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| 1 | Achieving the best bowel preparation for colonoscopy显示文摘Bowel preparation is a core issue in colonoscopy,as it is closely related to the quality of the procedure.Patients often find that bowel preparation is the most unpleasant part of the examination.It is widely accepted that the quality of cleansing must be excellent to facilitate detecting neoplastic lesions.In spite of its importance and potential implications,until recently,bowel preparation has not been the subject of much study.The most commonly used agents are high-volume polyethylene glycol(PEG)electrolyte solution and sodium phosphate.There has been some confusion,even in published meta-analyses,regarding which of the two agents provides better cleansing.It is clear now that both PEG and sodium phosphate are effectivewhen administered with proper timing.Consequently,the timing of administration is recognized as one of the central factors to the quality of cleansing.The bowel preparation agent should be administered,at least in part,a few hours in advance of the colonoscopy.Several low volume agents are available,and either new or modified schedules with PEG that usually improve tolerance.Certain adjuvants can also be used to reduce the volume of PEG,or to improve the efficacy of other agents.Other factors apart from the choice of agent can improve the quality of bowel cleansing.For instance,the effect of diet before colonoscopy has not been completely clarified,but an exclusively liquid diet is probably not required,and a low-fiber diet may be preferable because it improves patient satisfaction and the quality of the procedure.Some patients,such as diabetics and persons with heart or kidney disease,require modified procedures and certain precautions.Bowel preparation for pediatric patients is also reviewed here.In such cases,PEG remains the most commonly used agent.As detecting neoplasia is not the main objective with these patients,less intensive preparation may suffice.Special considerations must be made for patients with inflammatory bowel disease,including safety and diagnostic issues,so that the most adequate agent is chosen.Identifying neoplasia is one of the main objectives of colonoscopy with these patients,and the target lesions are often almost invisible with white light endoscopy.Therefore excellent quality preparation is required to find these lesions and to apply advanced methods such as chromoendoscopy.Bowel preparation for patients with lower gastrointestinal bleeding represents a challenge,and the strategies available are also reviewed here. | Adolfo Parra-Blanco Alex Ruiz Manuel Alvarez-Lobos Ana Amorós Juan Cristóbal Gana Patricio Ibáez Akiko Ono Takahiro Fujii | 2014 | World Journal of Gastroenterology2014，20，47： | 37 |
| 2 | Outcome in obscure gastrointestinal bleeding after capsule endoscopy显示文摘AIM: To investigate the clinical impact of capsule endoscopy(CE) after an obscure gastrointestinal bleeding(OGIB) episode, focusing on diagnostic work-up, followup and predictive factors of rebleeding. METHODS: Patients who were referred to Hospital del Mar(Barcelona, Spain) between 2007 and 2009 for OGIB who underwent a CE were retrospectively analyzed. Demographic data, current treatment with non-steroid antiinflammtory drugs or anticoagulant drugs, hemoglobin levels, transfusion requirements, previous diagnostic tests for the bleeding episode, as well as CE findings(significant or non-significant), work-up and patient out-comes were analyzed from electronic charts. Variables were compared by χ 2 analysis and Student t test. Risk factors of rebleeding were assessed by Log-rank test, Kaplan-Meier curves and Cox regression model. RESULTS: There were 105 patients [45.7% women, median age of 72 years old(interquartile range 56-79)] and a median follow-up of 326 d(interquartile range 123-641) included in this study. The overall diagnostic yield of CE was 58.1%(55.2% and 63.2%, for patients with occult OGIB and overt OGIB, respectively). In 73 patients(69.5%), OGIB was resolved. Multivariate analysis showed that hemoglobin levels lower than 8 g/dL at diagnosis [hazard ratios(HR) = 2.7, 95%CI: 1.9-6.3], patients aged 70 years and above(HR = 2.1, 95%CI: 1.2-6.1) and significant findings in CE(HR = 2.4, 95%CI: 1.1-5.8) were independent predictors of rebleeding. CONCLUSION: One third of the patients presented with rebleeding after CE; risk factors were hemoglobin levels < 8 g/dL, age ≥ 70 years or the presence of significant lesions. | Alex Caas-Ventura Lucia Márque Xavier Bessa Josep Maria DedeuDepartment of Gastroenterology Hospital del Mar Research Institute Pompeu Fabra University Marc Puigvehí Sílvia Delgado-Aros Ines Ana Ibáez Agustin Seoane Luis Barranco Felipe Bory Montserrat Andreu Begoa González-Suárez | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 4 |
| 3 | Urban Spatial Structure 显示文摘 | Alex Anas Richard Arnott Kenneth A Small | 1998 | Journal of Econometrics1998，，： | 1 |
| 4 | Urban spatial structure 显示文摘 | Alex Anas Richard Amott Kenneth A | 1998 | Journal of Economic Literature1998，，3： | 1 |
| 5 | Urban spatial structure 显示文摘 | Anas Alex Richard Amott | 1998 | Journal of Economics Literature1998，34，： | 1 |
| 6 | Bone marrow stromal cells and resorbable collagen guidance tubes enhance sciatic nerve regeneration in mice显示文摘 | Fátima Rosalina Pereira Lopes Lenira Camargo de Moura Campos José Dias Corrêa Alex Balduino Silvano Lora Francesco Langone Radovan Borojevic Ana Maria Blanco Martinez | 2005 | Experimental Neurology2005，，2： | 1 |
| 7 | Carbon Sequestration in a Large Hydroelectric Reservoir: An Integrative Seismic Approach显示文摘 | Raquel Mendon?a Sarian Kosten Sebastian Sobek Jonathan J. Cole Alex C. Bastos Ana Luiza Albuquerque Simone J. Cardoso Fábio Roland | 2014 | Ecosystems2014，，3： | 1 |
| 8 | Lugar de la cirugía local en el adenocarcinoma de recto T 2 N 0 M 0显示文摘 | Xavier Serra Aracil Jordi Bombardó Juncá Laura Mora López Manuel Alcantara Moral Isidro Ayguavives Garnica Ana Darnell Marti Alex Casalots Casado Carles Pericay Pijaume Rafael Campo Fernández de Los Ríos Salvador Navarro Soto | 2008 | Cirugia Espanola2008，，2： | 1 |
| 9 | Detection of QTL affecting fatty acid composition in the pig显示文摘 | Alex Clop Cristina Ovilo Miguel Perez-Enciso Albert Cercos Anna Tomas Ana Fernandez Agustina Coll Josep M. Folch Carmen Barragan Isabel Diaz Maria A. Oliver Luis Varona Luis Silio Armand Sanchez Jose L. Noguera | 2003 | Mammalian Genome2003，，9： | 1 |
| 10 | Urban spatial structure 显示文摘 | Alex Anas Richard Arnott Kenneth A Small | 1998 | Journal of Economic Literature1998，36，3： | 1 |
| 11 | Dynamic forecasting of travel demand, residential location and land development显示文摘 | Alex Anas Liang Shyong Duann | 1985 | Papers of the Regional Science Association1985，，1： | 1 |
| 12 | A Phase I/II Study of Erlotinib in Combination with the Anti-Insulin-Like Growth Factor-1 Receptor Monoclonal Antibody IMC-A12 (Cixutumumab) in Patients with Advanced Non-small Cell Lung Cancer显示文摘 | Andrew Weickhardt Robert Doebele Ana Oton Janice Lettieri DeLee Maxson Michele Reynolds Amy Brown Mary K. Jackson Grace Dy Araba Adjei Gerald Fetterly Xian Lu Wilbur Franklin Marileila Varella-Garcia Fred R. Hirsch Murry W. Wynes Hagop Youssoufian Alex Ad | 2012 | Journal of Thoracic Oncology2012，，2： | 1 |
| 13 | Viral genotype correlates with distinct liver gene transcription signatures in chronic hepatitis C virus infection显示文摘 | Mark W. Robinson Elihu Aranday‐Cortes Derek Gatherer Rachael Swann Jolanda M. P. Liefhebber Ana Da Silva Filipe Alex Sigruener Stephen T. Barclay Peter R. Mills Arvind H. Patel John McLauchlan | 2015 | Liver Int2015，，10： | 1 |
| 14 | The estimation of multinomial logit models of joint location and travel choice from aggregated data显示文摘 | Anas Alex | 1981 | Journal of Regional Science1981，21，2： | 1 |
| 15 | Nat Methods:利用CRISPR-Cas9组合筛选发现癌症弱点显示文摘导致癌症的基因突变也会削弱癌细胞,从而使得人们有机会开发选择性地杀死它们同时不影响正常细胞的药物。这一概念被称作”合成致死性(synthetic lethality)”,这是因为这些药物仅对发生突变的(或者说合成的)细胞是致命性的。在一项新的研究中。来自美国加州大学圣地亚哥分校、加州大学旧金山分校、斯坦福大学和癌细胞图谱项目(Cancer Cell Map Initiative)的研究人员开发出一种新的方法来寻找合成致死性的基因组合。 | John Paul Shen, Ana Bojorquez-Gomez, Katherine Licon, Kristin Klepper, Daniel Pekin, Alex N Beckett, Kyle Salinas Sanchez, Jason F Kreisberg, Trey Ideker John Paul Shen, Trey Ideker, Prashant Mali John Paul Shen, Dongxin Zhao, Dan Du, Assen Roguev, Jason F Kreisberg, Nevan Krogan, Lei Qi, Trey Ideker, Prashant Mali Dongxin Zhao, Chih-Chung Kuo, Prashant Mali Roman Sasik, Amanda Birmingham, Aaron N Chang, Trey Ideker Jens Luebeck, Alex Thomas Alex Thomas, Chih-Chung Kuo, Nathan E Lewis Dan Du Assen Roguev, Nevan Krogan Nathan E Lewis Lei Qi | 2017 | 现代生物医学进展2017，17，17： | 1 |
| 16 | An Unified Theory of Consumption Travel and Trip Chaining显示文摘 | Alex Anas | 2007 | Journal of Urban Economics2007，17，62： | 1 |
| 17 | When are urban growth bound- aries not second- best policies to congestion tolls? 显示文摘 | Alex Anas and Hyok - Joo Rhee | 2007 | Journal of Urban Economics2007，，61： | 1 |
| 18 | Detection of QTL affecting fatty acid composition in the pig显示文摘 | Alex Clop Cristina Ovilo Miguel Perez-Enciso Albert Cercos Anna Tomas Ana Fernandez Agustina Coll Josep M. Folch Carmen Barragan Isabel Diaz Maria A. Oliver Luis Varona Luis Silio Armand Sanchez Jose L. Noguera | 2003 | Mammalian Genome2003，，9： | 1 |
| 19 | Effect of different resistance exercise repetition velocities on excess post-exercise oxygen consumption and energetic expenditure显示文摘 | Ana Cristiana Barreto M Alex Souto Maior P Pedro Menezesl M | 2010 | International SportMed Journal2010，11，1： | 1 |
| 20 | Taste Heterogeneity and Urban Spatial Structure: The Logit Model and Monocentric Theory Reconciled显示文摘 | Alex | 1990 | Journal of Urban Economics1990，28，： | 1 |
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