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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 3 | Thymidinephosphorylase expression in patients with chronic viral hepati-tis显示文摘 | Konstantinos M Alexandra G Efthimios S | 2005 | Rom J Gastroenterol2005，14，1： | 1 |
| 4 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 5 | Emerging infectious diseases:public health issues for the 21st century显示文摘 | Alexandra M L Jeffrey J S | 1999 | Science1999，284，： | 1 |
| 6 | Substrate effect on bacterial communities from constructed wetlands planted with Typha latifolia treating industrial stewater显示文摘 | Cristina S C C Anouk F D Alexandra M | 2009 | Ecological Engineering2009，35，： | 1 |
| 7 | MONOPTEROS controls embryonic root initiation by regulating a mobile transcrip- tion factor显示文摘 | ALEXANDRA S BARBARA M GERD J | 2010 | Nature2010，464，7290： | 1 |
| 8 | The glycemic index:methodology and clinical implication显示文摘 | WOLEVER T M S DAVID J A ALEXANDRA L J | 1991 | Am J Clin Nutr1991，54，： | 1 |
| 9 | Vertical breast extensionduring treadmill running显示文摘 | Joanna S Jennifer W Alexandra M | 2011 | Portuguese Journal of Sport Sciences2011，11，2： | 1 |
| 10 | A Review of Operations Research in Mine Planning显示文摘 | Newman Alexandra M Rubio Enrique Caro Rodrigo Weintraub Andrés Eurek Kelly | 2010 | Interfaces2010，，： | 1 |
| 11 | Induction of metallothionein in the liver of carbon tetrachloride intoxicated rats:an immunohistochemical study显示文摘 | Stamatios E T Alexandra P M Spyridon D S | 2001 | Toxicology2001，161，12： | 1 |
| 12 | Kinetic determination of trace amounts of Cu (Ⅱ) in water based on its catalytic effect on the reation of mercaptosuccinic acid and Cr (Ⅵ)显示文摘 | Alexandra A R loan S B Dana D M | 2002 | Mierochim Acta2002，140，： | 1 |
| 13 | Characteriza- tion of poly( vinyl alcohol )/poly( ethylene glycol) hydrogels and PVA-derived hybrids by small-angle X-ray scattering and FTIR spectroscopy显示文摘 | Herrmn S M Rodrigo L O Alexandra A P M | 2004 | Polymer2004，45，： | 1 |
| 14 | Recombinant sucrose phosphorylase from Leuconostoc mesenteroides:characterization,kinetic studies of transglucosylation,and application of immobilized enzyme for production of D-glucose 1-phosphate显示文摘 | Christiane G Alexandra S Alphonse M | 2007 | Journal of Biotechnology2007，129，1： | 1 |
| 15 | Cancer genetic counseling:Communication and counselees' post-visit satisfaction,cognitions,anxiety,and needs fulfillment显示文摘 | Pieterse A Alexandra M Dulmen S | 2007 | Journal of Genetic Counseling2007，16，1： | 1 |
| 16 | Substrate effect on bacterial communities from constructed wetlands planted with Typha latifolia treating industrial wastewater显示文摘 | Cristina S C C Anouk F D Alexandra M | 2009 | Ecological Engineering2009，35，： | 1 |
| 17 | Emerging infectious diseases:public health issues for the 21st century显示文摘 | Alexandra M L Jeffrey J S | 1999 | Science1999，284，： | 1 |
| 18 | Substrate effect on bacterial communities from constructed wetlands planted with Typha latifolia treating industrial wastewater显示文摘 | CRISTINA S C C ANOUK F D ALEXANDRA M | 2009 | Ecological Engineering2009，35，： | 1 |
| 19 | Expression of lnterleukin - 18 in Human Atherosclerotic Plaques and Relation to Plaque Instability显示文摘 | Ziad M Anne C Alexandra S | 2001 | Circulation2001，104，： | 1 |
| 20 | Double muscling in cattle due to mutation in the myostation gene显示文摘 | Alexandra C M and Lee S J | 1997 | Proc Natl Acad Sci USA1997，94，12： | 1 |
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