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| 1 | Neo-adjuvant chemo(radio)therapy in gastric cancer: Current status and future perspectives显示文摘In the last 20 years, several clinical trials on neoadjuvant chemotherapy and chemo-radiotherapy as a therapeutic approach for locally advanced gastric cancer have been performed. Even if more data are necessary to define the roles of these approaches, the results of preoperative treatments in the combined treatment of gastric adenocarcinoma are encouraging because this approach has led to a higher rate of curative surgical resection. Owing to the results of most recent randomized phase III studies, neoadjuvant chemotherapy for locally advanced resectable gastric cancer has satisfied the determination of level I evidence. Remaining concerns pertain to the choice of the optimal therapy regimen, strict patient selection by accurate pre-operative staging, standardization of surgical procedures, and valid criteria for response evaluation. New well-designed trials will be necessary to find the best therapeutic approach in pre-operative settings and the best way to combine old-generation chemotherapeutic drugs with new-generation molecules. | Alberto Biondi Maria C Lirosi Domenico D'Ugo Valeria Fico Riccardo Ricci Francesco Santullo Antonia Rizzuto Ferdinando CM Cananzi Roberto Persiani | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 13 |
| 2 | Surgical treatment of ulcerative colitis in the biologic therapy era显示文摘Recently introduced in the treatment algorithms and guidelines for the treatment of ulcerative colitis,biological therapy is an effective treatment option for patients with an acute severe flare not responsive to conventional treatments and for patients with steroid dependent disease.The reduction in hospitalization and surgical intervention for patients affected by ulcerative colitis after the introduction of biologic treatment remains to be proven.Furthermore,these agents seem to be associated with increase in cost of treatment and risk for serious postoperative complications.Restorative proctocolectomy with ileal pouch-anal anastomosis is the surgical treatment of choice in ulcerative colitis patients.Surgery is traditionally recommended as salvage therapy when medical management fails,and,despite advances in medical therapy,colectomy rates remain unchanged between 20% and 30%.To overcome the reported increase in postoperative complications in patients on biologic therapies,several surgical strategies have been developed to maintain long-term pouch failure rate around 10%,as previously reported.Surgical staging along with the development of minimally invasive surgery are among the most promising advances in this field. | Alberto Biondi Marco Zoccali Stefano Costa Albert Troci Ettore Contessini-Avesani Alessandro Fichera | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 3 | R0 resection in the treatment of gastric cancer:Room for improvement显示文摘Gastric carcinoma is one of the most frequent malignancies in the world and its clinical behavior especially depends on the metastatic potential of the tumor.In particular,lymphatic metastasis is one of the main predictors of tumor recurrence and survival,and current pathological staging systems reflect the concept that lymphatic spread is the most relevant prognostic factor in patients undergoing curative resection.This is compounded by the observation that two-thirds of gastric cancer in the Western world presents at an advanced stage,with lymph node metastasis at diagnosis.All current therapeutic efforts in gastric cancer are directed toward individualization of therapeutic protocols,tailoring the extent of resection and the administration of preoperative and postoperative treatment.The goals of all these strategies are to improve prognosis towards the achievement of a curative resection(R0 resection) with minimal morbidity and mortality,and better postoperative quality of life. | Alberto Biondi Roberto Persiani Ferdinando Cananzi Marco Zoccali Vincenzo Vigorita Andrea Tufo Domenico D'Ugo | 2010 | World Journal of Gastroenterology2010，16，27： | 4 |
| 4 | Failure of interferon-γ pre-treated mesenchymal stem cell treatment in a patient with crohn's disease显示文摘Mesenchymal stem cells(MSC) are cells of stromal origin which exhibit unlimited self-renewal capacity and pluripotency in vitro.It has recently been observed that MSC may also exert a profound immunosuppressive and anti-inflammatory effect both in vitro and in vivo with consequent potential use in autoimmune disorders.We present the case of a patient suffering from childhood-onset, multidrug resistant and steroiddependent Crohn's disease who underwent systemic infusions of MSC, which led to a temporary reduction in CCR4, CCR7 and CXCR4 expression by T-cells, and a temporary decrease in switched memory B-cells, In addition, following MSC infusion, lower doses of steroids were needed to inhibit proliferation of the patient's peripheral blood mononuclear cells.Despite these changes, no significant clinical benefit was observed, and the patient required rescue therapy with infliximab and subsequent autologous hematopoietic stem cell transplantation.The results of biological and in vitro observations after MSC use and the clinical effects of infusion are discussed, and a brief description is provided of previous data on MSC-based therapy in autoimmune disorders. | Andrea Taddio Alberto Tommasini Erica Valencic Ettore Biagi Giuliana Decorti Sara De Iudicibus Eva Cuzzoni Giuseppe Gaipa Raffaela Badolato Alberto Prandini Andrea Biondi Alessandro Ventura | 2015 | World Journal of Gastroenterology2015，21，14： | 2 |
| 5 | Preoperative chemotherapy in gastric cancer: expanding the indications, limiting the overuse显示文摘 | Ferdinando C. M. Cananzi Alberto Biondi Luca Cozzaglio Domenico D’Ugo Roberto Persiani Vittorio Quagliuolo | 2015 | Gastric Cancer2015，，1： | 2 |
| 6 | Preoperative treatment and surgery in gastric cancer: friends or foes?显示文摘 | Domenico D’Ugo Stefano Rausei Alberto Biondi Roberto Persiani | 2009 | Lancet Oncology2009，，2： | 2 |
| 7 | Preoperative treatment and surgery in gastric cancer: friends or foes?显示文摘 | Domenico D’Ugo Stefano Rausei Alberto Biondi Roberto Persiani | 2009 | Lancet Oncology2009，，2： | 1 |
| 8 | 7-Year Survival Results of Perioperative Chemotherapy with Epidoxorubicin, Etoposide, and Cisplatin (EEP) in Locally Advanced Resectable Gastric Cancer: Up-to-date Analysis of a Phase-II Study显示文摘 | Roberto Persiani Stefano Rausei Carmelo Pozzo Alberto Biondi Carlo Barone Ferdinando C. M. Cananzi Giovanni Schinzari Domenico D’Ugo | 2008 | Annals of Surgical Oncology2008，，8： | 1 |
| 9 | Determinants of Surgical Morbidity in Gastric Cancer Treatment显示文摘 | Roberto Persiani Vincenzo Antonacci Alberto Biondi Stefano Rausei Antonio La Greca Marco Zoccali Luigi Ciccoritti Domenico D’Ugo | 2008 | Journal of the American College of Surgeons2008，，1： | 1 |
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