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| 1 | Obesity and kidney disease: hidden consequences of the epidemic显示文摘Obesity has become a worldwide epidemic,and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes,cardiovascular disease and also for Chronic Kidney Disease. A high body mass index is one of the strongest risk factors for new-onset Chronic Kidney Disease. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing Chronic Kidney Disease in the long-term. The incidence of obesity-related glomerulopathy has increased ten-fold in recent years. Obesity has also been shown to be a risk factor for nephrolithiasis,and for a number of malignancies including kidney cancer. This year the World Kidney Day promotes education on the harmful consequences of obesity and its association with kidney disease,advocating healthy lifestyle and health policy measures that makes preventive behaviors an affordable option. | Csaba P.Kovesdy Susan Furth Carmine Zoccali | 2017 | 肾脏病与透析肾移植杂志2017，26，1： | 14 |
| 2 | Role of negative affects in pathophysiology and clinical expression of irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS)is regarded as a multifactorial disease in which alterations in the brain-gut axis signaling play a major role.The biopsychosocial model applied to the understanding of IBS pathophysiology assumes that psychosocial factors,interacting with peripheral/central neuroendocrine and immune changes,may induce symptoms of IBS,modulate symptom severity,influence illness experience and quality of life,and affect outcome.The present review focuses on the role of negative affects,including depression,anxiety,and anger,on pathogenesis and clinical expression of IBS.The potential role of the autonomic nervous system,stress-hormone system,and immune system in the pathophysiology of both negative affects and IBS are taken into account.Psychiatric comorbidity and subclinical variations in levels of depression,anxiety,and anger are further discussed in relation to the main pathophysiological and symptomatic correlates of IBS,such as sensorimotor functions,gut microbiota,inflammation/immunity,and symptom reporting. | Maria Rosaria A Muscatello Antonio Bruno Giuseppe Scimeca Gianluca Polfo Rocco A Zoccali | 2014 | World Journal of Gastroenterology2014，20，24： | 9 |
| 3 | Surgical treatment of ulcerative colitis in the biologic therapy era显示文摘Recently introduced in the treatment algorithms and guidelines for the treatment of ulcerative colitis,biological therapy is an effective treatment option for patients with an acute severe flare not responsive to conventional treatments and for patients with steroid dependent disease.The reduction in hospitalization and surgical intervention for patients affected by ulcerative colitis after the introduction of biologic treatment remains to be proven.Furthermore,these agents seem to be associated with increase in cost of treatment and risk for serious postoperative complications.Restorative proctocolectomy with ileal pouch-anal anastomosis is the surgical treatment of choice in ulcerative colitis patients.Surgery is traditionally recommended as salvage therapy when medical management fails,and,despite advances in medical therapy,colectomy rates remain unchanged between 20% and 30%.To overcome the reported increase in postoperative complications in patients on biologic therapies,several surgical strategies have been developed to maintain long-term pouch failure rate around 10%,as previously reported.Surgical staging along with the development of minimally invasive surgery are among the most promising advances in this field. | Alberto Biondi Marco Zoccali Stefano Costa Albert Troci Ettore Contessini-Avesani Alessandro Fichera | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 4 | Personality traits and emotional patterns in irritable bowel syndrome显示文摘The review focuses on those personality traits(neuroticism, extraversion, openness to experience, agreeableness, and conscientiousness), constructs(alexithymia and distressed- Type D personality) and emotional patterns(negative and positive) that are of particular concern in health psychology, with the aim to highlight their potential role on the pathogenesis, onset, symptom clusters, clinical course, and outcome of irritable bowel syndrome(IBS). Personality traits and emotional patterns play key roles in affecting autonomic, immune, inflammatory, and endocrine functions, thus contributing not only to IBS clinical expression and symptomatic burden, but also to disease physiopathology. In this sense, psychological treatments should address those personality traits and emotional features that are constitutive of, and integral to IBS. The biopsychosocial model of illness applied to IBS acknowledges the interaction between biological, psychological, environmental, and social factors in relation to pain and functional disability. A holistic approach to IBS should take into account the heterogeneous nature of the disorder, and differentiate treatments for different types of IBS, also considering the marked individual differences in prevalent personality traits and emotional patterns. Beyond medications, and lifestyle/dietary interventions, psychological and educational treatments may provide the optimal chance of addressing clinical symptoms, comorbid conditions, and quality of life in IBS patients. | Maria Rosaria A Muscatello Antonio Bruno Carmela Mento Gianluca Pandolfo Rocco A Zoccali | 2016 | World Journal of Gastroenterology2016，22，28： | 7 |
| 5 | R0 resection in the treatment of gastric cancer:Room for improvement显示文摘Gastric carcinoma is one of the most frequent malignancies in the world and its clinical behavior especially depends on the metastatic potential of the tumor.In particular,lymphatic metastasis is one of the main predictors of tumor recurrence and survival,and current pathological staging systems reflect the concept that lymphatic spread is the most relevant prognostic factor in patients undergoing curative resection.This is compounded by the observation that two-thirds of gastric cancer in the Western world presents at an advanced stage,with lymph node metastasis at diagnosis.All current therapeutic efforts in gastric cancer are directed toward individualization of therapeutic protocols,tailoring the extent of resection and the administration of preoperative and postoperative treatment.The goals of all these strategies are to improve prognosis towards the achievement of a curative resection(R0 resection) with minimal morbidity and mortality,and better postoperative quality of life. | Alberto Biondi Roberto Persiani Ferdinando Cananzi Marco Zoccali Vincenzo Vigorita Andrea Tufo Domenico D'Ugo | 2010 | World Journal of Gastroenterology2010，16，27： | 4 |
| 6 | Depression, Anxiety and Anger in Subtypes of Irritable Bowel Syndrome Patients显示文摘 | Maria Rosaria A. Muscatello Antonio Bruno Gianluca Pandolfo Umberto Micò Simona Stilo Mariagrazia Scaffidi Pierluigi Consolo Andrea Tortora Socrate Pallio Giuseppa Giacobbe Luigi Familiari Rocco Zoccali | 2010 | Journal of Clinical Psychology in Medical Settings2010，，1： | 2 |
| 7 | Use of generated artificial road profiles in road roughness evaluation显示文摘In the evaluation of road roughness and its effects on vehicles response in terms of ride quality, loads induced on pavement, drivers' comfort, etc., it is very common to generate road profiles based on the equation provided by ISO 8608 standard, according to which it is possible to group road surface profiles into eight different classes. However, real profiles are significantly different from the artificial ones because of the non-stationary feature of the first ones and the not full capability of the ISO8608 equation to correctly describe the frequency content of real road profiles. In this paper, the international roughness index, the frequency-weighted vertical acceleration awzaccording to ISO 2631, and the dynamic load index are applied both on artificial and real profiles,highlighting the different results obtained. The analysis carried out in this work has highlighted some limitation of the ISO 8608 approach in the description of performance and conditions of real pavement profiles. Furthermore, the different sensitivity of the various indices to the fitted power spectral density parameters is shown, which should be taken into account when performing analysis using artificial profiles. | Giuseppe Loprencipe Pablo Zoccali | 2017 | Journal of Modern Transportation2017，25，1： | 2 |
| 8 | 他汀类药物在慢性肾脏病中的交感神经抑制效应是否具有临床意义显示文摘公元一世纪的古希腊和罗马时代,有一种被称为theriaca(底野迦)的万能药物,传说中可以治疗各种疾病。他汀类药物即为21世纪的theriaca。的确,他汀类药物不仅是高血脂症的最佳治疗药物,而且对于许多疾病具有潜在的应用价值,如骨质疏松症、阿尔茨海默病、抑郁症、高血压、败血症和癌症等[1]。如此广泛的治疗潜能源于他汀类药物作用于一系列对细胞功能有重要作用的信号分子。阻断这些分子机制将在器官或系统水平上产生一系列效应,如免疫系统和中枢神经系统的调节作用,骨髓造血干细胞对骨形成和修复的调节作用等。 | Zoccali C Seravalle G Grassi G 童保文 林志鸿 谢良地 | 2014 | 中华高血压杂志2014，22，6： | 2 |
| 9 | Low triiodothyronine:a new facet of inflammation in end-stage renal disease显示文摘 | Tripepi G Cutrupi S | 2005 | J Am Soc Nephrol2005，16，9： | 1 |
| 10 | Biomarkers in chronic kidney disease:utility and issues towards better understanding显示文摘 | Zoccali C | 2005 | Curr Opin Nephrol Hypertens2005，14，6： | 1 |
| 11 | Single-incision laparoscopic total ab- dominal colectomy for refractory ulcerative colitis 显示文摘 | Fichera A Zoccali M | 2012 | Surg En- dose2012，26，3： | 1 |
| 12 | Uric acid, hypertension, and cardiovascular and renal complications 显示文摘 | Zoccali C Mallamaci F | 2013 | Curt Hypertens Rcp2013，15，6： | 1 |
| 13 | Adiponectin, meta bolic risk factirs, and cardiovascular events among patients with end-stage renal disease 显示文摘 | Zoccali c Mallomaci F Tripeii G | 2002 | J Am Soc Nephrol2002，13，： | 1 |
| 14 | Traditional and emerging cardiovascular and renal risk factors:an epidemiologic perspective显示文摘 | Zoccali C | 2006 | Kidney Int2006，70，： | 1 |
| 15 | Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal disease显示文摘 | Zoccali C Mallamaci F Tripepi G Benedetto FA Cutrupi S Parlongo S Malatino LS Bonanno G Seminara G Rapisarda F Fatuzzo P Buemi M Nicocia G Tanaka S Ouchi N Kihara S Funahashi T Matsuzawa Y | 2002 | J Am Soc Nephrol2002，13，1： | 1 |
| 16 | Novel cardiovascular risk factors in end-stage renal disease显示文摘 | Zoccali C Mallamaci F Tripepi G | 2004 | J Am Soc Nephrol2004，15，1： | 1 |
| 17 | Uric acid and endothelial dysfunction in essential hypertension 显示文摘 | Zoccali C Maio R Mallamaei F | 2006 | J Am Soc Nephrol2006，17，5： | 1 |
| 18 | Uric acid and endothelial dysfunction in essential hypertension 显示文摘 | Zoccali C Maio R Mallamaci F | 2006 | J Am Soc Nephml2006，17，5： | 1 |
| 19 | Adiponectin in essential hy-pertension显示文摘 | Mallamaci F Zoccali C Cuzzola F | | 0，，05： | 1 |
| 20 | Surgical anatomy of the minimally invasive lateral lumbar approach显示文摘 | Bina RW Zoccali C Skoch J | 2015 | J Clin Neurosci2015，22，3： | 1 |
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