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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Naming and outline of Dothideomycetes-2014 including proposals for the protection or suppression of generic names显示文摘Article 59.1,of the International Code of Nomenclature for Algae,Fungi,and Plants(ICN;Melbourne Code),which addresses the nomenclature of pleomorphic fungi,became effective from 30 July 2011.Since that date,each fungal species can have one nomenclaturally correct name in a particular classification.All other previously used names for this species will be considered as synonyms.The older generic epithet takes priority over the younger name.Any widely used younger names proposed for use,must comply with Art.57.2 and their usage should be approved by the Nomenclature Committee for Fungi(NCF).In this paper,we list all genera currently accepted by us in Dothideomycetes(belonging to 23 orders and 110 families),including pleomorphic and nonpleomorphic genera.In the case of pleomorphic genera,we follow the rulings of the current ICN and propose single generic names for future usage.The taxonomic placements of 1261 genera are listed as an outline.Protected names and suppressed names for 34 pleomorphic genera are listed separately.Notes and justifications are provided for possible proposed names after the list of genera.Notes are also provided on recent advances in our understanding of asexual and sexual morph linkages in Dothideomycetes.A phylogenetic tree based on four gene analyses supported 23 orders and 75 families,while 35 families still lack molecular data. | Nalin N.Wijayawardene Pedro W.Crous Paul M.Kirk David L.Hawksworth Saranyaphat Boonmee Uwe Braun Dong-Qin Dai Melvina J.D’souza Paul Diederich Asha Dissanayake Mingkhuan Doilom Singang Hongsanan E.B.Gareth Jones Johannes Z.Groenewald Ruvishika Jayawardena James D.Lawrey Jian-Kui Liu Robert Lücking Hugo Madrid Dimuthu S.Manamgoda Lucia Muggia Matthew P.Nelsen Rungtiwa Phookamsak Satinee Suetrong Kazuaki Tanaka Kasun M.Thambugala Dhanushka N.Wanasinghe Saowanee Wikee Ying Zhang Andre Aptroot H.A.Ariyawansa Ali H.Bahkali D.Jayarama Bhat Cécile Gueidan Putarak Chomnunti G.Sybren De Hoog Kerry Knudsen Wen-Jing Li Eric H.C.McKenzie Andrew N.Miller Alan J.L.Phillips Marcin Piatek Huzefa A.Raja Roger S.Shivas Bernad Slippers Joanne E.Taylor Qing Tian Yong Wang Joyce H.C.Woudenberg Lei Cai Walter M.Jaklitsch Kevin D.Hyde | 2014 | Fungal Diversity2014，，6： | 2 |
| 3 | The vehicle routing problem with stochastic demand and duration constraints显示文摘 | ALAN L E JUAN C M MARTIN S | | 0，，4： | 1 |
| 4 | Total phenol, flavonoid, proanthocyanidin and vitamin C levels and antioxidant activities of Mauritian vegetables显示文摘 | Theeshan B Amitabye L R Alan C | 2004 | Journal of the Science of Food and Agriculture2004，84，9： | 1 |
| 5 | Ethanol-diesel fuel blends--A Review 显示文摘 | HANSEN Alan C ZHANG Qin LYNE Peter W L | 2005 | Bioresource Technology2005，96，3： | 1 |
| 6 | Omega-3 fatty acids and major depression: A primer for the mental health professional显示文摘 | Alan C L | 2004 | Lipids in Health and Disease2004，，3： | 1 |
| 7 | Highly concentrated,intercalated silicate nanocomposites:synthesis and characteri-zation显示文摘 | Adam S Z Terrence C C Alan J L | 2003 | Macromolecules2003，36，5： | 1 |
| 8 | Influence of prohexadione calcium on pod yield and pod loss of peanut显示文摘 | Joshua B B David L J Alan C Y | 2002 | Agronomy Journal2002，94，2： | 1 |
| 9 | Ethanol-diesel fuel blends:A review显示文摘 | Hansen Alan C Zhang Qing Lyne Peter W L | 2005 | Bioresource Technology2005，96，： | 1 |
| 10 | Ethanol-Diesel Fuel Blends-A Review显示文摘 | Hansen Alan C Zhang Qin Lyne Peter W L | 2005 | Bioresource Technology2005，96，3： | 1 |
| 11 | Fatty acids, volatile compounds and colour changes in high-pressure-treated oysters (Crassostrea gigas) 显示文摘 | Malco C C Joseph P K Alan L K | 2008 | Innovative Food Science and Emerging Technologies2008，9，： | 1 |
| 12 | Characterization of thematioxidant functions of flavonoids and proan- thocyanidins in Mauritianblack teas显示文摘 | AMITABYE L R THEESHAN B ALAN C | 2005 | Food Research International2005，38，： | 1 |
| 13 | Creep and microstructural stability of dispersion strengthened Al-Fe-V-Si alloy显示文摘 | SUBHASH C KHATRI ALAN L | 1993 | Mater Sci and Eng1993，167，： | 1 |
| 14 | The Haas procedure for the treatment of tibial torsional Deformities显示文摘 | Dror L Alan A and Leonel C | 2007 | Journal of Pediatric Orthopaedics B2007，16，： | 1 |
| 15 | Microwave pyrolysis,a novel process for recycling waste automotive engine oil显示文摘 | SU S L ALAN D R HOWARD A C | | 0，，35： | 1 |
| 16 | Ethanol-diesel fuel blends: a review显示文摘 | Alan C H Qin Z Peter W L L | 2005 | Bioresource Technology2005，96，3： | 1 |
| 17 | Betalain,acid ascorbic,phenolic contents and antioxidant properties of purple,red,yellow and white cactus pears显示文摘 | SUMAYA M M T CRUZ J S MADRIGAL S E GARCíA P CARIO C J CRUZ C R VALADEZ V MARTINEZ C C L ALANíS G E | 2011 | International Journal of Molecular Sciences2011，12，10： | 1 |
| 18 | CO2 capture by adsorption:materials and process development显示文摘 | Alan L C Gregory P K Zhijian L | 2007 | International Journal of Greenhouse Gas Control2007，，1： | 1 |
| 19 | Acute Hemodynamic Response to β-Blockers and Prediction of Long-term Outcome in Primary Prophylaxis of Variceal Bleeding显示文摘 | Càndid Villanueva Carles Aracil Alan Colomo Virginia Hernández–Gea Josep M. López–Balaguer Cristina Alvarez–Urturi Xavier Torras Joaquim Balanzó Carlos Guarner | 2009 | Gastroenterology2009，，1： | 1 |
| 20 | Managing Inventory in Global Supply Chains Facing Port-of-Entry Disruption Risks显示文摘 | Lewis Brian M Erera Alan L Nowak Maciek A White Chelsea C | 2013 | Transportation Science2013，，2： | 1 |
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