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| 1 | Incidental gallbladder cancer during laparoscopic cholecystectomy:Managing an unexpected finding显示文摘AIM:To evaluate the impact of incidental gallbladder cancer on surgical experience.METHODS:Between 1998 and 2008 all cases of cholecystectomy at two divisions of general surgery,one university based and one at a public hospital,were retrospectively reviewed.Gallbladder pathology was diagnosed by history,physical examination,and laboratory and imaging studies [ultrasonography and computed tomography(CT)].Patients with gallbladder cancer(GBC) were further analyzed for demographic data,and type of operation,surgical morbidity and mortality,histopathological classification,and survival.Incidental GBC was compared with suspected or preoperatively diagnosed GBC.The primary endpoint was diseasefree survival(DFS).The secondary endpoint was the difference in DFS between patients previously treated with laparoscopic cholecystectomy and those who had oncological resection as first intervention.RESULTS:Nineteen patients(11 women and eight men) were found to have GBC.The male to female ratio was 1:1.4 and the mean age was 68 years(range:45-82 years).Preoperative diagnosis was made in 10 cases,and eight were diagnosed postoperatively.One was suspected intraoperatively and confirmed by frozen sections.The ratio between incidental and nonincidental cases was 9/19.The tumor node metastasis stage was:pTis(1),pT1a(2),pT1b(4),pT2(6),pT3(4),pT4(2);five cases with stageⅠa(T1 a-b);two with stageⅠb(T2 N0);one with stage Ⅱa(T3 N0);six with stage Ⅱb(T1-T3 N1);two with stage Ⅲ(T4 Nx Nx);and one with stage Ⅳ(Tx Nx Mx).Eighty-eight percent of the incidental cases were discovered at an early stage(≤Ⅱ).Preoperative diagnosis of the 19 patients with GBC was:GBC with liver invasion diagnosed by preoperative CT(nine cases),gallbladder abscess perforated into hepatic parenchyma and involving the transversal mesocolon and hepatic hilum(one case),porcelain gallbladder(one case),gallbladder adenoma(one case),and chronic cholelithiasis(eight cases).Every case,except one,with a T1b or more advanced invasion underwent Ⅳb + Ⅴ wedge liver resection and pericholedochic/hepatoduodenal lymphadenectomy.One patient with stage T1b GBC refused further surgery.Cases with Tis and T1a involvement were treated with cholecystectomy alone.One incidental case was diagnosed by intraoperative frozen section and treated with cholecystectomy alone.Six of the nine patients with incidental diagnosis reached 5-year DFS.One patient reached 38 mo survival despite a port-site recurrence 2 years after original surgery.Cases with non incidental diagnosis were more locally advanced and only two patients experienced 5-year DFS.CONCLUSION:Laparoscopic cholecystectomy does not affect survival if implemented properly.Reoperation should have two objectives:R0 resection and clearance of the lymph nodes. | Andrea Cavallaro Gaetano Piccolo Vincenzo Panebianco Emanuele Lo Menzo Massimiliano Berretta Antonio Zanghì Maria Di Vita Alessandro Cappellani | 2012 | World Journal of Gastroenterology2012，18，30： | 33 |
| 2 | 三种南方典型水稻土长期试验下有机碳积累机制研究 Ⅲ.两种水稻土颗粒有机质结构特征的变化显示文摘采用固体交叉极化魔角自旋^(13)C核磁共振(CPMAS^(13)C-NMR)波谱技术对长期不同施肥处理下红壤性水稻土和太湖地区黄泥土本体土壤以及水稳性团聚体中颗粒有机质(POM)的化学结构特征进行了研究。结果表明,不同施肥处理下本体土壤和不同粒径水稳性团聚体中POM的结构组成相似,主要由烷氧C、烷基C和芳香C组成,其中以烷氧C含量最高。施肥改变了本体土壤POM中各类C原子的相对百分含量,有机肥以及化肥配施有机肥条件下烷氧C含量明显降低,芳香C和酚基C含量有不同程度的增加,表明POM的稳定性增强;单施化肥下烷氧C含量最高,而烷基C、芳香C和芳香度均最低,POM的稳定性减弱,不利于POM的积累。施肥改变了黄泥土不同粒径水稳性团聚体中POM各类C原子的相对百分含量,从而使得不同粒径中POM对其团聚体的稳定性作用发生变化;而红壤性水稻土不同粒径水稳性团聚体POM各类C原子的相对百分含量并未明显受到施肥措施的影响。 | 周萍 Alessandro Piccolo 潘根兴 Daniela Smejkalova | 2009 | 土壤学报2009，46，3： | 29 |
| 3 | 南方典型水稻土长期试验下有机碳积累机制研究 Ⅳ.颗粒有机质热裂解-气相-质谱法分子结构初步表征显示文摘采用热裂解-气相-质谱(Pyr-TMAH-GC/MS)技术对长期不同施肥处理下太湖地区黄泥土本体土壤及水稳性团聚体中颗粒有机碳(POC)的化学组分进行了研究。结果表明,POC的热裂解产物主要来源于脂肪族化合物和木质素类化合物。木质素类化合物主要以愈疮木基丙烷(G)和p-羟苯基(P)两种木质素单体为主,从而揭示黄泥土POC积累中草本植物(水稻、油菜的残茬和秸秆)的输入贡献。脂肪族化合物主要为C8-C30脂肪酸甲基酯(FAMEs),且大多为偶数碳结构。施肥改变了各裂解产物在本体土壤和水稳性团聚体中的分布,从而使得不同施肥处理下各类化合物对POC稳定性的贡献出现了差异。化肥配施猪粪下木质素类化合物以及微生物源的脂肪族化合物均贡献于本体土壤POC的积累与稳定,而化肥配施秸秆下本体土壤POC的化学稳定性主要归因于高等植物源化合物的贡献,其次为微生物源脂肪族化合物。化肥配施有机肥下水稳性团聚体中较高的POC主要归因于植物源有机物质的分解贡献。本研究揭示了合理施肥下水稻土中有机碳的化学抗性组分在土壤有机碳积累中的促进作用,各组分的相对分布差异可指示有机碳积累的不同来源。 | 周萍 潘根兴 Alessandro Piccolo Riccardo Spaccini | 2011 | 土壤学报2011，48，1： | 14 |
| 4 | 土壤修复:腐植酸作为天然表面活性剂淋洗高度污染土壤显示文摘修复位于意大利北部的前ACNA化工厂(萨沃纳)附近的高污染场地是意大利的当务之急。文章目的是致力于寻找环境友好型的新技术用于修复ACNA污染场地的土壤。从ACNA场地获取质地和有机污染物数量和类型都不同的两种土壤样本A和B,采用多种洗涤剂对两种土壤样本进行淋洗,比较这些洗涤剂去除土壤污染物的效率。实验采用的洗涤剂包括:水,两种合成表面活性剂:十二烷基硫酸钠(SDS)和Triton X-100(TX100)和腐殖酸(HA)作为临界胶束浓度的天然表面活性剂溶液。在土壤样本淋洗前后分别采用超声处理和索氏法提取污染物。土壤A富含多环芳烃,而土壤B含有大量噻吩。处理细质土壤B时,超声处理具有更高的分析效率,处理粗质土壤A,索氏法的处理效率处于正常水平。采用清水洗涤土壤不能完全从土壤中除去污染物,而用后几种方法除去污染物时,所有有机表面活性剂的效率基本相同(高达90%)。因此,使用含天然腐殖酸的溶液淋洗高度污染的土壤似乎是一个更好的选择,因为含天然腐殖酸的溶液能够促进土壤中微生物的活性,而合成表面活性剂则相反,会使被淋洗过的土壤出现进一步的自然衰减。 | Pellegrino Conte Anna Agretto Riccardo Spaccini Alessandro Piccolo | 2014 | 中国洗涤用品工业2014，，1： | 3 |
| 5 | Molecular characteris-tics of humic acids extracted from compost at increasing maturity stages显示文摘 | RICCARDO SPACCINI ALESSANDRO PICCOLO | 2009 | Soil Biology&Biochemistry2009，41，： | 1 |
| 6 | Isolation of human hepatocytes from livers rejected for liver transplantation on a national basis: Results of a 2-year experience显示文摘 | Umberto Baccarani Andrea Sanna Alessio Cariani Mauricio Sainz-Barriga Gian Luigi Adani Anna Maria Zambito Giuseppe Piccolo Andrea Risaliti Alessandro Nanni-Costa Lorenza Ridolfi Mario Scalamogna Fabrizio Bresadola Annibale Donini | 2003 | Liver Transplantation2003，，5： | 1 |
| 7 | Molecular characterization of dissolved organic matter (DOM): a critical review显示文摘 | Antonio Nebbioso Alessandro Piccolo | 2013 | Analytical and Bioanalytical Chemistry2013，，1： | 1 |
| 8 | Identification of new aminoacid amides containing the imidazo[2,1- b ]benzothiazol-2-ylphenyl moiety as inhibitors of tumorigenesis by oncogenic Met signaling显示文摘 | Alessandro Furlan Francesco Colombo Andrea Kover Nathalie Issaly Cristina Tintori Lucilla Angeli Vincent Leroux Sébastien Letard Mercedes Amat Yasmine Asses Bernard Maigret Patrice Dubreuil Maurizio Botta Rosanna Dono Joan Bosch Oreste Piccolo Daniele Pas | 2011 | European Journal of Medicinal Chemistry2011，，： | 1 |
| 9 | 土壤修复:腐植酸作为天然表面活性剂在严重污染土壤淋洗中的应用显示文摘修复位于意大利北部的原ACNA化工厂(在Savona附近)周围的严重污染地是意大利政府的当务之急。当前工作目的是寻找创新、环保的技术来修复ACNA污染的土壤。取自ACNA化工厂的两种不同质地、不同数量、不同有机污染物类型的土样(土壤A和土壤B),分别用水、两种合成表面活性剂——十二烷基硫酸钠(SDS)和非离子表面活性剂TritonX-100(TX100)以及一种天然表面活性剂溶液——处在临界胶束浓度(CMC)的腐植酸(HA)进行土壤淋洗后,比较它们的去除率。土壤淋洗前后均采用了超声波萃取法和索氏萃取法对污染物进行提取。土壤A富含多环芳烃(PAH),而土壤B含有大量的噻吩。在分析细质地土壤B时,超声波萃取法更为有效;而对于粗质地土壤A来说,索氏萃取法也同样有效。水不能彻底清除两种土壤中的污染物,而所有有机表面活性剂则都表现出相似的去除率(高达90%)。由于天然腐植酸溶液与合成表面活性剂相比具有增强微生物活性的功能,这样有利于淋洗土壤中污染物的进一步自然降解。因此,对于严重污染土壤的淋洗来说,HA应该是一个更好的选择。 | Pellegrino Conte Anna Agretto Riccardo Spaccini Alessandro Piccolo 韩毅 赵红艳 | 2008 | 腐植酸2008，，3： | 1 |
| 10 | Soil remediation: humic acids as natural surfactants in the washings of highly contaminated soils显示文摘 | Pellegrino Conte Anna Agretto Riccardo Spaccini Alessandro Piccolo | 2004 | Environmental Pollution2004，，3： | 1 |
| 11 | The role of HIPEC in the treatment of peritoneal carcinomatosis from gastric cancer: between lights and shadows显示文摘 | Maria Di Vita Alessandro Cappellani Gaetano Piccolo Antonio Zanghì Andrea Cavallaro Giulio Bertola Antonio Bolognese Gaetano Facchini Carmine D’Aniello Raffaele Di Francia Francesco Cardì Massimiliano Berretta | 2015 | Anti-Cancer Drugs2015，，2： | 1 |
| 12 | Enhanced Molecular Dimension of a Humic Acid Induced by PHotooxidation Catalyzed by Biomimetic Metalporp Hyrins显示文摘 | Daniela Smejkalova Alessandro Piccolo | 2005 | Biomacromolecules2005，，6： | 1 |
| 13 | 土壤修复:腐植酸作为天然表面活性剂淋洗高度污染土壤显示文摘修复位于意大利北部的前ACNA化工厂(萨沃纳)附近的高污染场地是意大利的当务之急。文章旨在寻找环境友好型的新技术修复ACNA污染场地的土壤。从ACNA场地获取质地、有机污染物数量和类型都不同的2种土壤样本A和B,采用多种洗涤剂对2种土壤样本进行淋洗,比较这些洗涤剂去除土壤污染物的效率。 | Pellegrino Conte Anna Agretto Riccardo Spaccini Alessandro Piccolo | 2016 | 腐植酸2016，，1： | 0 |
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