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| 1 | Diagnostic and prognostic potential of tissue and circulating long non-coding RNAs in colorectal tumors显示文摘Long non-coding RNAs(lncRNAs)are members of the non-protein coding RNA family longer than 200 nucleotides.They participate in the regulation of gene and protein expression influencing apoptosis,cell proliferation and immune responses,thereby playing a critical role in the development and progression of various cancers,including colorectal cancer(CRC).As CRC is one of the most frequently diagnosed malignancies worldwide with high mortality,its screening and early detection are crucial,so the identification of disease-specific biomarkers is necessary.LncRNAs are promising candidates as they are involved in carcinogenesis,and certain lncRNAs(e.g.,CCAT1,CRNDE,CRCAL1-4)show altered expression in adenomas,making them potential early diagnostic markers.In addition to being useful as tissue-specific markers,analysis of circulating lncRNAs(e.g.,CCAT1,CCAT2,BLACAT1,CRNDE,NEAT1,UCA1)in peripheral blood offers the possibility to establish minimally invasive,liquid biopsy-based diagnostic tests.This review article aims to describe the origin,structure,and functions of lncRNAs and to discuss their contribution to CRC development.Moreover,our purpose is to summarise lncRNAs showing altered expression levels during tumor formation in both colon tissue and plasma/serum samples and to demonstrate their clinical implications as diagnostic or prognostic biomarkers for CRC. | Orsolya Galamb Barbara K Barták Alexandra Kalmár Zsófia B Nagy Krisztina A Szigeti Zsolt Tulassay Peter Igaz Béla Molnár | 2019 | World Journal of Gastroenterology2019，25，34： | 18 |
| 2 | Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: Clinico-pathogenic aspects显示文摘Toll-like receptors (TLRs) recognize specific motifs which are frequently present in bacteria, fungi, prokaryotes and viruses. Amongst TLRs, TLR9 can be activated by such bacterial or viral DNA fragments, immunoglobulin-DNA complexes or synthetic oligonucleotides, which all contain unmethylated cytosineguanine nucleotide sequences (CpGs). Emerging data indicate that TLR9 signaling has a role in, and may influence, colorectal carcinogenesis and colonic inflammation. CpGs are classified into three groups according to their influence on both the antigen-specific humoraland cellular immunity, and the production of type 1 interferons and proinflammatory cytokines. TLR9 activation via CpGs may serve as a new therapeutic target for several cancerous and various inflammatory conditions. Due to its probable anti-cancer effects, the application possibilities of TLR9-signaling modulation may be extremely diverse even in colorectal tumors. In this review we aimed to summarize the current knowledge about TLR-signaling in the pathogenesis and therapy of inflammatory bowel diseases and colorectal cancer. Due to the species-specific differences in TLR9 expression, however, one must be careful in translating the animal model data into the human system, because of the differences between CpG-oligodeoxynucleotide-responsive cells. TLR9 agonist DNA-based immunomodulatory sequences could also represent a promising therapeutic alternative in systemic inflammatory conditions and chronic colonic inflammations as their side effects are not significant. | István Fri Ferenc Sipos Tiana M Germann Alexandra Kalmár Zsolt Tulassay Béla Molnár Gyrgyi Mzes | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 3 | Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma显示文摘AIM To analyze colorectal carcinogenesis and age-related DNA methylation alterations of gene sequences associated with epigenetic clock CpG sites. METHODS In silico DNA methylation analysis of 353 epigenetic clock Cp G sites published by Steve Horvath was performed using methylation array data for a set of 123 colonic tissue samples [64 colorectal cancer(CRC), 42 adenoma, 17 normal; GEO accession number: GSE48684]. Among the differentially methylated agerelated genes, secreted frizzled related protein 1(SFRP1) promoter methylation was further investigated in colonic tissue from 8 healthy adults, 19 normal children, 20 adenoma and 8 CRC patients using bisulfite-specific PCR followed by methylation-specific high resolution melting(MS-HRM) analysis. m RNA expression of age-related 'epigenetic clock' genes was studied using Affymetrix HGU133 Plus2.0 whole transcriptome data of 153 colonic biopsy samples(49 healthy adult, 49 adenoma, 49 CRC, 6 healthy children)(GEO accession numbers: GSE37364, GSE10714, GSE4183, GSE37267). Whole promoter methylation analysis of genes showing inverse DNA methylationgene expression data was performed on 30 colonic samples using methyl capture sequencing.RESULTS Fifty-seven age-related Cp G sites including hypermethylated PPP1R16 B, SFRP1, SYNE1 and hypomethylated MGP, PIPOX were differentially methylated between CRC and normal tissues(P < 0.05, ?β≥ 10%). In the adenoma vs normal comparison, 70 CpG sites differed significantly, including hypermethylated DKK3, SDC2, SFRP1, SYNE1 and hypomethylated CEMIP, SPATA18(P < 0.05, ?β≥ 10%). In MS-HRM analysis, the SFRP1 promoter region was significantly hypermethylated in CRC(55.0% ± 8.4 %) and adenoma tissue samples(49.9% ± 18.1%) compared to normal adult(5.2% ± 2.7%) and young(2.2% ± 0.7%) colonic tissue(P < 0.0001). DNA methylation of SFRP1 promoter was slightly, but significantly increased in healthy adults compared to normal young samples(P < 0.02). This correlated with significantly increased SFRP1 m RNA levels in children compared to normal adult samples(P < 0.05). In CRC tissue the mR NA expression of 117 agerelated genes were changed, while in adenoma samples 102 genes showed differential expression compared with normal colonic tissue(P < 0.05, logF C > 0.5). The change of expression for several genes including SYNE1, CLEC3 B, LTBP3 and SFRP1, followed the same pattern in aging and carcinogenesis, though not for all genes(e.g., MGP). CONCLUSION Several age-related DNA methylation alterations can be observed during CRC development and progression affecting the m RNA expression of certain CRC- and adenoma-related key control genes. | Orsolya Galamb Alexandra Kalmár Barbara Kinga Barták árpád V Patai Katalin Leiszter Bálint Péterfia Barnabás Wichmann Gábor Valcz Gábor Veres Zsolt Tulassay Béla Molnár | 2016 | World Journal of Gastroenterology2016，22，47： | 7 |
| 4 | An interactive genetic algorithm-based framework for handling qualitative criteria in design optimization显示文摘 | Alexandra M B Jeremy R Ashutosh T | 2007 | Computers in Industry2007，58，： | 1 |
| 5 | FoxMl is required for execution of the mitotic programme and chromosome stability 显示文摘 | Jamila L Matthijs R H Alexandra B | 2005 | Cell Biology2005，7，2： | 1 |
| 6 | Multiple regression analysis 显示文摘 | KOROL R M CANHAN P B ALEXANDRA L R | 2005 | Biophotonics International2005，12，8： | 1 |
| 7 | Multiple regression analysis 显示文摘 | Korol Renee M Canhan Peter B Lucas Alexandra R | 2005 | Biophotonies International2005，12，8： | 1 |
| 8 | On delay-dependent stability for a class of nonlinear stochastic systems with multiple state delays显示文摘 | Michael B Alexandra R | 2008 | Nonlinear Analysis:Theory Methods&Applications2008，68，8： | 1 |
| 9 | Development and evaluation in vlvo of a long-term dilivery system for vapreotide, a somatostain analogue显示文摘 | ALEXANDRA R W KAMEL B YVES D Z | 1998 | Controlled rel1998，52，： | 1 |
| 10 | Arterial percutaneous angioplasty in upper limbs with vascular access devices for haemodialysis 显示文摘 | Alexandra G Alain R Bernard B | 2002 | Nephrol Dial Transplant2002，17，5： | 1 |
| 11 | Kinetic determination of trace amounts of Cu (Ⅱ) in water based on its catalytic effect on the reation of mercaptosuccinic acid and Cr (Ⅵ)显示文摘 | Alexandra A R loan S B Dana D M | 2002 | Mierochim Acta2002，140，： | 1 |
| 12 | Electrokinetic remediation of organochlorines in soil: Enhancement techniques and integration with other remediation technologies显示文摘 | Helena I G Celia D F Alexandra B R | 2012 | Chemosphere2012，87，10： | 1 |
| 13 | Continuous analog of the Gauss-Newton method 显示文摘 | RUBEN G A ALEXANDER G R ALEXANDRA B S | 1999 | Mathematical Models and Methods in Applied Sciences1999，9，3： | 1 |
| 14 | Role of the cytoplasmic tail of pseudorabies virus glycoprotein E in virion formation 显示文摘 | Alexandra R B Barbara G K Harald G | 2000 | J Virol2000，74，9： | 1 |
| 15 | Barley HVA 1 gene confers salt tolerance in R3 transgenic oat显示文摘 | Hesham F O Callista B R Alexandra N K | 2005 | Crop Science2005，45，6： | 1 |
| 16 | Agility and Perturbation Training Techniques in Exercise Therapy for Reducing Pain and Improving Function in People With Knee Osteoarthritis: A Randomized Clinical Trial显示文摘 | Fitzgerald G Kelley Piva Sara R Gil Alexandra B Wisniewski Stephen R Oddis Chester V Irrgang James J | 2011 | Physical Therapy2011，，4： | 1 |
| 17 | Gas permeation parameters of mixed matrix membranes based on the polymer of intrinsic microporosity PIM - 1 and the zeolitic imidazolate framework ZIF - 8 显示文摘 | Alexandra F B Martin P A Christopher R M | 2013 | Journal of Membrane Science2013，427，1： | 1 |
| 18 | A novel peptide sansalvamide analogue inhibits pancreatic cancer cell growth through G0/G1 cell-cycle arrest 显示文摘 | Michael B U Ben M Xian-Zhong D Alexandra B R | 2006 | Biochemical and Biophysical Research Communications2006，340，4： | 1 |
| 19 | Carbon dioxide in montmorillonite clay hydrates: Thermodynamics, structure, and transport from molec- ular simulation 显示文摘 | Alexandra B Benjamin R | 2001 | The Journal of Chemical Physics C2001，114，14： | 1 |
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