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| 1 | Surgical treatment of ulcerative colitis in the biologic therapy era显示文摘Recently introduced in the treatment algorithms and guidelines for the treatment of ulcerative colitis,biological therapy is an effective treatment option for patients with an acute severe flare not responsive to conventional treatments and for patients with steroid dependent disease.The reduction in hospitalization and surgical intervention for patients affected by ulcerative colitis after the introduction of biologic treatment remains to be proven.Furthermore,these agents seem to be associated with increase in cost of treatment and risk for serious postoperative complications.Restorative proctocolectomy with ileal pouch-anal anastomosis is the surgical treatment of choice in ulcerative colitis patients.Surgery is traditionally recommended as salvage therapy when medical management fails,and,despite advances in medical therapy,colectomy rates remain unchanged between 20% and 30%.To overcome the reported increase in postoperative complications in patients on biologic therapies,several surgical strategies have been developed to maintain long-term pouch failure rate around 10%,as previously reported.Surgical staging along with the development of minimally invasive surgery are among the most promising advances in this field. | Alberto Biondi Marco Zoccali Stefano Costa Albert Troci Ettore Contessini-Avesani Alessandro Fichera | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 2 | R0 resection in the treatment of gastric cancer:Room for improvement显示文摘Gastric carcinoma is one of the most frequent malignancies in the world and its clinical behavior especially depends on the metastatic potential of the tumor.In particular,lymphatic metastasis is one of the main predictors of tumor recurrence and survival,and current pathological staging systems reflect the concept that lymphatic spread is the most relevant prognostic factor in patients undergoing curative resection.This is compounded by the observation that two-thirds of gastric cancer in the Western world presents at an advanced stage,with lymph node metastasis at diagnosis.All current therapeutic efforts in gastric cancer are directed toward individualization of therapeutic protocols,tailoring the extent of resection and the administration of preoperative and postoperative treatment.The goals of all these strategies are to improve prognosis towards the achievement of a curative resection(R0 resection) with minimal morbidity and mortality,and better postoperative quality of life. | Alberto Biondi Roberto Persiani Ferdinando Cananzi Marco Zoccali Vincenzo Vigorita Andrea Tufo Domenico D'Ugo | 2010 | World Journal of Gastroenterology2010，16，27： | 4 |
| 3 | Antimesenteric Functional End-to-End Handsewn (Kono-S) Anastomosis显示文摘 | Alessandro Fichera Marco Zoccali Toru Kono | 2012 | Journal of Gastrointestinal Surgery2012，，7： | 1 |
| 4 | Single-incision laparoscopic total abdominal colectomy for refractory ulcerative colitis显示文摘 | Alessandro Fichera Marco Zoccali | 2012 | Surgical Endoscopy2012，，3： | 1 |
| 5 | Determinants of Surgical Morbidity in Gastric Cancer Treatment显示文摘 | Roberto Persiani Vincenzo Antonacci Alberto Biondi Stefano Rausei Antonio La Greca Marco Zoccali Luigi Ciccoritti Domenico D’Ugo | 2008 | Journal of the American College of Surgeons2008，，1： | 1 |
| 6 | Minimally invasive approaches for the treatment of inflammatory bowel disease显示文摘Despite significant improvements in medical management of inflammatory bowel disease, many of these patients still require surgery at some point in the course of their disease. Their young age and poor general conditions, worsened by the aggressive medical treatments, make minimally invasive approaches particularly enticing to this patient population. However, the typical inflammatory changes that characterize these diseases have hindered wide diffusion of laparoscopy in this setting, currently mostly pursued in high-volume referral centers, despite accumulating evidences in the literature supporting the benefits of minimally invasive surgery. The largest body of evidence currently available for terminal ileal Crohn's disease shows improved short term outcomes after laparoscopic surgery, with prolonged operative times. For Crohn's colitis, high quality evidence supporting laparoscopic surgery is lacking.Encouraging preliminary results have been obtained with the adoption of laparoscopic restorative total proctocolectomy for the treatment of ulcerative colitis. A consensus about patients' selection and the need for staging has not been reached yet. Despite the lack of conclusive evidence, a wave of enthusiasm is pushing towards less invasive strategies, to further minimize surgical trauma, with single incision laparoscopic surgery being the most realistic future development. | Marco Zoccali Alessandro Fichera | 2012 | World Journal of Gastroenterology2012，18，46： | 0 |
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