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| 1 | 粉末材料压制过程的DEM分析显示文摘应用离散单元法(DEM)研究了粉末材料在开口容器中受到刚性凸模压制时的流动特点,获得了压制过程中颗粒的运动轨迹、运动速度以及粉末密度分布等重要信息;总结了几种典型的粉末流动模式,并在相关实验中得到了印证,说明了应用DEM分析具有强剪切行为的粉末流动是可行的,结论可供粉末冶金工艺和模具设计人员参考。 | 温彤 COCKS Alan C F | 2007 | 重庆大学学报(自然科学版)2007，30，7： | 4 |
| 2 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 3 | A statistical evaluation of recent full reference image quali- ty assessment algorithms显示文摘 | Sheikh Hamid R Sabir Muhammad F Bovik Alan C | 2006 | IEEE Transactions on Im- age Processing2006，15，11： | 1 |
| 4 | Very high strains recorded in mylonites along the alpine fault, New Zealand: implications for the deep structure of plate boundary faults 显示文摘 | Richard J N Alan F C | 2003 | Journal of Structural Geology2003，25，12： | 1 |
| 5 | Self-assembly of mesoscopicatly ordered chromatic polydiacetylene/silica nanocomposites显示文摘 | Lu Y F Yi Y Alan A Lu M C | 2001 | Nature2001，410，： | 1 |
| 6 | Hydrological processes and chemical characteristics of low--alpine patterned wetlands, south--central New Zealand显示文摘 | Catherne C G Alan F M Katharine J M | 2010 | Journal of Hydrology2010，385，14： | 1 |
| 7 | A gene family expressing a host-protective antigen of Echinococcus granulosus 显示文摘 | Chow C Charles G G Alan F C | 2001 | Mol Biochem Parasitol2001，118，1： | 1 |
| 8 | Electromagnetic coupling between wires inside a rectangular cavity using multiple- mode-analogous-transmission-line circuit theory 显示文摘 | Tadeusz K John F Alan C | 2001 | IEEE Transactions on Electromagnetic Compatibility2001，43，3： | 1 |
| 9 | Correlation of the tei index with invasive measurements of ventricular function in a porcine model显示文摘 | Jared C LaCorte Santos E Cabreriza David G Rabkin Beth F Printz Lindita Coku Alan Weinberg Welton M Gersony Henry M Spotnitz | 2003 | Journal of the American Society of Echocardiography2003，，5： | 1 |
| 10 | Use of fractional myocardial flow reserve to assess the functional significance of intermediate coronary stenoses显示文摘 | William F Fearon Atsushi Takagi Allen Jeremias Alan C Yeung James D Joye David J Cohen Tony M Chou Morton J Kern Paul G Yock | 2000 | The American Journal of Cardiology2000，，9： | 1 |
| 11 | The transformation of kaolin to low-silica X zeolite显示文摘 | Deepak A Alan C Russell F H | | Zeolites0，19，56： | 1 |
| 12 | Hydrological processes and chemical characteristics of low-alpine patterned wetlands, south-central New Zealand显示文摘 | CATHERNE C G ALAN F M KATHARINE J M | 2010 | Journal of Hydrology2010，385，： | 1 |
| 13 | A statistical e- valuation of recent full reference image quality assessment gorithms 显示文摘 | HAMID R S MUHAMMAD F S ALAN C B | 2006 | IEEE Transactions on Image Processing2006，15，11： | 1 |
| 14 | Kenya显示文摘 | Yongsong Huang Alayne Street-perrott F Alan Perrott R et ah Glacial-interglacial environmental changes inferred from molecular and compound-specific 813 C analyses of sediments from Sacred Lake Mt | 1999 | Geochlmica et Cosmo- chimica Acta1999，63，9： | 1 |
| 15 | Cerebrovascular Disease and Late-Life Depression显示文摘 | Helen C Daniel F Alan M | 2005 | Am J Geriatr Psychiatry2005，13，2： | 1 |
| 16 | Char- acterisation of lignite as an industrial adsorbent显示文摘 | YING Q ANDREW F A H ALAN L C | 2011 | Fuel2011，90，4： | 1 |
| 17 | Competing Models of Entrepreneurial Of Intentions显示文摘 | Norris F K Michael D R Alan L C | 2000 | Journal of Business Venturing2000，15，1： | 1 |
| 18 | A gene family expressing a host-protective antigen of Echinococcus granulosus显示文摘 | Chow C Charles G G Alan F C | 2001 | Mol Biochem Parasitol2001，118，1： | 1 |
| 19 | Hydrological processes and chemical characteristics of low-alpine patterned wetlands, south-central New Zealand 显示文摘 | Catheme C G Alan F M Katharinc J M | 2010 | Journal of Hydrology2010，385，3： | 1 |
| 20 | Cerebrovaseular disease and late - life depression 显示文摘 | Helen C Daniel F Alan M | 2005 | Am J Geriatr Psychiatry2005，13，2： | 1 |
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