Katano N Acyama M et al | 1997 | Rinsho Ketsueki1997，38，7： | 2 |
| 11 | Evaluation of CA72-4 as a tumormarker in patients with gastric cancer显示文摘 | Ubukata H Katano M Motohashi G | 2003 | Gan To Kagaku Ryoho2003，30，： | 1 |
| 12 | Epstein-Barr virus(EBV) and Kaposi' s sarcoma-associatedherpesvirus ( KSHV, HHV-8 ) 显示文摘 | Katano H | 2007 | Uirusu2007，60，2： | 1 |
| 13 | Abnormal embryonic karyotype is the most frequent cause of recurrent miscarriage 显示文摘 | SUGIURA M OZAKI Y KATANO K | 2012 | Hum Reprod2012，27，8： | 1 |
| 14 | The past, the present and future of the Picibanil therapy for patient with malignant effusion显示文摘 | Katano M Morisaki | 1998 | Cancer Res1998，18，： | 1 |
| 15 | Biochemical characterization of an effective substrate and potent activators of CK2copurified with Bowman-Birk-type proteinase inhibitor from soybean seeds in vitro显示文摘 | Katano T Kamata Y Ueno T | 2005 | Biochim Biophys Acta2005，7，1： | 1 |
| 16 | Tissue plasminogen activator in chronic subdural hematomas as a predictor of recurrence 显示文摘 | Katano H Kamiya K Mase M | 2006 | J Neurosurg2006，104，1： | 1 |
| 17 | Efficacy of ribavirin plus interferon-alpha in patients aged 》 or =60 years with chronic hepatitis C显示文摘 | Honda T Katano Y Urano F | | 0，，： | 1 |
| 18 | A new synthetic route to 7α-methoxy- cephalosporins显示文摘 | Kunio Atsumi Kiyoaki Katano Ken Nishihata | | 0，，： | 1 |
| 19 | Nitric oxide (NO) serves as aretrograde messenger to activate neuronal NO synthase in the spinalcord via NMDA receptors显示文摘 | Xu L Mabuchi T Katano T | 2007 | Nitric Oxide2007，17，1： | 1 |
| 20 | Vasodilator effect of urotensin Ⅱ,one of the most potent vasoconstricting factors,on rat coronary arteries显示文摘 | Ishhata A Aita T | 2000 | Eur J Pharmacol2000，402，： | 1 |
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